Cited by 211Menopause: Health Impacts and TreatmentsSkin Protection and AgingEstrogen and related hormone effects

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

Skin Aging and Menopause: Implications for Treatment

Raine-Fenning, Nicholas J, Brincat, Mark P, Muscat-Baron, Yves·2003·American Journal of Clinical Dermatology

DOI 10.2165/00128071-200304060-00001

Open this paper in CoChat — free account

Abstract

The skin is one of the largest organs of the body, which is significantly affected by the aging process and menopause. The significant changes sustained by the skin during the menopause are due to the effect sustained on the skin's individual components. The estrogen receptor has been detected on the cellular components of the skin. Accordingly, dermal cellular metabolism is influenced by the hypoestrogenoemic state of menopause leading to changes in the collagen content, alterations in the concentration of glycoaminoglycans and most importantly the water content. Consequently changes in these basic components leads to an alteration in function compatible with skin aging. Changes in the skin collagen leads to diminished elasticity and skin strength. Collagen content may be measured by various methods such as direct skin biopsy, skin blister assessment for collagen markers and skin thickness measurement. All these variables indicate a reduction in collagen content following menopause. This may be reversed with the administration of estrogen given both topically and systemically.A reduction in hydrophilic glycoaminglycans leads to a direct reduction in water content, which influences the skin turgor. These effects on glycoaminoglycans, due to the hypoestrogenia, have been clearly shown in animal studies and appeared to be rapidly reversed with the application of estrogens. The sum total of these basic effects on the skin leads to wrinkles, the skin condition typifying skin aging.Structures resident in the skin are likewise influenced by menopause. Changes to the cutaneous vascular reactivity are noted following menopause. Capillary blood flow velocity decreases significantly in postmenopausal women. Postmenopausal flushing is due to profound vasodilatation in the dermal papillae. Hair growth is also influenced by the hormonal milieu and consequently hair loss has been associated with the beginning of menopause. Treatments administered for menopause, in particular hormone replacement therapy, appear to alter its effects on the basic components of the skin as well as the more complex structures residing in the skin, consequently retarding the skin aging process.

Integrity signals

Registry

Crossref · 10.2165/00128071-200304060-00001

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Estrogen production and action
Nelson, L. R., & Bulun, S. E. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.117432 · Cited by 834
The influence of age and sex on skin thickness, skin collagen and density
SHUSTER, S., BLACK, M. M., & McVITIE, E. (1975) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1975.tb05113.x · Cited by 640
Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels
Ashcroft, G. S., Dodsworth, J., Boxtel, E. V., Tarnuzzer, R. W., Horan, M. A., Schultz, G. S., & Ferguson, M. W. J. (1997) · Nature Medicine · doi:10.1038/nm1197-1209 · Cited by 573
Topical Estrogen Accelerates Cutaneous Wound Healing in Aged Humans Associated with an Altered Inflammatory Response
Ashcroft, G. S., Greenwell-Wild, T., Horan, M. A., Wahl, S. M., & Ferguson, M. W. J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65217-0 · Cited by 420
Postmenopausal frontal fibrosing alopecia: A frontal variant of lichen planopilaris
Kossard, S., Lee, M., & Wilkinson, B. (1997) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(97)70326-8 · Cited by 388
Skin thickness measurement by pulsed ultrasound: its reproducibility, validation and variability
Tan, C. Y., Statham, B. N., Marks, R., & Payne, P. A. (1982) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1982.tb14702.x · Cited by 346
Long‐term effects of the menopause and sex hormones on skin thickness
Brincat, M., Moniz, C., Studd, J. W. W., Darby, A. J., Magos, A. L., EMBUREY, G., & Versi, E. (1985) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01091.x · Cited by 259
Self-citation
The effect of pregnancy and labor on the human cervix: Changes in collagen, glycoproteins, and glycosaminoglycans
Danforth, D. N., Veis, A., Breen, M., WEINSTEIN, H. G., Buckingham, J. C., & Manalo, P. B. (1974) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(74)90608-5 · Cited by 235
Estrogen and Skin
Shah, M., & Maïbach, H. I. (2001) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200102030-00003 · Cited by 220
A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness
Maheux, R., Naud, F., Rioux, M., Grenier, R., Lemay, A., Guy, J., & Langevin, M. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(94)70242-x · Cited by 219

