Treadmill exercise prevents learning and memory impairment in Alzheimer's disease-like pathology

Dao, An T.; Zagaar, Munder A.; Levine, Amber T.; Salim, Samina; Eriksen, Jason L.; Alkadhi, Karim A.

doi:10.2174/1567205011310050006

Cited by 99Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchMemory and Neural Mechanisms

Treadmill exercise prevents learning and memory impairment in Alzheimer's disease-like pathology

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Dao, An T., Zagaar, Munder A., Levine, Amber T., Salim, Samina, Eriksen, Jason L., Alkadhi, Karim A.·2013·Current Alzheimer Research

DOI 10.2174/1567205011310050006PMC PMC4004077

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by progressive memory loss. In contrast, accumulating evidence suggests a neuroprotective role of regular exercise in aging associated memory impairment. In this study, we investigated the ability of regular exercise to prevent impairments of short-term memory (STM) and early long-term potentiation (E-LTP) in area CA1 of the hippocampus in a rat model of AD (i.c.v. infusion of 250 pmol/day Aβ1-42 peptides). We utilized behavioral assessment, in vivo electrophysiological recording, and immunoblotting in 4 groups of adult Wistar rats: control, treadmill exercise (Ex), β-amyloid-infused (Aβ), and amyloid-infused/treadmill exercised (Ex/Aβ). Our findings indicated that Aβ rats made significantly more errors in the radial arm water maze (RAWM) compared to all other groups and exhibited suppressed E-LTP in area CA1, which correlated with deleterious alterations in the levels of memory and E-LTP-related signaling molecules including calcineurin (PP2B), brain derivedneurotrophic factor (BDNF) and phosphorylated CaMKII (p-CaMKII). Compared to controls, Ex and Ex/Aβ rats showed a similar behavioral performance and a normal E-LTP with no detrimental changes in the levels of PP2B, BDNF, and p- CaMKII. We conclude that treadmill exercise maybe able to prevent cognitive impairment associated with AD pathology.

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Authors: Dao, A. T., Zagaar, M. A., Levine, A. T., Salim, S., Eriksen, J. L., & Alkadhi, K. A.
Affiliations: University of Houston (US)
Texas Southern University (US)
ORCID: Zagaar, Munder A.
Salim, Samina
Eriksen, Jason L.
Alkadhi, Karim A.
Venue: Current Alzheimer Research
Publisher: Bentham Science Publishers Ltd.
Published: 2013-05-01
Volume: 10
Issue: 5
Pages: 507-515
ISSN: 1567-2050 (ISSN-L)
DOI: 10.2174/1567205011310050006
PMC: PMC4004077
OpenAlex: W1992079632
Cited by: 99
References: 89
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 14 · 2017: 9 · 2016: 3 · 2015: 12 · 2014: 9 · 2013: 2 · 2012: 1
FWCI: 6.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Alzheimer Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R15AG039008)
National Institute of Mental Health (R15MH093918)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: Alzheimer's disease, treadmill exercise, physical activity, short-term memory, long-term potentiation, hippocampal CA1, amyloid-beta, radial arm water maze, calcineurin, brain-derived neurotrophic factor, CaMKII, neuroprotection, cognitive impairment
MeSH terms: Alzheimer Disease, Analysis of Variance, Animals, Disease Models, Animal, Electric Stimulation, Exercise Test, Learning Disabilities, Male, Memory Disorders, Memory, Short-Term, Peptide Fragments, Physical Conditioning, Animal, Up-Regulation, Amyloid beta-Peptides, Drug Delivery Systems, Rats, Wistar, Long-Term Potentiation, Maze Learning, Brain-Derived Neurotrophic Factor, Calcineurin, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2, CA1 Region, Hippocampal

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Treadmill exercise prevents learning and memory impairment in Alzheimer's disease-like pathology

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