Breaking Down the Barriers to Precision Cancer Nanomedicine

The blockade of immune checkpoints in cancer immunotherapy

Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838 · see citing works

Nanocarriers as an emerging platform for cancer therapy

Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710 · see citing works

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Rizvi, N. A., Hellmann, M. D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J. J., Lee, W., Yuan, J., Wong, P., Ho, T. S., et al. (2015) · Science · doi:10.1126/science.aaa1348 · Cited by 7,802 · see citing works

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002 · cited 4× · see citing works

Analysis of nanoparticle delivery to tumours

Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218 · see citing works

Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells

Chithrani, D. B., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,887 · see citing works

Renal clearance of quantum dots

Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476 · see citing works

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

Albanese, A., Tang, P. S., & Chan, W. C. W. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150124 · Cited by 3,876 · see citing works

Effect of pegylation on pharmaceuticals

Harris, J. M., & Chess, R. B. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1033 · Cited by 3,431 · see citing works

Delivering nanomedicine to solid tumors

Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,196 · see citing works

Shape effects of filaments versus spherical particles in flow and drug delivery

Geng, Y., Dalhaimer, P., Cai, S., Tsai, R., Tewari, M., Minko, T., & Discher, D. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.70 · Cited by 2,565 · see citing works

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

Hu, C. J., Zhang, L., Aryal, S., Cheung, C., Fang, R. H., & Zhang, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106634108 · Cited by 2,449 · see citing works

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429 · see citing works

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

Tenzer, S., Docter, D., Kuharev, J., Musyanovych, A., Fetz, V., Hecht, R., Schlenk, F., Fischer, D., Kiouptsi, K., Reinhardt, C., et al. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.181 · Cited by 2,283 · see citing works

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

Kigerl, K. A., Gensel, J. C., Ankeny, D. P., Alexander, J. K., Donnelly, D. J., & Popovich, P. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3257-09.2009 · Cited by 2,130 · see citing works

Role of target geometry in phagocytosis

Champion, J. A., & Mitragotri, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600997103 · Cited by 2,082 · see citing works

The Path to Personalized Medicine

Hamburg, M. A., & Collins, F. S. (2010) · New England Journal of Medicine · doi:10.1056/nejmp1006304 · Cited by 1,970 · see citing works

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926 · see citing works

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

Salvati, A., Pitek, A. S., Monopoli, M. P., Prapainop, K., Bombelli, F. B., Hristov, D. R., Kelly, P. M., Åberg, C., Mahon, E., & Dawson, K. A. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.237 · Cited by 1,912 · see citing works

Immunological properties of engineered nanomaterials

Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823 · see citing works

Nanoparticle biointerfacing by platelet membrane cloaking

Hu, C. J., Fang, R. H., Wang, K.-C., Luk, B. T., Thamphiwatana, S., Dehaini, D., Nguyen, P., Angsantikul, P., Wen, C. H., Kroll, A. V., et al. (2015) · Nature · doi:10.1038/nature15373 · Cited by 1,795 · see citing works

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

Kranz, L. M., Diken, M., Haas, H., Kreiter, S., Loquai, C., Reuter, K. C., Meng, M., Fritz, D., Vascotto, F., Hefesha, H., et al. (2016) · Nature · doi:10.1038/nature18300 · Cited by 1,771 · see citing works

Tumor angiogenesis: molecular pathways and therapeutic targets

Weis, S. M., & Cheresh, D. A. (2011) · Nature Medicine · doi:10.1038/nm.2537 · Cited by 1,726 · see citing works

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D. J., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.046 · Cited by 1,578 · see citing works

Nanocarriers’ entry into the cell: relevance to drug delivery

Hillaireau, H., & Couvreur, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0053-z · Cited by 1,549 · see citing works

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

Schöttler, S., Becker, G., Winzen, S., Steinbach, T., Mohr, K., Landfester, K., Mailänder, V., & Wurm, F. R. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2015.330 · Cited by 1,272 · see citing works

