The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Nanoparticles for Tumor Targeted Therapies and Their Pharmacokinetics
Abstract
Various types of nanoparticles, such as liposomes, polymeric micelles, dendrimers, superparamagnetic iron oxide crystals, and colloidal gold, have been employed in targeted therapies for cancer. Both passive and active targeting strategies can be utilized for nano-drug delivery. Passive targeting is based on the enhanced permeability and retention (EPR) effect of the vasculature surrounding tumors. Active targeting relies on ligand-directed binding of nanoparticles to receptors expressed by tumor cells. Release of loaded drugs from nanoparticles may be controlled in response to changes in environmental condition such as temperature and pH. Biodistribution profiles and anticancer efficacy of nano-drugs in vivo would be different depending upon their size, surface charge, PEGylation and other biophysical properties. This review focuses on the recent development of nanoparticles for tumor targeted therapies, including physicochemical properties, tumor targeting, control of drug release, pharmacokinetics, anticancer efficacy and safety. Future perspectives are discussed as well.
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Nanoparticle therapeutics: an emerging treatment modality for cancer
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High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy
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Light‐sensitive Intelligent Drug Delivery Systems†
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Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery
Ge, X., Wei, M., He, S., & Yuan, W.-E. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020055 · Cited by 578
Paclitaxel Nano-Delivery Systems: A Comprehensive Review
Ma, P. (2013) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.1000164 · Cited by 559
Nanoparticle-mediated Hyperthermia in Cancer Therapy
Chatterjee, D. K., Diagaradjane, P., & Krishnan, S. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.72 · Cited by 417
Application of Nanotechnology in Cancer Diagnosis and Therapy - A Mini-Review
Jin, C., Wang, K., Oppong-Gyebi, A., & Hu, J. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.49801 · Cited by 353
Metadata
- Authors
- Wang, J., Sui, M., & Fan, W.
- Venue
- Current Drug Metabolism
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-02-01
- Volume
- 11
- Issue
- 2
- Pages
- 129-141
- ISSN
- 1389-2002 (ISSN-L)
- OpenAlex
- W2128654928
- Cited by
- 205
- References
- 7
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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