Cited by 232Antioxidant Activity and Oxidative StressRedox biology and oxidative stressNitric Oxide and Endothelin Effects

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4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases

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Shoeb, Mohammad, Ansari, Naseem, Srivastava, Satish, Ramana, Kota·2013·Current Medicinal Chemistry

DOI 10.2174/09298673113209990181PMC PMC3964795

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Abstract

Metastable aldehydes produced by lipid peroxidation act as 'toxic second messengers' that extend the injurious potential of free radicals. 4-hydroxy 2-nonenal (HNE), a highly toxic and most abundant stable end product of lipid peroxidation, has been implicated in the tissue damage, dysfunction, injury associated with aging and other pathological states such as cancer, Alzheimer, diabetes, cardiovascular and inflammatory complications. Further, HNE has been considered as a oxidative stress marker and it act as a secondary signaling molecule to regulates a number of cell signaling pathways. Biological activity of HNE depends on its intracellular concentration, which can differentially modulate cell death, growth and differentiation. Therefore, the mechanisms responsible for maintaining the intracellular levels of HNE are most important, not only in the defense against oxidative stress but also in the pathophysiology of a number of disease processes. In this review, we discussed the significance of HNE in mediating various disease processes and how regulation of its metabolism could be therapeutically effective.

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Authors: Shoeb, M., Ansari, N., Srivastava, S., & Ramana, K.
Affiliations: The University of Texas Medical Branch at Galveston (US)
Corresponding author: Ramana, Kota
ORCID: Ramana, Kota
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2013-12-31
Volume: 21
Issue: 2
Pages: 230-237
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/09298673113209990181
PMC: PMC3964795
OpenAlex: W2111649022
Cited by: 230
References: 122
Citations by year: 2026: 26 · 2025: 34 · 2024: 26 · 2023: 26 · 2022: 18 · 2021: 23 · 2020: 18 · 2019: 17 · 2018: 11 · 2017: 4 · 2016: 14 · 2015: 6 · 2014: 7
FWCI: 6.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA129383, R01CA129383)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK036118, Z01DK036116, R37DK036118)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: 4-hydroxynonenal, lipid peroxidation, oxidative stress, aldehydes, free radicals, pathogenesis, aging, cancer, Alzheimer's disease, diabetes mellitus, cardiovascular disease, inflammation, signal transduction, disease progression
MeSH terms: Aldehydes, Alzheimer Disease, Cardiovascular Diseases, Diabetes Mellitus, Humans, Neoplasms, Inflammatory Bowel Diseases, Lipid Peroxidation, Molecular Structure, Disease Progression

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4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases

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