The benefits of exercise on structural and functional plasticity in the rodent hippocampus of different disease models.
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In this review, the benefits of physical exercise on structural and functional plasticity in the hippocampus are discussed. The evidence is clear that voluntary exercise in rats and mice can lead to increases in hippocampal neurogenesis and enhanced synaptic plasticity which ultimately result in improved performance in hippocampal-dependent tasks. Furthermore, in models of neurological disorders, including fetal alcohol spectrum disorders, traumatic brain injury, stroke, and neurodegenerative disorders including Alzheimer's, Parkinson's and Huntington's disease exercise can also elicit beneficial effects on hippocampal function. Ultimately this review highlights the multiple benefits of exercise on hippocampal function in both the healthy and the diseased brain.
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AE has been demonstrated to counteract pathologically induced hippocampal harm and improve the region's functioning in a range of animal disease models.
“While its therapeutic potential has only been explored very recently, AE has been demonstrated to counteract pathologically induced hippocampal harm and improve the region’s functioning in a range of animal disease models including fetal alcohol spectrum disorders, traumatic brain injury, stroke, and Parkinson’s, Alzheimer’s and Huntington’s diseases (Patten et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Patten et al., 2015
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366 · see citing works
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322 · see citing works
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151 · see citing works
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
Heart Disease and Stroke Statistics—2014 Update
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., et al. (2013) · Circulation · doi:10.1161/01.cir.0000441139.02102.80 · Cited by 5,207 · see citing works
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,513 · see citing works
National Center for Injury Prevention and Control (U.S.). Division of Injury Response., Faul, M., Wald, M. M., Wu, L., & Coronado, V. G. (2010) · doi:10.15620/cdc.5571 · Cited by 3,494 · see citing works
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
Self-citationFunctional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works
Self-citationAggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain
DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J., & D, N. A. M. (1997) · Science · doi:10.1126/science.277.5334.1990 · Cited by 2,849 · see citing works
RECOGNITION OF THE FETAL ALCOHOL SYNDROME IN EARLY INFANCY
Jones, K., & Smith, D. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91092-1 · Cited by 2,780 · see citing works
The novel object recognition memory: neurobiology, test procedure, and its modifications
Antunes, M., & Biala, G. (2012) · Cognitive Processing · doi:10.1007/s10339-011-0430-z · Cited by 2,390 · see citing works
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Differential Effects of Early Hippocampal Pathology on Episodic and Semantic Memory
Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Connelly, A., Van Paesschen, W., & Mishkin, M. (1997) · Science · doi:10.1126/science.277.5324.376 · Cited by 1,746 · see citing works
Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
Leutgeb, J. K., Leutgeb, S., Moser, M.-B., & Moser, E. I. (2007) · Science · doi:10.1126/science.1135801 · Cited by 1,601 · cited 1× · see citing works
“At the neuronal level this is thought to occur either through change in neuronal firing rate or through the firing of different neuronal sets [24, 25].”
BackgroundThe effects of changes in the environment on the spatial firing of hippocampal complex-spike cells
Muller, R., & Kubie, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-07-01951.1987 · Cited by 1,581 · see citing works
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works
Cellular networks underlying human spatial navigation
Ekstrom, A. D., Kahana, M. J., Caplan, J. B., Fields, T. A., Isham, E. A., Newman, E. L., & Fried, I. (2003) · Nature · doi:10.1038/nature01964 · Cited by 1,425 · see citing works
Animal models of traumatic brain injury
Xiong, Y., Mahmood, A., & Chopp, M. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3407 · Cited by 1,413 · see citing works
Spatial representation in the entorhinal cortex
Fyhn, M., Molden, S., Witter, M. P., Moser, E. I., & Moser, M.-B. (2004) · Science · doi:10.1126/science.1099901 · Cited by 1,339 · see citing works
Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease
Wilson, R. S. (2002) · JAMA · doi:10.1001/jama.287.6.742 · Cited by 1,312 · see citing works
Vonsattel, J. P., & DiFiglia, M. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199805000-00001 · Cited by 1,305 · see citing works
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall
Nakazawa, K., Quirk, M. C., Chitwood, R. A., Watanabe, M., Yeckel, M. F., Sun, L. D., Kato, A., Carr, C. A., Johnston, D., Wilson, M. A., et al. (2002) · Science · doi:10.1126/science.1071795 · Cited by 1,090 · see citing works
Exercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · see citing works
Bridging animal and human models of exercise-induced brain plasticity
Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works
Adult hippocampal neurogenesis and its role in Alzheimer’s disease
Mu, Y., & Gage, F. H. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-85 · Cited by 1,021 · see citing works
Neeper, S. A., Gómez‐Pinilla, F., Choi, J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/0006-8993(96)00273-9 · Cited by 1,015 · see citing works
Hippocampal place units in the freely moving rat: Why they fire where they fire
O'Keefe, J. M., & Conway, D. H. (1978) · Experimental Brain Research · doi:10.1007/bf00239813 · Cited by 1,007 · see citing works
Beneficial effects of physical exercise on neuroplasticity and cognition
Hötting, K., & Röder, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.005 · Cited by 991 · see citing works
Dopamine depletion impairs precursor cell proliferation in Parkinson disease
Höglinger, G. U., Rizk, P., Mp, M., Duyckaerts, C. J., Oertel, W. H., Caillé, I., & Hirsch, É. C. (2004) · Nature Neuroscience · doi:10.1038/nn1265 · Cited by 946 · see citing works
Lamellar organization of hippocampal excitatory pathways
Andersen, P. N., Bliss, T. V. P., & Skrede, K. K. (1971) · Experimental Brain Research · doi:10.1007/bf00234087 · Cited by 943 · see citing works
Physical Activity, Diet, and Risk of Alzheimer Disease
Scarmeas, N. (2009) · JAMA · doi:10.1001/jama.2009.1144 · Cited by 916 · see citing works
Taube, J. S., Muller, R., & Ranck, J. B. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-02-00436.1990 · Cited by 887 · see citing works
Dopamine-mediated regulation of corticostriatal synaptic plasticity
Calabresi, P., Picconi, B., Tozzi, A., & Di Filippo, M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.001 · Cited by 865 · see citing works
Staging of Alzheimer-Related Cortical Destruction
Braak, H., Braak, E., & Bohl, J. (2008) · European Neurology · doi:10.1159/000116984 · Cited by 836 · cited 1× · see citing works
“Despite this controversy, the hippocampus is known to be particularly vulnerable to AD, and is one of the first regions to be affected [187].”
BackgroundFarmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F. H., & Christie, B. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.029 · Cited by 836 · see citing works
Self-citationGenetic Animal Models of Parkinson's Disease
Dawson, T. M., Ko, H. S., & Dawson, V. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.034 · Cited by 825 · see citing works
Neuropathology of Alzheimer's Disease
Perl, D. P. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20157 · Cited by 825 · see citing works
Suh, H., Consiglio, A., Ray, J., Sawai, T., D’Amour, K. A., & Gage, F. H. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.09.002 · Cited by 818 · see citing works
Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
Yin, H. H., Mulcare, S. P., Hilário, M. R. F., Clouse, E., Holloway, T., Davis, M. I., Hansson, A. C., Lovinger, D. M., & Costa, R. M. (2009) · Nature Neuroscience · doi:10.1038/nn.2261 · Cited by 818 · see citing works
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
Brown, J., Cooper‐Kuhn, C. M., Kempermann, G., Van Praag, H., Winkler, J., Gage, F. H., & Kuhn, H. G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02647.x · Cited by 809 · see citing works
Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease
Adlard, P. A., Perreau, V. M., Pop, V., & Cotman, C. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0496-05.2005 · Cited by 806 · see citing works
Parkinson’s disease: genetics and pathogenesis
Shulman, J. M., De Jager, P. L., & Feany, M. B. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130242 · Cited by 801 · see citing works
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798 · see citing works
Spatial selectivity of unit activity in the hippocampal granular layer
Jung, M. W., & McNaughton, B. L. (1993) · Hippocampus · doi:10.1002/hipo.450030209 · Cited by 789 · see citing works
Fetal Alcohol Spectrum Disorder
Sokol, R. J. (2003) · JAMA · doi:10.1001/jama.290.22.2996 · Cited by 767 · see citing works
Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
Akers, K. G., Martinez-Canabal, A., Restivo, L., Yiu, A. P., De Cristofaro, A., Hsiang, H.-L. (., Wheeler, A. L., Guskjolen, A., Niibori, Y., Shoji, H., et al. (2014) · Science · doi:10.1126/science.1248903 · Cited by 761 · see citing works
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740 · see citing works
Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
Gómez-Pinilla, F., Ying, Z., Roy, R. R., Molteni, R., & Edgerton, V. R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00152.2002 · Cited by 724 · see citing works
Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704 · see citing works
An oscillatory interference model of grid cell firing
Burgess, N., Barry, C., & O'Keefe, J. M. (2007) · Hippocampus · doi:10.1002/hipo.20327 · Cited by 688 · see citing works
