eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

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Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

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Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

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Reactive oxygen species (ROS) in macrophage activation and function in diabetes

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Nitric Oxide and Endothelial Dysfunction

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Oxidative Stress and Hypertension

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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

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Targeting vascular (endothelial) dysfunction

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Endothelial dysfunction and preeclampsia: role of oxidative stress

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COVID-19 pandemic: the effects of quarantine on cardiovascular risk

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Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

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The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art

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Emerging Roles of the Mineralocorticoid Receptor in Pathology: Toward New Paradigms in Clinical Pharmacology

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Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches

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European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

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New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease

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The use of human umbilical vein endothelial cells (HUVECs) as an in vitro model to assess the toxicity of nanoparticles to endothelium: a review

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Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice

Münzel, T. F., Daiber, A., Steven, S., Tran, L. P., Ullmann, E., Kossmann, S., Schmidt, F. P., Oelze, M. W., Xia, N., Li, H., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx081 · Cited by 292

Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function

Daiber, A., Lisa, F. D., Oelze, M. W., Kröller‐Schön, S., Steven, S., Schulz, E., & Münzel, T. F. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13403 · Cited by 274

Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy

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Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

Mikhed, Y., Daiber, A., & Steven, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160715918 · Cited by 257

Endothelial dysfunction: molecular mechanisms and clinical implications

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Cellular and Oxidative Mechanisms Associated with Interleukin-6 Signaling in the Vasculature

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Antioxidants in Translational Medicine

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Health Benefits of Fasting and Caloric Restriction

Golbidi, S., Daiber, A., Korać, B., Li, H., Essop, M. F., & Laher, I. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0951-7 · Cited by 227

Hyperuricemia and Cardiovascular Disease

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Redox Regulation of Inflammation: Old Elements, a New Story

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Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications

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Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability

Janaszak‐Jasiecka, A., Siekierzycka, A., Płoska, A., Dobrucki, I. T., & Kalinowski, L. (2021) · Biomolecules · doi:10.3390/biom11070982 · Cited by 197

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair

Mikhed, Y., Görlach, A., Knaus, U. G., & Daiber, A. (2015) · Redox Biology · doi:10.1016/j.redox.2015.05.008 · Cited by 189

Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies

Daiber, A., & Chłopicki, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.026 · Cited by 171

Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

Wenzel, P., Kossmann, S., Münzel, T. F., & Daiber, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.027 · Cited by 161

Endothelial Dysfunction and Its Clinical Implications

Poredoš, P., Visnovič-Poredoš, A., & Gregorič, I. D. (2021) · Angiology · doi:10.1177/0003319720987752 · Cited by 176

Oxidative Stress, Antioxidants and Hypertension

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Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity

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Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States

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Redox Regulation via Glutaredoxin-1 and Protein S -Glutathionylation

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Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease

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Chronic inflammation within the vascular wall in pulmonary arterial hypertension: more than a spectator

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Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics

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Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases

Daiber, A., Kröller‐Schön, S., Oelze, M. W., Hahad, O., Li, H., Schulz, R., Steven, S., & Münzel, T. F. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101506 · Cited by 136

Endothelial Dysfunction: Redox Imbalance, NLRP3 Inflammasome, and Inflammatory Responses in Cardiovascular Diseases

Penna, C. R. R., & Pagliaro, P. (2025) · Antioxidants · doi:10.3390/antiox14030256 · Cited by 142

The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies

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Evaluation of oxidative stress and antioxidant status: Correlation with the severity of sepsis

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Oral administration of bisphenol A induces high blood pressure through angiotensin II/CaMKII‐dependent uncoupling of eNOS

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Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

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Peripheral artery disease, redox signaling, oxidative stress – Basic and clinical aspects

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Astaxanthin-antioxidant impact on excessive Reactive Oxygen Species generation induced by ischemia and reperfusion injury

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Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency

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Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond

Daiber, A., Hahad, O., Andreadou, I., Steven, S., Daub, S., & Münzel, T. F. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101875 · Cited by 110

Mechanisms and Clinical Implications of Endothelial Dysfunction in Arterial Hypertension

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Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase

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Nanodomain Regulation of Cardiac Cyclic Nucleotide Signaling by Phosphodiesterases

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Central Role of Metabolism in Endothelial Cell Function and Vascular Disease

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Allopurinol as a therapeutic option in cardiovascular disease

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Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease

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Oxidative Stress and Erectile Dysfunction: Pathophysiology, Impacts, and Potential Treatments