Show all 66 references

Research works printed but not linked: 9

Raine-Fenning, 2001, Contemp Clin Gynecol Obstets, 1, 7
MacLean, 1990, J Reprod Med, 35, 1015
Albright, 1940, Trans Assoc Am Physicians, 55, 298
Rauramo, 1969, Z Haut Geschlechtskr, 44, 463
Tan, 1982, Br J Dermatol, 106, 657
Holland, 1994, Obstet Gynecol, 83, 180
Grosman, 1971, Acta Pharmacol Toxicol, 30, 458
Lim, 1999, J Clin Endocrinol Metab, 84, 4159
Brincat, 1987, Obstet Gynaecol, 70, 840

Sorted by citations

Intrinsic and extrinsic factors in skin ageing: a review
Farage, M. A., Miller, K. W., Elsner, P., & Maibach, H. I. (2008) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2007.00415.x · Cited by 950
Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369
Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin
Hall, G. K., & Phillips, T. J. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.08.039 · Cited by 337
Regulatory roles of sex hormones in cutaneous biology and immunology
Kanda, N., & Watanabe, S. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2004.10.011 · Cited by 257
Biology of estrogens in skin: implications for skin aging
Verdier‐Sévrain, S., Bonté, F., & Gilchrest, B. A. (2005) · Experimental Dermatology · doi:10.1111/j.1600-0625.2005.00377.x · Cited by 228
Intracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217
The role of estrogen in cutaneous ageing and repair
Wilkinson, H. N., & Hardman, M. J. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.06.026 · Cited by 162
Estrogen and Skin
Shu, Y., & Maïbach, H. I. (2011) · American Journal of Clinical Dermatology · doi:10.2165/11589180-000000000-00000 · Cited by 149
Skin connective tissue and ageing
Calleja-Agius, J., Brincat, M., & Borg, M. (2013) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2013.06.004 · Cited by 131
Self-citation
Sex hormones and mucosal wound healing
Engeland, C. G., Sabzehei, B., & Marucha, P. T. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.12.001 · Cited by 125
Age‐specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro
Makrantonaki, E., Adjaye, J., Herwig, R., Brink, T. C., Groth, D., Hultschig, C., Lehrach, H. R., & Zouboulis, C. C. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00223.x · Cited by 109
Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena
Trojahn, C., Dobos, G., Lichterfeld, A., Blume‐Peytavi, U., & Kottner, J. (2015) · BioMed Research International · doi:10.1155/2015/318586 · Cited by 99
An experimental study of the mouse skin behaviour: Damage and inelastic aspects
Muñoz, M. J., Bea, J. A., Matas, J. F. R., Ochoa, I., Grasa, J., del Palomar, A. P., Zaragoza, P., Osta, R., & Doblaré, M. (2007) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2007.07.013 · Cited by 96
Explainable AI reveals changes in skin microbiome composition linked to phenotypic differences
Carrieri, A. P., Haiminen, N., Maudsley-Barton, S., Gardiner, L., Murphy, B., Mayes, A. E., Paterson, S., Grimshaw, S. G., Winn, M., Shand, C., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83922-6 · Cited by 98
The role of cytokines in skin aging
Borg, M., Brincat, S. D., Camilleri, G., Schembri-Wismayer, P., Brincat, M., & Calleja‐Agius, J. (2013) · Climacteric · doi:10.3109/13697137.2013.802303 · Cited by 95
Self-citation
Estrogen-deficient skin: The role of topical therapy
Rzepecki, A. K., Murase, J. E., Juran, R., Fabi, S. G., & McLellan, B. N. (2019) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2019.01.001 · Cited by 100
Induction of Collagen by Estradiol
Rittié, L., Kang, S., Voorhees, J. J., & Fisher, G. J. (2008) · Archives of Dermatology · doi:10.1001/archderm.144.9.1129 · Cited by 89
The skin as a mirror of the aging process in the human organism – State of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2)
Makrantonaki, E., & Zouboulis, C. C. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.07.002 · Cited by 87
Menopause and dry eye. A possible relationship
Versura, P., & Campos, E. C. (2005) · Gynecological Endocrinology · doi:10.1080/09513590400027257 · Cited by 87
Estrogens and phytoestrogens in body functions
Ceccarelli, I., Bioletti, L., Peparini, S., Solomita, E., Ricci, C., Casini, I., Miceli, E., & Aloisi, A. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.007 · Cited by 86
A prospective, randomized, double-blind, placebo-controlled study on the influence of a hormone replacement therapy on skin aging in postmenopausal women
