The DOI matches its Crossref record; 73 of the 76 references it cites were found in a registry or an index.
CNS Drug Delivery Systems: Novel Approaches
Abstract
The brain is a delicate organ, and nature has very efficiently protected it. The brain is shielded against potentially toxic substances by the presence of two barrier systems: the blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB). Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. Despite aggressive research, patients suffering from fatal and/or debilitating central nervous system (CNS) diseases, such as brain tumours, HIV encephalopathy, epilepsy, cerebrovascular diseases and neurodegenerative disorders, far outnumber those dying of all types of systemic cancers or heart diseases. The abysmally low number of potential therapeutics reaching commercial success is primarily due to the complexity of the CNS drug development. The clinical failure of many probable candidates is often, ascribable to poor delivery methods which do not pervade the unyielding BBB. It restricts the passive diffusion of many drugs into the brain and constitutes a significant obstacle in the pharmacological treatment of central nervous system (CNS) disorders. General methods that can enhance drug delivery to the brain are, therefore, of great pharmaceutical interest. Various strategies like non-invasive methods, including drug manipulation encompassing transformation into lipophilic analogues, prodrugs, chemical drug delivery, carrier-mediated drug delivery, receptor/vector mediated drug delivery and intranasal drug delivery, which exploits the olfactory and trigeminal neuronal pathways to deliver drugs to the brain, are widely used. On the other hand the invasive methods which primarily rely on disruption of the BBB integrity by osmotic or biochemical means, or direct intracranial drug delivery by intracerebroventricular, intracerebral or intrathecal administration after creating reversible openings in the head, are recognised. Extensive review pertaining specifically, to the patents relating to drug delivery across the CNS is currently available. However, many patents e.g. US63722506, US2002183683 etc., have been mentioned in a few articles. It is the objective of this article to expansively review drug delivery systems for CNS by discussing the recent patents available.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“One of the most common challenge is the difficulty in delivering agents such as drugs, nucleic acids, proteins, imaging agents and other macromolecules to the CNS across the peripheral barriers, namely blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), particularly the BBB (Pathan et al., 2009; Wong et al., 2012).”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Pathan et al., 2009
Citations
Cites
Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art
Müller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,836
Solid lipid nanoparticles Production, characterization and applications
Mehnert, W. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00105-3 · Cited by 3,158
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661
THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE
Endicott, J. A., & Ling, V. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.001033 · Cited by 2,071
Cordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750
Nano-engineering block copolymer aggregates for drug delivery
Allen, C., Maysinger, D., & Eisenberg, A. (1999) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/s0927-7765(99)00058-2 · Cited by 1,358
Polymeric micelles—A new generation of colloidal drug carriers
Jones, M.-C., & Leroux, J.-C. (1999) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00039-9 · Cited by 1,256
Amphiphilic block copolymers for drug delivery
Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10397 · Cited by 1,078
Nanoparticulate systems for brain delivery of drugs
Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 965
Levin, V. A. (1980) · Journal of Medicinal Chemistry · doi:10.1021/jm00180a022 · Cited by 817
Cited by
Sorted by citations
Items 101–193 of 193
Synthesis of Biocompatible Titanate Nanofibers for Effective Delivery of Neuroprotective Agents
