Suicide and the Polyamine System

Psychiatric diagnoses in 3275 suicides: a meta-analysis

Arsenault-Lapierre, G., Kim, C., & Turecki, G. (2004) · BMC Psychiatry · doi:10.1186/1471-244x-4-37 · Cited by 985 · see citing works

The neurodevelopmental origins of suicidal behavior

Turecki, G., Ernst, C., Jollant, F., Labonté, B., & Mechawar, N. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.008 · Cited by 299 · see citing works

Implication of the polyamine system in mental disorders

Fiori, L. M., & Turecki, G. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0812 · Cited by 135 · see citing works

Antidepressant-like effect of agmatine and its possible mechanism

Li, Y. F., Gong, Z. H., Cao, J., Wang, H. L., Luo, Z. P., & Li, J. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01735-7 · Cited by 108 · see citing works

Global gene expression profiling of the polyamine system in suicide completers

Fiori, L. M., Bureau, A., Labbe, A., Croteau, J., Noël, S., Mérette, C., & Turecki, G. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001574 · Cited by 50 · see citing works

Molecular pathways of major depressive disorder converge on the synapse

Fries, G. R., Saldana, V. A., Finnstein, J., & Rein, T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01806-1 · Cited by 504 · see citing works

Adolescent Suicide as a Failure of Acute Stress-Response Systems.

Miller, A. B., & Prinstein, M. J. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095625 · Cited by 235 · see citing works

Neuropathology of suicide: Recent findings and future directions

Lutz, P.-E., Mechawar, N., & Turecki, G. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.141 · Cited by 158 · see citing works

Agmatine: multifunctional arginine metabolite and magic bullet in clinical neuroscience?

Laube, G., & Bernstein, H. (2017) · Biochemical Journal · doi:10.1042/bcj20170007 · Cited by 110 · see citing works

Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers

Lopez, J. P., Fiori, L. M., Gross, J. A., Labonte, B., Yerko, V., Mechawar, N., & Turecki, G. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000941 · Cited by 103 · see citing works

Altered brain arginine metabolism in schizophrenia

Liu, X., Yu, J., Collie, N. D., Dean, B., Bilkey, D. K., & Zhang, H. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.144 · Cited by 72 · see citing works

Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder

Kovtun, A. S., Averina, O. V., Angelova, I. Y., Yunes, R. А., Zorkina, Y., Morozova, A. Y., Pavlichenko, A. V., Syunyakov, T., Karpenko, O., Kostyuk, G. P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092162 · Cited by 67 · see citing works

An overview of the neurobiology of suicidal behaviors as one meta-system

Sokolowski, M., Wasserman, J., & Wasserman, D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.101 · Cited by 50 · see citing works

Altered plasma levels of arginine metabolites in depression

Arısoy, Ö., Halaris, A. E., Feyza, A., Wild, E., & Piletz, J. E. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.10.004 · Cited by 42 · see citing works

Molecular characterization of depression trait and state

Shukla, R., Newton, D. F., Sumitomo, A., Zare, H., McCullumsmith, R. E., Lewis, D. A., Tomoda, T., & Sibille, E. L. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01347-z · Cited by 41 · see citing works

Suicídio de mulheres no Brasil: necessária discussão sob a perspectiva de gênero

Dantas, E. S. O., Meira, K. C., Bredemeier, J., & Amorim, K. P. C. (2023) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232023285.16212022 · Cited by 25 · see citing works

Sex differences in brain gene expression among suicide completers

Cabrera‐Mendoza, B., Fresno, C., Monroy‐Jaramillo, N., Fries, G. R., Walss‐Bass, C., Glahn, D. C., Ostrosky‐Wegman, P., Mendoza-Morales, R., García‐Dolores, F., Díaz‐Otañez, C. E., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.167 · Cited by 24 · see citing works

Metabolic Alterations Associated with γ-Hydroxybutyric Acid and the Potential of Metabolites as Biomarkers of Its Exposure

Jung, S., Kim, S., Seo, Y., & Lee, S. (2021) · Metabolites · doi:10.3390/metabo11020101 · Cited by 20 · see citing works

How to save a life: From neurobiological underpinnings to psychopharmacotherapies in the prevention of suicide

Gonda, X., Döme, P., Serafini, G., & Pompili, M. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108390 · Cited by 21 · see citing works

Polyamines: The possible missing link between mental disorders and epilepsy (Review)

Baroli, G., Sanchez, J., Agostinelli, E., Mariottini, P., & Cervelli, M. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4401 · Cited by 19 · see citing works

Metabolomic study of polyamines in rat urine following intraperitoneal injection of γ-hydroxybutyric acid

Lee, H., Seo, C., Kim, Y., Park, M., Choi, B., Ji, M., Lee, S., & Paik, M. (2019) · Metabolomics · doi:10.1007/s11306-019-1517-2 · Cited by 18 · see citing works

Understanding the Neuroepigenetic Constituents of Suicide Brain

Roy, B., & Dwivedi, Y. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2018.01.007 · Cited by 17 · see citing works

Noncoding RNAs in Depression

Lin, R., & Turecki, G. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_11 · Cited by 17 · see citing works

Suicidal behavior-advances in clinical and neurobiological research and improvement of prevention strategies

Sobanski, T., Peikert, G., Kastner, U. W., & Wagner, G. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i9.1115 · Cited by 16 · see citing works

Polyamines and suicide risk

Turecki, G. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.153 · Cited by 14 · see citing works

Unveiling the hidden players: noncoding RNAs orchestrating polyamine metabolism in disease

Rossi, M. N., Fiorucci, C., Mariottini, P., & Cervelli, M. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01235-3 · Cited by 12 · see citing works