Sator, P. G., Sator, M. O., Schmidt, J. B., Nahavandi, H., Radaković, S., Huber, J. C., & Hönigsmann, H. (2007) · Climacteric · doi:10.1080/13697130701444073 · Cited by 81
Estrogen deficiency in the menopause and the role of hormone therapy: integrating the findings of basic science research with clinical trials
Yang, J. L., Hodara, E., Sriprasert, I., Shoupe, D., & Stanczyk, F. Z. (2024) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000002407 · Cited by 80
Perioral Wrinkles: Histologic Differences Between Men and Women
Paes, E. C., Teepen, H. L. J. M., Koop, W. A., & Kon, M. (2009) · Aesthetic Surgery Journal · doi:10.1016/j.asj.2009.08.018 · Cited by 81
A Role for the Androgen Receptor in Collagen Content of the Skin
Markova, M., Zeskand, J., McEntee, B. J., Rothstein, J. L., Jiménez, S. A., & Siracusa, L. D. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23494.x · Cited by 77
Skin steroidogenesis in health and disease
Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9390-z · Cited by 76
Skin aging and sex hormones in women – clinical perspectives for intervention by hormone replacement therapy
Sator, P.-G., Schmidt, J. B., Rabe, T., & Zouboulis, C. C. (2004) · Experimental Dermatology · doi:10.1111/j.1600-0625.2004.00259.x · Cited by 74
Does hormone therapy improve age-related skin changes in postmenopausal women?
Phillips, T. J., Symons, J. P., & Menon, S. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.05.009 · Cited by 71
Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production
Fede, C., Pirri, C., Fan, C., Albertin, G., Porzionato, A., Macchi, V., De, R., & Stecco, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223195 · Cited by 66
Aldosterone and Mineralocorticoid Receptor Antagonists Modulate Elastin and Collagen Deposition in Human Skin
Mitts, T. F., Bunda, S., Wang, Y., & Hinek, A. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.155 · Cited by 66
Sex steroid synthesis in human skin in situ: the roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin
Inoue, T., Miki, Y., Abe, K., Hatori, M., Hosaka, M., Kariya, Y., Kakuo, S., Fujimura, T., Hachiya, A., Honma, S., et al. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.05.005 · Cited by 62
Menopausal symptoms: Do life events predict severity of symptoms in peri- and post-menopause?
Pimenta, F., Leal, I. M. P., Marôco, J. P., & Ramos, C. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.04.006 · Cited by 62
Long-term effects of hormone therapy on skin rigidity and wrinkles
Wolff, E. F., Narayan, D., & Taylor, H. S. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.12.062 · Cited by 61
Estrogens, estrogen receptors and melanoma
GIORGI, V. D., Gori, A., Grazzini, M., Rossari, S., Scarfì, F., Corciova, S., Verdelli, A., Lotti, T., & Massi, D. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.11.42 · Cited by 60
Royal Jelly—A Traditional and Natural Remedy for Postmenopausal Symptoms and Aging-Related Pathologies
Bălan, A., Moga, M., Dima, L., Toma, S. I., Neculau, A. E., & Anastasiu, C. V. (2020) · Molecules · doi:10.3390/molecules25143291 · Cited by 60
Effects of Isoflavones on the Skin of Postmenopausal Women: A Pilot Study
Neto, A. C. A., Haidar, M. A., Simões, R. S., Simões, M. D. J., Soares, J. M., & Baracat, E. C. (2009) · Clinics · doi:10.1590/s1807-59322009000600004 · Cited by 58
Female-specific pruritus from childhood to postmenopause: clinical features, hormonal factors, and treatment considerations
Rimoin, L. P., Kwatra, S. G., & Yosipovitch, G. (2013) · Dermatologic Therapy · doi:10.1111/dth.12034 · Cited by 58
Cysteine‐rich protein 61 (CCN1) mediates replicative senescence‐associated aberrant collagen homeostasis in human skin fibroblasts
Quan, T., Qin, Z., Voorhees, J. J., & Fisher, G. J. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24179 · Cited by 55
Photoaging: Current Concepts on Molecular Mechanisms, Prevention, and Treatment
Kaltchenko, M. V., & Chien, A. L.-L. (2025) · American Journal of Clinical Dermatology · doi:10.1007/s40257-025-00933-z · Cited by 60
Pleiotropic actions of estrogen: a mitochondrial matter
Velarde, M. C. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00155.2012 · Cited by 50
Skin Academy: Hair, skin, hormones and menopause – current status/knowledge on the management of hair disorders in menopausal women
Blume‐Peytavi, U., Atkin, S. L., Gieler, U., & Grimalt, R. (2012) · European Journal of Dermatology · doi:10.1684/ejd.2012.1692 · Cited by 47
Organ‐on‐a‐Chip Systems for Women's Health Applications