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

Parodi, A., Quattrocchi, N., van de Ven, A. L., Chiappini, C., Evangelopoulos, M., Martinez, J. O., Brown, B. S., Khaled, S. Z., Yazdi, I. K., Enzo, M. V., et al. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.212 · Cited by 1,174 · see citing works

Challenges in Development of Nanoparticle-Based Therapeutics

Desai, N. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9339-4 · Cited by 1,173 · see citing works

Treating metastatic cancer with nanotechnology

Schroeder, A., Heller, D. A., Winslow, M. M., Dahlman, J. E., Pratt, G. W., Langer, R., Jacks, T., & Anderson, D. G. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3180 · Cited by 1,154 · see citing works

Nanomedicine

Kim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912273 · Cited by 1,153 · see citing works

Nasal drug delivery—possibilities, problems and solutions

Illum, L. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00363-2 · Cited by 1,107 · see citing works

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.45 · Cited by 1,101 · see citing works

Multistage nanoparticle delivery system for deep penetration into tumor tissue

Wong, C., Stylianopoulos, T., Cui, J., Martin, J. D., Chauhan, V. P., Jiang, W., Popović, Z., Jain, R. K., Bawendi, M. G., & Fukumura, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018382108 · Cited by 1,067 · see citing works

Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells

Leśniak, A., Fenaroli, F., Monopoli, M. P., Åberg, C., Dawson, K. A., & Salvati, A. L. (2012) · ACS Nano · doi:10.1021/nn300223w · Cited by 1,064 · see citing works

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

Rodriguez, P. L., Harada, T., Christian, D. A., Pantano, D. A., Tsai, R. K., & Discher, D. E. (2013) · Science · doi:10.1126/science.1229568 · Cited by 985 · see citing works

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Stylianopoulos, T., Martin, J. D., Chauhan, V. P., Jain, S. R., Diop-Frimpong, B., Bardeesy, N., Smith, B. L., Ferrone, C. R., Hornicek, F. J., Boucher, Y., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213353109 · Cited by 943 · see citing works

Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking

Duan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926 · see citing works

Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model

Foged, C., Brodin, B., Frøkjær, S., & Sundblad, A. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.035 · Cited by 874 · see citing works

Strategies for advancing cancer nanomedicine

Chauhan, V. P., & Jain, R. K. (2013) · Nature Materials · doi:10.1038/nmat3792 · Cited by 815 · see citing works

Lymphangiogenesis and lymphatic vessel remodelling in cancer

Stacker, S. A., Williams, S. P., Karnezis, T., Shayan, R., Fox, S. B., & Achen, M. G. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3677 · Cited by 812 · see citing works

Therapeutic vaccines for cancer: an overview of clinical trials

Melero, I., Gaudernack, G., Gerritsen, W. R., Huber, C., Parmiani, G., Scholl, S., Thatcher, N. J., Wagstaff, J., Zielinski, C. C., Faulkner, I., et al. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.111 · Cited by 773 · see citing works

Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability

Lockman, P. R., Koziara, J. M., Mumper, R. J., & Allen, D. D. (2004) · Journal of drug targeting · doi:10.1080/10611860400015936 · Cited by 742 · see citing works

Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications

Tasciotti, E., Liu, X., Bhavane, R. C., Plant, K. D., Leonard, A. D., Price, B. K., Cheng, M. M., Decuzzi, P., Tour, J. M., Robertson, F. M., et al. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.34 · Cited by 669 · see citing works

Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo

Niikura, K., Matsunaga, T., Suzuki, T., Kobayashi, S., Yamaguchi, H., Orba, Y., Kawaguchi, A., Hasegawa, H., Kajino, K., Ninomiya, T., et al. (2013) · ACS Nano · doi:10.1021/nn3057005 · Cited by 639 · see citing works

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

Niewoehner, J., Bohrmann, B., Collin, L., Urich, E., Sade, H., Maier, P., Rueger, P., Stracke, J. O., Lau, W., Tissot, A. C., et al. (2014) · Neuron · doi:10.1016/j.neuron.2013.10.061 · Cited by 622 · see citing works

Passive Tumor Targeting of Renal-Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance

Liu, J., Yu, M., Zhou, C., Yang, S., Ning, X., & Zheng, J. (2013) · Journal of the American Chemical Society · doi:10.1021/ja401612x · Cited by 598 · see citing works

Shaping Cancer Nanomedicine: The Effect of Particle Shape on The In Vivo Journey of Nanoparticles

Toy, R., Peiris, P. M., Ghaghada, K. B., & Karathanasis, E. (2013) · Nanomedicine · doi:10.2217/nnm.13.191 · Cited by 596 · see citing works

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

Ulbrich, K., Hekmatara, T., Herbert, E., & Kreuter, J. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.08.021 · Cited by 591 · see citing works

Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development

Kushnir, N., Streatfield, S. J., & Yusibov, V. M. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.10.083 · Cited by 590 · see citing works

Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

McDannold, N. J., Arvanitis, C., Vykhodtseva, N. I., & Livingstone, M. S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0128 · Cited by 588 · see citing works

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

Kreuter, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.008 · Cited by 554 · see citing works

Overcoming the barriers in micellar drug delivery: loading efficiency,in vivostability, and micelle–cell interaction

Kim, S., Shi, Y., Kim, J. Y., Park, K., & Cheng, J. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903380446 · Cited by 549 · see citing works

TAT Peptide-Functionalized Gold Nanostars: Enhanced Intracellular Delivery and Efficient NIR Photothermal Therapy Using Ultralow Irradiance

Yuan, H., Fales, A. M., & Vo‐Dinh, T. (2012) · Journal of the American Chemical Society · doi:10.1021/ja304180y · Cited by 525 · see citing works

CSF, blood-brain barrier, and brain drug delivery

Pardridge, W. M. (2016) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2016.1171315 · Cited by 508 · see citing works

In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer

Lizotte, P. H., Wen, A. M., Sheen, M. R., Fields, J., Rojanasopondist, P., Steinmetz, N. F., & Fiering, S. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.292 · Cited by 484 · see citing works

Construction and Characterization of Virus-Like Particles: A Review

Zeltiņš, A. (2012) · Molecular Biotechnology · doi:10.1007/s12033-012-9598-4 · Cited by 479 · see citing works

Nanoparticle Hydrophobicity Dictates Immune Response

Moyano, D. F., Goldsmith, M., Solfiell, D. J., Landesman‐Milo, D., Miranda, O. R., Peer, D., & Rotello, V. M. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2108905 · Cited by 479 · see citing works

Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones

Zensi, A., Begley, D., Pontikis, C., Legros, C., Mihoreanu, L., Wagner, S., Büchel, C., von Briesen, H., & Kreuter, J. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.03.002 · Cited by 438 · see citing works

Paradoxical glomerular filtration of carbon nanotubes

Ruggiero, A., Villa, C. H., Bander, E. D., Rey, D. A., Bergkvist, M., Batt, C. A., Manova-Todorova, K. O., Deen, W. M., Scheinberg, D. A., & McDevitt, M. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913667107 · Cited by 426 · see citing works

Compact Cysteine-Coated CdSe(ZnCdS) Quantum Dots for in Vivo Applications

Liu, W., Choi, H. S., Zimmer, J. P., Tanaka, E., Frangioni, J. V., & Bawendi, M. G. (2007) · Journal of the American Chemical Society · doi:10.1021/ja073790m · Cited by 415 · see citing works

Lactoferrin-conjugated PEG–PLA nanoparticles with improved brain delivery: In vitro and in vivo evaluations

Hu, K., Li, J., Shen, Y., Lü, W., Gao, X., Zhang, Q., & Jiang, X. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.10.016 · Cited by 354 · see citing works

Renal clearable inorganic nanoparticles: a new frontier of bionanotechnology

Liu, J., Yu, M., Zhou, C., & Zheng, J. (2013) · Materials Today · doi:10.1016/j.mattod.2013.11.003 · Cited by 352 · see citing works

Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles

Ruan, S., Yuan, M., Zhang, L., Hu, G., Chen, J., Cun, X., Zhang, Q., Yang, Y., He, Q., & Gao, H. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.007 · Cited by 333 · see citing works