A pilot case-control study on the association between N-acetyl derivatives in serum and first-episode schizophrenia

Huang, N., Cao, B., Brietzke, E. M., Park, C., Cha, D. S., Pan, Z., Zhu, J., Liu, Y., Xie, Q., Zeng, J., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.11.064 · Cited by 11 · see citing works

Brain Gene Expression-DNA Methylation Correlation in Suicide Completers: Preliminary Results

Cabrera‐Mendoza, B., Martínez‐Magaña, J. J., Mendoza, A. D. G., Monroy‐Jaramillo, N., Walss‐Bass, C., Fries, G. R., García‐Dolores, F., López‐Armenta, M., Flores, G., Vázquez‐Roque, R. A., et al. (2020) · Revista de investigaci�n Cl�nica · doi:10.24875/ric.19003250 · Cited by 10 · see citing works

Commensal Microbiota Regulation of Metabolic Networks During Olfactory Dysfunction in Mice

Wang, H., Liu, L., Rao, X., Chai, T., Zeng, B., Zhang, X., Yu, Y., Zhou, C., Pu, J., Zhou, W., et al. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s236541 · Cited by 7 · see citing works

Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy

Bernstein, H., Keilhoff, G., Laube, G., Dobrowolny, H., & Steiner, J. H. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i12.1177 · Cited by 7 · see citing works

Psychotropic drugs interaction with the lipid nanoparticle of COVID-19 mRNA therapeutics

Sfera, A., Hazan, S., Anton, J. J., Sfera, D. O., Andronescu, C. V., Sasannia, S., Rahman, L., & Kozlakidis, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.995481 · Cited by 6 · see citing works

Suicide among women in Brazil: a necessary discussion from a gender perspective

Dantas, E. S. O., Meira, K. C., Bredemeier, J., & Amorim, K. P. C. (2023) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232023285.16212022en · Cited by 5 · see citing works

Altered Arginine/Agmatine Pathway and Polyamines in Adolescents Diagnosed with Major Depressive Disorder

Yazıcı, K. U., Öztürk, Ş. K., Yazıcı, İ. P., & Üstündağ, B. (2024) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.24.1176 · Cited by 5 · see citing works

Structure and mechanism of human vesicular polyamine transporter

Guo, Y. C., Yang, G., Liu, H., Chai, J. L., Chen, J., Shanklin, J., Liu, Q., Liu, B., & Lu, M. (2025) · Nature Communications · doi:10.1038/s41467-025-59549-w · Cited by 5 · see citing works

miRNAs As Critical Epigenetic Players in Determining Neurobiological Correlates of Major Depressive Disorder

Roy, B., & Dwivedi, Y. (2017) · Springer eBooks · doi:10.1007/978-981-10-6580-4_4 · Cited by 2 · see citing works

Genetic predisposition of suicidal behavior: variants in GRIN2B, GABRG2, and ODC1 genes in attempted and completed suicide in two Balkan populations

Karanović, J., Beraković, D., Katrašnik, M., Arčan, I. Š., Pantović-Stefanović, M., Radenković, L., Garai, N., Ivković, M., Pavicevic, D. S., Zupanc, T., et al. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01895-9 · Cited by 1 · see citing works

Neurobiological basis of suicidal behavior in adolescents

Omelchenko, M. A., Klyushnik, T. P., Obodzinskaya, I. E., & Generalov, V. O. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20251251025 · Cited by 1 · see citing works

Polyamine stress response in schizophrenia: A translational framework beyond monoamine-centered models

Uzbay, T. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111894 · Cited by 1 · see citing works

Biological theories of suicidal behaviour

Turecki, G. (2021) · doi:10.1093/med/9780198834441.003.0022 · Cited by 1 · see citing works

Metabolomic Study of Polyamines in Rat Urine Following Intraperitoneal Injection of γ-Hydroxybutyric AcidPreprint

Lee, H., Seo, C., Kim, Y., Park, M., Choi, B., Ji, M., Lee, S., & Paik, M. (2018) · Preprints.org · doi:10.20944/preprints201808.0519.v1 · Cited by 1 · see citing works

Biological theories of suicidal behaviour

Fiori, L. M., & Turecki, G. (2021) · doi:10.1093/med/9780198834441.003.0022_update_001

Биомаркеры в суицидологии (обзор)

Давидовский, С. В. (2025) · Психиатрия психотерапия и клиническая психология · doi:10.34883/pi.2025.16.4.012

Neurobiological Basis of Suicidal Behavior in Adolescents

Omelchenko, M. A., Klyushnik, T. P., Obodzinskaya, I. E., & Generalov, V. O. (2026) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-026-01989-y

Neuroprotective effects of spermidine in stroke and other neurological disorders: mechanisms and translational challenges

Qi, L., Guo, P., Bizhanova, A., Qian, J., Hu, C., Chen, Y., Yong, V. W., & Xue, M. (2026) · Brain Hemorrhages · doi:10.1016/j.hest.2026.08.006

Involvement of the polyamine system in suicide

Fiori, L. (2010) · eScholarship@McGill (McGill) · doi:10.82308/4284

358. Stress Response and Polyamines in Depression and Suicide

Sequeira, P. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.375

Global gene expression profiling of the polyamine system in suicide completers

Fiori, L. M., Bureau, A., Labbe, A., Croteau, J., Noël, S., Mérette, C., & Turecki, G. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001574 · Cited by 50 · see citing works

Research on potential biomarker correlates for suicidal behavior: A review

Kim, S., & Lee, K.-U. (2017) · Asia-Pacific Psychiatry · doi:10.1111/appy.12291 · Cited by 8 · see citing works

The neurobiology of suicide

Shirakawa, O. (2007) · Institutional Repositories DataBase (IRDB)