The role of androgen receptor mutations in prostate cancer progression.
Open accessAbstract
Prostate tumour growth is almost always dependent upon the androgen receptor pathway and hence therapies aimed at blocking this signalling axis are useful tools in the management of this disease. Unfortunately such therapies invariably fail; and the tumour progresses to an "androgen-independent" stage. In such cases androgen receptor expression is almost always maintained and much evidence exists to suggest that it may still be driving growth. One mechanism by which the receptor is thought to remain active is mutation. This review summarises the present data on androgen receptor mutations in prostate cancer, and how such substitutions offer a growth advantage by affecting cofactor interactions or by reducing ligand specificity. Such alterations appear to have a subsequent effect upon gene expression suggesting that tumours may "behave" differently dependent upon the ligand promoting growth and if a mutation is present.
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Activating mutations of the androgen receptor can create a promiscuous receptor, alter interactions with coregulatory proteins, and impair intramolecular N-C interactions.
“Activating mutations of the AR have the capacity to create a promiscuous receptor, alter interactions with coregulatory proteins, and impair intramolecular N-C interactions (71).”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [71]
Approximately 70 different missense mutations have been described in patient samples, with varying consequences upon androgen receptor activity.
“Approximately 70 different missense mutations have been described in patient samples, with varying consequences upon AR activity.”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [71]
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The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383 · see citing works
Molecular basis of agonism and antagonism in the oestrogen receptor
Brzozowski, A. M., Pike, A. C. W., Dauter, Z., Hubbard, R. E., Bonn, T., Engström, O., Öhman, L., Greene, G. L., Gustafsson, J.-Å., & Carlquist, M. (1997) · Nature · doi:10.1038/39645 · Cited by 3,355 · see citing works
MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS
Tsai, M., & O’Malley, B. W. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.002315 · Cited by 2,887 · see citing works
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
Spada, A. L., Wilson, E. M., Lubahn, D. B., Harding, A., & Fischbeck, K. (1991) · Nature · doi:10.1038/352077a0 · Cited by 2,801 · see citing works
The development of androgen-independent prostate cancer.
Feldman, B. J., & Feldman, D. (2001) · Nature reviews. Cancer · doi:10.1038/35094009 · Cited by 2,326 · see citing works
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
Heery, D. M., Kalkhoven, E., Hoare, S., & Parker, M. G. (1997) · Nature · doi:10.1038/42750 · Cited by 2,128 · see citing works
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791 · see citing works
Mutation of the Androgen-Receptor Gene in Metastatic Androgen-Independent Prostate Cancer
Taplin, M., Bubley, G. J., Shuster, T. D., Frantz, M. E., Spooner, A. E., Ogata, G. K., Keer, H. N., & Balk, S. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505253322101 · Cited by 1,243 · see citing works
Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid
Renaud, J., Rochel, N., Ruff, M., Vivat, V., Chambon, P., Gronemeyer, H., & Moras, D. (1995) · Nature · doi:10.1038/378681a0 · Cited by 1,098 · see citing works
Pike, A. C. W., Brzozowski, A. M., Hubbard, R. E., Bonn, T., Thorsell, A., Engström, O., Ljunggren, J., Gustafsson, J., & Carlquist, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4608 · Cited by 987 · see citing works
A canonical structure for the ligand-binding domain of nuclear receptors
Wurtz, J., Bourguet, W., Renaud, J., Vivat, V., Chambon, P., Moras, D., & Gronemeyer, H. (1996) · Nature Structural Biology · doi:10.1038/nsb0196-87 · Cited by 986 · see citing works
Determinants of target gene specificity for steroid/thyroid hormone receptors
Umesono, K., & Evans, R. M. (1989) · Cell · doi:10.1016/0092-8674(89)90051-2 · Cited by 948 · see citing works
Structure and specificity of nuclear receptor–coactivator interactionsPreprint
Darimont, B. D., Wagner, R. L., Apriletti, J. W., Stallcup, M. R., Kushner, P. J., Baxter, J. D., Fletterick, R. J., & Yamamoto, K. R. (1998) · Genes & Development · doi:10.1101/gad.12.21.3343 · Cited by 921 · see citing works
The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand
