Cited by 307Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionRedox biology and oxidative stress

The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

Karbach, Susanne, Wenzel, Philip, Waisman, Ari, Munzel, Thomas, Daiber, Andreas·2014·Current Pharmaceutical Design

DOI 10.2174/13816128113196660748

Open this paper in CoChat — free account

Abstract

Many cardiovascular diseases and drug-induced complications are associated with - or even based on - an imbalance between the formation of reactive oxygen and nitrogen species (RONS) and antioxidant enzymes catalyzing the break-down of these harmful oxidants. According to the "kindling radical" hypothesis, the formation of RONS may trigger in certain conditions the activation of additional sources of RONS. According to recent reports, vascular dysfunction in general and cardiovascular complications such as hypertension, atherosclerosis and coronary artery diseases may be connected to inflammatory processes. The present review is focusing on the uncoupling of endothelial nitric oxide synthase (eNOS) by different mechanisms involving so-called "redox switches". The oxidative depletion of tetrahydrobiopterin (BH4), oxidative disruption of the dimeric eNOS complex, S-glutathionylation and adverse phosphorylation as well as RONS-triggered increases in levels of asymmetric dimethylarginine (ADMA) will be discussed. But also new concepts of eNOS uncoupling and state of the art detection of this process will be described. Another part of this review article will address pharmaceutical interventions preventing or reversing eNOS uncoupling and thereby normalize vascular function in a given disease setting. We finally turn our attention to the inflammatory mechanisms that are also involved in the development of endothelial dysfunction and cardiovascular disease. Inflammatory cell and cytokine profiles as well as their interactions, which are among the kindling mechanisms for the development of vascular dysfunction will be discussed on the basis of the current literature.

Integrity signals

Registry

Crossref · 10.2174/13816128113196660748

Cites

155 of 155 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Uncoupling of Endothelial Nitric Oxidase Synthase by Hypochlorous Acid
Xu, J., Xie, Z., Reece, R., Pimental, D. R., & Zou, M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000249394.94588.82 · Cited by 146
Retracted
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker
Bradley, P. P., Priebat, D. A., Christensen, R. D., & Rothstein, G. (1982) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12506462 · Cited by 3,628
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591
Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease
Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736

