Distinct Regions of Prefrontal Cortex Mediate Resistance and Vulnerability to Depression
Open accessAbstract
The neuroanatomical correlates of depression remain unclear. Functional imaging data have associated depression with abnormal patterns of activity in prefrontal cortex (PFC), including the ventromedial (vmPFC) and dorsolateral (dlPFC) sectors. If vmPFC and dlPFC are critical neural substrates for the pathogenesis of depression, then damage to either area should affect the expression of depressive symptoms. Using patients with brain lesions we show that, relative to nonfrontal lesions, bilateral vmPFC lesions are associated with markedly low levels of depression, whereas bilateral dorsal PFC lesions (involving dorsomedial and dorsolateral areas in both hemispheres) are associated with substantially higher levels of depression. These findings demonstrate that vmPFC and dorsal PFC are critically and causally involved in depression, although with very different roles: vmPFC damage confers resistance to depression, whereas dorsal PFC damage confers vulnerability.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Damage to DLPFC is associated with high levels of depression.
“damage to VMPFC is associated with low levels of depression, and damage to DLPFC is associated with high levels of depression 206.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [206]
Damage to VMPFC is associated with low levels of depression.
“damage to VMPFC is associated with low levels of depression, and damage to DLPFC is associated with high levels of depression 206.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [206]
The dorsolateral prefrontal cortex has a well-established capacity for regulating mood, attention, memory, and action.
“By virtue of its well-established capacity for regulating mood, attention, memory, and action34, 54-56”
From Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety (2014) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Beck, A. T., Steer, R. A., & Brown, G. (2011) · PsycTESTS Dataset · doi:10.1037/t00742-000 · Cited by 7,535 · see citing works
Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications.
Clark, L., & Watson, D. (1991) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.100.3.316 · Cited by 4,616 · see citing works
Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications
Clark, L. A., & Watson, D. (1991) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.100.3.316 · Cited by 4,601 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431 · cited 1× · see citing works
“The CT image of each brain was spatially normalized to a CT template brain image in MNI space (Collins et al., 1994).”
MethodRethinking feelings: an fMRI study of the cognitive regulation of emotion
Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807212 · Cited by 2,520 · see citing works
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214 · see citing works
Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D. E., & Gross, J. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.030 · Cited by 2,113 · see citing works
KRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977 · see citing works
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585 · see citing works
Damage to the prefrontal cortex increases utilitarian moral judgements
Koenigs, M., Young, L., Adolphs, R., Tranel, D., Cushman, F., Hauser, M., & Damasio, A. (2007) · Nature · doi:10.1038/nature05631 · Cited by 1,545 · see citing works
Self-citationRethinking the mood and anxiety disorders: A quantitative hierarchical model for DSM-V.
Watson, D. (2005) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.114.4.522 · Cited by 1,332 · cited 1× · see citing works
“The finding of both diminished depression and diminished PTSD among patients with vmPFC lesions supports the assertion that mood and anxiety disorders share a common higher order dimension of general distress or “negative affectivity” (Clark and Watson, 1991; Watson, 2005), and moreover, that vmPFC may be a critical n…”
BackgroundReduction of Prefrontal Cortex Glucose Metabolism Common to Three Types of Depression
Baxter, L. R. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810030049007 · Cited by 1,320 · see citing works
A functional anatomical study of unipolar depression
Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266 · see citing works
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · see citing works
MOOD DISORDERS IN STROKE PATIENTS: IMPORTANCE OF LOCATION OF LESION