Rochel, N., Wurtz, J. M., Mitschler, A., Klaholz, B., & Moras, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80413-x · Cited by 842 · see citing works
Formation of the Androgen Receptor Transcription Complex
Shang, Y., Myers, M., & Brown, M. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00471-9 · Cited by 673 · see citing works
Atomic structure of progesterone complexed with its receptor
Williams, S. P., & Sigler, P. B. (1998) · Nature · doi:10.1038/30775 · Cited by 659 · see citing works
Structural Evidence for Ligand Specificity in the Binding Domain of the Human Androgen Receptor
Matias, P. M., Donner, P., Coelho, R., Thomaz, M., Peixoto, C., Macedo, S., Otto, N., Joschko, S., Scholz, P., Wegg, A., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004571200 · Cited by 608 · see citing works
The nuclear receptor superfamily
Robinson‐Rechavi, M., Escrivá, H., & Laudet, V. (2003) · Journal of Cell Science · doi:10.1242/jcs.00247 · Cited by 588 · see citing works
Mader, S., Kumar, V., de Verneuil, H., & Chambon, P. (1989) · Nature · doi:10.1038/338271a0 · Cited by 500 · see citing works
Sack, J. S., Kish, K. F., Wang, C., Attar, R. M., Kiefer, S. E., An, Y., Wu, G. Y., Scheffler, J. E., Salvati, M. E., Krystek, S. R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081565498 · Cited by 491 · see citing works
The Promoter of the Prostate-Specific Antigen Gene Contains a Functional Androgen Responsive Element
Riegman, P. H. J., Vlietstra, R. J., van der Korput, J. A. G. M., Brinkmann, A. O., & Trapman, J. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-12-1921 · Cited by 448 · see citing works
Kazemi‐Esfarjani, P., Trifiro, M. A., & Pinsky, L. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.4.523 · Cited by 447 · see citing works
Veldscholte, J., Berrevoets, C., Ris‐Stalpers, C., Kuiper, G. G. J. M., Jenster, G. W., Trapman, J., Brinkmann, A. O., & Mulder, E. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90401-4 · Cited by 442 · see citing works
He, B., Kemppainen, J., & Wilson, E. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002807200 · Cited by 441 · see citing works
The structure of the nuclear hormone receptors
Kumar, R., & Thompson, E. B. (1999) · Steroids · doi:10.1016/s0039-128x(99)00014-8 · Cited by 433 · see citing works
Jenster, G., van der Korput, H. A. G. M., Trapman, J., & Brinkmann, A. O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7341 · Cited by 419 · see citing works
Cleutjens, K. B. J. M., Eekelen, C. C. E.-V., van der Korput, H. A. G. M., Brinkmann, A. O., & Trapman, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6379 · Cited by 408 · see citing works
Structural basis of androgen receptor binding to selective androgen response elements
Shaffer, P. L., Jivan, A., Dollins, D. E., Claessens, F., & Gewirth, D. T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401123101 · Cited by 400 · see citing works
Egea, P. F., Mitschler, A., Rochel, N., Ruff, M., Chambon, P., & Moras, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.11.2592 · Cited by 343 · see citing works
Ham, J., Thomson, A. A., Needham, M., Webb, P., & Parker, M. G. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.12.5263 · Cited by 339 · see citing works
Zhou, Z. X., Sar, M., Simental, J. A., Lane, M. V., & Wilson, E. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36806-0 · Cited by 312 · see citing works
The androgen receptor gene mutations database (ARDB): 2004 update
Gottlieb, B., Beitel, L. K., Wu, J. H., & Trifiro, M. A. (2004) · Human Mutation · doi:10.1002/humu.20044 · Cited by 311 · see citing works
Hsing, A. W., Gao, Y., Wu, G., Wang, X., Deng, J., Chen, Y., Sesterhenn, I. A., Mostofi, F. K., Bénichou, J., & Chang, C. (2000) · PubMed · Cited by 311 · see citing works
Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development
Cunha, G. R., Ricke, W. A., Thomson, A. A., Marker, P. C., Risbridger, G. P., Hayward, S. W., Wang, Y. Z., Donjacour, A. A., & Kurita, T. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.017 · Cited by 310 · see citing works
Androgen receptor mutations in prostate cancer.
Barrack, E. R. (1996) · PubMed · Cited by 301 · see citing works
Tyagi, R. K., Lavrovsky, Y., Ahn, S., Song, C. S., Chatterjee, B., & Roy, A. K. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.8.0497 · Cited by 291 · see citing works
Cato, A. C., Henderson, D., & Ponta, H. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb04763.x · Cited by 278 · see citing works
The androgen receptor gene mutations database
Gottlieb, B. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.1.151 · Cited by 271 · see citing works
Androgen receptor mutations in prostate cancer.