Show all 155 references

Sorted by citations

Items 101–200 of 305

Vascular and Cardiac Oxidative Stress and Inflammation as Targets for Cardioprotection
Daiber, A., Steven, S., Euler, G., & Schulz, R. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210125155821 · Cited by 40
Self-citation
Reduced endothelial nitric oxide synthase activation contributes to cardiovascular injury during chronic kidney disease progression
Amador‐Martínez, I., Pérez‐Villalva, R., Uribe, N., Cortés‐González, C., Bobadilla, N. A., & Barrera‐Chimal, J. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00020.2019 · Cited by 37
Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects
Frenis, K., Helmstädter, J., Ruan, Y., Schramm, E., Kalinovic, S., Kröller‐Schön, S., Jiménez, M. T. B., Hahad, O., Oelze, M. W., Jiang, S., et al. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00869-5 · Cited by 37
Self-citation
Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies
Peleli, M., Moustakas, A., & Papapetropoulos, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197371 · Cited by 38
Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite
Dent, M. R., DeMartino, A. W., Tejero, J., & Gladwin, M. T. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.1c01048 · Cited by 35
Impaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus
Akoumianakis, I., & Antoniades, C. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7421 · Cited by 37
Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling
Hashimoto, T., Sivakumaran, V., Carnicer, R., Zhu, G., Hahn, V. S., Bedja, D., Récalde, A., Duglan, D., Channon, K. M., Casadei, B., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003208 · Cited by 36
Analysis of the antioxidant potential in aerial parts of Trigonella arabica and Trigonella berythea grown widely in Palestine: A comparative study
Jaradat, N. A., Shawahna, R., Hussein, F., & Al-Lahham, S. (2016) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2016.04.004 · Cited by 34
Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation
Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K. M., Zhang, M., Kim, G. E., Tsujita, K., & Kass, D. A. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004740 · Cited by 34
Periplaneta americana Extract Pretreatment Alleviates Oxidative Stress and Inflammation and Increases the Abundance of Gut Akkermansia muciniphila in Diquat-Induced Mice
Lu, S., Xu, S., Chen, L., Deng, Y., & Feng, J. (2022) · Antioxidants · doi:10.3390/antiox11091806 · Cited by 34
Differential contribution of endothelium-derived relaxing factors to vascular reactivity in conduit and resistance arteries from normotensive and hypertensive rats
Jiang, J., Zheng, J., Li, Y., Gan, Z., Jiang, Y., Huang, D., Li, H., Liu, Z., & Ke, Y. (2016) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2016.1148155 · Cited by 32
Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology
Otašević, V., Stančić, A., Korać, A., Janković, A., & Korać, B. (2019) · BioFactors · doi:10.1002/biof.1535 · Cited by 32
Fenugreek (Trigonella Foenum-Graecum) Seed Flour and Diosgenin Preserve Endothelium-Dependent Arterial Relaxation in a Rat Model of Early-Stage Metabolic Syndrome
Szabó, K., Gesztelyi, R., Lampé, N., Kiss, R., Remenyik, J., Pesti‐Asbóth, G., Priksz, D., Szilvássy, Z., & Juhász, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030798 · Cited by 31
Uncoupled Endothelial Nitric Oxide Synthase Enhances p-Tau in Chronic Traumatic Encephalopathy Mouse Model
Shin, N., Kim, H.-G., Shin, H. J., Kim, S., Kwon, H. H., Baek, H., Yi, M., Zhang, E., Kim, J.-J., Hong, J., et al. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7280 · Cited by 30
Functional and Biochemical Endothelial Profiling In Vivo in a Murine Model of Endothelial Dysfunction; Comparison of Effects of 1-Methylnicotinamide and Angiotensin-converting Enzyme Inhibitor
Bar, A., Olkowicz, M., Tyrankiewicz, U., Kuś, E., Jasiński, K., Smolenski, R. T., Skórka, T., & Chłopicki, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00183 · Cited by 30
Role of CD40(L)-TRAF signaling in inflammation and resolution—a double-edged sword
Strohm, L., Ubbens, H., Münzel, T. F., Daiber, A., & Daub, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.995061 · Cited by 29
Self-citation
Mitigation of aircraft noise-induced vascular dysfunction and oxidative stress by exercise, fasting, and pharmacological α1AMPK activation: molecular proof of a protective key role of endothelial α1AMPK against environmental noise exposure