Nawroth, J. C., Rogal, J., Weiß, M., Brucker, S. Y., & Loskill, P. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700550 · Cited by 44
Skin surface topography grading is a valid measure of skin photoaging
Battistutta, D., Pandeya, N., Strutton, G., Fourtanier, A. M., Tison, S., & Green, A. C. (2006) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2006.00194.x · Cited by 45
The Long-Term Efficacy and Safety of a Subcutaneously Injected Large-Particle Stabilized Hyaluronic Acid–Based Gel of NonAnimal Origin in Esthetic Facial Contouring
DeLorenzi, C., Weinberg, M. J., Solish, N. J., & Swift, A. (2009) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2008.01039.x · Cited by 43
Feasibility of a Wearable Reflectometric System for Sensing Skin Hydration
Schiavoni, R., Monti, G., Piuzzi, E., Tarricone, L., Tedesco, A., Benedetto, E. D., & Cataldo, A. (2020) · Sensors · doi:10.3390/s20102833 · Cited by 44
Revisiting the effects of menopause on the skin: Functional changes, clinical studies, in vitro models and therapeutic alternatives
Reus, T. L., Brohem, C. A., Schuck, D. C., & Lorencini, M. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111193 · Cited by 46
Intrinsische Hautalterung
Zouboulis, C. C. (2003) · Der Hautarzt · doi:10.1007/s00105-003-0581-7 · Cited by 42
Restorative oncodermatology: Diagnosis and management of dermatologic sequelae from cancer therapies
Rossi, A. M., Hibler, B. P., Navarrete‐Dechent, C., & Lacouture, M. E. (2020) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2020.08.005 · Cited by 39
Skin mirrors human aging
Nikolakis, G. D., Makrantonaki, E., & Zouboulis, C. C. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0018 · Cited by 40
Skin bacterial transplant in atopic dermatitis: Knowns, unknowns and emerging trends
Hendricks, A. J., Mills, B. W., & Shi, V. Y. (2019) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2019.07.001 · Cited by 42
Dermatological Management of Aged Skin
Rostkowska, E., Poleszak, E., Wojciechowska, K., & Szewczyk, K. D. S. (2023) · Cosmetics · doi:10.3390/cosmetics10020055 · Cited by 41
Cause of Androgenic Alopecia: Crux of the Matter
Ustuner, E. T. (2013) · Plastic and Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000000005 · Cited by 37
Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women
Hamer, M. A., Pardo, L. M., Jacobs, L. C., Ikram, M. A., Laven, J. S. E., Kayser, M., Hollestein, L. M., Gunn, D. A., & Nijsten, T. E. C. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.04.002 · Cited by 36
Bullous pemphigoid: An immune disorder related to aging (Review)
Deotto, M. L., Spiller, A., Sernicola, A., & Alaibac, M. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10972 · Cited by 36
Proteolytic digest derived from bovine Ligamentum Nuchae stimulates deposition of new elastin-enriched matrix in cultures and transplants of human dermal fibroblasts
Hinek, A., Wang, Y., Liu, K., Mitts, T. F., & Jimenez, F. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.04.002 · Cited by 36
The Use of Natural Compounds and Botanicals in the Development of Anti-Aging Skin Care Products
Angerhofer, C. K., Maes, D. H., & Giacomoni, P. U. (2009) · Elsevier eBooks · doi:10.1016/b978-0-8155-1584-5.50014-4 · Cited by 37
Stem cells and aberrant signaling of molecular systems in skin aging
Peng, Y., Xuan, M., Leung, V. Y. L., & Cheng, B. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.006 · Cited by 35
Revisiting the Cutaneous Impact of Oral Hormone Replacement Therapy
Pierard, G., Humbert, P. G., Berardesca, E., GASPARD, U. J., Hermanns‐Lê, T., & Piérard-Franchimont, C. (2013) · BioMed Research International · doi:10.1155/2013/971760 · Cited by 35
Immunohistochemical analysis of connective tissue in patients with pelvic organ prolapse
Yücel, N., Usta, A., Güzin, K., Kanter, M., Bilgiç, E., Ozel, N. O., & Ozgul, M. (2012) · Journal of Molecular Histology · doi:10.1007/s10735-012-9456-5 · Cited by 35
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Memi, E., Pavli, P., Papagianni, M., Vrachnis, N., & Mastorakos, G. P. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-024-09882-0 · Cited by 39
Menopause, skin and common dermatoses. Part 2: skin disorders
Kamp, E., Ashraf, M., Musbahi, E., & DeGiovanni, C. (2022) · Clinical and Experimental Dermatology · doi:10.1111/ced.15308 · Cited by 33
Effect of Porcine Placenta Extract Supplement on Skin Condition in Healthy Adult Women: A Randomized, Double-Blind Placebo-Controlled Study