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Redox implications in adipose tissue (dys)function-A new look at old acquaintances

Jankovic, A., Korac, A., Buzadzic, B., Otasevic, V., Stancic, A., Daiber, A., & Korac, B. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.018 · Cited by 91

Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging

Ministrini, S., Puspitasari, Y. M., Beer, G., Liberale, L., Montecucco, F., & Camici, G. G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.733696 · Cited by 94

Tobacco smoking and vascular biology and function: evidence from human studies

Hahad, O., Kuntić, M., Kuntić, I., Daiber, A., & Münzel, T. F. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02805-z · Cited by 91

Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases

Ma, Y., Peng, D., Liu, C., Chen, H., & Luo, J. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0475-8 · Cited by 82

Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of Atherosclerosis

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Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and downstream pathways against environmental stressors

Jiménez, M. T. B., Frenis, K., Hahad, O., Steven, S., Cohen, G., Cuadrado, A., Münzel, T. F., & Daiber, A. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.05.016 · Cited by 77

Endothelial-Derived Oxidative Stress Drives Myofibroblastic Activation and Calcification of the Aortic Valve

Farrar, E. J., Huntley, G. D., & Butcher, J. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123257 · Cited by 74

Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease

Steven, S., Münzel, T. F., & Daiber, A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160818185 · Cited by 68

Sex differences in abdominal aortic aneurysms

Boese, A. C., Chang, L., Yin, K., Chen, Y. E., Lee, J., & Hamblin, M. H. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00519.2017 · Cited by 68

Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G

Rainer, P. P., & Kass, D. A. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw107 · Cited by 63

Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate

Zhu, J., Wang, Q., Li, C., Lu, Y., Hu, H., Qin, B., Xun, Y., Zhu, Y., Wu, Y., Zhang, J., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.033 · Cited by 61

Taking up the cudgels for the traditional reactive oxygen and nitrogen species detection assays and their use in the cardiovascular system

Daiber, A., Oelze, M. W., Steven, S., Kröller‐Schön, S., & Münzel, T. F. (2017) · Redox Biology · doi:10.1016/j.redox.2017.02.001 · Cited by 65

Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications

Chen, J., Zhong, J., Wang, L., & Chen, Y. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.771298 · Cited by 64

Polydatin Protects Diabetic Heart against Ischemia‐Reperfusion Injury via Notch1/Hes1‐Mediated Activation of Pten/Akt Signaling

Yu, L., Li, Z., Dong, X., Xue, X., Liu, Y., Xu, S. C., Zhang, J., Han, J., Yang, Y., & Wang, H. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2750695 · Cited by 61

Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall

Zanetti, M., Grillo, A., Losurdo, P., Panizon, E., Mearelli, F., Cattin, L., Barazzoni, R., & Carretta, R. (2015) · BioMed Research International · doi:10.1155/2015/791978 · Cited by 59

Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management

Janković, A., Korać, A., Buzadžić, B., Stančić, A., Otašević, V., Ferdinándy, P., Daiber, A., & Korać, B. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13498 · Cited by 60

Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation

Dimitroulas, T., Hodson, J. A., Sandoo, A., Smith, J., & Kitas, G. D. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1232-1 · Cited by 61

Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase—Implications for Diabetes Progression

Daiber, A., Steven, S., Vujačić-Mirski, K., Kalinovic, S., Oelze, M. W., Lisa, F. D., & Münzel, T. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103405 · Cited by 59

The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases

Zarembska, E., Ślusarczyk, K., & Wrzosek, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010193 · Cited by 56

CD40/CD40L and Related Signaling Pathways in Cardiovascular Health and Disease—The Pros and Cons for Cardioprotection

Daub, S., Lutgens, E., Münzel, T. F., & Daiber, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228533 · Cited by 56

Therapeutic augmentation of NO-sGC-cGMP signalling: lessons learned from pulmonary arterial hypertension and heart failure

Triposkiadis, F. K., Xanthopoulos, A. V., Skoularigis, J. S., & Starling, R. C. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10239-5 · Cited by 52

l-Leucine and NO-mediated cardiovascular function

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CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice

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Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota

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Phthalate exposure as a risk factor for hypertension

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Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development

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Lycopene mitigates atrazine-induced cardiac inflammation via blocking the NF-κB pathway and NO production

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Improvement of Endothelial Dysfunction of Berberine in Atherosclerotic Mice and Mechanism Exploring through TMT-Based Proteomics

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