The DOI matches its Crossref record; 114 of the 117 references it cites were found in a registry or an index, and 3 are not checked yet.
The Role of Cytokines in Sleep Regulation
Open accessAbstract
Interleukin-1 beta (IL1) and tumor necrosis factor alpha (TNF) promote non-rapid eye movement sleep under physiological and inflammatory conditions. Additional cytokines are also likely involved but evidence is insufficient to conclude that they are sleep regulatory substances. Many of the symptoms induced by sleep loss, e.g. sleepiness, fatigue, poor cognition, enhanced sensitivity to pain, can be elicited by injection of exogenous IL1 or TNF. We propose that ATP, released during neurotransmission, acting via purine P2 receptors on glia releases IL1 and TNF. This mechanism may provide the means by which the brain keeps track of prior usage history. IL1 and TNF in turn act on neurons to change their intrinsic properties and thereby change input-output properties (i.e. state shift) of the local network involved. Direct evidence indicates that cortical columns oscillate between states, one of which shares properties with organism sleep. We conclude that sleep is a local use-dependent process influenced by cytokines and their effector molecules such as nitric oxide, prostaglandins and adenosine.
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“IL-1 and TNF stimulate NF-κB, a DNA-binding protein involved in transcription of hundreds of gene products.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Krueger, 2008
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“Administration of either IL-1 or TNF promotes NREM sleep (Obal and Krueger, 2003;Opp, 2005;Krueger, 2008).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Krueger, 2008
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Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
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Sleep and inflammation: partners in sickness and in health
Irwin, M. R. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0190-z · Cited by 1,138
Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity
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Metadata
- Authors
- Krueger, J.
- Affiliations
- Washington State University (US)
- Corresponding author
- Krueger, James
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2008-11-01
- Volume
- 14
- Issue
- 32
- Pages
- 3408-3416
- ISSN
- 1381-6128 (ISSN-L)
- PMC
- PMC2692603
- OpenAlex
- W2023517019
- Cited by
- 507
- References
- 114
- Citations by year
- 2026: 18 · 2025: 42 · 2024: 43 · 2023: 32 · 2022: 28 · 2021: 32 · 2020: 30 · 2019: 33 · 2018: 19 · 2017: 23 · 2016: 27 · 2015: 19 · 2014: 31 · 2013: 52 · 2012: 26
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, R01NS027250, R01NS025378)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-36520, R01HD036520)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- cytokines, sleep regulation, IL-1β, TNF-α, NREM sleep, ATP release, purinergic P2 receptors, glial activation, sleep deprivation, cortical columns, cortical oscillations, nitric oxide, prostaglandins, adenosine
- MeSH terms
- Humans, Sleep, Cytokines
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