Nagae, M., Nagata, M., Teramoto, M., Yamakawa, M., Matsuki, T., Ohnuki, K., & Shimizu, K. (2020) · Nutrients · doi:10.3390/nu12061671 · Cited by 35
Skin climacteric aging and hormone replacement therapy
Quatresooz, P., Piérard-Franchimont, C., Gaspard, U., & Pierard, G. (2006) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2006.00215.x · Cited by 31
Sex hormones and sex hormone-targeting therapies in systemic sclerosis: A systematic literature review
Ciaffi, J., van Leeuwen, N. M., Schoones, J. W., Huizinga, T. W. J., & Vries-Bouwstra, J. K. D. (2019) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2019.07.007 · Cited by 30
Nanoparticle platforms for dermal antiaging technologies: Insights in cellular and molecular mechanisms
Bhatia, E., Kumari, D., Sharma, S., Ahamad, N., & Banerjee, R. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1746 · Cited by 30
Skin and Hormone Therapy
Hall, G. K., & Phillips, T. J. (2004) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-200406000-00020 · Cited by 29
Ovariectomy Reduces the Gelatinolytic Activity and Expression of Matrix Metalloproteinases and Collagen in Rat Molar Extraction Wounds
Zecchin, K. G., Pereira, M. C., Coletta, R. D., Graner, E., & Jorge, J. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0013-4 · Cited by 29
Skin treatments and dermatological procedures to promote youthful skin
Sator, P. G. (2006) · Clinical Interventions in Aging · doi:10.2147/ciia.2006.1.1.51 · Cited by 28
Far-infrared ray patches relieve pain and improve skin sensitivity in myofascial pain syndrome: A double-blind randomized controlled study
Lai, Y., Chan, H.-L., Lin, S.-H., Lin, C., Li, S., Liu, C.-K., Teng, H., & Liu, W. (2017) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2017.10.007 · Cited by 29
Accuracy and reliability of a hand‐held in vivo skin indentation device to assess skin elasticity
Virén, T., Iivarinen, J. T., Sarin, J. K., Harvima, I. T., & MAYROVITZ, H. N. (2018) · International Journal of Cosmetic Science · doi:10.1111/ics.12444 · Cited by 26
Female Genital Itch
Savas, J. A., & Pichardo, R. O. (2018) · Dermatologic Clinics · doi:10.1016/j.det.2018.02.006 · Cited by 26
Menopause, skin and common dermatoses. Part 1: hair disorders
Kamp, E., Ashraf, M., Musbahi, E., & DeGiovanni, C. (2022) · Clinical and Experimental Dermatology · doi:10.1111/ced.15327 · Cited by 26
Gender-Dependent Levels of Hyaluronic Acid in Cerebrospinal Fluid of Patients with Neurodegenerative Dementia
Nielsen, H. M., Palmqvist, S., Minthon, L., Londos, E., & Wennström, M. (2012) · Current Alzheimer Research · doi:10.2174/156720512800107537 · Cited by 26
A Holistic Approach to Antiaging as an Adjunct to Antiaging Procedures: A Review of the Literature
Saluja, S. S., & Fabi, S. G. (2017) · Dermatologic Surgery · doi:10.1097/dss.0000000000001027 · Cited by 27
Dermatoendokrinologie
Makrantonaki, E., & Zouboulis, C. C. (2010) · Der Hautarzt · doi:10.1007/s00105-009-1889-8 · Cited by 25
Menopause Symptoms' Predictors: The Influence of Lifestyle, Health- and Menopause-Related, and Sociodemographic Characteristics
Pimenta, F., Leal, I. M. P., Marôco, J. P., & Ramos, C. (2012) · Journal of Women & Aging · doi:10.1080/08952841.2012.639653 · Cited by 25
Tubulin Beta‐3 Chain as a New Candidate Protein Biomarker of Human Skin Aging: A Preliminary Study
Lehmann, S. G., Bourgoin‐Voillard, S., Seve, M., & Rachidi, W. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5140360 · Cited by 23
Physiological and functional changes in the stratum corneum restored by oestrogen in an ovariectomized mice model of climacterium
Chen, Y., Yokozeki, H., & Katagiri, K. (2016) · Experimental Dermatology · doi:10.1111/exd.13214 · Cited by 22
Microwave Wearable System for Sensing Skin Hydration
Schiavoni, R., Monti, G., Tedesco, A., Tarricone, L., Piuzzi, E., Benedetto, E. D., Masciullo, A., & Cataldo, A. (2021) · IEEE International Instrumentation and Measurement Technology Conference · doi:10.1109/i2mtc50364.2021.9460018 · Cited by 22
Anatomic Predictors of Unsatisfactory Outcomes in Surgical Rejuvenation of the Midface
Jacono, A. A., & Ransom, E. R. (2013) · JAMA Facial Plastic Surgery · doi:10.1001/jamafacial.2013.443 · Cited by 22
Synthetic ligands of the elastin receptor induce elastogenesis in human dermal fibroblasts via activation of their IGF-1 receptors
Qa’aty, N., Vincent, M. L., Wang, Y., Wang, A., Mitts, T. F., & Hinek, A. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.10.001 · Cited by 23
Usage Patterns and Self-Esteem of Female Consumers of Antiaging Cosmetic Products
