Cited by 35Trypanosoma species research and implicationsMalaria Research and ControlParasites and Host Interactions

The central role of macrophages in trypanosomiasis-associated anemia: rationale for therapeutical approaches

Stijlemans, Benoit, Vankrunkelsven, Ann, Caljon, Guy, Bockstal, Viki, Guilliams, Martin, Bosschaerts, Tom, Beschin, Alain, Raes, Geert +2 more·2010·Endocrine, Metabolic & Immune Disorders - Drug Targets

Abstract

Bovine African trypanosomiasis causes severe economical problems on the African continent and one of the most prominent immunopathological parameters associated with this parasitic infection is anemia. In this report we review the current knowledge of the mechanisms underlying trypanosomiasis-associated anemia. In first instance, the central role of macrophages and particularly their activation state in determining the outcome of the disease (i.e. trypanosusceptibility versus trypanotolerance) will be discussed. In essence, while persistence of classically activated macrophages (M1) contributes to anemia development, switching towards alternatively activated macrophages (M2) alleviates pathology including anemia. Secondly, while parasite-derived glycolipids such as the glycosylphosphatidylinositol (GPI) induce M1, host-derived IL-10 blocks M1-mediated inflammation, promotes M2 development and prevents anemia development. In this context, strategies aimed at inducing the M1 to M2 switch, such as GPI-based treatment, adenoviral delivery of IL-10 and induction of IL-10 producing regulatory T cells will be discussed. Finally, the crucial role of iron-homeostasis in trypanosomiasis-associated anemia development will be documented to stress the analogy with anemia of chronic disease (ACD), hereby providing new insight that might contribute to the treatment of ACD.

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Registry

Crossref · 10.2174/187153010790827966

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  • Trypanotolerant animals switch from innate immune response to adaptive immune response with the induction of active macrophages (M2) following trypanosome infection.

    “In previous studies, trypanotolerant animals were reported to switch from innate immune response to adaptive immune response with the induction of active macrophages (M2) following trypanosome infection (Stijlemans et al., 2010; Bosschaerts et al., 2011).”

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Authors
Stijlemans, B., Vankrunkelsven, A., Caljon, G., Bockstal, V., Guilliams, M., Bosschaerts, T., Beschin, A., Raes, G., Magez, S., & Baetselier, P.
Affiliations
Vrije Universiteit Brussel (BE)
Corresponding author
Baetselier, Patrick
Venue
Endocrine, Metabolic & Immune Disorders - Drug Targets
Published
2010-03-01
Volume
10
Issue
1
Pages
71-82
ISSN
1871-5303 (ISSN-L)
OpenAlex
W2159423681
Cited by
35
References
114
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 2
FWCI
0.93
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Metabolic & Immune Disorders - Drug Targets (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords
macrophage activation, M1 macrophages, M2 macrophages, glycosylphosphatidylinositol, IL-10, regulatory T cells, iron homeostasis, anemia of chronic disease, trypanotolerance
MeSH terms
Anemia, Animals, Homeostasis, Humans, Iron, Macrophage Activation, Macrophages, Trypanosoma, Trypanosomiasis, African, Interleukin-10, Glycosylphosphatidylinositols, T-Lymphocytes, Regulatory

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