Microglial Response to Gold Nanoparticles

Hutter, E., Boridy, S., Labrecque, S., Lalancette–Hébert, M., Križ, J., Winnik, F. M., & Maysinger, D. (2010) · ACS Nano · doi:10.1021/nn901869f · Cited by 321 · see citing works

Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots

Choi, H. S., Ipe, B. I., Misra, P., Lee, J. H., Bawendi, M. G., & Frangioni, J. V. (2009) · Nano Letters · doi:10.1021/nl900872r · Cited by 305 · see citing works

Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations

Hamdy, S. I., Haddadi, A., Hung, R., & Lavasanifar, A. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.05.021 · Cited by 297 · see citing works

Neurotoxicity of Silica Nanoparticles: Brain Localization and Dopaminergic Neurons Damage Pathways

Wu, J., Wang, C., Sun, J., & Xue, Y. (2011) · ACS Nano · doi:10.1021/nn103530b · Cited by 286 · see citing works

Tailoring nanoparticle designs to target cancer based on tumor pathophysiology

Sykes, E. A., Dai, Q., Sarsons, C. D., Chen, J., Rocheleau, J. V., Hwang, D. M., Zheng, G., Cramb, D. T., Rinker, K. D., & Chan, W. C. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521265113 · Cited by 280 · see citing works

Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)

Ulbrich, K., Knobloch, T., & Kreuter, J. (2011) · Journal of Drug Targeting · doi:10.3109/10611861003734001 · Cited by 259 · see citing works

Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging

Koffie, R. M., Farrar, C. T., Saidi, L.-J., William, C. M., Hyman, B. T., & Spires‐Jones, T. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111405108 · Cited by 259 · see citing works

Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes

Qie, Y., Yuan, H., Roemeling, C. A. V., Chen, Y., Liu, X., Shih, K. D., Knight, J. A., Tun, H. W., Wharen, R. E., Jiang, W., et al. (2016) · Scientific Reports · doi:10.1038/srep26269 · Cited by 259 · see citing works

Frontiers in cancer nanomedicine: directing mass transport through biological barriers

Mauro Ferrari, B. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2009.12.007 · Cited by 256 · see citing works

The effect of nanoparticle size on the probability to cross the blood-brain barrier: an in-vitro endothelial cell model

Shilo, M., Sharon-Buller, A., Baranes, K., Motiei, M., Lellouche, J., & Popovtzer, R. (2015) · Journal of Nanobiotechnology · doi:10.1186/s12951-015-0075-7 · Cited by 236 · see citing works

Biodegradable Particles as Vaccine Delivery Systems: Size Matters

Joshi, V. B., Geary, S. M., & Salem, A. K. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9418-6 · Cited by 233 · see citing works

Targeting of Tumor-Associated Macrophages Made Possible by PEG-Sheddable, Mannose-Modified Nanoparticles

Zhu, S., Niu, M., O’Mary, H. L., & Cui, Z. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400216r · Cited by 233 · see citing works

Surface Characteristics of Nanoparticles Determine Their Intracellular Fate in and Processing by Human Blood–Brain Barrier Endothelial Cells In Vitro

Georgieva, J. V., Kalicharan, D., Couraud, P., Romero, I. A., Weksler, B. B., Hoekstra, D., & Zuhorn, I. S. (2010) · Molecular Therapy · doi:10.1038/mt.2010.236 · Cited by 211 · see citing works

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

Sager, H. B., Dutta, P., Dahlman, J. E., Hulsmans, M., Courties, G., Sun, Y., Heidt, T., Vinegoni, C., Borodovsky, A., Fitzgerald, K. J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf1435 · Cited by 205 · see citing works

DNA-controlled dynamic colloidal nanoparticle systems for mediating cellular interaction

Ohta, S., Glancy, D., & Chan, W. C. W. (2016) · Science · doi:10.1126/science.aad4925 · Cited by 204 · see citing works

