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Cited by 173Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchFatty Acid Research and Health

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Lipid Biomarkers in Alzheimer's Disease

Zarrouk, Amira, Debbabi, Meryam, Bezine, Maryem, Karym, El Mostafa, Badreddine, Asmaa, Rouaud, Olivier, Moreau, Thibault, Cherkaoui-Malki, Mustapha, El Ayeb, Mohamed, Nasser, Boubker, Hammami, Mohamed, Lizard, Gerard·2018·Current Alzheimer Research
DOI 10.2174/1567205014666170505101426
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Abstract

Background: There are now significant evidences that lipid metabolism is affected in numerous neurodegenerative diseases including Alzheimer’s disease. These dysfunctions lead to abnormal levels of certain lipids in the brain, cerebrospinal fluid and plasma. It is consequently of interest to establish lipid profiles in neurodegenerative diseases. This approach, which can contribute to identify lipid biomarkers of Alzheimers' disease, can also permit to identify new therapeutic targets. It was therefore of interest to focus on central and peripheral biomarkers in Alzheimer's disease. Methods: A review of the literature on 148 papers was conducted. Based on this literature, the involvement of lipids (cholesterol and oxysterols, fatty acids, phospholipids) in Alzheimer's disease has been proposed. Results: Of the 148 references cited for lipid biomarkers for Alzheimer's disease, 65 refer to cholesterol and oxysterols, 35 to fatty acids and 40 to phospholipids. Among these lipids, some of them such as 24S-hydroxyckolesterol, open up new therapeutic perspectives in gene therapy, in particular. The results on the very long-chain fatty acids suggest the potential of peroxisomal dysfunctions in Alzheimer's disease. As for the phospholipids, they could constitute interesting biomarkers for detecting the disease at the prodromal stage. Conclusion: There are now several lines of evidence that lipids play fundamental roles in the pathogenesis of AD and that some of them have a prognostic and diagnosis value. This may pave the way for the identification of new therapeutic targets, new effective drugs and / or new treatments.

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Authors
Zarrouk, A., Debbabi, M., Bezine, M., Karym, E. M., Badreddine, A., Rouaud, O., Moreau, T., Cherkaoui-Malki, M., El Ayeb, M., Nasser, B., Hammami, M., & Lizard, G.
Affiliations
  • Inserm (FR)
  • CHU Dijon Bourgogne (FR)
  • Université de Bourgogne (FR)
  • Department of Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism', University of Bourgogne Franche-Comte / INSERM, Dijon, France
  • Laboratory ‘Venoms and Therapeutic Biomolecules', University of Tunis El Manar - Pasteur Institut, Tunis, Tunisia
  • Université Hassan 1er (MA)
  • University of Monastir (TN)
ORCID
Venue
Current Alzheimer Research
Publisher
Bentham Science Publishers Ltd.
Published
2018-02-22
Volume
15
Issue
4
Pages
303-312
ISSN
1567-2050 (ISSN-L)
DOI
10.2174/1567205014666170505101426
OpenAlex
W2611926195
Cited by
170
References
0
Citations by year
2026: 5 · 2025: 12 · 2024: 18 · 2023: 21 · 2022: 21 · 2021: 22 · 2020: 23 · 2019: 20 · 2018: 10
FWCI
11.52
Type
journal article
Language
en
Open access
closed
Locations
  • Current Alzheimer Research (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
Alzheimer's disease, lipid biomarkers, lipid metabolism, cholesterol, oxysterols, 24S-hydroxycholesterol, fatty acids, very long chain fatty acids, peroxisomal dysfunction, phospholipids, cerebrospinal fluid, plasma lipids, neurodegeneration, therapeutic target, gene therapy
MeSH terms
Alzheimer Disease, Animals, Humans, Lipids, Biomarkers, Lipid Metabolism

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