Cited by 125Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesPosttraumatic Stress Disorder Research

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Depression Following Traumatic Brain Injury: Epidemiology, Risk Factors and Management

Rapoport, Mark J.·2012·CNS Drugs

DOI 10.2165/11599560-000000000-00000

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Abstract

It is important for clinicians to recognize major depression following traumatic brain injury (TBI) because of its association with poor global and psychosocial outcome, postconcussive symptoms and cognitive deficits. The purpose of this review is to provide an up-to-date selective review of the current understanding of epidemiology, risk factors and management of major depression following TBI. Many studies of prevalence of depression following TBI have not used accepted structured criteria for the diagnoses, but those that did found wide ranges of rates, from 17% to 61%. The risk factors for development of depression following TBI are poorly understood, but past psychiatric history, frontal lesions and atrophy, and family dysfunction have been shown in more than one study to play important roles. There are few controlled trials of the treatment of major depression in patients with TBI using accepted diagnostic criteria for major depression, as well as defined criteria for response and remission. As such, it is important for clinicians to use best practice guidelines for the treatment of major depression in the absence of TBI.

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Authors: Rapoport, M. J.
Affiliations: Sunnybrook Health Science Centre (CA)
Corresponding author: Rapoport, Mark J.
ORCID: Rapoport, Mark J.
Venue: CNS Drugs
Publisher: Springer Science and Business Media LLC
Published: 2012-02
Volume: 26
Issue: 2
Pages: 111-121
ISSN: 1172-7047 (ISSN-L)
DOI: 10.2165/11599560-000000000-00000
OpenAlex: W2035993893
Cited by: 125
References: 76
Citations by year: 2026: 2 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 30 · 2020: 3 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 6 · 2015: 13 · 2014: 14 · 2013: 11
FWCI: 9.07
Type: journal article
Language: en
Open access: closed
Locations: CNS Drugs (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords: major depressive disorder, traumatic brain injury, post-traumatic depression, depression prevalence, risk factors, frontal lobe lesions, brain atrophy, family dysfunction, post-concussion symptoms, cognitive impairment, depression treatment, psychosocial outcomes
MeSH terms: Brain Injuries, Depressive Disorder, Humans, Psychiatric Status Rating Scales, Risk Factors, Disease Management

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Depression Following Traumatic Brain Injury: Epidemiology, Risk Factors and Management

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