Marcelli, M., Ittmann, M., Mariani, S., Sutherland, R. W., Nigam, R., Murthy, L., Zhao, Y., DiConcini, D., Puxeddu, E., Esen, A., et al. (2000) · PubMed · Cited by 262 · see citing works
Crystal Structure of the Ligand Binding Domain of the Human Nuclear Receptor PPARγ
Uppenberg, J., Svensson, C., Jaki, M., Bertilsson, G., Jendeberg, L., & Berkenstam, A. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31108 · Cited by 261 · see citing works
Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer
Dehm, S. M., & Tindall, D. J. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0223 · Cited by 252 · see citing works
Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset
Hardy, D. O., Scher, H. I., Bogenreider, T., Sabbatini, P. J., Zhang, Z., Nanus, D. M., & Catterall, J. F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954049 · Cited by 248 · see citing works
Recognition and Accommodation at the Androgen Receptor Coactivator Binding Interface
Hur, E., Pfaff, S. J., Payne, E. S., Grøn, H., Buehrer, B. M., & Fletterick, R. J. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020274 · Cited by 235 · see citing works
Langley, E., Kemppainen, J. A., & Wilson, E. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.92 · Cited by 233 · see citing works
Structural and functional consequences of glutamine tract variation in the androgen receptor
Buchanan, G. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh181 · Cited by 225 · see citing works
Dahlman‐Wright, K., Wright, A. P. H., Gustafsson, J.-Α., & Carlstedt‐Duke, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49960-7 · Cited by 221 · see citing works
Hsiao, P., Lin, D., Nakao, R., & Chang, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20229 · Cited by 221 · see citing works
Doesburg, P., Kuil, C. W., Berrevoets, C., Steketee, K., Faber, P. W., Mulder, E., Brinkmann, A. O., & Trapman, J. (1997) · Biochemistry · doi:10.1021/bi961775g · Cited by 209 · see citing works
Modulation of Androgen Receptor Activation Function 2 by Testosterone and Dihydrotestosterone
Askew, E. B., Gampe, R. T., Stanley, T. B., Faggart, J. L., & Wilson, E. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703268200 · Cited by 208 · see citing works
Lu, S., Tsai, S. Y., & Tsai, M. (1997) · PubMed · Cited by 176 · see citing works
Dependence of Selective Gene Activation on the Androgen Receptor NH2- and COOH-terminal Interaction
He, B., Lee, L. W., Minges, J. T., & Wilson, E. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202809200 · Cited by 168 · see citing works
Molecular Determinants of the Estrogen Receptor-Coactivator Interface
Mak, H. Y., Hoare, S., Henttu, P. M. A., & Parker, M. G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3895 · Cited by 166 · see citing works
Protein Secretion and Secretory Processes in Male Accessory Sex Glands
Aumüller, G., & Seitz, J. (1990) · International review of cytology · doi:10.1016/s0074-7696(08)60660-9 · Cited by 154 · see citing works
Haelens, A., Tanner, T., Denayer, S., Callewaert, L., & Claessens, F. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1701 · Cited by 153 · see citing works
Functional analysis of 44 mutant androgen receptors from human prostate cancer.
Shi, X., Ma, A., Xia, L. P., Kung, H.-J., & White, R. D. (2002) · PubMed · Cited by 150 · see citing works
Androgen Receptor: Structural Domains and Functional Dynamics after Ligand‐Receptor Interaction
Roy, A. K., Tyagi, R. K., Song, C. S., Lavrovsky, Y., Ahn, S., Oh, T., & Chatterjee, B. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb04001.x · Cited by 132 · see citing works
Han, G., Foster, B. A., Mistry, S. G., Buchanan, G., Harris, J. M., Tilley, W. D., & Greenberg, N. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008207200 · Cited by 123 · see citing works
Freedman, L. P., & Luisi, B. F. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240510205 · Cited by 122 · see citing works
Buchanan, G., Yang, M., Harris, J. M., Nahm, H. S., Han, G., Moore, N. L. T., Bentel, J. M., Matusik, R. J., Horsfall, D. J., Marshall, V. R., et al. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.1.0581 · Cited by 122 · see citing works
Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor
Dubbink, H. J., Hersmus, R., Verma, C. S., van der Korput, H. A. G. M., Berrevoets, C. A., van Tol, J., Ziel-van der Made, A. C. J., Brinkmann, A. O., Pike, A. C. W., & Trapman, J. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0375 · Cited by 118 · see citing works
Androgen receptor corepressors: An overview
Wang, L., Hsu, C., & Chang, C. (2004) · The Prostate · doi:10.1002/pros.20170 · Cited by 115 · see citing works
Induced α-Helix Structure in AF1 of the Androgen Receptor upon Binding Transcription Factor TFIIF
Kumar, R., Betney, R., Li, J., Thompson, E. B., & McEwan, I. J. (2004) · Biochemistry · doi:10.1021/bi035934p · Cited by 107 · see citing works
Transcriptional regulation of prostate kallikrein-like genes by androgen
Wolf, D. A., Schulz, P. J., & Fittler, F. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.5.1376410 · Cited by 98 · see citing works
Skeletal muscle response to tenotomy
Jamali, A. A., Afshar, P., Abrams, R. A., & Lieber, R. L. (2000) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(200006)23:6 · Cited by 97 · see citing works
Duff, J. M., & McEwan, I. J. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0231 · Cited by 92 · see citing works
Science behind total androgen blockade: from gene to combination therapy.
Labrie, F., Bèlanger, A., Dupont, A., The, V. L., Simard, J., & Labrie, C. (1993) · PubMed · Cited by 91 · see citing works
Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate.
