The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches
Open accessAbstract
A typical feature of ageing is a chronic, low-grade inflammation characterized by a general increase in the production of pro-inflammatory cytokines and inflammatory markers ("inflamm-ageing"). This status may slowly damage one or several organs, especially when unfavorable genetic polymorphisms and epigenetic alterations are concomitant, leading to an increased risk of frailty together with the onset of age-related chronic diseases. The contribution of different tissues (adipose tissue, muscle), organs (brain, liver), immune system and ecosystems (gut microbiota) to age-related inflammation ("inflamm-ageing") will be discussed in this review in the context of its onset/progression leading to site-restricted and systemic effects. Moreover, some of the possible strategies and therapies to counteract the different sources of molecular mediators which lead to the age-related inflammatory phenotype will be presented.
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Cites
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Cited by
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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
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Metadata
- Authors
- Cevenini, E., Caruso, C., Candore, G., Capri, M., Nuzzo, D., Duro, G., Rizzo, C., Colonna-Romano, G., Lio, D., Carlo, D., Palmas, M., Scurti, M., Pini, E., Franceschi, C., & Vasto, S.
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-02-01
- Volume
- 16
- Issue
- 6
- Pages
- 609-618
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W2128402823
- Cited by
- 167
- References
- 25
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Cevenini, E., Caruso, C., Candore, G., Capri, M., Nuzzo, D., Duro, G., Rizzo, C., Colonna-Romano, G., Lio, D., Carlo, D., Palmas, M., Scurti, M., Pini, E., Franceschi, C., & Vasto, S. (2010). Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches. Current Pharmaceutical Design. https://doi.org/10.2174/138161210790883840
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
