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Cited by 142Adipokines, Inflammation, and Metabolic DiseasesAtherosclerosis and Cardiovascular DiseasesCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.

Inflammation, Adiponectin, Obesity and Cardiovascular Risk

Mangge, H., Almer, G., Truschnig-Wilders, M., Schmidt, A., Gasser, R., Fuchs, D.·2010·Current Medicinal Chemistry
DOI 10.2174/092986710794183006
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Abstract

The development of atherosclerotic lesions leading to myocardial infarction (MI) or stroke encompasses a cascade of cellular and molecular events that can well be characterized as a chronic immune-mediated inflammation occurring preferentially in the biologic surrounding of the so called metabolic syndrome. Adipokines, chemokines, cytokines, and their receptors are critically involved in the initiation and perpetuation of atherosclerosis, and they play important roles at all levels in the pathogenesis of this disease. Metabolic risk profiles associated with sedentary lifestyle, obesity, especially intra-abdominal fat accumulation, insulin resistance, and dyslipidemia pave the way for a chronic, immunemediated vascular inflammation around vascular lipid deposits. In the present article, the impact of adiponectin, monocyte and T-cell associated cytokines (with emphasis on Neopterin), individual adipose tissue - distribution, and pleiotropic drug effects on the individual course of atherosclerosis and associated cardiovascular disease are reviewed. Keywords: Adiposity, immune-mediated inflammation, cardiovascular risk, atherosclerotic lesions, metabolic syndrome, adiponectin, monocyte, T-cell, cytokines, Neopterin, cardiovascular disease (CVD), systemic disease, T-lymphocytes, neopterin,obesity, myocardial infarction (MI), homocystein, lowdensity lipoproteins (LDL), atherogenesis, angiogenesis, high sensitive C-reactive protein (hsCRP), intima-media thickness, remodelling, cytokine, chemokine, metalloproteinase, dendritic, foam,osteoclast, nuclear factor, kappaB ligand, osteoprotegerin, T-helper lymphocytes of type 1 (Th-1), reactive oxygen species (ROS), macrophages, monocyte chemotactic protein (MCP), endocannabinoids, oxidation, anti-atherogenic role, sympathetic nervous system, Hypoxia, kappa-B, hypoadiponectinemia, nitric oxide (NO), endothelial NO synthase (eNOS), asymmetric dimethylarginine, bioavailibility, VSMCs, rheumatoid arthritis (RA), systemic lupus erythematodes

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Crossref · 10.2174/092986710794183006

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133 of 133 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Mangge, H., Almer, G., Truschnig-Wilders, M., Schmidt, A., Gasser, R., & Fuchs, D.
Affiliations
Medical University of Graz (AT)
Corresponding author
Fuchs, D.
ORCID
Venue
Current Medicinal Chemistry
Publisher
Bentham Science Publishers Ltd.
Published
2010-12-01
Volume
17
Issue
36
Pages
4511-4520
ISSN
0929-8673 (ISSN-L)
DOI
10.2174/092986710794183006
OpenAlex
W2134473992
Cited by
142
References
133
Citations by year
2026: 2 · 2024: 2 · 2023: 11 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 2 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 14 · 2013: 17 · 2012: 30
FWCI
13.50
Type
journal article
Language
en
Open access
closed
Locations
  • Current Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
adiponectin, obesity, atherosclerosis, cardiovascular risk, metabolic syndrome, immune-mediated inflammation, neopterin, cytokines, chemokines, body fat distribution, insulin resistance, dyslipidemia, intra-abdominal fat, homocysteine, low-density lipoprotein, atherogenesis, angiogenesis, C-reactive protein, intima-media thickness, NF-κB, osteoprotegerin, reactive oxygen species, macrophages, MCP-1, endocannabinoids, hypoadiponectinemia, nitric oxide, asymmetric dimethylarginine, endothelial dysfunction, rheumatoid arthritis, systemic lupus erythematosus
MeSH terms
Animals, Cardiovascular Diseases, Humans, Inflammation, Obesity, Risk Factors, Adiponectin

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