Powell, S. M., Christiaens, V., Voulgaraki, D., Waxman, J., Claessens, F., & Bevan, C. L. (2004) · Endocrine Related Cancer · doi:10.1677/erc.0.0110117 · Cited by 90 · see citing works
Verrijdt, G., Schoenmakers, E., Alen, P., Haelens, A., Peeters, B., Rombauts, W., & Claessens, F. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.9.0347 · Cited by 85 · see citing works
Functional domains of the human androgen receptor
Jenster, G., van der Korput, J. A. G. M., Trapman, J., & Brinkmann, A. O. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90402-5 · Cited by 80 · see citing works
McEwan, I. J., Lavery, D. N., Fischer, K., & Watt, K. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05001 · Cited by 80 · see citing works
Brooke, G. N., Parker, M. G., & Bevan, C. L. (2008) · Oncogene · doi:10.1038/sj.onc.1210955 · Cited by 79 · see citing works
Gregory, C. W., Johnson, R. T., Presnell, S. C., Mohler, J. L., & French, F. S. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb02213.x · Cited by 68 · see citing works
Endocrine Therapy for Prostate Cancer
Labrie, F. (1991) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30247-0 · Cited by 65 · see citing works
McDonald, S. M., Brive, L., Agus, D. B., Scher, H. I., & Ely, K. R. (2000) · PubMed · Cited by 64 · see citing works
Berrevoets, C., Veldscholte, J., & Mulder, E. A. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90313-l · Cited by 63 · see citing works
Nuclear receptors spring into action
Parker, M. G., & White, R. (1996) · Nature Structural Biology · doi:10.1038/nsb0296-113 · Cited by 61 · see citing works
Steroid/nuclear receptor coactivators
Chen, J. D. (2000) · Vitamins and hormones · doi:10.1016/s0083-6729(00)58032-7 · Cited by 59 · see citing works
Ozers, M. S., Marks, B. D., Gowda, K., Kupcho, K. R., Ervin, K. M., Rosier, T. D., Qadir, N., Eliason, H. C., Riddle, S. M., & Shekhani, M. S. (2006) · Biochemistry · doi:10.1021/bi061321b · Cited by 59 · see citing works
Callewaert, L., Verrijdt, G., Christiaens, V., Haelens, A., & Claessens, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210744200 · Cited by 59 · see citing works
Moilanen, A., Rouleau, N., Ikonen, T., Palvimo, J. J., & Jänne, O. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00791-6 · Cited by 56 · see citing works
Bourguet, W., Ruff, M., Bonnier, D., Granger, F., Boeglin, M., Chambon, P., Moras, D., & Gronemeyer, H. (1995) · Protein Expression and Purification · doi:10.1006/prep.1995.1079 · Cited by 38 · see citing works
Whitaker, H. C., Hanrahan, S. J., Totty, N., Gamble, S. C., Waxman, J., Cato, A. C. B., Hurst, H. C., & Bevan, C. L. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0388 · Cited by 37 · see citing works
Lavery, D. N., & McEwan, I. J. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341054 · Cited by 36 · see citing works
Tanner, T., Claessens, F., & Haelens, A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.068 · Cited by 34 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [59]Brooks J Walsh P A.R Darracott Vaughan E Wein A Anatomy of the lower urinary tract and male genitalia Campbell's Urology 2002 London Saunders 41 80
- [64]Shepherd DL Harris M Thompson I Syrigos K Radical Prostatectomy in the management of localised prostate cancer Prostate Cancer: Biology, Diagnosis and Management 2001 Oxford Oxford University Press 229 242
- [72]Taplin M-E Bubley GJ Shuster TD Frantz ME Spooner AE Ogata GK Keer HN Balk SP Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer N. Engl. J. Med 1995 332 1393 1398 7723794
Cited by
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Bisphenol A (BPA) and cell signaling pathways
Murata, M., & Kang, J. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.002 · Cited by 366 · see citing works
Drug resistance in metastatic castration-resistant prostate cancer
Šeruga, B., Ocaña, A., & Tannock, I. F. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.136 · Cited by 337 · see citing works
Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer
Knudsen, K. E., & Penning, T. M. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.01.002 · Cited by 291 · see citing works
Steroid Hormone Receptors in Prostate Cancer: A Hard Habit to Break?
Attard, G., Cooper, C. S., & de Bono, J. S. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.11.006 · Cited by 242 · see citing works
Shen, Z., Zhou, L., Zhang, C., & Xu, J. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.10.006 · Cited by 194 · see citing works
Ferraldeschi, R., Welti, J. C., Luo, J., Attard, G., & Bono, J. S. D. (2014) · Oncogene · doi:10.1038/onc.2014.115 · Cited by 194 · see citing works
Androgen action and metabolism in prostate cancer
Green, S. M., Mostaghel, E. A., & Nelson, P. S. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.046 · Cited by 182 · see citing works
Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer
Lamont, K. R., & Tindall, D. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0469 · Cited by 150 · see citing works
Androgen Receptor Signaling in Prostate Cancer and Therapeutic Strategies
Jacob, A., Raj, R., Allison, D. B., & Myint, Z. W. (2021) · Cancers · doi:10.3390/cancers13215417 · Cited by 140 · see citing works
Steroid hormone receptors in cancer development: A target for cancer therapeutics
Ahmad, N., & Kumar, R. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.09.008 · Cited by 126 · see citing works
Shiota, M., Yokomizo, A., & Naito, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.07.011 · Cited by 124 · see citing works
Wahab, N. A. A., Lajis, N. H., Abas, F., Othman, I., & Naidu, R. (2020) · Nutrients · doi:10.3390/nu12030679 · Cited by 123 · see citing works
Abali, G. K., Alptekin, A., Lewis, M. S., Garraway, I. P., & Cinar, B. (2015) · Nature Communications · doi:10.1038/ncomms9126 · Cited by 119 · see citing works
Androgen regulation of gene expression.