Robinson, R. G., Kubos, K. L., Starr, L. B., Rao, K. C. V. G., & Price, T. R. (1984) · Brain · doi:10.1093/brain/107.1.81 · Cited by 1,111 · see citing works
Phan, K. L., Fitzgerald, D. A., Nathan, P. J., Moore, G. J., Uhde, T. W., & Tancer, M. E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.030 · Cited by 892 · see citing works
The Involvement of the Orbitofrontal Cortex in the Experience of Regret
Camille, N., Coricelli, G., Sallet, J., Pradat-Diehl, P., Duhamel, J.-R., & Sirigu, A. (2004) · Science · doi:10.1126/science.1094550 · Cited by 716 · see citing works
Storch, E. A., Roberti, J. W., & Roth, D. A. (2004) · Depression and Anxiety · doi:10.1002/da.20002 · Cited by 694 · see citing works
Neural circuitry underlying voluntary suppression of sadness
Lévesque, J., Eugène, F., Joanette, Y., Paquette, V., Mensour, B., Beaudoin, G., Leroux, J.-M., Bourgouin, P., & Beauregard, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01817-6 · Cited by 689 · see citing works
Depression after stroke and lesion location: a systematic review
Carson, A. J., MacHale, S., Allen, K. E., Lawrie, S. M., Dennis, M. S., House, A. O., & Sharpe, M. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02448-x · Cited by 650 · see citing works
Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S. J., & Dolan, R. J. (1993) · Psychological Medicine · doi:10.1017/s0033291700025368 · Cited by 530 · see citing works
Functional neuroimaging studies of depression: The anatomy of melancholia
Drevets, W. C. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.341 · Cited by 500 · see citing works
Levin, H. S., High, W. M., Goethe, K. E., Sisson, R. A., Overall, J. E., Rhoades, H. M., Eisenberg, H. M., Kalisky, Z., & Gary, H. E. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.2.183 · Cited by 483 · see citing works
Beer, J. S., John, O. P., Scabini, D., & Knight, R. T. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.6.871 · Cited by 455 · see citing works
Regulation of emotional responses elicited by threat-related stimuli
Eippert, F., Veit, R., Weiskopf, N., Erb, M., Birbaumer, N., & Anders, S. (2007) · Human Brain Mapping · doi:10.1002/hbm.20291 · Cited by 419 · see citing works
Orbitofrontal cortex function and structure in depression
DREVETS, W. C. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.029 · Cited by 417 · see citing works
Prevalence of anxiety disorders and their comorbidity with mood and addictive disorders
Regier, D. A., Rae, D. S., Narrow, W. E., Kaelber, C. T., & Schatzberg, A. F. (1998) · British Journal of Psychiatry · doi:10.1192/s0007125000293483 · Cited by 407 · see citing works
Barrash, J., Tranel, D., & Anderson, S. W. (2000) · Developmental Neuropsychology · doi:10.1207/s1532694205barrash · Cited by 395 · see citing works
Self-citationAdult and geriatric normative data and validation of the profile of mood states
Nyenhuis, D. L., Yamamoto, C., Luchetta, T., Terrien, A., & Parmentier, A. H. (1999) · Journal of Clinical Psychology · doi:10.1002/(sici)1097-4679(199901)55:1 · Cited by 337 · see citing works
Avery, D. H., Holtzheimer, P. E., Fawaz, W., Russo, J., Neumaier, J., Dunner, D. L., Haynor, D. R., Claypoole, K. H., Wajdik, C., & Roy-Byrne, P. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.003 · Cited by 318 · see citing works
Frontal and parietal metabolic disturbances in unipolar depression
Biver, F., Goldman, S., Delvenne, V., Luxen, A., De Maertelaer, V., Hubain, P., Mendlewicz, J., & Lotstra, F. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91213-0 · Cited by 313 · see citing works
Functional heterogeneity of the prefrontal cortex in the monkey: a review
Rosenkilde, C. E. (1979) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(79)90404-7 · Cited by 306 · see citing works
Berman, R., Narasimhan, M., Sanacora, G., Miano, A. P., Hoffman, R. E., Hu, X. S., Charney, D. S., & Boutros, N. N. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00243-7 · Cited by 283 · see citing works
Wagner, G., Sinsel, E., Sobanski, T., Köhler, S., Marinou, V., Mentzel, H.-J., Sauer, H., & Schlösser, R. G. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.025 · Cited by 278 · see citing works
Focal brain damage protects against post-traumatic stress disorder in combat veterans
Koenigs, M., Huey, E. D., Raymont, V., Cheon, B., Solomon, J., Wassermann, E. M., & Grafman, J. (2008) · Nature Neuroscience · doi:10.1038/nn2032 · Cited by 255 · see citing works
Self-citationHypofrontality and negative symptoms in major depressive disorder.
