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4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases
Open accessAbstract
Metastable aldehydes produced by lipid peroxidation act as 'toxic second messengers' that extend the injurious potential of free radicals. 4-hydroxy 2-nonenal (HNE), a highly toxic and most abundant stable end product of lipid peroxidation, has been implicated in the tissue damage, dysfunction, injury associated with aging and other pathological states such as cancer, Alzheimer, diabetes, cardiovascular and inflammatory complications. Further, HNE has been considered as a oxidative stress marker and it act as a secondary signaling molecule to regulates a number of cell signaling pathways. Biological activity of HNE depends on its intracellular concentration, which can differentially modulate cell death, growth and differentiation. Therefore, the mechanisms responsible for maintaining the intracellular levels of HNE are most important, not only in the defense against oxidative stress but also in the pathophysiology of a number of disease processes. In this review, we discussed the significance of HNE in mediating various disease processes and how regulation of its metabolism could be therapeutically effective.
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“However, 4-HNE is activating or inhibiting certain age-related signaling pathways, including NF-ĸB, Nrf2 or mTOR pathways, and might be therefore contributing to the aging process [179,180].”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [180]
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“However, 4-HNE is activating or inhibiting certain age-related signaling pathways, including NF-ĸB, Nrf2 or mTOR pathways, and might be therefore contributing to the aging process [179,180].”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [180]
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Cites
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Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment
Chikara, S., Nagaprashantha, L. D., Singhal, J., Horne, D. A., Awasthi, S., & Singhal, S. S. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.002 · Cited by 576
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Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases
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“However, 4-HNE is activating or inhibiting certain age-related signaling pathways, including NF-ĸB, Nrf2 or mTOR pathways, and might be therefore contributing to the aging process [179,180].”
BackgroundOxidative Stress in Health and Disease
Reddy, V. P. (2023) · Biomedicines · doi:10.3390/biomedicines11112925 · Cited by 391
Metadata
- Authors
- Shoeb, M., Ansari, N., Srivastava, S., & Ramana, K.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Ramana, Kota
- ORCID
- Ramana, Kota
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2013-12-31
- Volume
- 21
- Issue
- 2
- Pages
- 230-237
- ISSN
- 0929-8673 (ISSN-L)
- PMC
- PMC3964795
- OpenAlex
- W2111649022
- Cited by
- 230
- References
- 122
- Citations by year
- 2026: 26 · 2025: 34 · 2024: 26 · 2023: 26 · 2022: 18 · 2021: 23 · 2020: 18 · 2019: 17 · 2018: 11 · 2017: 4 · 2016: 14 · 2015: 6 · 2014: 7
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA129383, R01CA129383)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK036118, Z01DK036116, R37DK036118)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- 4-hydroxynonenal, lipid peroxidation, oxidative stress, aldehydes, free radicals, pathogenesis, aging, cancer, Alzheimer's disease, diabetes mellitus, cardiovascular disease, inflammation, signal transduction, disease progression
- MeSH terms
- Aldehydes, Alzheimer Disease, Cardiovascular Diseases, Diabetes Mellitus, Humans, Neoplasms, Inflammatory Bowel Diseases, Lipid Peroxidation, Molecular Structure, Disease Progression
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