The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.
Chronic Stress and Diabetes Mellitus: Interwoven Pathologies
Abstract
Stress threatens the homeostasis and mobilizes a plethora of adaptive physiological and behavioral changes via the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system. The HPA axis influences the pituitary gland, hypothalamus and adrenal gland via a complex set of positive and negative feedback system. The feedback system operates in a well regulated neuroendocrine manner to reestablish the threatened body equilibrium. The HPA axis secreted major product is a glucocorticoid (cortisol) which is kept within a physiologically optimal range and serves to accomplish the various physiological functions crucial for survival. In chronically stressed individuals dishabituation of HPA axis is followed by increased release of glucocorticoids and catecholamines. Higher secretion of glucocorticoids influences glucose metabolism by promoting gluconeogenesis in the liver, suppressing glucose uptake (adipocytes and skeletal muscles), promoting lipolysis in adipocytes, suppressing insulin secretion, inflicting insulin resistance and inflammation. These biological changes alter neuroendocrine mechanisms and lead to maladaptive congregation of events that form the underlying cause of development of Type 2 diabetes (T2D). The currently reviewed evidences advocate that targeting stress mediated hypersecretion of glucocorticoids may be a viable approach for the treatment of T2D and to reinstate glucose homeostasis.
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“Cortisol, with a primary role in stimulating gluconeogenesis, might be understood to be a metabolic rather than a 'stress' hormone.228,229”
From A new science of emotion: implications for functional neurological disorder (2022) · cites this paper as [229]
Citations
Cites
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Self-citationApoptotic Pathways and Alzheimer’s Disease: Probing Therapeutic Potential
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Self-citationA new science of emotion: implications for functional neurological disorder
Jungilligens, J., Paredes-Echeverri, S., Popkirov, S., Barrett, L. F., & Perez, D. L. (2022) · Brain · doi:10.1093/brain/awac204 · Cited by 164
Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies
Shen, Y., Li, M., Wang, K., Qi, G., Liu, H., Wang, W., Ji, Y., Chang, M., Deng, C., Xu, F., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.917113 · Cited by 104
Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?
Crigna, A. T., Samec, M., Koklesová, L., Líšková, A., Giordano, F. A., Kubatka, P., & Golubnitschaja, O. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00226-x · Cited by 80
Metadata
- Authors
- Sharma, V. K., & Singh, T. G.
- Affiliations
- Chitkara University (IN)
- Corresponding author
- Singh, Thakur Gurjeet
- Venue
- Current Diabetes Reviews
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2020-06-14
- Volume
- 16
- Issue
- 6
- Pages
- 546-556
- ISSN
- 1573-3998 (ISSN-L)
- OpenAlex
- W2985311368
- Cited by
- 116
- References
- 119
- Citations by year
- 2026: 12 · 2025: 27 · 2024: 23 · 2023: 23 · 2022: 20 · 2021: 8 · 2020: 3
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Diabetes Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- chronic stress, type 2 diabetes, hypothalamic-pituitary-adrenal axis, glucocorticoids, cortisol, insulin resistance, glucose metabolism, gluconeogenesis, sympathetic nervous system, catecholamines, neuroendocrine feedback, inflammation, glucose homeostasis
- MeSH terms
- Chronic Disease, Diabetes Mellitus, Type 2, Glucocorticoids, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Insulin Resistance, Stress, Physiological, Stress, Psychological, Sympathetic Nervous System
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