GALYNKER, I. I., Cai, J., Ongseng, F., Finestone, H., Dutta, E., & Serseni, D. (1998) · PubMed · Cited by 239 · see citing works
The Factor Structure of the Beck Depression Inventory–II
Vanheule, S., Desmet, M., Groenvynck, H., Rosseel, Y., & Fontaine, J. R. J. (2008) · Assessment · doi:10.1177/1073191107311261 · Cited by 171 · see citing works
A psychometric evaluation of the BDI-II in treatment-seeking substance abusers
Buckley, T. C., Parker, J. D., & Heggie, J. (2001) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(00)00169-0 · Cited by 156 · see citing works
Herwig, U., Lampe, Y. M., Juengling, F. D., Wunderlich, A. P., Walter, H., Spitzer, M., & Schönfeldt‐Lecuona, C. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00042-6 · Cited by 129 · see citing works
User-friendly software for the analysis of brain lesions (ABLe)
Solomon, J., Raymont, V., Braun, A., Butman, J., & Grafman, J. (2007) · Comput. Methods Programs Biomed. · doi:10.1016/j.cmpb.2007.02.006 · Cited by 120 · see citing works
Self-citationThe Importance of Lesion Location in Poststroke Depression: A Critical Review
Singh, A., Herrmann, N., & Black, S. E. (1998) · The Canadian Journal of Psychiatry · doi:10.1177/070674379804300907 · Cited by 116 · see citing works
Prospective assessment of stereotactic ablative surgery for intractable major depression
Shields, D. C., Asaad, W., Eskandar, E. N., Jain, F. A., Cosgrove, G. R., Flaherty, A. W., Cassem, E. H., Price, B. H., Rauch, S. L., & Dougherty, D. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.009 · Cited by 109 · see citing works
Outcome after the psychosurgical operation of stereotactic subcaudate tractotomy, 1979-1991
Hodgkiss, A., Malizia, A. L., Bartlett, J. R., & Bridges, P. K. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.2.230 · Cited by 100 · see citing works
DeVane, C. L., Chiao, E., Franklin, M., & Kruep, E. J. (2005) · PubMed · Cited by 91 · see citing works
Quantification of brain lesions using interactive automated software
Makale, M., Solomon, J. M., Patronas, N. J., Danek, A., Butman, J. A., & Grafman, J. H. (2002) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03195419 · Cited by 83 · see citing works
Self-citationNofzinger, E., Buysse, D. J., Germain, A., Price, J., Meltzer, C., Miewald, J., & Kupfer, D. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.387 · Cited by 62 · see citing works
Relationship Between Post‐stroke Depression and Lesion Location: A Meta‐Analysis
Yu, L., Liu, C., Chen, J., Wang, S.-Y., Wu, Y., & Yu, S. (2004) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/s1607-551x(09)70173-1 · Cited by 50 · see citing works
Surgery for Psychiatric Disorders
Cosgrove, G. R. (2000) · CNS Spectrums · doi:10.1017/s1092852900007665 · Cited by 43 · see citing works
Parikh, R. M., Lipsey, J. R., Robinson, R. G., & Price, T. R. (1989) · The International Journal of Psychiatry in Medicine · doi:10.2190/lw46-3e9f-kyjm-wxgq · Cited by 41 · see citing works
Orbital Versus Dorsolateral Prefrontal Cortex
Zald, D. H. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.012 · Cited by 33 · see citing works
Ventromedial frontal lobe trauma
Ellenbogen, J. M., Hurford, M. O., Liebeskind, D. S., Neimark, G. B., & Weiss, D. (2005) · Neurology · doi:10.1212/wnl.64.4.757 · Cited by 20 · see citing works
Central Nervous System Opportunistic Infections in HIV-1 Infection
Concha, M., & Rabinstein, A. A. (2000) · CNS Spectrums · doi:10.1017/s1092852900013110 · Cited by 10 · see citing works
Flagged first, then by citations
1 of the 58 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Damasio H Damasio AR 1989 Lesion analysis in neurospychology New York Oxford UP
- First MB Spitzer RL Gibbon M Williams JBW 2002 Structured clinical interview for DSM-IV-TR axis I disorders, research version, patient edition. (SCID-I/P) New York Biometrics Research, New York State Psychiatric Institute
Cited by
Sorted by citations
Fox, M. D., Buckner, R. L., White, M. P., Greicius, M. D., & Pascual-Leone, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.028 · Cited by 1,270 · see citing works
Hiser, J., & Koenigs, M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.030 · Cited by 972 · see citing works
Self-citationKoenigs, M., & Grafman, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.004 · Cited by 956 · see citing works
Self-citationEmotion and the prefrontal cortex: an integrative review
Dixon, M. L., Thiruchselvam, R., Todd, R., & Christoff, K. (2017) · Psychological Bulletin · doi:10.1037/bul0000096 · Cited by 745 · see citing works
Targeted electrode-based modulation of neural circuits for depression.
