Cited by 549Cardiovascular Health and Disease PreventionSmoking Behavior and CessationBlood Pressure and Hypertension Studies

Cigarette Smoking and Hypertension

Virdis, A., Giannarelli, C., Fritsch Neves, M., Taddei, S., Ghiadoni, L.·2010·Current Pharmaceutical Design

Abstract

Cigarette smoking is a powerful cardiovascular risk factor and smoking cessation is the single most effective lifestyle measure for the prevention of a large number of cardiovascular diseases. Impairment of endothelial function, arterial stiffness, inflammation, lipid modification as well as an alteration of antithrombotic and prothrombotic factors are smoking-related major determinants of initiation, and acceleration of the atherothrombotic process, leading to cardiovascular events. Cigarette smoking acutely exerts an hypertensive effect, mainly through the stimulation of the sympathetic nervous system. As concern the impact of chronic smoking on blood pressure, available data do not put clearly in evidence a direct causal relationship between these two cardiovascular risk factors, a concept supported by the evidence that no lower blood pressure values have been observed after chronic smoking cessation. Nevertheless, smoking, affecting arterial stiffness and wave reflection might have greater detrimental effect on central blood pressure, which is more closely related to target organ damage than brachial blood pressure. Hypertensive smokers are more likely to develop severe forms of hypertension, including malignant and renovascular hypertension, an effect likely due to an accelerated atherosclerosis.

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Registry

Crossref · 10.2174/138161210792062920

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87 of 87 references verified0 citation errors · 0 not checkable

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Authors
Virdis, A., Giannarelli, C., Fritsch Neves, M., Taddei, S., & Ghiadoni, L.
Affiliations
University of Pisa (IT)
Venue
Current Pharmaceutical Design
Published
2010-08-01
Volume
16
Issue
23
Pages
2518-2525
ISSN
1381-6128 (ISSN-L)
OpenAlex
W2106507216
Cited by
549
References
87
Citations by year
2026: 18 · 2025: 37 · 2024: 47 · 2023: 90 · 2022: 58 · 2021: 61 · 2020: 51 · 2019: 34 · 2018: 31 · 2017: 20 · 2016: 18 · 2015: 17 · 2014: 21 · 2013: 12 · 2012: 17
FWCI
9.88
Type
journal article
Language
en
Open access
closed
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
cigarette smoking, hypertension, smoking cessation, cardiovascular risk factors, endothelial dysfunction, arterial stiffness, wave reflection, central blood pressure, sympathetic nervous system, atherothrombosis, malignant hypertension, renovascular hypertension, atherosclerosis, inflammation, lipid modification
MeSH terms
Animals, Blood Pressure, Cardiovascular Diseases, Endothelium, Vascular, Humans, Hypertension, Risk Factors, Smoking, Vascular Resistance

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