Chaddock, L., Erickson, K. I., Prakash, R. S., Kim, J. S., Voss, M. W., VanPatter, M., Pontifex, M. B., Raine, L. B., Konkel, A., Hillman, C. H., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.049 · Cited by 687 · see citing works
Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1
Gilbert, P. E., Kesner, R. P., & Lee, I. (2001) · Hippocampus · doi:10.1002/hipo.1077 · Cited by 641 · see citing works
Kronenberg, G., Reuter, K., Steiner, B., Brandt, M. D., Jessberger, S., Yamaguchi, M., & Kempermann, G. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10945 · Cited by 640 · see citing works
Physical activity, fitness, and gray matter volume
Erickson, K. I., Leckie, R. L., & Weinstein, A. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.034 · Cited by 630 · see citing works
Erickson, K. I., Miller, D. L., & Roecklein, K. A. (2011) · The Neuroscientist · doi:10.1177/1073858410397054 · Cited by 550 · see citing works
Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory
北村, 貴., Saitoh, Y., Takashima, N., Murayama, A., Niibori, Y., Ageta, H., Sekiguchi, M., Sugiyama, H., & Inokuchi, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.020 · Cited by 489 · see citing works
Griesbach, G. S., Hovda, D. A., Molteni, R., Wu, A., & Gómez‐Pinilla, F. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.030 · Cited by 488 · see citing works
Shen, J., & Kelleher, R. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608332104 · Cited by 485 · see citing works
Mechanisms of neurodegeneration in Huntington’s disease
Gil‐Mohapel, J., & Rego, A. C. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06310.x · Cited by 480 · see citing works
Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D., & Kempermann, G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.016 · Cited by 477 · see citing works
Fisher, B. E., Wu, A. D., Salem, G. J., Song, J., Lin, C.-H. (., Yip, J., Cen, S., Gordon, J., Jakowec, M., & Petzinger, G. (2008) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.01.013 · Cited by 474 · see citing works
Feng, R., Rampon, C., Tang, Y., Shrom, D., Jin, J., Kyin, M., Sopher, B. L., Martin, G. M., Kim, S., Langdon, R. B., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00523-2 · Cited by 467 · see citing works
Social isolation delays the positive effects of running on adult neurogenesis
Stranahan, A. M., Khalil, D., & Gould, E. (2006) · Nature Neuroscience · doi:10.1038/nn1668 · Cited by 467 · see citing works
Eadie, B. D., Redila, V. A., & Christie, B. R. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20493 · Cited by 466 · see citing works
Self-citationHaughey, N. J., Nath, A., Chan, S. L., Borchard, A. C., Rao, M. S., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01267.x · Cited by 466 · see citing works
H. M.’s Medial Temporal Lobe Lesion: Findings from Magnetic Resonance Imaging
Corkin, S., Amaral, D. G., González, R., Johnson, K. A., & Hyman, B. T. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03964.1997 · Cited by 451 · see citing works
Concussion in Sports: Postconcussive Activity Levels, Symptoms, and Neurocognitive Performance
Majerske, C. W., Mihalik, J. P., Ren, D., Collins, M. W., Reddy, C. C., Lovell, M. R., & Wagner, A. K. (2008) · Journal of Athletic Training · doi:10.4085/1062-6050-43.3.265 · Cited by 448 · see citing works
Molteni, R., Ying, Z., & Gómez‐Pinilla, F. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02158.x · Cited by 441 · see citing works
Friedland, R. P., Fritsch, T., Smyth, K. A., Koss, E., Lerner, A. J., Chen, C. H., Petot, G. J., & Debanne, S. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061002998 · Cited by 438 · see citing works
A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis
Kesner, R. P., Lee, I., & Gilbert, P. E. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.5.333 · Cited by 435 · see citing works
Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP Sw,Ind ) mice
Jin, K., Galván, V., Xie, L., Mao, X. O., Gorostiza, O. F., Bredesen, D. E., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403678101 · Cited by 433 · see citing works
Fabel, K. (2009) · Frontiers in Neuroscience · doi:10.3389/neuro.22.002.2009 · Cited by 429 · see citing works
Konishi, K., & Bohbot, V. D. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00001 · Cited by 404 · see citing works
Tillerson, J. L., Caudle, W. M., Reverón, M. E., & Miller, G. W. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00096-4 · Cited by 399 · see citing works
Schindowski, K., Bretteville, A., Leroy, K., Bégard, S., Brion, J., Hamdane, M., & Buée, L. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060002 · Cited by 396 · see citing works
Rodríguez, J. J., Jones, V. C., Tabuchi, M., Allan, S. M., Knight, E. M., LaFerla, F. M., Oddo, S., & Verkhratsky, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002935 · Cited by 377 · see citing works
Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity.
Cowansage, K., LeDoux, J., & Monfils, M.-H. (2010) · Current Molecular Pharmacology · doi:10.2174/1874467211003010012 · Cited by 372 · cited 1× · see citing works
“tic plasticity and learning and memory [275, 276].”
Brain‐Derived Neurotrophic Factor in Neuronal Survival and Behavior‐Related Plasticity
LIPSKY, R. H., & MARINI, A. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1403.009 · Cited by 361 · see citing works
Hicks, R. R., Smith, D. H., Lowenstein, D. H., Marie, R. L. S., & McIntosh, T. K. (1993) · Journal of Neurotrauma · doi:10.1089/neu.1993.10.405 · Cited by 359 · see citing works
Mental Illness in Adults With Fetal Alcohol Syndrome or Fetal Alcohol Effects
Famy, C., Streissguth, A. P., & Unis, A. S. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.4.552 · Cited by 357 · see citing works
Postnatal Neurogenesis in the Guinea-pig
Altman, J., & Das, G. D. (1967) · Nature · doi:10.1038/2141098a0 · Cited by 356 · see citing works
O'Reilly, R. C., & Norman, K. A. (2002) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(02)02005-3 · Cited by 351 · see citing works
Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease
Donovan, M. H., Yazdani, U., Norris, R. D., Games, D., German, D. C., & Eisch, A. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20840 · Cited by 350 · see citing works
Vakil, E. (2005) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390490919245 · Cited by 348 · see citing works
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
Hardy, J., Duff, K., Hardy, K. G., Pérez‐Tur, J., & Hutton, M. (1998) · Nature Neuroscience · doi:10.1038/1565 · Cited by 345 · see citing works
Dong, H., Goico, B., Martin, M., Csernansky, C. A., Bertchume, A., & Csernansky, J. G. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.040 · Cited by 342 · see citing works
Behavioral functions of the CA3 subregion of the hippocampusPreprint
Kesner, R. P. (2007) · Learning & Memory · doi:10.1101/lm.688207 · Cited by 337 · see citing works
Evidence for two physiologically distinct perforant pathways to the fascia dentata
McNaughton, B. L. (1980) · Brain Research · doi:10.1016/0006-8993(80)90226-7 · Cited by 336 · see citing works
Forced and voluntary exercise differentially affect brain and behavior
Leasure, J. L., & Jones, M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.041 · Cited by 335 · see citing works
Parkinson's disease is associated with hippocampal atrophy
Camicioli, R. M., Moore, M. M., Kinney, A. E. “., Corbridge, E., Glassberg, K., & Kaye, J. A. (2003) · Movement Disorders · doi:10.1002/mds.10444 · Cited by 330 · see citing works
Petzinger, G. M., Walsh, J. P., Akopian, G., Hogg, E., Abernathy, A., Arevalo, P., Turnquist, P., Vučković, M., Fisher, B. E., Togasaki, D. M., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1069-07.2007 · Cited by 329 · see citing works
Yau, S. Y., Li, A., Hoo, R. L. C., Ching, Y. P., Christie, B. R., Lee, T. M. C., Xu, A., & So, K.-F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415219111 · Cited by 326 · see citing works
Self-citationMarlatt, M. W., Potter, M. C., Lucassen, P. J., & van Praag, H. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22009 · Cited by 314 · see citing works
Fisher, B. E., Petzinger, G. M., Nixon, K., Hogg, E., Bremmer, S., Meshul, C. K., & Jakowec, M. W. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20162 · Cited by 311 · see citing works
Exercise exerts neuroprotective effects on Parkinson's disease model of rats
Tajiri, N., Yasuhara, T., Shingo, T., Kondo, A., Yuan, W., Kadota, T., Wang, F., Baba, T., Tayra, J. T., Morimoto, T., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2009.10.075 · Cited by 308 · see citing works
Wozniak, D. F., Hartman, R. E., Boyle, M. A., Vogt, S. K., Brooks, A., Tenkova, T. I., YOUNG, C., Olney, J. W., & Muglia, L. J. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.08.006 · Cited by 302 · see citing works
Physical Activity, Brain Plasticity, and Alzheimer's Disease
Erickson, K. I., Weinstein, A. M., & Lopez, O. L. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.09.008 · Cited by 288 · see citing works
Wolf, S. A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., & Kempermann, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.004 · Cited by 288 · see citing works
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
Intlekofer, K. A., & Cotman, C. W. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.011 · Cited by 286 · see citing works
What is the mammalian dentate gyrus good for?
Treves, A., Tashiro, A., Witter, M. P., & Moser, E. I. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.073 · Cited by 282 · see citing works
Ke, Z., Yip, S. P., Li, L., Zheng, X., & Tong, R. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016643 · Cited by 281 · see citing works
Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration
Patten, D. A., Germain, M., Kelly, M., & Slack, R. S. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100498 · Cited by 280 · see citing works
Griesbach, G. S., Hovda, D. A., & Gómez‐Pinilla, F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.045 · Cited by 274 · see citing works
Rhodes, J. S., van Praag, H., Jeffrey, S., Girard, I., Mitchell, G. S., Garland, T., & Gage, F. H. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.5.1006 · Cited by 269 · see citing works
A role for BDNF in the late-phase of hippocampal long-term potentiation
Körte, M., Kang, H., Bonhoeffer, T., & Schuman, E. M. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00035-5 · Cited by 268 · see citing works
Lee, I., & Kesner, R. P. (2004) · Hippocampus · doi:10.1002/hipo.10177 · Cited by 268 · see citing works
O'Callaghan, R., OHLE, R., & Kelly, A. M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.10.018 · Cited by 268 · see citing works
Pang, T. Y. C., Stam, N. C., Nithianantharajah, J., Howard, M. L., & Hannan, A. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.013 · Cited by 265 · see citing works
Kim, S., Ko, I., Kim, B.-K., Shin, M., Cho, S., Kim, C., Kim, S., Baek, S., Lee, E. K., & Jee, Y. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.02.005 · Cited by 255 · see citing works
Cued and Contextual Fear Conditioning for Rodents
Rustay, N. R., Browman, K. E., & Curzon, P. (2008) · Frontiers in neuroscience · doi:10.1201/noe1420052343.ch2 · Cited by 254 · see citing works
Physical Exercise Protects Against Alzheimer's Disease in 3xTg-AD Mice
García‐Mesa, Y., López, J. C., Giménez‐Llort, L., Revilla, S., Guerra, R., Gruart, A., LaFerla, F. M., Cristòfol, R. M., Delgado-Garcia, J. M., & Sanfeliu, C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101635 · Cited by 253 · see citing works
Yuede, C. M., Zimmerman, S., Dong, H., Kling, M. J., Bero, A. W., Holtzman, D. M., Timson, B. F., & Csernansky, J. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.002 · Cited by 250 · see citing works
Paradoxical influence of hippocampal neurogenesis on working memory
Saxe, M., Malleret, G., Vronskaya, S., Mendez‐David, I., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., & Hen, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611718104 · Cited by 244 · see citing works
Neurogenesis in the adult hippocampus
Ehninger, D., & Kempermann, G. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0478-3 · Cited by 243 · see citing works
Astley, S. J., Aylward, E., Olson, H. C., Kerns, K. A., Brooks, A., Coggins, T. E., Davies, J. K., Dorn, S., Gendler, B., Jirikowic, T., et al. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01004.x · Cited by 243 · see citing works
Clark, P., Brzezinska, W. J., Thomas, M. W., Ryzhenko, N. A., Toshkov, S. A., & Rhodes, J. S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.051 · Cited by 236 · see citing works
Behavioral and Psychosocial Profiles of Alcohol‐Exposed Children
Roebuck, T. M., Mattson, S. N., & Riley, E. P. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04227.x · Cited by 235 · see citing works
Redila, V. A., & Christie, B. R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.050 · Cited by 235 · see citing works
Self-citationAdult hippocampal neurogenesis and voluntary running activity: Circadian and dose‐dependent effects
Holmes, M. M., Galea, L. A. M., Mistlberger, R. E., & Kempermann, G. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20039 · Cited by 233 · see citing works
Aerobic endurance exercise benefits memory and affect in young adults.
Stroth, S., Hille, K., Spitzer, M., & Reinhardt, R. (2009) · Neuropsychological Rehabilitation · doi:10.1080/09602010802091183 · Cited by 232 · see citing works
Hamilton, D. A., Kodituwakku, P. W., Sutherland, R. J., & Savage, D. D. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00028-7 · Cited by 232 · see citing works
van der Borght, K., Havekes, R., Bos, T., Eggen, B. J. L., & van der Zee, E. A. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.324 · Cited by 227 · see citing works
Verret, L., Jankowsky, J. L., Xu, G. M., Borchelt, D., & Rampon, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5564-06.2007 · Cited by 226 · see citing works
Neurogenesis in the adult hippocampus
Christie, B. R., & Cameron, H. A. (2006) · Hippocampus · doi:10.1002/hipo.20151 · Cited by 224 · see citing works
Self-citationLearning and Memory in Transgenic Mice Modeling Alzheimer's Disease
Ashe, K. H. (2001) · Learning & Memory · doi:10.1101/lm.43701 · Cited by 224 · see citing works
The organization of spatial coding in the hippocampus: a study of neural ensemble activity
Eichenbaum, H., Wiener, S. I., Shapiro, M., & Cohen, N. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02764.1989 · Cited by 221 · see citing works
Patten, A. R., Fontaine, C. J., & Christie, B. R. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00093 · Cited by 218 · see citing works
Self-citationClinical and neuropathologic assessment of severity in Huntington's disease
Myers, R. H., Vonsattel, J. P., Stevens, T. J., Cupples, L. A., Richardson, E. P., Martin, J. B., & Bird, E. D. (1988) · Neurology · doi:10.1212/wnl.38.3.341 · Cited by 217 · see citing works
Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms
Costa, D. A., Cracchiolo, J. R., Bachstetter, A. D., Hughes, T. F., Bales, K. R., Paul, S. M., Mervis, R. F., Arendash, G. W., & Potter, H. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.04.009 · Cited by 217 · see citing works
Staging of Alzheimer-Related Cortical Destruction
Braak, H., & Braak, E. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004973 · Cited by 217 · see citing works
Zhang, C., McNeil, E. M., Dressler, L., & Siman, R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.09.018 · Cited by 217 · see citing works
Exercise improves cognition and hippocampal plasticity in <i>APOE</i> ɛ4 mice
Nichol, K., Deeny, S. P., Seif, J., Camaclang, K., & Cotman, C. W. (2009) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2009.02.006 · Cited by 213 · see citing works
Exercise influences spatial learning in the radial arm maze
Anderson, B. J., Rapp, D. N., Baek, D. H., McCloskey, D. P., Coburn-Litvak, P. S., & Robinson, J. K. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00282-1 · Cited by 213 · see citing works
Um, H.-S., Kang, E., Koo, J., Kim, H.-T., Jin-Lee, Kim, E.-J., Yang, C., An, G.-Y., Cho, I., & Cho, J. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.10.004 · Cited by 212 · see citing works
Uecker, A., & Nadel, L. (1996) · Neuropsychologia · doi:10.1016/0028-3932(95)00096-8 · Cited by 212 · see citing works
Van der Borght, K., Kóbor‐Nyakas, D. É., Klauke, K., Eggen, B. J. L., Nyakas, C., Van der Zee, E. A., & Meerlo, P. (2009) · Hippocampus · doi:10.1002/hipo.20545 · Cited by 210 · see citing works
Mirochnic, S., Wolf, S. A., Staufenbiel, M., & Kempermann, G. (2009) · Hippocampus · doi:10.1002/hipo.20560 · Cited by 208 · see citing works
Fornix and hippocampal atrophy in traumatic brain injury.Preprint
Tate, D., & Bigler, E. (2000) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.33000 · Cited by 203 · see citing works
Adlard, P. A., Perreau, V. M., Engesser‐Cesar, C., & Cotman, C. W. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.03.058 · Cited by 202 · see citing works
Gil‐Mohapel, J., Ehret, F., Kainer, L., & Christie, B. R. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.04.011 · Cited by 194 · see citing works
Self-citationUda, M., Ishido, M., Kami, K., & Masuhara, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.066 · Cited by 193 · see citing works
Mustroph, M. L., Chen, S., Desai, S. C., Cay, E. B., DeYoung, E. K., & Rhodes, J. S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.007 · Cited by 190 · see citing works
Wen, P. H., Hof, P. R., Chen, X., Gluck, K., Austin, G., Younkin, S. G., Younkin, L. H., DeGasperi, R., Sosa, M. A. G., Robakis, N. K. R. K., et al. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.04.002 · Cited by 190 · see citing works
Brocardo, P. S., Boehme, F., Patten, A., Cox, A., Gil-Mohapel, J., & Christie, B. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.10.006 · Cited by 186 · see citing works
Self-citationPloughman, M., Granter‐Button, S., Chernenko, G. A., Tucker, B. A., Mearow, K. M., & Corbett, D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.037 · Cited by 184 · see citing works
Kallarackal, A. J., Kvarta, M. D., Cammarata, E., Jaberi, L., Cai, X., Bailey, A. M., & Thompson, S. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2588-13.2013 · Cited by 181 · see citing works
The effects of exercise and stress on the survival and maturation of adult‐generated granule cells
Snyder, J. S., Glover, L. R., Sanzone, K. M., Kamhi, J. F., & Cameron, H. A. (2009) · Hippocampus · doi:10.1002/hipo.20552 · Cited by 181 · see citing works
Cognitive disorders and neurogenesis deficits in Huntington’s disease mice are rescued by fluoxetine
Grote, H. E., Bull, N. D., Howard, M. L., Van Dellen, A., Blakemore, C., Bartlett, P. F., & Hannan, A. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04365.x · Cited by 179 · see citing works
Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury
Piao, C.-S., Stoica, B. A., Wu, J., Sabirzhanov, B. E., Zhao, Z., Cabatbat, R. M., Loane, D. J., & Faden, A. I. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.017 · Cited by 178 · see citing works
Increased Neurogenesis in Young Transgenic Mice Overexpressing Human APPSw,Ind
López-Toledano, M. A., & Shelanski, M. L. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12304 · Cited by 177 · see citing works
Thomas, J. D., Idrus, N. M., Monk, B., & Dominguez, H. D. (2010) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20713 · Cited by 175 · see citing works
Colino, A., & Malenka, R. C. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.4.1150 · Cited by 175 · see citing works
Volpe, B. T., Davis, H. P., Towle, A. C., & Dunlap, W. P. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.3.457 · Cited by 175 · see citing works
Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease
Nuber, S., Petrasch‐Parwez, E., Winner, B., Winkler, J., von Hörsten, S., Schmidt, T., Boy, J., Kuhn, M., Nguyen, H. P., Teismann, P., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3040-07.2008 · Cited by 175 · see citing works
Peng, Q., Masuda, N., Jiang, M., Li, Q., Zhao, M., Ross, C. A., & Duan, W. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.10.015 · Cited by 173 · see citing works
Lazic, S. E., Grote, H., Blakemore, C. B., Hannan, A. J., van Dellen, A., Phillips, W., & Barker, R. A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04715.x · Cited by 172 · see citing works
Griesbach, G. S., Gómez‐Pinilla, F., & Hovda, D. A. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0255 · Cited by 171 · see citing works
Tapia‐Rojas, C., Aránguiz, F. C., Varela‐Nallar, L., & Inestrosa, N. C. (2015) · Brain Pathology · doi:10.1111/bpa.12255 · Cited by 168 · see citing works
Aggleton, J. P., Albasser, M. M., Aggleton, D. J., Poirier, G. L., & Pearce, J. M. (2010) · Behavioral Neuroscience · doi:10.1037/a0018320 · Cited by 166 · see citing works
Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice
Gil‐Mohapel, J., Mohapel, P., Araújo, I. M., Popović, N., Li, J., Brundin, P., & Petersén, Å. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.05.006 · Cited by 166 · see citing works
Involvement of Adult Hippocampal Neurogenesis in Learning and Forgetting
Yau, S., Li, A., & So, K. (2015) · Neural Plasticity · doi:10.1155/2015/717958 · Cited by 165 · see citing works
Self-citationGalimberti, I., Gogolla, N., Alberi, S., Santos, A. F., Müller, D., & Caroni, P. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.026 · Cited by 163 · see citing works
Liu, H., Zhao, G., Cai, K., Zhao, H., & Li-de, S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.030 · Cited by 162 · see citing works
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology
Bélarbi, K., Burnouf, S., Fernández-Gómez, F.-J., Laurent, C., Lestavel, S., Figeac, M., Sultan, A., Troquier, L., Leboucher, A., Caillierez, R., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.022 · Cited by 162 · see citing works
Hopkins, M. E., Nitecki, R., & Bucci, D. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.071 · Cited by 160 · see citing works
Christie, B. R., Swann, S. E., Fox, C. J., Froc, D. J., Lieblich, S. E., Redila, V. A., & Webber, A. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04004.x · Cited by 154 · see citing works
Self-citationBi, M., Ittner, A., Ke, Y. D., Götz, J., & Ittner, L. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026860 · Cited by 153 · see citing works
Decreased hippocampal cell proliferation in R6/1 Huntington’s mice
Lazic, S. E., Grote, H., Armstrong, R. J. E., Blakemore, C. B., Hannan, A. J., van Dellen, A., & Barker, R. A. (2004) · Neuroreport · doi:10.1097/00001756-200404090-00014 · Cited by 151 · see citing works
Costa, C., Sgobio, C., Siliquini, S., Tozzi, A., Tantucci, M., Ghiglieri, V., Filippo, M. D., Pendolino, V., de Iure, A., Marti, M., et al. (2012) · Brain · doi:10.1093/brain/aws101 · Cited by 150 · see citing works
An analysis of the dentate gyrus function
Kesner, R. P. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.012 · Cited by 148 · see citing works
Herring, A., Ambrée, O., Tomm, M., Habermann, H., Sachser, N., Paulus, W., & Keyvani, K. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.027 · Cited by 147 · see citing works
Luo, C. X., Jiang, J., Zhou, Q. G., Zhu, X. J., Wang, W., Zhang, Z. J., Han, X., & Zhu, D. Y. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21317 · Cited by 146 · see citing works
Perturbed Neurogenesis in the Adult Hippocampus Associated with Presenilin-1 A246E Mutation
Chevallier, N. L., Soriano, S., Kang, D. E., Masliah, E., Hu, G., & Koo, E. H. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62962-8 · Cited by 145 · see citing works
Redila, V. A., Olson, A. K., Swann, S. E., Mohaddes, G., Webber, A. J., Weinberg, J., & Christie, B. R. (2006) · Hippocampus · doi:10.1002/hipo.20164 · Cited by 141 · see citing works
Self-citationLiu, H., Zhao, G., Zhang, H., & Li-de, S. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.008 · Cited by 141 · see citing works
Hopkins, M. E., & Bucci, D. J. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.06.006 · Cited by 139 · see citing works
Monti, J. M., Voss, M. W., Pence, A., McAuley, E., Kramer, A. F., & Cohen, N. J. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00041 · Cited by 138 · see citing works
Implicit and explicit memory functioning in children with heavy prenatal alcohol exposure
Mattson, S. N., & Riley, E. P. (1999) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617799555082 · Cited by 136 · see citing works
Bliss, T. V. P., & Lømo, T. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010273 · Cited by 135 · see citing works
Pothakos, K., Kurz, M. J., & Lau, Y.-S. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-6 · Cited by 134 · see citing works
Streissguth, A. P., Sampson, P. D., & Barr, H. M. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb21013.x · Cited by 133 · see citing works
Crews, L. A., Mizuno, H., Desplats, P., Rockenstein, E. M., Adame, A., Patrick, C., Winner, B., Winkler, J., & Masliah, E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0066-08.2008 · Cited by 131 · see citing works
Herting, M. M., & Nagel, B. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.012 · Cited by 126 · see citing works
Ridley, R. M., Timothy, C., Maclean, C. J., & Baker, H. F. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00063-o · Cited by 126 · see citing works
Deficits on a spatial navigation task following prenatal exposure to ethanol
Blanchard, B. (1987) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(87)90010-9 · Cited by 124 · see citing works
Phillips, W., Morton, A. J., & Barker, R. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3796-05.2005 · Cited by 123 · see citing works
van Dellen, A., Cordery, P., Spires, T., Blakemore, C., & Hannan, A. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-34 · Cited by 123 · see citing works
Zhu, G., Li, J., He, L., Wang, X., & Hong, X. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13061 · Cited by 118 · see citing works
Malisza, K. L., Allman, A.-A., Shiloff, D., Jakobson, L. S., Longstaffe, S. E. A., & Chudley, A. E. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000185479.92484.a1 · Cited by 116 · see citing works
Caldwell, K. E., Sheema, S., Paz, R., Samudio‐Ruiz, S. L., LAUGHLIN, M., SPENCE, N., Roehlk, M. J., Alcon, S. N., & Allan, A. M. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.05.004 · Cited by 116 · see citing works
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- [1]Anderson P, Morris R, Amaral D, Bliss T, O’Keefe J. The Hippocampus Book [Internet]. Oxford University Press. 2007. 872 p. Available from: http://books.google.com/books/about/The_hippocampus_book.html?id=zg6oyF1DziQC
- [65]Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Gotz M, et al. Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell [Internet]. 2010;6(5):445-56. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20452319 20452319
- [79]Van Praag H Schinder AF Christie BR Toni N Palmer TD Gage FH 2002 Functional neurogenesis in the adult hippocampus Nature 415 1030 1034 11875571 PMC9284568
- [111]Helfer JL Goodlett CR Greenough WT Klintsova AY 2009 The effects of exercise on adolescent hippocampal neurogenesis in a rat model of binge alcohol exposure during the brain growth spurt Brain Res 1294 1 11 19647724 PMC2756176
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Sorted by citations
Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works
“…been demonstrated to counteract pathologically induced hippocampal harm and improve the region’s functioning in a range of animal disease models including fetal alcohol spectrum disorders, traumatic brain injury, stroke, and Parkinson’s, Alzheimer’s and Huntington’s diseases (Patten et al., 2015).”
Running rewires the neuronal network of adult-born dentate granule cells
Vivar, C., Peterson, B. D., & van Praag, H. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.031 · Cited by 143 · see citing works
Running Changes the Brain: the Long and the Short of It
Vivar, C., & van Praag, H. (2017) · Physiology · doi:10.1152/physiol.00017.2017 · Cited by 114 · see citing works
- Authors
- Patten, A. R., Yau, S. Y., Fontaine, C. J., Meconi, A., Wortman, R. C., & Christie, B. R.
- Affiliations
- University of Victoria (CA)
- University of British Columbia (CA)
- Corresponding author
- Christie, Brian R.
- Venue
- Brain Plasticity
- Publisher
- IOS Press
- Published
- 2015-06
- Volume
- 1
- Issue
- 1
- Pages
- 97-127
- ISSN
- 2213-6304 (ISSN-L)
- 2213-6312
- PMC
- PMC5928528
- OpenAlex
- W2338468094
- Cited by
- 64
- References
- 291
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 12 · 2021: 3 · 2020: 7 · 2019: 16 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 3
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Plasticity (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- voluntary exercise, hippocampus, structural plasticity, functional plasticity, hippocampal neurogenesis, synaptic plasticity, fetal alcohol spectrum disorders, traumatic brain injury, stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease, neurodegenerative diseases, disease models
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