Evangelista, M., Mota, S., Almeida, I. F., & Pereira, M. G. (2022) · Cosmetics · doi:10.3390/cosmetics9030049 · Cited by 28
The influence of water, lanolin, urea, proline, paraffin and fatliquor on collagen D-spacing in leather
Sizeland, K. H., Wells, H. C., Kelly, S. J., Edmonds, R. L., Kirby, N. M., Hawley, A. M., Mudie, S., Ryan, T. M., & Haverkamp, R. (2017) · RSC Advances · doi:10.1039/c7ra05560a · Cited by 21
Dual functional bioactive‐peptide, AIMP 1‐derived peptide (AdP), for anti‐aging
Kim, J., Kang, S., Kwon, H., Moon, H., & Park, M. C. (2018) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12671 · Cited by 22
Effects of non-ablative Er:YAG laser on the skin and the vaginal wall: systematic review of the clinical and experimental literature
Hympanova, L. H., Macková, K., El-Domyati, M. M., Vodegel, E. V., Roovers, J., Bosteels, J., Krofta, L., & Deprest, J. A. (2020) · International Urogynecology Journal · doi:10.1007/s00192-020-04452-9 · Cited by 22
Initial laparoscopic access in postmenopausal women
Tinelli, A., Malvası, A., Guido, M., Istre, O., Keckstein, J., & Mettler, L. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181a037ed · Cited by 20
A theory of eu-estrogenemia: a unifying concept
Turner, R. J., & Kerber, I. J. (2017) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000895 · Cited by 20
Peau et ménopause
Bensaleh, H., Belgnaoui, F., Douira, L., Berbiche, L., Senouci, K., & Hassam, B. (2006) · Annales d Endocrinologie · doi:10.1016/s0003-4266(06)73009-8 · Cited by 20
Skin diseases in consequence of endocrine alterations
Krause, W. K. H. (2006) · The Aging Male · doi:10.1080/13685530600708573 · Cited by 20
Proposed shade guide for human facial skin and lip: A pilot study
Wee, A. G., Beatty, M. W., Gozalo-Diaz, D. J., Kim-Pusateri, S., & Marx, D. B. (2013) · Journal of Prosthetic Dentistry · doi:10.1016/s0022-3913(13)60344-3 · Cited by 19
Decades of beauty: Achieving aesthetic goals throughout the lifespan
Cohen, J. L., Goodman, G. J., de Almeida, A. R. T., Jones, D., Carruthers, J., Grimes, P. E., de Maio, M., Swift, A., Solish, N. J., Fagien, S., et al. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15968 · Cited by 18
Dermatological Changes during Menopause and HRT: What to Expect?
Bravo, B. S. F., Penedo, L. B. D. M., Carvalho, R. D. M., Vesco, C. D., Calomeni, M., Gapanowicz, D. P., Kemen, E., Paes, R., & Renke, G. (2024) · Cosmetics · doi:10.3390/cosmetics11010009 · Cited by 18
Effects of a combination of botanical actives on skin health and antioxidant status in post‐menopausal women: A randomized, double‐blind, placebo‐controlled clinical trial
Tumsutti, P., Maiprasert, M., Sugkraroek, P., Wanitphakdeedecha, R., & Bumrungpert, A. (2021) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14345 · Cited by 18
Hormone-Dependent Aging Problems in Women
Jung, B. H., Jeon, M. J., & Bai, S. W. (2008) · Yonsei Medical Journal · doi:10.3349/ymj.2008.49.3.345 · Cited by 18
Skin in maturity: the endocrine and neuroendocrine pathways
Quatresooz, P., Piérard-Franchimont, C., Kharfi, M., Rustom, K. A., Chian-García, C., García, R., Kamoun, M. R., & Pierard, G. (2007) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2007.00350.x · Cited by 17
An Algorithmic Approach to Multimodality Midfacial Rejuvenation Using a New Classification System for Midfacial Aging
Jacono, A. A., & Rousso, J. J. (2014) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2014.08.002 · Cited by 16
Downgrading skin climacteric aging by hormone replacement therapy
Quatresooz, P., & Pierard, G. (2007) · Expert Review of Dermatology · doi:10.1586/17469872.2.4.373 · Cited by 16
Managing Menopausal Skin Changes: A Narrative Review of Skin Quality Changes, Their Aesthetic Impact, and the Actual Role of Hormone Replacement Therapy in Improvement
Viscomi, B., Muniz, M., & Sattler, S. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70393 · Cited by 23
Menopausal transition and postmenopausal health problems: a review on its bio-cultural perspectives
Mishra, S. K. (2011) · Health · doi:10.4236/health.2011.34041 · Cited by 15
Vieillissement cutané – Vieillissement facial global : orientation thérapeutique
Beylot, C. (2018) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/j.annder.2018.10.015 · Cited by 15
Asymmetric facial skin viscoelasticity during climacteric aging
Piérard, G. E., GASPARD, U. J., Hermanns‐Lê, T., & Piérard-Franchimont, C. (2014) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s60313 · Cited by 14

