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Cited by 507Sleep and Wakefulness ResearchNeuroinflammation and Neurodegeneration MechanismsCircadian rhythm and melatonin

The DOI matches its Crossref record; 114 of the 117 references it cites were found in a registry or an index, and 3 are not checked yet.

The Role of Cytokines in Sleep Regulation

Open access
Krueger, James·2008·Current Pharmaceutical Design
DOI 10.2174/138161208786549281PMC PMC2692603
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Abstract

Interleukin-1 beta (IL1) and tumor necrosis factor alpha (TNF) promote non-rapid eye movement sleep under physiological and inflammatory conditions. Additional cytokines are also likely involved but evidence is insufficient to conclude that they are sleep regulatory substances. Many of the symptoms induced by sleep loss, e.g. sleepiness, fatigue, poor cognition, enhanced sensitivity to pain, can be elicited by injection of exogenous IL1 or TNF. We propose that ATP, released during neurotransmission, acting via purine P2 receptors on glia releases IL1 and TNF. This mechanism may provide the means by which the brain keeps track of prior usage history. IL1 and TNF in turn act on neurons to change their intrinsic properties and thereby change input-output properties (i.e. state shift) of the local network involved. Direct evidence indicates that cortical columns oscillate between states, one of which shares properties with organism sleep. We conclude that sleep is a local use-dependent process influenced by cytokines and their effector molecules such as nitric oxide, prostaglandins and adenosine.

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Research works printed but not linked: 4

  1. [32]Krueger JM, Obál F., Jr . Sleep Factors. Sleep and Breathing. New York: Marcel Dekker, Inc.; 1994. pp. 79–112. [Google Scholar]
  2. [33]Jouvet M. Neuromediateurs et facteurs hypnogenes. Rev Neurol (Paris) 1984;140:389–400. [PubMed] [Google Scholar]
  3. [34]Inoué S. Biology of sleep substances. Boca Raton, Florida: CRC Press, Inc.; 1989. [Google Scholar]
  4. [76]Fix C, Churchill L, Hall S, Krueger JM. The number of tumor necrosis factor α-immunoreactive cells increases in layer IV of the barrel field in response to whisker deflection in rats. Sleep. 2006;29:A11. [Google Scholar]

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Metadata

Authors
Krueger, J.
Affiliations
Washington State University (US)
Corresponding author
Krueger, James
Venue
Current Pharmaceutical Design
Publisher
Bentham Science Publishers Ltd.
Published
2008-11-01
Volume
14
Issue
32
Pages
3408-3416
ISSN
1381-6128 (ISSN-L)
DOI
10.2174/138161208786549281
PMC
PMC2692603
OpenAlex
W2023517019
Cited by
507
References
114
Citations by year
2026: 18 · 2025: 42 · 2024: 43 · 2023: 32 · 2022: 28 · 2021: 32 · 2020: 30 · 2019: 33 · 2018: 19 · 2017: 23 · 2016: 27 · 2015: 19 · 2014: 31 · 2013: 52 · 2012: 26
FWCI
8.96
Type
journal article
Language
en
Open access
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, R01NS027250, R01NS025378)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-36520, R01HD036520)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
cytokines, sleep regulation, IL-1β, TNF-α, NREM sleep, ATP release, purinergic P2 receptors, glial activation, sleep deprivation, cortical columns, cortical oscillations, nitric oxide, prostaglandins, adenosine
MeSH terms
Humans, Sleep, Cytokines

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