Mayberg, H. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38454 · Cited by 542 · see citing works
Neural correlates of rumination in depression
Cooney, R. E., Joormann, J., Eugène, F., Dennis, E. L., & Gotlib, I. H. (2010) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.10.4.470 · Cited by 493 · see citing works
Ventromedial Prefrontal Cortex Is Critical for the Regulation of Amygdala Activity in Humans
Motzkin, J. C., Philippi, C. L., Wolf, R. C., Baskaya, M. K., & Koenigs, M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.014 · Cited by 454 · see citing works
Self-citationExploring the convergence of posttraumatic stress disorder and mild traumatic brain injury
Stein, M. B., & McAllister, T. W. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08101604 · Cited by 391 · see citing works
Okon-Singer, H., Hendler, T., Pessoa, L., & Shackman, A. J. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00058 · Cited by 371 · see citing works
Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders
Myers-Schulz, B., & Koenigs, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.88 · Cited by 333 · see citing works
Self-citationDownar, J. H., Geraci, J., Salomons, T. V., Dunlop, K., Wheeler, S. M., McAndrews, M. P., Bakker, N., Blumberger, D. M., Daskalakis, Z. J., Kennedy, S. H., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.026 · Cited by 338 · see citing works
Fettes, P., Schulze, L., & Downar, J. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00025 · Cited by 299 · see citing works
Yan, Z., & Rein, B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01092-3 · Cited by 300 · see citing works
“While both DLPFC and VMPFC are involved in MDD, they play different roles: damage to VMPFC is associated with low levels of depression, and damage to DLPFC is associated with high levels of depression [206].”
BackgroundAcute and sustained effects of cognitive emotion regulation in major depression
Erk, S., Mikschl, A., Stier, S., Ciaramidaro, A., Gapp, V., Weber, B., & Walter, H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1856-10.2010 · Cited by 313 · see citing works
Posttraumatic stress disorder: the role of medial prefrontal cortex and amygdala.
Koenigs, M., & Grafman, J. (2009) · The Neuroscientist · doi:10.1177/1073858409333072 · Cited by 368 · see citing works
Self-citationFTD and ALS: A Tale of Two Diseases
Ferrari, R., Kapogiannis, D., Huey, E. D., & Momeni, P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795563700 · Cited by 270 · see citing works
Self-citationNew targets for rTMS in depression: A review of convergent evidence
Downar, J., & Daskalakis, Z. J. (2013) · Brain Stimulation · doi:10.1016/j.brs.2012.08.006 · Cited by 257 · see citing works
A Human Depression Circuit Derived From Focal Brain Lesions
Padmanabhan, J. L., Cooke, D. L., Joutsa, J., Siddiqi, S., Ferguson, M., Darby, R. R., Soussand, L., Horn, A., Kim, N. Y., Voss, J. L., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.023 · Cited by 239 · see citing works
Self-citationMitchell, D. G. V. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.030 · Cited by 219 · see citing works
Yoshimura, S., Okamoto, Y., Onoda, K., Matsunaga, M., Ueda, K., Suzuki, S.-I., & ShigetoYamawaki (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.017 · Cited by 199 · see citing works
Impact of early adversity on glucocorticoid regulation and later mental disorders
Strüber, N., Strüber, D., & Roth, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.015 · Cited by 173 · see citing works
Tata, D. A., & Anderson, B. J. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.09.008 · Cited by 173 · see citing works
“Like the hippocampus, the frontal lobe dysfunction has been implicated in depression [29-31] and the frontal lobe, like the hippocampus undergoes structural modification in response to glucocorticoids and stress [32-35].”