(2010) · Advances in cancer research · doi:10.1016/s0065-230x(10)07005-3 · Cited by 117 · see citing works
The hallmarks of castration-resistant prostate cancers
Katsogiannou, M., Ziouziou, H., Karaki, S., Andrieu, C., de Villeneuve, M. H., & Rocchi, P. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.05.003 · Cited by 107 · see citing works
Kallio, H. M. L., Hieta, R., Latonen, L., Brofeldt, A., Annala, M., Kivinummi, K. K., Tammela, T. L. J., Nykter, M., Isaacs, W. B., Lilja, H. G., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0172-0 · Cited by 100 · see citing works
Steroidogenic cytochrome P450 17A1 structure and function
Burris‐Hiday, S. D., & Scott, E. E. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111261 · Cited by 94 · see citing works
Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer
Khurana, N., & Sikka, S. C. (2018) · Cancers · doi:10.3390/cancers10100352 · Cited by 91 · see citing works
Androgen receptor gene mutation, rearrangement, polymorphism.
Eisermann, K., Wang, D., Jing, Y., Pascal, L. E., & Wang, Z. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2223-4683.2013.09.15 · Cited by 91 · see citing works
Leach, D. A., Mohr, A., Giotis, E. S., Cil, E., Isac, A. M., Yates, L. L., Barclay, W., Zwacka, R. M., Bevan, C. L., & Brooke, G. N. (2021) · Nature Communications · doi:10.1038/s41467-021-24342-y · Cited by 87 · see citing works
Menthol Inhibits the Proliferation and Motility of Prostate Cancer DU145 Cells
Wang, Y., Wang, X., Yang, Z., Zhu, G., Chen, D., & Meng, Z. (2012) · Pathology & Oncology Research · doi:10.1007/s12253-012-9520-1 · Cited by 88 · see citing works
Revising the role of the androgen receptor in breast cancer
Fioretti, F. M., Sita-Lumsden, A. R., Bevan, C. L., & Brooke, G. N. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0030 · Cited by 86 · see citing works
CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis
Penfold, L., Woods, A., Muckett, P. J., Nikitin, A. Y., Kent, T. R., Zhang, S., Graham, R., Pollard, A., & Carling, D. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0585 · Cited by 79 · see citing works
Montgomery, B., Eisenberger, M. A., Rettig, M. B., Chu, F. M., Пили, Р., Stephenson, J. J., Vogelzang, N. J., Koletsky, A. J., Nordquist, L. T., Edenfield, W. J., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1432 · Cited by 81 · see citing works
Khurana, N., & Sikka, S. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092066 · Cited by 78 · see citing works
Evolving standards in the treatment of docetaxel-refractory castration-resistant prostate cancer
Antonarakis, E. S., & Armstrong, A. J. (2011) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2011.23 · Cited by 71 · see citing works
Testosterone, financial risk-taking, and pathological gambling.
Stenstrom, E. P., & Saad, G. (2011) · Journal of Neuroscience Psychology and Economics · doi:10.1037/a0025963 · Cited by 70 · see citing works
Mini-review: Foldosome regulation of androgen receptor action in prostate cancer
Cano, L. Q., Lavery, D. N., & Bevan, C. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.023 · Cited by 70 · see citing works
Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer
Lucarelli, G. T., Rutigliano, M., Galleggiante, V., Giglio, A., Palazzo, S., Ferro, M., Simone, C., Bettocchi, C., Battaglia, M., & Ditonno, P. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1069711 · Cited by 69 · see citing works
Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces
Grosdidier, S., Carbó, L. R., Buzón, V., Brooke, G. N., Nguyen, P., Baxter, J. D., Bevan, C. L., Webb, P., Estébanez‐Perpiñá, E., & Fernández‐Recio, J. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1281 · Cited by 68 · see citing works
Shiota, M., Yokomizo, A., & Naito, S. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0232 · Cited by 70 · see citing works
Recent developments in antiandrogens and selective androgen receptor modulators
Haendler, B., & Cleve, A. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.002 · Cited by 68 · see citing works
Insight into Recent Advances in Degrading Androgen Receptor for Castration-Resistant Prostate Cancer
Chen, Q., Munoz, E., & Ashong, D. (2024) · Cancers · doi:10.3390/cancers16030663 · Cited by 64 · see citing works
Molecular Pathways: Targeting Resistance in the Androgen Receptor for Therapeutic Benefit
Mostaghel, E. A., Plymate, S. R., & Montgomery, B. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3601 · Cited by 61 · see citing works
Lohiya, V., Aragon‐Ching, J. B., & Sonpavde, G. (2016) · Clinical Medicine Insights Oncology · doi:10.4137/cmo.s34535 · Cited by 59 · see citing works
Constitutive Activity of the Androgen Receptor