Kvandová, M., Rajlic, S., Stamm, P., Schmal, I., Mihaliková, D., Kuntić, M., Jiménez, M. T. B., Hahad, O., Kollárová, M., Ubbens, H., et al. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad075 · Cited by 28
Self-citation
Effects of Cornelian Cherry on Atherosclerosis and Its Risk Factors
Lietava, J., Beerová, N., Klymenko, S. V., Panghyová, E., Varga, I., & Pecháňová, O. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2515270 · Cited by 33
Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging
Bartolo, A. D., Angelone, T., & Rocca, C. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107462 · Cited by 30
Noise-Induced Vascular Dysfunction, Oxidative Stress, and Inflammation Are Improved by Pharmacological Modulation of the NRF2/HO-1 Axis
Jiménez, M. T. B., Frenis, K., Kröller‐Schön, S., Kuntić, M., Stamm, P., Kvandová, M., Oelze, M. W., Li, H., Steven, S., Münzel, T. F., et al. (2021) · Antioxidants · doi:10.3390/antiox10040625 · Cited by 27
Self-citation
Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats
Carvalho‐Galvão, A., Ogunlade, B., Xu, J., Silva-Alves, C. R. A., Mendes-Júnior, L. G., Guimarães, D. D., Cruz, J. C., de Queiroz, T. M., Balarini, C. M., Braga, V. A., et al. (2018) · Clinical Science · doi:10.1042/cs20180222 · Cited by 26
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension
Wang, R., Guo, Y., Li, L., Luo, M., Peng, L., Lv, D., Cheng, Z., Xue, Q., Wang, L., & Huang, J. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.08.008 · Cited by 24
BIOFLAVONOIDS AS AGENTS FOR CORRECTING NITRO-OXIDATIVE STRESS AND SALIVARY GLAND FUNCTIONS IN RATS EXPOSED TO ALCOHOL DURING MODELED LIPOPOLYSACCHARIDE-INDUCED SYSTEMIC INFLAMMATORY RESPONSE
Kozaeva, R., Klymenko, M. O., Катрушов, О. В., & Kostenko, V. O. (2022) · Wiadomości Lekarskie · doi:10.36740/wlek202203121 · Cited by 25
Hydrogen sulfide prevents the vascular dysfunction induced by severe traumatic brain injury in rats by reducing reactive oxygen species and modulating eNOS and H2S-synthesizing enzyme expression
López-Preza, F. I., de la Cruz, S. H., Santiago-Castañeda, C., Silva‐Velasco, D. L., Beltran‐Ornelas, J. H., Tapia-Martínez, J. A., Sánchez‐López, A., Rocha, L., & Centurión, D. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121218 · Cited by 25
Optimization of ultrasonic-assisted extraction of eugenol-rich fraction from basil leaves: Characterization of extract for phenols, flavonoids and antioxidant activity
Kousar, M. U., Jabeen, A., Fatima, T., Hussain, S. Z., Zargar, I. A., Amin, T., & Yaseen, M. (2023) · Food Chemistry Advances · doi:10.1016/j.focha.2023.100374 · Cited by 26
Nitric Oxide Signaling in Cardiovascular Physiology and Pathology: Mechanisms, Dysregulation, and Therapeutic Frontiers
Venkatesan, S., Smirne, C., Aquino, C. I., Surico, D., Remorgida, V., Pour, M. M. O., Pirisi, M., & Grossini, E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020629 · Cited by 30
Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure
Milewski, K., Czarnecka, A. M., Albrecht, J., & Zielińska, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136662 · Cited by 23
Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases
Erre, G. L., Mangoni, A. A., Castagna, F., Paliogiannis, P., Carru, C., Passiu, G., & Zinellu, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-41994-5 · Cited by 24
Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein–Coupled Receptor 5
Cai, Z., Yuan, S., Zhong, Y., Deng, L., Li, J., Tan, X., & Feng, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.637051 · Cited by 23
Deacetylation mimetic mutation of mitochondrial SOD2 attenuates ANG II-induced hypertension by protecting against oxidative stress and inflammation
Dikalova, A., Ao, M., Tkachuk, L., & Dikalov, S. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00162.2024 · Cited by 23
PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction
Ma, X., Su, M., He, Q., Zhang, Z., Zhang, F., Liu, Z., Sun, L., Weng, J., & Xu, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.958677 · Cited by 23
Chronic anemia is associated with systemic endothelial dysfunction
Chennupati, R., Solga, I., Wischmann, P., Dahlmann, P., Celik, F. G., Pacht, D., Şahin, A., Yogathasan, V., Hosen, M. R., Gerdes, N., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1099069 · Cited by 23
Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction
Chang, K., Lee, A., Chen, W., Lin, Y., Hsu, J., Chan, H., Chang, C., Chang, S., Pan, C.-C., Sawamura, T., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.03.016 · Cited by 23
Ebselen reduces cigarette smoke‐induced endothelial dysfunction in mice
Brassington, K., Chan, S. M. H., Seow, H. J., Dobric, A., Bozinovski, S., Selemidis, S., & Vlahos, R. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15400 · Cited by 23
Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathology
Choi, S., Singh, I., Singh, A. K., Khan, M., & Won, J. (2020) · The FASEB Journal · doi:10.1096/fj.201901318r · Cited by 22
Redox Switches in Noise-Induced Cardiovascular and Neuronal Dysregulation
Frenis, K., Kuntić, M., Hahad, O., Jiménez, M. T. B., Oelze, M. W., Daub, S., Steven, S., Münzel, T. F., & Daiber, A. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.784910 · Cited by 22
Self-citation
Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow
Datar, S. A., Gong, W., He, Y., Johengen, M. J., Kameny, R. J., Raff, G. W., Maltepe, E., Oishi, P. E., & Fineman, J. R. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00649.2015 · Cited by 21
Dietary practices of adult Egyptians before and during the COVID-19 lockdown
Ali, S. A. E. M., Aly, M. O., & El-Nimr, N. (2021) · Nutrire · doi:10.1186/s41110-021-00139-3 · Cited by 20
Understanding the erectile dysfunction–cardiovascular disease connection: clinical and pathophysiological insights
An, J., Xiang, B., Peng, J., & Li, D. (2025) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeaf014 · Cited by 20
NO Signaling in the Cardiovascular System and Exercise
Fernandes, T. M., Gomes‐Gatto, C. D. V., Pereira, N. P., Alayafi, Y. R., das Neves, V. J., & de Oliveira, E. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4304-8_13 · Cited by 22
Environmental Alterations during Embryonic Development: Studying the Impact of Stressors on Pluripotent Stem Cell-Derived Cardiomyocytes
Lamberto, F., Peral-Sanchez, I., Muenthaisong, S., Zana, M., Willaime‐Morawek, S., & Dinnyés, A. (2021) · Genes · doi:10.3390/genes12101564 · Cited by 25
Nomilin and its analogue obacunone alleviate NASH and hepatic fibrosis in mice via enhancing antioxidant and anti‐inflammation capacity
Han, Y., Luo, L., Li, H., Zhang, L., Yan, Y., Fang, M., Yu, J., Gao, X., Liu, Y., Huang, C., et al. (2023) · BioFactors · doi:10.1002/biof.1987 · Cited by 20
κ-Opioid Receptor Stimulation Improves Endothelial Function via Akt-stimulated NO Production in Hyperlipidemic Rats
Tian, F., Zheng, X., Li, J., Zhang, S., Feng, N., Guo, H.-T., Jia, M., Wang, Y.-M., Fan, R., & Pei, J. (2016) · Scientific Reports · doi:10.1038/srep26807 · Cited by 20
Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS)
Krzystek‐Korpacka, M., Wiśniewski, J. Ł., Fleszar, M. G., Bednarz-Misa, I. S., Bronowicka-Szydełko, A., Gacka, M., Masłowski, L., Kędzior, K., Witkiewicz, W., & Gamian, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5965721 · Cited by 20
From winery by-product to healthy product: bioavailability, redox signaling and oxidative stress modulation by wine pomace product
Gerardi, G., Cavia-Sáiz, M., & Múñiz, P. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1914542 · Cited by 23
Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease
Liu, C., Yang, Y., Peng, D., Chen, L., & Luo, J. (2015) · Saudi Medical Journal · doi:10.15537/smj.2015.7.11453 · Cited by 20
Investigation of the antiobesity and antioxidant properties of wild Plumbago europaea and Plumbago auriculata from North Palestine
Jaradat, N. A., Zaid, A. N., & Hussein, F. (2016) · Chemical and Biological Technologies in Agriculture · doi:10.1186/s40538-016-0082-4 · Cited by 20
Systematic exploration of the potential material basis and molecular mechanism of the Mongolian medicine Nutmeg-5 in improving cardiac remodeling after myocardial infarction.
Liu, T., Yan, T.-T., Jia, X., Liu, J., Ma, R., Wang, Y., Wang, X., Liang, Y., Xiao, Y., & Dong, Y. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114847 · Cited by 17
Role of Protein Kinase C and Nox2‐Derived Reactive Oxygen Species Formation in the Activation and Maturation of Dendritic Cells by Phorbol Ester and Lipopolysaccharide
Stein, J., Steven, S., Bros, M., Sudowe, S., Hausding, M., Oelze, M. W., Münzel, T. F., Grabbe, S., Reske‐Kunz, A. B., & Daiber, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4157213 · Cited by 19
Self-citation