Influence of Engineered Nanoparticles from Metals on the Blood-Brain Barrier Permeability, Cerebral Blood Flow, Brain Edema and Neurotoxicity. An Experimental Study in the Rat and Mice Using Biochemical and Morphological Approaches

Sharma, H. S., Ali, S. F., Hussain, S. M., Schlager, J. J., & Sharma, A. (2009) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2009.gr09 · Cited by 189 · see citing works

Generation of Effector Memory T Cell–Based Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination

Li, A. V., Moon, J. J., Abraham, W. D., Suh, H., Elkhader, J. A., Seidman, M. A., Yen, M., Im, E., Foley, M. H., Barouch, D. H., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006516 · Cited by 187 · see citing works

Central nervous system toxicity of metallic nanoparticles

Wei, L., Shao, L., Feng, X., Chen, A., Zhang, Y., & Wang, J. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s78308 · Cited by 184 · see citing works

Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines

Demento, S. L., Siefert, A. L., Bandyopadhyay, A., Sharp, F. A., & Fahmy, T. M. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.02.004 · Cited by 177 · see citing works

Transmutable nanoparticles with reconfigurable surface ligands

Kim, Y., Macfarlane, R. J., Jones, M. R., et al. (2016) · Science · doi:10.1126/science.aad2212 · Cited by 172 · see citing works

Remodeling Tumor Vasculature to Enhance Delivery of Intermediate-Sized Nanoparticles

Jiang, W., Huang, Y., An, Y., & Kim, B. Y. S. (2015) · ACS Nano · doi:10.1021/acsnano.5b02028 · Cited by 148 · see citing works

Influence of surface charge and inner composition of porous nanoparticles to cross blood–brain barrier in vitro

Jallouli, Y., Paillard, A., Chang, J., Sevin, E., & Betbeder, D. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.023 · Cited by 139 · see citing works

Potentiating Cancer Immunotherapy Using Papaya Mosaic Virus-Derived Nanoparticles

Lebel, M., Chartrand, K., Tarrab, E., Savard, P. E., Leclerc, D., & Lamarre, A. (2016) · Nano Letters · doi:10.1021/acs.nanolett.5b04877 · Cited by 138 · see citing works

The role of surface charge density in cationic liposome-promoted dendritic cell maturation and vaccine-induced immune responses

Ma, Y., Zhuang, Y., Xie, X., et al. (2011) · Nanoscale · doi:10.1039/c1nr10166h · Cited by 131 · see citing works

Human serum albumin nanoparticles modified with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain

Zensi, A., Begley, D. J., Pontikis, C., Legros, C., Mihoreanu, L., Büchel, C., & Kreuter, J. (2010) · Journal of drug targeting · doi:10.3109/1061186x.2010.513712 · Cited by 119 · see citing works

Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury

Papa, S., Ferrari, R., Paola, M. D., Rossi, F., Mariani, A., Caron, I., Sammali, E., Peviani, M., Dell’Oro, V., Colombo, C., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.11.001 · Cited by 113 · see citing works

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

Yang, Han, Tian, T., et al. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s18507 · Cited by 106 · see citing works

Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen

Hanlon, D. J., Saluja, S. S., Sharp, F. A., et al. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s66639 · Cited by 103 · see citing works

Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model

Ambruosi, A., Gelperina, S. E., Khalansky, A. S., Tanski, S., Theisen, A., & Kreuter, J. (2006) · Journal of Microencapsulation · doi:10.1080/02652040600788080 · Cited by 100 · see citing works

Hybrid nanoparticles improve targeting to inflammatory macrophages through phagocytic signals

Bagalkot, V., Badgeley, M. A., Kampfrath, T., Deiuliis, J. A., Rajagopalan, S., & Maiseyeu, A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.027 · Cited by 99 · see citing works

Stable cationic microparticles for enhanced model antigen delivery to dendritic cells

Wischke, C., Borchert, H., Zimmermann, J., Siebenbrodt, I., & Lorenzen, D. R. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.06.020 · Cited by 87 · see citing works

