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Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting
Open accessAbstract
Gene delivery vectors based on Adenoviral (Ad) vectors have enormous potential for the treatment of both hereditary and acquired disease. Detailed structural analysis of the Ad virion, combined with functional studies has broadened our knowledge of the structure/function relationships between Ad vectors and host cells/tissues and substantial achievement has been made towards a thorough understanding of the biology of Ad vectors. The widespread use of Ad vectors for clinical gene therapy is compromised by their inherent immunogenicity. The generation of safer and more effective Ad vectors, targeted to the site of disease, has therefore become a great ambition in the field of Ad vector development. This review provides a synopsis of the structure/function relationships between Ad vectors and host systems and summarizes the many innovative approaches towards achieving Ad vector targeting.
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“Similar to recombinant AAV vectors, the AV genome remains in an extrachromosomal form following infection.”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [66]
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Metadata
- Authors
- Campos, S., & Barry, M.
- Affiliations
- University of New Mexico (US)
- Mayo Clinic (US)
- Venue
- Current Gene Therapy
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2007-06-01
- Volume
- 7
- Issue
- 3
- Pages
- 189-204
- ISSN
- 1566-5232 (ISSN-L)
- PMC
- PMC2244792
- OpenAlex
- W2025616153
- Cited by
- 210
- References
- 196
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 6 · 2015: 17 · 2014: 20 · 2013: 15 · 2012: 21
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Gene Therapy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA093942)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- adenoviral vector, gene delivery vectors, gene therapy, viral vector targeting, immunogenicity, structure-function relationship, host-virus interaction, clinical gene therapy
- MeSH terms
- Adenoviruses, Human, Genetic Vectors, Humans, Transduction, Genetic, Genetic Therapy, Capsid Proteins, Virus Internalization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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