A Recombinant Dimethylarginine Dimethylaminohydrolase-1–Based Biotherapeutics to Pharmacologically Lower Asymmetric Dimethyl Arginine, thus Improving Postischemic Cardiac Function and Cardiomyocyte Mitochondrial Activity
Lee, Y., Singh, J., Scott, S. R., Ellis, B., Zorlutuna, P., & Wang, M. (2022) · Molecular Pharmacology · doi:10.1124/molpharm.121.000394 · Cited by 18
Flavonoid Compounds in Hippophae rhamnoides L. Protect Endothelial Cells from Oxidative Damage Through the PI3K/AKT‐eNOS Pathway
Wang, M., Zhang, X., Zhang, Z., Li, T., Yu, S., Liu, Y., & Yang, F. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202400300 · Cited by 18
Monoamine Oxidases as Potential Contributors to Oxidative Stress in Diabetes: Time for a Study in Patients Undergoing Heart Surgery
Duicu, O., Lighezan, R., Sturza, A., Ceauşu, R. A., Borza, C., Văduva, A., Noveanu, L., Gaşpar, M., Ionac, A., Feier, H. B., et al. (2015) · BioMed Research International · doi:10.1155/2015/515437 · Cited by 18
The role of polydatin in inhibiting oxidative stress through SIRT1 activation: A comprehensive review of molecular targets
Liu, K., Liu, J., Xu, A., & Ding, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118322 · Cited by 17
Atorvastatin protects endothelium by decreasing asymmetric dimethylarginine in dyslipidemia rats
Zheng, D., Liang, Q., Zeng, F., Mai, Z., Cai, A., Qiu, R., Xu, R., Li, D.-J., & Mai, W. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0041-2 · Cited by 17
Endothelial Dysfunction in Type 2 Diabetes: Targeting Inflammation
Sena, C. M., Carrilho, F., & Seiça, R. M. F. (2018) · InTech eBooks · doi:10.5772/intechopen.76994 · Cited by 21
A Review of the Actions of Endogenous and Exogenous Vasoactive Substances during the Estrous Cycle and Pregnancy in Rats
Jaimes, L., Vinet, R., Knox, M., Morales, B., Benites, J. F., Laurido, C., & Martínez, J. L. (2019) · Animals · doi:10.3390/ani9060288 · Cited by 18
The Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1α–Heme Oxygenase 1 Axis, a Powerful Antioxidative Pathway with Potential to Attenuate Diabetic Cardiomyopathy
Waldman, M., Arad, M., Abraham, N. G., & Hochhauser, E. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7989 · Cited by 17
Brief High Oxygen Concentration Induces Oxidative Stress in Leukocytes and Platelets: A Randomized Cross-over Pilot Study in Healthy Male Volunteers
Hafner, C. M., Pramhas, S., Schaubmayr, W., Assinger, A., Gleiß, A., Tretter, V. E., Klein, K. U., & Scharbert, G. (2021) · Shock · doi:10.1097/shk.0000000000001728 · Cited by 17
Development of an Adverse Outcome Pathway for the Onset of Hypertension by Oxidative Stress-Mediated Perturbation of Endothelial Nitric Oxide Bioavailability
Lowe, F., Luettich, K., Talikka, M., Hoang, V., Haswell, L. E., Hoeng, J., & Gaça, M. (2017) · Applied In Vitro Toxicology · doi:10.1089/aivt.2016.0031 · Cited by 17
Cornelian cherry consumption increases the l -arginine/ADMA ratio, lowers ADMA and SDMA levels in the plasma, and enhances the aorta glutathione level in rabbits fed a high-cholesterol diet
Sozański, T., Kucharska, A. Z., Szumny, D., Magdalan, J., Merwid‐Ląd, A., Nowak, B., Piórecki, N., Dzimira, S., Jodkowska, A., Szeląg, A., et al. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.04.028 · Cited by 17
The Role of Vascular Aging in Atherosclerotic Plaque Development and Vulnerability
Liberale, L., & Camici, G. G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190830175424 · Cited by 18
The effect of selected hemp seed protein hydrolysates in modulating vascular function
Mahbub, R., Callcott, E. T., Rao, S. A., Ansari, O., Waters, D. L., BLANCHARD, C. L., & Santhakumar, A. B. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101504 · Cited by 17
Autophagy Inhibits Inflammation via Down-Regulation of p38 MAPK/mTOR Signaling Cascade in Endothelial Cells
Zhou, L., Wang, J., Hou, H., Li, J., Li, J., Liang, J., Li, J., Niu, X., Hou, R., & Zhang, K. (2023) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s405068 · Cited by 16
Current progress on the mechanisms of hyperhomocysteinemia-induced vascular injury and use of natural polyphenol compounds
Jiang, Q., Wang, L., Si, X., Tian, J., Zhang, Y., Gui, H., Li, B., & Tan, D. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174168 · Cited by 19
Association of Impaired Vascular Endothelial Function with Increased Cardiovascular Risk in Asymptomatic Adults
Zhong, Q., Nong, Q., Mao, B., Pan, X., & Meng, L. (2018) · BioMed Research International · doi:10.1155/2018/3104945 · Cited by 16
Advancements in the Research of New Modulators of Nitric Oxide Synthases Activity