BackgroundEconomic decision-making in psychopathy: A comparison with ventromedial prefrontal lesion patients
Koenigs, M. R., Kruepke, M., & Newman, J. P. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.04.012 · Cited by 173 · see citing works
Self-citationMcCormick, C., Ciaramelli, E., Luca, F. D., & Maguire, E. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.066 · Cited by 159 · see citing works
Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety
Birn, R. M., Shackman, A. J., Oler, J. A., Williams, L. E., McFarlin, D. R., Rogers, G. M., Shelton, S. E., Alexander, A. L., Pine, D. S., Slattery, M. J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.46 · Cited by 159 · see citing works
The future is here: A review of foresight systems in anxiety and depression
Miloyan, B., Pachana, N. A., & Suddendorf, T. (2014) · Cognition and Emotion · doi:10.1080/02699931.2013.863179 · Cited by 160 · see citing works
The Neurobiological Role of the Dorsolateral Prefrontal Cortex in Recovery From Trauma
Lyoo, I. K., Kim, J. E., Yoon, S. J., Hwang, J., Bae, S., & Kim, D. J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.70 · Cited by 156 · see citing works
Fotopoulou, A., Pernigo, S., Maeda, R., Rudd, A., & Kopelman, M. (2010) · Brain : a journal of neurology · doi:10.1093/brain/awq233 · Cited by 126 · see citing works
Human lesion studies of ventromedial prefrontal cortex
Schneider, B., & Koenigs, M. R. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.09.035 · Cited by 155 · see citing works
Self-citationThe role of prefrontal cortex in psychopathy
Koenigs, M. R. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0036 · Cited by 153 · see citing works
Self-citation“Studying Injured Minds” – The Vietnam Head Injury Study and 40 Years of Brain Injury Research
Raymont, V., Salazar, A. Μ., Krüeger, F., & Grafman, J. H. (2011) · Frontiers in Neurology · doi:10.3389/fneur.2011.00015 · Cited by 151 · see citing works
Self-citationVoineskos, D., Blumberger, D. M., Zomorrodi, R., Rogasch, N. C., Farzan, F., Foussias, G., Rajji, T. K., & Daskalakis, Z. J. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.032 · Cited by 135 · see citing works
McLaughlin, R. J., Hill, M. N., & Gorzalka, B. B. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.006 · Cited by 130 · see citing works
Depression Following Traumatic Brain Injury: Epidemiology, Risk Factors and Management
Rapoport, M. J. (2012) · CNS Drugs · doi:10.2165/11599560-000000000-00000 · Cited by 125 · see citing works
Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Aberrant Emotional and Social Behaviors
Yadav, R., Gupta, S. C., Hillman, B. G., Bhatt, J. M., Stairs, D. J., & Dravid, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032969 · Cited by 123 · see citing works
Synaptic Modifications in the Medial Prefrontal Cortex in Susceptibility and Resilience to Stress
Wang, M., Perova, Z., Arenkiel, B. R., & Li, B. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5294-13.2014 · Cited by 116 · see citing works
Edwards, S., Baynes, B. B., Carmichael, C. Y., Zamora-Martinez, E. R., Barrus, M. M., Koob, G. F., & Gilpin, N. W. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.70 · Cited by 118 · see citing works
A voxel-based lesion study on facial emotion recognition after penetrating brain injury
Monte, O. D., Krüeger, F., Solomon, J. M., Schintu, S., Knutson, K. M., Strenziok, M., Pardini, M., Leopold, A., Raymont, V., & Grafman, J. H. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss041 · Cited by 115 · see citing works
Self-citationDamage to the left ventromedial prefrontal cortex impacts affective theory of mind
Leopold, A., Krüeger, F., Monte, O. D., Pardini, M., Pulaski, S. J., Solomon, J. M., & Grafman, J. H. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr071 · Cited by 110 · see citing works
Self-citationGreening, S. G., Osuch, E. A., Williamson, P. C., & Mitchell, D. G. V. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst027 · Cited by 99 · see citing works
Clinical Considerations for the Diagnosis of Major Depression After Moderate to Severe TBI
Seel, R. T., Macciocchi, S. N., & Kreutzer, J. S. (2010) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181ce3966 · Cited by 104 · see citing works
Philippi, C. L., Motzkin, J. C., Pujara, M. S., & Koenigs, M. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.10.005 · Cited by 93 · see citing works
Self-citationQi, X., Kamphuis, W., Wang, S., Wang, Q., Lucassen, P. J., Zhou, J., & Swaab, D. F. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.014 · Cited by 97 · see citing works
