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Cited by 134Diet and metabolism studiesDietary Effects on HealthDiabetes Management and Research

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

A Non-calorie-restricted Low-carbohydrate Diet is Effective as an Alternative Therapy for Patients with Type 2 Diabetes

Open access
Yamada, Yoshifumi, Uchida, Junichi, Izumi, Hisa, Tsukamoto, Yoko, Inoue, Gaku, Watanabe, Yuichi, Irie, Junichiro, Yamada, Satoru·2014·Internal Medicine
DOI 10.2169/internalmedicine.53.0861
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Abstract

OBJECTIVE: Although caloric restriction is a widely used intervention to reduce body weight and insulin resistance, many patients are unable to comply with such dietary therapy for long periods. The clinical effectiveness of low-carbohydrate diets was recently described in a position statement of Diabetes UK and a scientific review conducted by the American Diabetes Association. However, randomised trials of dietary interventions in Japanese patients with type 2 diabetes are scarce. Therefore, the aim of this study was to examine the effects of a non-calorie-restricted, low-carbohydrate diet in Japanese patients unable to adhere to a calorie-restricted diet. METHODS: The enrolled patients were randomly allocated to receive a conventional calorie-restricted diet or low-carbohydrate diet. The patients received consultations every two months from a registered dietician for six months. We compared the effects of the two dietary interventions on glycaemic control and metabolic profiles. RESULTS: The HbA1c levels decreased significantly from baseline to six months in the low-carbohydrate diet group (baseline 7.6±0.4%, six months 7.0±0.7%, p=0.03) but not in the calorie-restricted group (baseline 7.7±0.6%, six months 7.5±1.0%, n.s.), (between-group comparison, p=0.03). The patients in the former group also experienced improvements in their triglyceride levels, without experiencing any major adverse effects or a decline in the quality of life. CONCLUSION: Our findings suggest that a low-carbohydrate diet is effective in lowering the HbA1c and triglyceride levels in patients with type 2 diabetes who are unable to adhere to a calorie-restricted diet.

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Crossref · 10.2169/internalmedicine.53.0861

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  1. 22. Institute of Medicine of the National Academies. Protein and Amino Acids, in Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. The National Academies Press, Washington DC, 2005: 589-768.

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Metadata

Authors
Yamada, Y., Uchida, J., Izumi, H., Tsukamoto, Y., Inoue, G., Watanabe, Y., Irie, J., & Yamada, S.
Affiliations
Kitasato Institute Hospital (JP)
ORCID
Venue
Internal Medicine
Publisher
Japanese Society of Internal Medicine
Published
2014
Volume
53
Issue
1
Pages
13-19
ISSN
  • 0918-2918 (ISSN-L)
  • 1349-7235
DOI
10.2169/internalmedicine.53.0861
OpenAlex
W2080204420
Cited by
133
References
27
Citations by year
2026: 2 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 20 · 2021: 12 · 2020: 17 · 2019: 16 · 2018: 16 · 2017: 9 · 2016: 7 · 2015: 3 · 2014: 1
FWCI
2.55
Type
journal article
Language
en
Open access
Locations
  • Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 2 diabetes, low-carbohydrate diet, calorie-restricted diet, dietary adherence, glycemic control, HbA1c, triglycerides, Japanese patients
MeSH terms
Aged, Complementary Therapies, Blood Glucose, Energy Intake, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Weight Loss, Treatment Outcome, Diet, Carbohydrate-Restricted

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