Three-Dimensional Optical Mapping of Nanoparticle Distribution in Intact Tissues

Sindhwani, S., Syed, A. M., Wilhelm, S., Glancy, D., Chen, Y. Y., Dobosz, M., & Chan, W. C. W. (2016) · ACS Nano · doi:10.1021/acsnano.6b01879 · Cited by 84 · see citing works

Antibodies in oncology

Pillay, V., Gan, H. K., & Scott, A. M. (2011) · New Biotechnology · doi:10.1016/j.nbt.2011.03.021 · Cited by 80 · see citing works

Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody

Jobsri, J., Allen, A., Rajagopal, D., Shipton, M. J., Kanyuka, K., Lomonossoff, G. P., Ottensmeier, C. H. H., Diebold, S. S., Stevenson, F. K., & Savelyeva, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118096 · Cited by 70 · see citing works

Paracrine signalling of inflammatory cytokines from an in vitro blood brain barrier model upon exposure to polymeric nanoparticles

Raghnaill, M. N., Bramini, M., Dong, Y., Couraud, P., Romero, I. A., Weksler, B. B., Åberg, C., Salvati, A. L., Lynch, I., & Dawson, K. A. (2013) · The Analyst · doi:10.1039/c3an01621h · Cited by 44 · see citing works

Engineering precision nanoparticles for drug delivery

Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0090-8 · Cited by 7,933 · see citing works

Targeting Tumor Microenvironment for Cancer Therapy

Roma-Rodrigues, C., Mendes, R., Baptista, P. V., & Fernandes, A. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040840 · Cited by 1,187 · see citing works

Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

Waheed, S., Li, Z., Zhang, F., Chiarini, A., Armato, U., & Wu, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01605-4 · Cited by 259 · see citing works

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

Ioannidis, J. P. A., Kim, B. Y. S., & Trounson, A. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0314-y · Cited by 175 · see citing works

Neurotheranostics as Personalized Medicines

Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J., Gorantla, S., Bronich, T. K., Edagwa, B., & Gendelman, H. E. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.011 · Cited by 124 · see citing works

Enhancing the therapeutic delivery of oligonucleotides by chemical modification and nanoparticle encapsulation

Sun, Y., Zhao, Y., Zhao, X., Lee, R. J., Teng, L., & Zhou, C. (2017) · Molecules · doi:10.3390/molecules22101724 · Cited by 56 · see citing works

Drug Delivery Based on Nanotechnology for Target Bone Disease

Yang, X., Chen, S., Liu, X., Yu, M., & Liu, X. (2019) · Current Drug Delivery · doi:10.2174/1567201816666190917123948 · Cited by 15 · see citing works

Precisely Controlling the Activation of an Iron-Locked Drug Generator in the Liver Sinusoid to Enhance Barrier Penetration and Reduction of Liver Fibrosis

Sun, Q., Yang, W., Song, Z., Lu, H., Shang, W., Li, H., Yang, Z., Gao, W., Li, Y., Xu, Y., et al. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c11988 · Cited by 6 · see citing works

Image-Guided Cancer Nanomedicine

Kim, D. (2018) · Journal of Imaging · doi:10.3390/jimaging4010018 · Cited by 32 · see citing works

Cancer nanomedicine: is targeting our target?

Lammers, T., Kiessling, F. M., Ashford, M. B., Hennink, W. E., Crommelin, D. J. A., & Storm, G. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.69 · Cited by 232 · see citing works

NANOMEDICINE—PRESENT AND FUTURE OF DISEASE MANAGEMENT

Mehamalini, V. (2022) · INTERNATIONAL JOURNAL OF NANOBIOTECHNOLOGY · doi:10.37628/ijn.v8i1.892

Promoting Inter-/Intra- Cellular Process of Nanomedicine through its Physicochemical Properties Optimization

Chen, D., Wang, J., Wang, Y., et al. (2017) · Current Drug Metabolism · doi:10.2174/1389200219666171221122119 · Cited by 12 · see citing works

Nanomedicine: Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines (Adv. Healthcare Mater. 1/2018)

Balasubramanian, V., Liu, Z., Hirvonen, J. J., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201870005 · Cited by 7 · see citing works