Diagnosis and Management of Behavioral Issues in Frontotemporal Dementia
Manoochehri, M., & Huey, E. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0302-7 · Cited by 89 · see citing works
Self-citationTrapp, N. T., Purgianto, A., Taylor, J. J., Singh, M. K., Oberman, L. M., Mickey, B. J., Youssef, N. A., Solzbacher, D., Zebley, B., Cabrera, L. Y., et al. (2025) · Clinical Neurophysiology · doi:10.1016/j.clinph.2024.12.015 · Cited by 89 · see citing works
The neuropsychology of self-reflection in psychiatric illness
Philippi, C. L., & Koenigs, M. R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.03.004 · Cited by 94 · see citing works
Self-citationPrefrontal cortical regulation of REM sleep
Hong, J., Lozano, D. E., Beier, K. T., Chung, S., & Weber, F. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01398-1 · Cited by 83 · see citing works
Zhou, F., Geng, Y., Xin, F., Li, J., Feng, P., Liu, C., Zhao, W., Feng, T., Guastella, A. J., Ebstein, R. P., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.007 · Cited by 69 · see citing works
Yang, X., Peng, Z., Ma, X., Meng, Y., Li, M., Zhang, J., Song, X., Liu, Y., Fan, H., Zhao, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02828-4 · Cited by 72 · see citing works
Detaching from the negative by reappraisal: the role of right superior frontal gyrus (BA9/32)
Falquez, R., Couto, B., Ibanez, A., Freitag, M. T., Berger, M., Arens, E., Lang, S., & Barnow, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00165 · Cited by 55 · see citing works
Classifying Major Depressive Disorder Using fNIRS During Motor Rehabilitation
Zhu, Y., Jayagopal, J. K., Mehta, R. K., Erraguntla, M., Nuamah, J. K., McDonald, A. D., Taylor, H. B., & Chang, S. (2020) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2020.2972270 · Cited by 70 · see citing works
Noda, Y., Zomorrodi, R., Vila‐Rodriguez, F., Downar, J. H., Farzan, F., Cash, R. F. H., Rajji, T. K., Daskalakis, Z. J., & Blumberger, D. M. (2018) · Depression and Anxiety · doi:10.1002/da.22738 · Cited by 69 · see citing works
Downar, J., Sankar, A., Giacobbe, P., Woodside, B., & Colton, P. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00030 · Cited by 74 · see citing works
Chung, J. K., Initiative, A. D. N., Plitman, E., Nakajima, S., Chow, T. W., Chakravarty, M. M., Caravaggio, F., Gerretsen, P., Brown, E. E., Iwata, Y., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142931 · Cited by 65 · see citing works
The predator odor avoidance model of post-traumatic stress disorder in rats
Albrechet-Souza, L., & Gilpin, N. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000460 · Cited by 51 · see citing works
Another major function of the anterior cingulate cortex: The representation of requirements
Weston, C. S. E. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.014 · Cited by 64 · see citing works
Human ventromedial prefrontal lesions alter incentivisation by reward
Manohar, S. G., & Husain, M. (2016) · Cortex · doi:10.1016/j.cortex.2016.01.005 · Cited by 62 · see citing works
Horato, N., Quagliato, L. A., & Nardi, A. E. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01927-9 · Cited by 62 · see citing works
Zhu, W., Wang, S., Liu, M.-M., Shi, H., Zhang, R., Liu, J., Ding, Z., & Lü, L. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120228 · Cited by 62 · see citing works
Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience
Trapp, N. T., Bruss, J., Manzel, K. W., Grafman, J. H., Tranel, D., & Boes, A. D. (2022) · Brain · doi:10.1093/brain/awac361 · Cited by 59 · see citing works
Self-citationScopinho, A. A., Scopinho, M., Lisboa, S. F. D. S., Corrêa, F. M. D. A., Guimarães, F. S., & Joca, S. R. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.06.018 · Cited by 59 · see citing works
Grajny, K., Pyata, H., Katherine, S., Lacey, E. H., Xing, S., Brophy, C. M., & Turkeltaub, P. E. (2016) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.16010004 · Cited by 58 · see citing works
The tie that binds: temporal coding and adaptive emotion
Wang, J., Tambini, A., & Lapate, R. C. (2022) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2022.09.005 · Cited by 58 · see citing works
Lesion studies of human emotion and feeling
Feinstein, J. S. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.12.007 · Cited by 55 · see citing works
Management of frontotemporal dementia in mental health and multidisciplinary settings