Chan, S. C., & Dehm, S. M. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-417197-8.00011-0 · Cited by 59 · see citing works
The AR dependent cell cycle: Mechanisms and cancer relevance
Schiewer, M. J., Augello, M. A., & Knudsen, K. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.033 · Cited by 58 · see citing works
Knudsen, K. E., & Kelly, W. K. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.11.33 · Cited by 57 · see citing works
Interactions and relationships of PTEN, ERG, SPINK1 and AR in castration‐resistant prostate cancer
Bismar, T. A., Yoshimoto, M., Duan, Q., Liu, S., Sircar, K., & Squire, J. A. (2012) · Histopathology · doi:10.1111/j.1365-2559.2011.04116.x · Cited by 58 · see citing works
Huang, W., Zhau, H. E., & Chung, L. W. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092759 · Cited by 55 · see citing works
Molecular alterations and emerging targets in castration resistant prostate cancer
Lorente, D., & Bono, J. S. D. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2013.12.004 · Cited by 55 · see citing works
Abiraterone in the treatment of metastatic castration-resistant prostate cancer
Mostaghel, E. A. (2014) · Cancer Management and Research · doi:10.2147/cmar.s39318 · Cited by 55 · see citing works
Kounatidou, E. E., Nakjang, S., McCracken, S. R., Dehm, S. M., Robson, C. N., Jones, D. L., & Gaughan, L. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz286 · Cited by 52 · see citing works
The role of DAB2IP in androgen receptor activation during prostate cancer progression
Wu, K., Liu, J., Tseng, S.-F., O’Brien-Gore, C., Ning, Z., Sharifi, N., Fazli, L., Gleave, M. E., Kapur, P., Xiao, G., et al. (2013) · Oncogene · doi:10.1038/onc.2013.143 · Cited by 52 · see citing works
Lavery, D. N., Villaronga, M. Á., Walker, M. M., Patel, A., Belandia, B., & Bevan, C. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.198655 · Cited by 51 · see citing works
FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer
Jones, D. L., Wade, M., Nakjang, S., Chaytor, L., Grey, J., Robson, C. N., & Gaughan, L. (2015) · Oncotarget · doi:10.18632/oncotarget.4927 · Cited by 49 · see citing works
Khurana, N., Kim, H., Chandra, P. K., Talwar, S., Sharma, P., Abdel‐Mageed, A. B., Sikka, S. C., & Mondal, D. (2017) · Oncology Reports · doi:10.3892/or.2017.5932 · Cited by 50 · see citing works
Androgen receptor variation affects prostate cancer progression and drug resistance
McCrea, E. M., Sissung, T. M., Price, D. K., Chau, C. H., & Figg, W. D. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.10.001 · Cited by 49 · see citing works
Regulation of Androgen-Responsive Transcription by the Chromatin Remodeling Factor CHD8
Menon, T., Yates, J. A., & Bochar, D. A. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0421 · Cited by 49 · see citing works
Adaptation and clonal selection models of castration‐resistant prostate cancer: Current perspective
Ahmed, M., & Li, L. (2012) · International Journal of Urology · doi:10.1111/iju.12005 · Cited by 48 · see citing works
Morken, J. D., Packer, A., Everett, R. A., Nagy, J. D., & Kuang, Y. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3162 · Cited by 47 · see citing works
Androgen regulation of epithelial–mesenchymal transition in prostate tumorigenesis
Matuszak, E. A., & Kyprianou, N. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.11.32 · Cited by 48 · see citing works
Nadiminty, N., & Gao, A. C. (2011) · World Journal of Urology · doi:10.1007/s00345-011-0771-3 · Cited by 47 · see citing works
H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility
Giambartolomei, C., Seo, J.-H., Schwarz, T., Freund, M. K., Johnson, R., Spisák, S., Baca, S. C., Gusev, A., Mancuso, N., Paşaniuc, B., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.11.007 · Cited by 48 · see citing works
Ha, S., Luo, G., & Xiang, H. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01487 · Cited by 48 · see citing works
Kutasovic, J. R., Reed, A. E. M., Males, R., Sim, S., Saunus, J. M., Dalley, A. J., McEvoy, C. R. E., Dedina, L., Miller, G. C., Peyton, S., et al. (2018) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.118 · Cited by 45 · see citing works
Nyquist, M. D., & Dehm, S. M. (2013) · Hormones and Cancer · doi:10.1007/s12672-013-0131-4 · Cited by 43 · see citing works
Mohammad, O. S., Nyquist, M. D., Schweizer, M. T., Balk, S. P., Corey, E., Plymate, S. R., Nelson, P. S., & Mostaghel, E. A. (2017) · Cancers · doi:10.3390/cancers9120166 · Cited by 42 · see citing works
Androgen receptor molecular biology and potential targets in prostate cancer
Wilson, E. M. (2010) · Therapeutic Advances in Urology · doi:10.1177/1756287210372380 · Cited by 40 · see citing works
Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells
Liao, C., Chen, L., Luethy, A., Kim, Y., Kani, K., MacLeod, A. R., & Gross, M. E. (2017) · Endocrine Related Cancer · doi:10.1530/erc-16-0138 · Cited by 40 · see citing works
Pharmacology and Clinical Use of Sex Steroid Hormone Receptor Modulators
Cleve, A., Fritzemeier, K., Haendler, B., Heinrich, N., Möller, C., Schwede, W., & Wintermantel, T. M. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_24 · Cited by 37 · see citing works
Mouse Prostate Cancer Cell Lines Established from Primary and Postcastration Recurrent Tumors
Liao, C., Liang, M., Cohen, M. B., Flesken‐Nikitin, A., Jeong, J. H., Nikitin, A. Y., & Roy‐Burman, P. (2010) · Hormones and Cancer · doi:10.1007/s12672-009-0005-y · Cited by 36 · see citing works
Androgen Receptor Signalling in Prostate Cancer: The Functional Consequences of Acetylation
Lavery, D. N., & Bevan, C. L. (2010) · BioMed Research International · doi:10.1155/2011/862125 · Cited by 36 · see citing works
Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer
McBeth, L., Grabnar, M., Selman, S. H., & Hinds, T. D. (2015) · International Journal of Endocrinology · doi:10.1155/2015/384860 · Cited by 35 · see citing works
Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms
Verma, S., Prajapati, K. S., Kushwaha, P. P., Shuaib, M., Singh, A. K., Kumar, S., & Gupta, S. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2020.45 · Cited by 36 · see citing works
The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance
Cronin, R., Brooke, G. N., & Prischi, F. (2021) · Oncogene · doi:10.1038/s41388-021-01810-9 · Cited by 32 · see citing works
Sakkiah, S., Ng, H. W., Tong, W., & Hong, H. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1192131 · Cited by 35 · see citing works
Yen, P. M. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.07.005 · Cited by 33 · see citing works
Poutiainen, P., Oravilahti, T., Peräkylä, M., Palvimo, J. J., Ihalainen, J. A., Laatikainen, R., & Pulkkinen, J. T. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300233k · Cited by 33 · see citing works
Qu, F., Gu, Y. Q., Wang, Q., He, M., Zhou, F., Sun, J., Wang, G., & Peng, Y. H. (2020) · Investigational New Drugs · doi:10.1007/s10637-020-00901-w · Cited by 33 · see citing works
Ha, S., Zhu, J., Xiang, H., & Luo, G. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.109192 · Cited by 34 · see citing works
The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease
Benarroch, R., Austin, J. M., Ahmed, F., & Isaacson, R. L. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.11.002 · Cited by 32 · see citing works
GENETIC DETERMINANTS OF PROSTATE CANCER: A REVIEW
Král, M., Rosinska, V., Študent, V., Grepl, M., Hrabec, M., & Bouchal, J. (2011) · Biomedical Papers · doi:10.5507/bp.155.2011.001 · Cited by 31 · see citing works
O’Neill, D. J., Jones, D. L., Wade, M., Grey, J., Nakjang, S., Guo, W., Cork, D. M. W., Davies, B. R., Wedge, S. R., Robson, C. N., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4347 · Cited by 30 · see citing works
ARF Represses Androgen Receptor Transactivation in Prostate Cancer
Lu, W., Xie, Y., Ma, Y., Matusik, R. J., & Chen, Z. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1294 · Cited by 30 · see citing works
Relationship between LSD1 expression and E-cadherin expression in prostate cancer
Wang, M., Liu, X., Jiang, G., Chen, H., Guo, J., & Weng, X. (2015) · International Urology and Nephrology · doi:10.1007/s11255-015-0915-2 · Cited by 30 · see citing works
Khurana, N., Talwar, S., Chandra, P. K., Sharma, P., Abdel‐Mageed, A. B., Mondal, D., & Sikka, S. C. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3641 · Cited by 30 · see citing works
Hu, H., Zhou, H., & Xu, D. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13811 · Cited by 26 · see citing works
Targeting sex steroid biosynthesis for breast and prostate cancer therapy
POUTANEN, M. H., Thulin, M. H., & Härkönen, P. L. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00609-y · Cited by 28 · see citing works
WOMEN IN CANCER THEMATIC REVIEW: New roles for nuclear receptors in prostate cancer
Leach, D. A., Powell, S. M., & Bevan, C. L. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0319 · Cited by 25 · see citing works
Bhati, S., Kaushik, V., & Singh, J. (2018) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-018-9734-5 · Cited by 25 · see citing works
Khurana, N., Chandra, P. K., Kim, H., Abdel‐Mageed, A. B., Mondal, D., & Sikka, S. C. (2020) · Antioxidants · doi:10.3390/antiox9010068 · Cited by 24 · see citing works
Li, S., Yu, C., Zhang, Y., Liu, J., Jia, Y., Sun, F., Zhang, P., Li, J., Guo, L., Xiao, H., et al. (2020) · BioMed Research International · doi:10.1155/2020/7586521 · Cited by 24 · see citing works
The Culinary-Medicinal Mushroom Coprinus comatus as a Natural Antiandrogenic Modulator
Dotan, N., Wasser, S. P., & Mahajna, J. A. (2010) · Integrative Cancer Therapies · doi:10.1177/1534735410383169 · Cited by 24 · see citing works
Dart, D. A., Brooke, G. N., Sita-Lumsden, A. R., Waxman, J., & Bevan, C. L. (2011) · Oncogene · doi:10.1038/onc.2011.591 · Cited by 23 · see citing works
Targeting the androgen receptor in metastatic castrate-resistant prostate cancer: A review
Anantharaman, A., & Friedlander, T. W. (2015) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2015.11.003 · Cited by 23 · see citing works
Zhang, M., Sun, Y., Huang, C., Luo, J., Zhang, L., Meng, J., Liang, C. Y., & Chang, C. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03966-4 · Cited by 21 · see citing works
In touch with your feminine side: how oestrogen metabolism impacts prostate cancer
Rahman, H. P., Hofland, J., & Foster, P. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0118 · Cited by 21 · see citing works
Khan, A., Mao, Y., Tahreem, S., Wei, D., & Wang, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.058 · Cited by 20 · see citing works
de Albuquerque, A. C. C., Bezerra, K. S., Vianna, J. F., Batista, S. D. O., Neto, J. X., Campos, D. M. D. O., Oliveira, J. I. N., Galvao, D. S., & Fulco, U. L. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.3c01103 · Cited by 20 · see citing works
Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators
Sundén, H., Holland, M. C., Poutiainen, P., Jääskeläinen, T. J., Pulkkinen, J. T., Palvimo, J. J., & Olsson, R. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501995n · Cited by 20 · see citing works
Androgen Receptor Signalling in Prostate Cancer: Mechanisms of Resistance to Endocrine Therapies
Quistini, A., Chierigo, F., Fallara, G., Depalma, M., Tozzi, M., Maggi, M., Jannello, L. M. I., Pellegrino, F., Mantica, G., Terracciano, D., et al. (2025) · Research and Reports in Urology · doi:10.2147/rru.s388265 · Cited by 19 · see citing works
Vizeacoumar, F. S., Guo, H., Dwernychuk, L., Zaidi, A., Freywald, A., Wu, F., Vizeacoumar, F. J., & Ahmed, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-87037-w · Cited by 19 · see citing works
Wang, T. T. Y., Schoene, N. W., Kim, E., & Kim, Y. S. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21906 · Cited by 19 · see citing works
AR activates YAP/TAZ differentially in prostate cancer
Salem, O., Jia, S., Qian, B., & Hansen, C. G. (2023) · Life Science Alliance · doi:10.26508/lsa.202201620 · Cited by 18 · see citing works
Djigoué, G. B., Kenmogne, L. C., Roy, J., Maltais, R., & Poirier, D. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.07.049 · Cited by 18 · see citing works
Brooke, G. N., Gamble, S. C., Hough, M. A., Begum, S., Dart, D. A., Odontiadis, M., Powell, S. M., Fioretti, F. M., Bryan, R. A., Waxman, J., et al. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.036764 · Cited by 17 · see citing works
Mascareno, E. J., Belashov, I. A., Siddiqui, M. A. Q., Liu, F., & Dhar-Mascareño, M. (2011) · The Prostate · doi:10.1002/pros.21510 · Cited by 16 · see citing works
Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner
Kim, S.-H., Kim, S. Y., Park, E., Kim, J., Park, H. H., So, I., Kim, S. J., & Jeon, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.01.094 · Cited by 16 · see citing works
Precision medicine applications in prostate cancer
McCrea, E. M., Lee, D. K., Sissung, T. M., & Figg, W. D. (2018) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835918776920 · Cited by 16 · see citing works
- Authors
- Brooke, G., & Bevan, C.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Bevan, C.
- ORCID
- Venue
- Current Genomics
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-03-01
- Volume
- 10
- Issue
- 1
- Pages
- 18-25
- ISSN
- 1389-2029 (ISSN-L)
- PMC
- PMC2699836
- OpenAlex
- W2082107721
- Cited by
- 181
- References
- 83
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 14 · 2017: 7 · 2016: 11 · 2015: 17 · 2014: 13 · 2013: 12 · 2012: 12
- FWCI
- 12.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Current Genomics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Access at Essex (University of Essex) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- androgen receptor, androgen receptor mutations, prostate cancer progression, castration-resistant prostate cancer, androgen receptor signaling, cofactor interactions, ligand specificity, gene expression, androgen receptor antagonists
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