Cited by 64Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

The benefits of exercise on structural and functional plasticity in the rodent hippocampus of different disease models.

Open access
Patten, Anna R., Yau, Suk Yu, Fontaine, Christine J., Meconi, Alicia, Wortman, Ryan C., Christie, Brian R.·2015·Brain Plasticity

Abstract

In this review, the benefits of physical exercise on structural and functional plasticity in the hippocampus are discussed. The evidence is clear that voluntary exercise in rats and mice can lead to increases in hippocampal neurogenesis and enhanced synaptic plasticity which ultimately result in improved performance in hippocampal-dependent tasks. Furthermore, in models of neurological disorders, including fetal alcohol spectrum disorders, traumatic brain injury, stroke, and neurodegenerative disorders including Alzheimer's, Parkinson's and Huntington's disease exercise can also elicit beneficial effects on hippocampal function. Ultimately this review highlights the multiple benefits of exercise on hippocampal function in both the healthy and the diseased brain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3233/bpl-150016

Cites

291 of 291 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • AE has been demonstrated to counteract pathologically induced hippocampal harm and improve the region's functioning in a range of animal disease models.

    “While its therapeutic potential has only been explored very recently, AE has been demonstrated to counteract pathologically induced hippocampal harm and improve the region’s functioning in a range of animal disease models including fetal alcohol spectrum disorders, traumatic brain injury, stroke, and Parkinson’s, Alzheimer’s and Huntington’s diseases (Patten et al., 2015).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 4

  1. [1]Anderson P, Morris R, Amaral D, Bliss T, O’Keefe J. The Hippocampus Book [Internet]. Oxford University Press. 2007. 872 p. Available from: http://books.google.com/books/about/The_hippocampus_book.html?id=zg6oyF1DziQC
  2. [65]Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Gotz M, et al. Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell [Internet]. 2010;6(5):445-56. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20452319 20452319
  3. [79]Van Praag H Schinder AF Christie BR Toni N Palmer TD Gage FH 2002 Functional neurogenesis in the adult hippocampus Nature 415 1030 1034 11875571 PMC9284568
  4. [111]Helfer JL Goodlett CR Greenough WT Klintsova AY 2009 The effects of exercise on adolescent hippocampal neurogenesis in a rat model of binge alcohol exposure during the brain growth spurt Brain Res 1294 1 11 19647724 PMC2756176

Cited by

Sorted by citations

Authors
Patten, A. R., Yau, S. Y., Fontaine, C. J., Meconi, A., Wortman, R. C., & Christie, B. R.
Affiliations
  • University of Victoria (CA)
  • University of British Columbia (CA)
Corresponding author
Christie, Brian R.
Venue
Brain Plasticity
Publisher
IOS Press
Published
2015-06
Volume
1
Issue
1
Pages
97-127
ISSN
  • 2213-6304 (ISSN-L)
  • 2213-6312
OpenAlex
W2338468094
Cited by
64
References
291
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 12 · 2021: 3 · 2020: 7 · 2019: 16 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 3
FWCI
0.46
Type
journal article
Language
en
Open access
Locations
  • Brain Plasticity (publishedVersion, other-oa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
voluntary exercise, hippocampus, structural plasticity, functional plasticity, hippocampal neurogenesis, synaptic plasticity, fetal alcohol spectrum disorders, traumatic brain injury, stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease, neurodegenerative diseases, disease models

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review