Wylie, M. A., Shnall, A., Onyike, C. U., & Huey, E. D. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.776949 · Cited by 56 · see citing works
Self-citationVentromedial prefrontal cortex modulates fatigue after penetrating traumatic brain injury
Pardini, M., Krüeger, F., Raymont, V., & Grafman, J. H. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d25b6b · Cited by 54 · see citing works
Self-citationImpaired social decision making in patients with major depressive disorder
Wang, Y., Zhou, Y., Li, S., Wang, P., Wu, G.-W., & Liu, Z.-N. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-18 · Cited by 53 · see citing works
Mechanisms of Reward Circuit Dysfunction in Psychiatric Illness
Pujara, M. S., & Koenigs, M. R. (2013) · The Neuroscientist · doi:10.1177/1073858413499407 · Cited by 51 · see citing works
Self-citationMotzkin, J. C., Philippi, C. L., Oler, J. A., Kalin, N. H., Başkaya, M. K., & Koenigs, M. R. (2014) · Cortex · doi:10.1016/j.cortex.2014.11.013 · Cited by 48 · see citing works
Self-citationPrecise Modulation Strategies for Transcranial Magnetic Stimulation: Advances and Future Directions
Zhong, G., Yang, Z., & Jiang, T. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00781-x · Cited by 49 · see citing works
Scult, M. A., Knodt, A. R., Swartz, J. R., Brigidi, B. D., & Hariri, A. R. (2016) · Clinical Psychological Science · doi:10.1177/2167702616654688 · Cited by 47 · see citing works
Placebo aiTBS attenuates suicidal ideation and frontopolar cortical perfusion in major depression
Baeken, C., Wu, G., & van Heeringen, K. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0377-x · Cited by 46 · see citing works
Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy
Butler, T., Blackmon, K., McDonald, C. R., Carlson, C., Barr, W., Devinsky, O., Kuzniecky, R., DuBois, J. M., French, J. A., Halgren, E., et al. (2011) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.10.001 · Cited by 45 · see citing works
Prefrontal Cortical Deficits in Type 1 Diabetes Mellitus
Lyoo, I. K., Yoon, S. J., Jacobson, A. M., Hwang, J., Musen, G., Kim, J. E., Simonson, D. C., Bae, S., Bolo, N. R., Kim, D. J., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.543 · Cited by 43 · see citing works
Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder
Zhong, J., Li, S., Zeng, W., Li, X., Gu, C., Liu, J., & Luo, X. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0345-4 · Cited by 45 · see citing works
Neural correlates of social exchanges during the Prisoner’s Dilemma game in depression
Gradin, V. B., Pérez, A., Macfarlane, J. A., Cavin, I., Waiter, G., Tone, E. B., Dritschel, B., Maiche, A., & Steele, J. D. (2016) · Psychological Medicine · doi:10.1017/s0033291715002834 · Cited by 41 · see citing works
Unschuld, P. G., Joel, S. E., Pekar, J. J., Reading, S. A. J., Oishi, K., McEntee, J., Shanahan, M. R., Bakker, A., Margolis, R. L., Bassett, S. S., et al. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.01.002 · Cited by 43 · see citing works
Schulze, L., Wheeler, S. M., McAndrews, M., Solomon, C. J. E., Giacobbe, P., & Downar, J. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.04.004 · Cited by 38 · see citing works
Ploski, J. E., & Vaidya, V. A. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.009 · Cited by 42 · see citing works
Reward responsiveness and fatigue in multiple sclerosis
Pardini, M., Capello, E., Krüeger, F., Mancardi, G., & Uccelli, A. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512451509 · Cited by 42 · see citing works
Song, Z., Zhang, M., & Huang, P. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.81 · Cited by 41 · see citing works
Naghibi, S., Joneydi, M. S., Barzegari, A., Davoodabadi, A., Ebrahimi, A., Eghdami, E., Fahimpour, N., Ghorbani, M., Mohammadikia, E., Rostami, M., et al. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113595 · Cited by 40 · see citing works
Steffens, D. C., Wang, L., Manning, K. J., & Pearlson, G. D. (2017) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.03.017 · Cited by 40 · see citing works
Genetic Polymorphisms Influence Recovery from Traumatic Brain Injury
Weaver, S. M., Chau, A., Tremont, J. N. P., & Grafman, J. H. (2012) · The Neuroscientist · doi:10.1177/1073858411435706 · Cited by 40 · see citing works
Self-citationLeWinn, K. Z., Strigo, I. A., Connolly, C. G., Ho, T. C., Tymofiyeva, O., Sacchet, M. D., Weng, H. Y., Blom, E. H., Simmons, A. N., & Yang, T. T. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.020 · Cited by 38 · see citing works
Biological substrates of addiction