Maccallini, C., Budriesi, R., Filippis, B. D., & Amoroso, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158486 · Cited by 16
Symmetric dimethylarginine (SDMA) serum levels in rheumatoid arthritis: correlations with insulin resistance and disease activity scores
Dimitroulas, T., Hodson, J. A., Sandoo, A., Smith, J., & Kitas, G. D. (2015) · Amino Acids · doi:10.1007/s00726-015-1953-x · Cited by 15
Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjects
Ras, R. T., Fuchs, D., Koppenol, W. P., Schalkwijk, C., Otten-Hofman, A., Garczarek, U., Greyling, A., Wagner, F. D., & Trautwein, E. A. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.40 · Cited by 15
The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection
Zhang, Z., Wang, H., Kan, X., Zhang, X., Xu, S., Cai, J., & Guo, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1519273 · Cited by 17
Gold nanoparticles application to the treatment of brain dysfunctions related to metabolic diseases: evidence from experimental studies
Silveira, P. C. L., Rodrigues, M. S., Gelain, D. P., & de Oliveira, J. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00929-2 · Cited by 16
Emerging roles of interferon-stimulated gene-15 in age-related telomere attrition, the DNA damage response, and cardiovascular disease
González‐Amor, M., Dorado, B., & Andrés, V. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1128594 · Cited by 14
Relationship between dimethylarginine dimethylaminohydrolase gene variants and asymmetric dimethylarginine in patients with rheumatoid arthritis
Dimitroulas, T., Sandoo, A., Hodson, J. A., Smith, J., Panoulas, V. F., & Kitas, G. D. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.07.033 · Cited by 14
Glycosylation with O-linked β-N-acetylglucosamine induces vascular dysfunction via production of superoxide anion/reactive oxygen species
Souza-Silva, L., Alves-Lopes, R., Miguez, J. S., Justina, V. D., Neves, K. B., Mestriner, F., Tostes, R. C., Giachini, F. R. C., & Lima, V. V. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0225 · Cited by 15
Hydromorphine postconditioning protects isolated rat heart against ischemia‐reperfusion injury via activating P13K/Akt/eNOS signaling
Liu, Q. H., Li, Z., Liu, Y., Xiao, Q., Peng, X., Chen, Q., Deng, R., Gao, Z., Yu, F., & Zhang, Y. (2018) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12481 · Cited by 14
Significance of neutrophil microparticles in ischaemia‐reperfusion: Pro‐inflammatory effectors of endothelial senescence and vascular dysfunction
Habhab, A. E., Altamimy, R., Abbas, M., Kassem, M., Amoura, L., Qureshi, A. W., Itawi, H. E., Kreutter, G., Khemais-Benkhiat, S., Zobairi, F., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15289 · Cited by 11
Recommendations for Cardiovascular Prevention During the Sars-Cov-2 Pandemic: An Executive Document by the Board of the Italian Society of Cardiovascular Prevention
Volpe, M., Battistoni, A., the board of the Italian Society of Cardiovascular Prevention, Bellotti, P., Bellone, S., Bertolotti, M., Biffi, A., Consoli, A., Corsini, A., Desideri, G., et al. (2020) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-020-00401-1 · Cited by 15
Computational analysis of interactions of oxidative stress and tetrahydrobiopterin reveals instability in eNOS coupling
Panday, S., Kar, S., & Kavdia, M. (2017) · Microvascular Research · doi:10.1016/j.mvr.2017.07.001 · Cited by 14
The Inhibitory Effect of Ojeoksan on Early and Advanced Atherosclerosis
Han, B. H., Seo, C., Yoon, J. J., Kim, H. Y., Ahn, Y. M., Eun, S. Y., Hong, M. H., Lee, J., Shin, H., Lee, H. S., et al. (2018) · Nutrients · doi:10.3390/nu10091256 · Cited by 14
Small Molecules Targeting Mitochondria: A Mechanistic Approach to Combating Doxorubicin-Induced Cardiotoxicity
Pal, C. (2024) · Cardiovascular Toxicology · doi:10.1007/s12012-024-09941-7 · Cited by 14
Organ preservation: current limitations and optimization approaches
Ran, Q., Zhang, J., Zhong, J., Lin, J., Zhang, S., Li, G., & You, B. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1566080 · Cited by 16
Associations between asymmetric dimethylarginine, homocysteine, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in rheumatoid arthritis
Dimitroulas, T., Sandoo, A., Hodson, J. A., Smith, J., Douglas, K., & Kitas, G. D. (2015) · Scandinavian Journal of Rheumatology · doi:10.3109/03009742.2015.1086433 · Cited by 14
Signal pathways involved in contrast-induced acute kidney injury
Deng, K., Pei, M., Li, B., Yang, N., Wang, Z. L., Wan, X., Zhong, Z., Yang, Z., & Chen, Y. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1490725 · Cited by 14
The therapeutic role of exercise training during menopause for reducing vascular disease
Shing, C. L. H., Bond, B., Moreau, K. L., Coombes, J. S., & Taylor, J. L. (2024) · Experimental Physiology · doi:10.1113/ep092191 · Cited by 12
Protective Effects of Total Flavonoids from Lysimachia christinae on Calcium Oxalate-Induced Oxidative Stress in a Renal Cell Line and Renal Tissue
Wang, J., Chen, J., Huang, J., Lv, B., Huang, X., Hu, Q., Fu, J. Q., Huang, W., & Tao, T. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6667902 · Cited by 12
Carbon Monoxide (CO), Nitric Oxide, and Hydrogen Sulfide Signaling During Acute CO Poisoning
Coburn, R. F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.830241 · Cited by 12
Influenza A(H1N1)pdm09 Virus Alters Expression of Endothelial Factors in Pulmonary Vascular Endothelium in Rats
Marchenko, V., Mukhametdinova, D. V., Amosova, I. V., Lioznov, D. A., & Zhilinskaya, I. N. (2022) · Viruses · doi:10.3390/v14112518 · Cited by 11
L-sepiapterin restores SLE serum-induced markers of endothelial function in endothelial cells
Buie, J. N. J., Jenkins, D. P., Muise‐Helmericks, R. C., & Oates, J. C. (2019) · Lupus Science & Medicine · doi:10.1136/lupus-2018-000294 · Cited by 12
Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice
Brassington, K., Chan, S. M. H., Luca, S. N. D., Dobric, A., Almerdasi, S. A., Mou, K., Seow, H. J., Oseghale, O., Bozinovski, S., Selemidis, S., et al. (2022) · Clinical Science · doi:10.1042/cs20211090 · Cited by 12
VLDL Induced Modulation of Nitric Oxide Signalling and Cell Redox Homeostasis in HUVEC
Magnifico, M. C., Oberkersch, R. E., Mollo, A., Giambelli, L., Grooten, Y., Sarti, P., Calabrese, G. C., & Arese, M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2697364 · Cited by 12
On the Role of Dietary Nitrate in the Maintenance of Systemic and Oral Health
Schlagenhauf, U. (2022) · Dentistry Journal · doi:10.3390/dj10050084 · Cited by 13
Overexpression of Endothelial β3-Adrenergic Receptor Induces Diastolic Dysfunction in Rats
Dhot, J., Ferron, M., Prat, V., Persello, A., Roul, D., Stevant, D., Guijarro, D., Piriou, N., Aillerie, V., Erraud, A., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.13040 · Cited by 13
Role of endothelial and macrophage tetrahydrobiopterin in development and progression of atherosclerosis: BH4 puzzle solved?
Münzel, T. F., & Daiber, A. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy118 · Cited by 11
Self-citation
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress‑impaired endothelial cell angiogenic response: A critical role for cell survival
Abdelsalam, S. S., Pasha, M., Gamal, H. E., Hasan, M. H., Elrayess, M. A., Zeidan, A., Korashy, H. M., & Agouni, A. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12304 · Cited by 10
The long‐term health risks of ART
Hunter, P. (2017) · EMBO Reports · doi:10.15252/embr.201744479 · Cited by 10
Muramyl Dipeptide Induces Reactive Oxygen Species Generation Through the NOD2/COX-2/NOX4 Signaling Pathway in Human Umbilical Vein Endothelial Cells
Kong, L., Liu, X., Xue, Y., Gao, W., & Lv, Q. (2018) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000581 · Cited by 10
LIPOPOLYSACCHARIDE-INDUCED SYSTEMIC INFLAMMATORY RESPONSE ENHANCES THE DEVELOPMENT OF OXIDATIVE-NITROSATIVE STRESS IN SALIVARY GLANDS OF RATS UNDER ALCOHOL DAMAGE
Kozaeva, R., Klymenko, M. O., & Kostenko, V. О. (2021) · Fìzìologìčnij žurnal · doi:10.15407/fz67.06.060 · Cited by 10
Resistin Contribution to Cardiovascular Risk in Chronic Kidney Disease Male Patients
Romejko, K., Rymarz, A., Szamotulska, K., Bartoszewicz, Z., Rozmysłowicz, T., & Niemczyk, S. (2023) · Cells · doi:10.3390/cells12070999 · Cited by 9
H Pylori and Cardiovascular Diseases
Aksoy, H., & Şebin, S. Ö. (2015) · General Medicine Open Access · doi:10.4172/2327-5146.1000s1-007 · Cited by 8
Vascular Health Triad in Humans With Hypertension—Not the Usual Suspects
Ranadive, S. M., Dillon, G. A., Mascone, S. E., & Alexander, L. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746278 · Cited by 9
Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice
Brassington, K., (18029743), M. H. S. C., Luca, S. N. D., Dobric, A., Almerdasi, S. A., Mou, K., Seow, H. J., Oseghale, O., Bozinovski, S., Selemidis, S., et al. (2024) · Figshare · Cited by 9

Authors: Karbach, S., Wenzel, P., Waisman, A., Munzel, T., & Daiber, A.
Affiliations: University Medical Center of the Johannes Gutenberg University Mainz (DE)
ORCID: Karbach, Susanne
Wenzel, Philip
Waisman, Ari
Daiber, Andreas
Venue: Current Pharmaceutical Design
Publisher: Bentham Science Publishers Ltd.
Published: 2014-06
Volume: 20
Issue: 22
Pages: 3579-3594
ISSN: 1381-6128 (ISSN-L)
DOI: 10.2174/13816128113196660748
OpenAlex: W2157350806
Cited by: 307
References: 155
Citations by year: 2026: 19 · 2025: 22 · 2024: 21 · 2023: 20 · 2022: 34 · 2021: 40 · 2020: 26 · 2019: 23 · 2018: 23 · 2017: 29 · 2016: 19 · 2015: 24 · 2014: 7
FWCI: 17.51
Type: journal article
Language: en
Open access: closed
Locations: Current Pharmaceutical Design (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: endothelial nitric oxide synthase, eNOS uncoupling, oxidative stress, inflammation, tetrahydrobiopterin, S-glutathionylation, asymmetric dimethylarginine, reactive oxygen and nitrogen species, endothelial dysfunction, hypertension, atherosclerosis, coronary artery disease, vascular dysfunction, cytokines, redox switch
MeSH terms: Cardiovascular Diseases, Humans, Inflammation, Oxidative Stress, Nitric Oxide Synthase Type III

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks