Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment

Neural consequences of enviromental enrichment

van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works

Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain

Louissaint, A., Rao, S., Leventhal, C., & Goldman, S. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00722-5 · Cited by 735 · see citing works

Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli

Kronenberg, G., Reuter, K., Steiner, B., Brandt, M. D., Jessberger, S., Yamaguchi, M., & Kempermann, G. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10945 · Cited by 640 · see citing works

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity

Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359 · see citing works

The role of adult hippocampal neurogenesis in brain health and disease

Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works

Stress and adult neurogenesis

Mirescu, C., & Gould, E. (2006) · Hippocampus · doi:10.1002/hipo.20155 · Cited by 701 · see citing works

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works

Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease

Mattson, M. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.005 · Cited by 640 · see citing works

Neurogenesis and Exercise: Past and Future Directions

van Praag, H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8028-z · Cited by 645 · see citing works

Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

Liu, P. Z., & Nusslock, R. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00052 · Cited by 533 · see citing works

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

Taliaz, D., Stall, N., Dar, D. E., & Zangen, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.67 · Cited by 454 · see citing works

Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy

Sale, A., Berardi, N., & Maffei, L. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2012 · Cited by 402 · see citing works

Exercise Attenuates the Major Hallmarks of Aging

Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413 · see citing works

Running is the neurogenic and neurotrophic stimulus in environmental enrichment

Kobilo, T., Liu, Q.-R., Gandhi, K., Mughal, M., Shaham, Y., & van Praag, H. (2011) · Learning & Memory · doi:10.1101/lm.2283011 · Cited by 385 · see citing works

Adult neuroplasticity: more than 40 years of research

Fuchs, E., & Flügge, G. (2014) · Neural Plasticity · doi:10.1155/2014/541870 · Cited by 325 · see citing works

Neuronal plasticity and antidepressant actions

Castrén, E., & Hen, R. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.010 · Cited by 243 · see citing works

Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles

Vilar, M., & Mira, H. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00026 · Cited by 235 · see citing works

Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases

Volkman, R., & Offen, D. (2017) · Stem Cells · doi:10.1002/stem.2651 · Cited by 222 · see citing works

Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling

Garza, J. C., Guo, M., Zhang, W., & Lu, X.-Y. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.161 · Cited by 209 · see citing works

Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment

Singhal, G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00097 · Cited by 186 · see citing works

Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis

Stephenson, D. T., O'Neill, S. M., Narayan, S., Tiwari, A., Arnold, E., Samaroo, H. D., Du, F., Ring, R. H., Campbell, B., Pletcher, M., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-7 · Cited by 180 · see citing works

The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology

Homberg, J. R., Molteni, R., Calabrese, F., & Riva, M. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.012 · Cited by 177 · see citing works

A time to remember: The role of circadian clocks in learning and memory.

Smarr, B. L., Jennings, K. J., Driscoll, J. R., & Kriegsfeld, L. J. (2014) · Behavioral Neuroscience · doi:10.1037/a0035963 · Cited by 166 · see citing works

Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats

Yau, S.-Y., Lau, B. W.-M., Tong, J.-B., Wong, R., Ching, Y.-P., Qiu, G., Tang, S.-W., Lee, T. M. C., & So, K.-F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024263 · Cited by 169 · see citing works

A comprehensive review of genetic and epigenetic mechanisms that regulate <i>BDNF</i> expression and function with relevance to major depressive disorder

Hing, B., Sathyaputri, L., & Potash, J. B. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32616 · Cited by 137 · see citing works

Environmental enrichment and the sensory brain: The role of enrichment in remediating brain injury

Alwis, D. S., & Rajan, R. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00156 · Cited by 129 · see citing works

BDNF in the dentate gyrus is required for consolidation of “pattern-separated” memories.

Bekinschtein, P., Kent, B. A., Oomen, C. A., Clemenson, G. D., Gage, F. H., Saksida, L. M., & Bussey, T. J. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.09.027 · Cited by 124 · see citing works

Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation

E, L., Burns, J. M., & Swerdlow, R. H. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.033 · Cited by 106 · see citing works

Treadmill exercise prevents learning and memory impairment in Alzheimer's disease-like pathology

Dao, A. T., Zagaar, M. A., Levine, A. T., Salim, S., Eriksen, J. L., & Alkadhi, K. A. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310050006 · Cited by 99 · see citing works

Environmental enrichment is associated with rapid volumetric brain changes in adult mice

Scholz, J., Allemang-Grand, R., Dazai, J., & Lerch, J. P. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.027 · Cited by 90 · see citing works

Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories.

Bekinschtein, P., Kent, B. A., Oomen, C. A., Clemenson, G. D., Gage, F. H., Saksida, L. M., & Bussey, T. J. (2014) · Hippocampus · doi:10.1002/hipo.22304 · Cited by 94 · see citing works

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck, B., & Pourié, G. (2013) · Nutrition Reviews · doi:10.1111/nure.12045 · Cited by 86 · see citing works

iPlasticity: Induced juvenile‐like plasticity in the adult brain as a mechanism of antidepressants

Umemori, J., Winkel, F., Didio, G., Llach Pou, M., & Castrén, E. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12683 · Cited by 80 · see citing works

High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations

Jang, Y. J., Park, H. R., Kim, T. H., Yang, W.-J., Lee, J.-J., Choi, S. Y., Oh, S. B., Lee, E., Park, J.-H., Kim, H.-P., et al. (2012) · Toxicology · doi:10.1016/j.tox.2012.03.007 · Cited by 82 · see citing works

Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease

Hullinger, R., & Puglielli, L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.008 · Cited by 68 · see citing works

Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: possible role of BDNF

Ambrogini, P., Lattanzi, D., Ciuffoli, S., Betti, M., Fanelli, M., & Cuppini, R. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.023 · Cited by 61 · see citing works

A Role of BDNF in the Depression Pathogenesis and a Potential Target as Antidepressant: The Modulator of Stress Sensitivity “Shati/Nat8l-BDNF System” in the Dorsal Striatum

Miyanishi, H., & Nitta, A. (2021) · Pharmaceuticals · doi:10.3390/ph14090889 · Cited by 57 · see citing works

A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity

Hing, B., Davidson, S., Lear, M., Breen, G., Quinn, J., McGuffin, P., & MacKenzie, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.030 · Cited by 52 · see citing works

Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model

Vitaliano, G. D., Kim, J. K., Kaufman, M. J., Adam, C. W., Zeballos, G., Shanmugavadivu, A., Subburaju, S., McLaughlin, J. P., Lukas, S. E., & Vitaliano, F. (2022) · Communications Biology · doi:10.1038/s42003-022-03177-3 · Cited by 48 · see citing works

Effects of treadmill exercise on neural stem cells, cell proliferation, and neuroblast differentiation in the subgranular zone of the dentate gyrus in cyclooxygenase-2 knockout mice

Nam, S. M., Kim, J. W., Yoo, D. Y., Choi, J. H., Kim, W., Jung, H. Y., Won, M.-H., Hwang, I. K., Seong, J. K., & Yoon, Y. S. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1169-y · Cited by 26 · see citing works

Effects of increased opportunity for physical exercise and learning experiences on recognition memory and brain-derived neurotrophic factor levels in brain and serum of rats

Vedovelli, K., Silveira, E., Velho, E., Stertz, L., Kapczinski, F., Schröder, N., & Bromberg, E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.012 · Cited by 26 · see citing works

Anxiolytic- and antidepressant-like effects of fish oil-enriched diet in brain-derived neurotrophic factor deficient mice

Zemdegs, J., Rainer, Q., Grossmann, C. P., Rousseau-Ralliard, D., Grynberg, A., Ribeiro, E., & Guiard, B. P. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00974 · Cited by 23 · see citing works