Authors: Raine-Fenning, N. J., Brincat, M. P., & Muscat-Baron, Y.
Affiliations: University of Malta (MT)
Corresponding author: Brincat, Mark P
Venue: American Journal of Clinical Dermatology
Publisher: Springer Science and Business Media LLC
Published: 2003
Volume: 4
Issue: 6
Pages: 371-378
ISSN: 1175-0561 (ISSN-L)
DOI: 10.2165/00128071-200304060-00001
OpenAlex: W2110977684
Cited by: 211
References: 66
Citations by year: 2026: 6 · 2025: 9 · 2024: 10 · 2023: 10 · 2022: 12 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 14 · 2012: 14
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Clinical Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: skin aging, menopause, estrogen deficiency, estrogen receptor, collagen, skin hydration, skin elasticity, wrinkles, skin turgor, hot flashes, hair loss, hormone replacement therapy, topical estrogen
MeSH terms: Acne Vulgaris, Alopecia, Collagen, Drug Eruptions, Esthetics, Estrogens, Extracellular Matrix, Female, Humans, Menopause, Receptors, Estrogen, Skin, Skinfold Thickness, Wound Healing, Bone Density, Skin Aging, Estrogen Replacement Therapy, Hot Flashes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Skin Aging and Menopause: Implications for Treatment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks