Cited by 185Prostate Cancer Treatment and ResearchProstate Cancer Diagnosis and TreatmentChromatin Remodeling and Cancer

The role of androgen receptor mutations in prostate cancer progression.

Open access
Brooke, G., Bevan, C.·2009·Current Genomics

Abstract

Prostate tumour growth is almost always dependent upon the androgen receptor pathway and hence therapies aimed at blocking this signalling axis are useful tools in the management of this disease. Unfortunately such therapies invariably fail; and the tumour progresses to an "androgen-independent" stage. In such cases androgen receptor expression is almost always maintained and much evidence exists to suggest that it may still be driving growth. One mechanism by which the receptor is thought to remain active is mutation. This review summarises the present data on androgen receptor mutations in prostate cancer, and how such substitutions offer a growth advantage by affecting cofactor interactions or by reducing ligand specificity. Such alterations appear to have a subsequent effect upon gene expression suggesting that tumours may "behave" differently dependent upon the ligand promoting growth and if a mutation is present.

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Crossref · 10.2174/138920209787581307

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85 of 85 references verified0 citation errors · 0 not checkable

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  • Activating mutations of the androgen receptor can create a promiscuous receptor, alter interactions with coregulatory proteins, and impair intramolecular N-C interactions.

    “Activating mutations of the AR have the capacity to create a promiscuous receptor, alter interactions with coregulatory proteins, and impair intramolecular N-C interactions (71).”
  • Approximately 70 different missense mutations have been described in patient samples, with varying consequences upon androgen receptor activity.

    “Approximately 70 different missense mutations have been described in patient samples, with varying consequences upon AR activity.”

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Research works printed but not linked: 3

  1. [59]Brooks J Walsh P A.R Darracott Vaughan E Wein A Anatomy of the lower urinary tract and male genitalia Campbell's Urology 2002 London Saunders 41 80
  2. [64]Shepherd DL Harris M Thompson I Syrigos K Radical Prostatectomy in the management of localised prostate cancer Prostate Cancer: Biology, Diagnosis and Management 2001 Oxford Oxford University Press 229 242
  3. [72]Taplin M-E Bubley GJ Shuster TD Frantz ME Spooner AE Ogata GK Keer HN Balk SP Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer N. Engl. J. Med 1995 332 1393 1398 7723794

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Authors
Brooke, G., & Bevan, C.
Affiliations
Imperial College London (GB)
Corresponding author
Bevan, C.
Venue
Current Genomics
Published
2009-03-01
Volume
10
Issue
1
Pages
18-25
ISSN
1389-2029 (ISSN-L)
OpenAlex
W2082107721
Cited by
181
References
83
Citations by year
2026: 4 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 14 · 2017: 7 · 2016: 11 · 2015: 17 · 2014: 13 · 2013: 12 · 2012: 12
FWCI
12.39
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Current Genomics (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Open Access at Essex (University of Essex) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
androgen receptor, androgen receptor mutations, prostate cancer progression, castration-resistant prostate cancer, androgen receptor signaling, cofactor interactions, ligand specificity, gene expression, androgen receptor antagonists

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