Joffe, M. E., Grueter, C. A., & Grueter, B. A. (2014) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1273 · Cited by 39 · see citing works
Zhu, H., Zhang, J., Wang, Z., Qiu, C., Wu, R., Meng, Y., Cui, H., Huang, X., Li, T., Gong, Q., et al. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.06.009 · Cited by 39 · see citing works
Patience, J., Lai, K. S. P., Russell, E., Vasudev, A., Montero‐Odasso, M., & Burhan, A. M. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.07.007 · Cited by 39 · see citing works
New insights on brain‐derived neurotrophic factor epigenetics: from depression to memory extinction
Poon, C. H., Heng, B. C., & Lim, L. W. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14458 · Cited by 40 · see citing works
Kuniishi, H., Ichisaka, S., Matsuda, S., Futora, E., Harada, R., & Hata, Y. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00250 · Cited by 34 · see citing works
Regret and the negative evaluation of decision outcomes in major depression
Chase, H. W., Camille, N., Michael, A., Bullmore, E. T., Robbins, T. W., & Sahakian, B. J. (2010) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.10.3.406 · Cited by 37 · see citing works
Waber, D. P., Eaglesfield, D., Fitzmaurice, G. M., Bryce, C. P., Harrison, R. H., & Galler, J. R. (2011) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e31820b7707 · Cited by 34 · see citing works
Weaver, S. M., Tremont, J. N. P., Chau, A., Cristofori, I., Moretti, L., & Grafman, J. H. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9197-9 · Cited by 33 · see citing works
Self-citationCheran, G., Silverman, H., Manoochehri, M., Goldman, J., Lee, S., Wu, L., Cines, S., Fallon, E., Kelly, B. D., Olszewska, D. A., et al. (2018) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317263 · Cited by 32 · see citing works
Self-citationImpaired Valuation Leads to Increased Apathy Following Ventromedial Prefrontal Cortex Damage
Hogeveen, J., Hauner, K. K. Y., Chau, A., Krüeger, F., & Grafman, J. H. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhv317 · Cited by 30 · see citing works
Self-citationFettes, P., Moayedi, M., Dunlop, K., Mansouri, F., Vila‐Rodriguez, F., Giacobbe, P., Davis, K. D., Lam, R. W. M., Kennedy, S. H., Daskalakis, Z. J., et al. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.12.003 · Cited by 30 · see citing works
Emotional Context Sculpts Action Goal Representations in the Lateral Frontal Pole
Lapate, R. C., Ballard, I. C., Heckner, M. K., & D’Esposito, M. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1522-21.2021 · Cited by 32 · see citing works
Lapate, R. C., Samaha, J., Rokers, B., Hamzah, H., Postle, B. R., & Davidson, R. J. (2017) · Psychological Science · doi:10.1177/0956797617699837 · Cited by 29 · see citing works
Yu, L. Q., Kan, I. P., & Kable, J. W. (2019) · Cognitive Neuropsychology · doi:10.1080/02643294.2019.1690981 · Cited by 32 · see citing works
DNA methylation in stress and depression: from biomarker to therapeutics
Sales, A. J., Guimarães, F. S., & Joca, S. R. L. (2021) · Acta Neuropsychiatrica · doi:10.1017/neu.2021.18 · Cited by 27 · see citing works
- Authors
- Koenigs, M., Huey, E. D., Calamia, M., Raymont, V., Tranel, D., & Grafman, J.
- Affiliations
- University of Wisconsin–Madison (US)
- National Institutes of Health (US)
- University of Iowa (US)
- Henry M. Jackson Foundation (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-11-19
- Volume
- 28
- Issue
- 47
- Pages
- 12341-12348
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2644261
- OpenAlex
- W2128478192
- Cited by
- 243
- References
- 58
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 11 · 2020: 17 · 2019: 16 · 2018: 6 · 2017: 19 · 2016: 13 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 17
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Civil War Book Review (submittedVersion)
- Funders
- National Institutes of Health (Z99 NS999999)
- National Institute on Drug Abuse (R01DA022549)
- National Institute of Neurological Disorders and Stroke (P01 NS19632, P01NS019632, NS-19632, Z01NS002792)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- depression, prefrontal cortex, ventromedial prefrontal cortex, dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, brain lesions, lesion studies, depression vulnerability
- MeSH terms
- Adult, Brain Injuries, Brain Mapping, Cognition Disorders, Depression, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Movement Disorders, Severity of Illness Index, Tomography, X-Ray Computed, Veterans, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
