CoChat
Sign Up
Cited by 507Sleep and Wakefulness ResearchNeuroinflammation and Neurodegeneration MechanismsCircadian rhythm and melatonin

The DOI matches its Crossref record; 114 of the 117 references it cites were found in a registry or an index, and 3 are not checked yet.

The Role of Cytokines in Sleep Regulation

Open access
Krueger, James·2008·Current Pharmaceutical Design
DOI 10.2174/138161208786549281PMC PMC2692603
Open this paper in CoChat — free account

Abstract

Interleukin-1 beta (IL1) and tumor necrosis factor alpha (TNF) promote non-rapid eye movement sleep under physiological and inflammatory conditions. Additional cytokines are also likely involved but evidence is insufficient to conclude that they are sleep regulatory substances. Many of the symptoms induced by sleep loss, e.g. sleepiness, fatigue, poor cognition, enhanced sensitivity to pain, can be elicited by injection of exogenous IL1 or TNF. We propose that ATP, released during neurotransmission, acting via purine P2 receptors on glia releases IL1 and TNF. This mechanism may provide the means by which the brain keeps track of prior usage history. IL1 and TNF in turn act on neurons to change their intrinsic properties and thereby change input-output properties (i.e. state shift) of the local network involved. Direct evidence indicates that cortical columns oscillate between states, one of which shares properties with organism sleep. We conclude that sleep is a local use-dependent process influenced by cytokines and their effector molecules such as nitric oxide, prostaglandins and adenosine.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2174/138161208786549281

Cites

114 of 117 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 114 references

Research works printed but not linked: 4

  1. [32]Krueger JM, Obál F., Jr . Sleep Factors. Sleep and Breathing. New York: Marcel Dekker, Inc.; 1994. pp. 79–112. [Google Scholar]
  2. [33]Jouvet M. Neuromediateurs et facteurs hypnogenes. Rev Neurol (Paris) 1984;140:389–400. [PubMed] [Google Scholar]
  3. [34]Inoué S. Biology of sleep substances. Boca Raton, Florida: CRC Press, Inc.; 1989. [Google Scholar]
  4. [76]Fix C, Churchill L, Hall S, Krueger JM. The number of tumor necrosis factor α-immunoreactive cells increases in layer IV of the barrel field in response to whisker deflection in rats. Sleep. 2006;29:A11. [Google Scholar]

Cited by

Sorted by citations

Items 401–500 of 507

Related

See all

Metadata

Authors
Krueger, J.
Affiliations
Washington State University (US)
Corresponding author
Krueger, James
Venue
Current Pharmaceutical Design
Publisher
Bentham Science Publishers Ltd.
Published
2008-11-01
Volume
14
Issue
32
Pages
3408-3416
ISSN
1381-6128 (ISSN-L)
DOI
10.2174/138161208786549281
PMC
PMC2692603
OpenAlex
W2023517019
Cited by
507
References
114
Citations by year
2026: 18 · 2025: 42 · 2024: 43 · 2023: 32 · 2022: 28 · 2021: 32 · 2020: 30 · 2019: 33 · 2018: 19 · 2017: 23 · 2016: 27 · 2015: 19 · 2014: 31 · 2013: 52 · 2012: 26
FWCI
8.96
Type
journal article
Language
en
Open access
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, R01NS027250, R01NS025378)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-36520, R01HD036520)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
cytokines, sleep regulation, IL-1β, TNF-α, NREM sleep, ATP release, purinergic P2 receptors, glial activation, sleep deprivation, cortical columns, cortical oscillations, nitric oxide, prostaglandins, adenosine
MeSH terms
Humans, Sleep, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review