Ozkızılcık, A., Williams, R., Tian, Z. R., Muresanu, D. F., Sharma, A., & Sharma, H. S. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7571-6_35 · Cited by 18
Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain
Clausi, M. G., Paez, P. M., Pasquini, L. A., & Pasquini, J. M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.010 · Cited by 18
Engineering Biomaterials to Influence Oligodendroglial Growth, Maturation, and Myelin Production
Russell, L. N., & Lampe, K. J. (2016) · Cells Tissues Organs · doi:10.1159/000446645 · Cited by 18
Designing drugs optimized for both blood–brain barrier permeation and intra-cerebral partition
Dichiara, M., Cosentino, G., Giordano, G., Pasquinucci, L., Marrazzo, A., Costanzo, G., & Amata, E. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2294118 · Cited by 17
Effects of n-hexanal on dopamine release in the striatum of living rats
Kako, H., Kobayashi, Y., & Yokogoshi, H. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.11.004 · Cited by 17
Minimally invasive probes for programmed microfluidic delivery of molecules in vivo
McCall, J. G., & Jeong, J. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.08.010 · Cited by 16
Novel Approaches for the Delivery of Biologics to the Central Nervous System
Karande, P., Trasatti, J. P., & Chandra, D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-416603-5.00004-3 · Cited by 18
Assadpour, S., Akhtari, J., & Shiran, M. R. (2022) · PubMed Central · doi:10.22088/cjim.13.1.90 · Cited by 16
Helmy, W. A., Ragab, T. I. M., Salama, B. M., Basha, M., Shamma, R. N., El‐Rahman, S. S. A., & Shawky, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.279 · Cited by 16
Fumigation in Ayurveda: Potential strategy for drug discovery and drug delivery
Vishnuprasad, C. N., Pradeep, N. S., Cho, Y. W., Gangadharan, G. G., & Han, S. S. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.07.028 · Cited by 16
Rodriguez, M., Soler, Y., Karuppan, M. K. M., Zhao, Y., Batrakova, E. V., & El‐Hage, N. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020223 · Cited by 15
Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors
Visentin, C., Musso, L., Broggini, L., Bonato, F., Russo, R., Moriconi, C., Bolognesi, M., Miranda, E., Dallavalle, S., Passarella, D., et al. (2020) · Life · doi:10.3390/life10070111 · Cited by 14
Pawar, G. N., Parayath, N. N., Sharma, A., Coito, C., Khorkova, O., Hsiao, J. H., Curry, W. T., Amiji, M. M., & Bleier, B. S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.660841 · Cited by 14
An optimistic approach to nanotechnology in Alzheimer's disease management: An overview
Tiwari, V., Tiwari, A., Sharma, A., Kumar, M., Kaushik, D. K., & Sagadevan, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104722 · Cited by 13
Dvořáková, M., Rollerová, E., Scsuková, S., Mlynarčíková, A. B., Laubertová, L., & Žitňanová, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7430435 · Cited by 12
Curcumin and Its Nanoformulations as Therapeutic for Alzheimer’s Disease
Kakkar, V., Kumari, P., Adlakha, S., & Kaur, I. P. (2019) · Springer eBooks · doi:10.1007/978-3-030-30930-5_14 · Cited by 12
Rusdipoetra, R. A., Suwito, H., Puspaningsih, N. N. T., & Haq, K. U. (2024) · RSC Advances · doi:10.1039/d3ra08346b · Cited by 11
Embelin and levodopa combination therapy for improved Parkinson’s disease treatment
Ramachandra, V. H., Sivanesan, S., Koppal, A., Anandakumar, S., Howell, M. D., Sukumar, E., & Vijayaraghavan, R. (2022) · Translational Neuroscience · doi:10.1515/tnsci-2022-0224 · Cited by 12
Growing Utilization of Radical Chemistry in the Synthesis of Pharmaceuticals
Gupta, A., & Laha, J. K. (2023) · The Chemical Record · doi:10.1002/tcr.202300207 · Cited by 13
Nanocarriers as cns drug delivery systems for enhanced neuroprotection
Ozkizilcik, A., Davidson, P., Turgut, H., Sharma, H. S., Sharma, A., & Tian, Z. R. (2017) · Drug and Gene Delivery to the Central Nervous System for Neuroprotection · doi:10.1007/978-3-319-57696-1_2 · Cited by 10
Neuropharmacologic Approaches to Restore the Brain’s Microenvironment
Li, W., Tong, H.-I., Gorantla, S., Poluektova, L. Y., Gendelman, H. E., & Lu, Y. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9686-5 · Cited by 10
Application of Chitosan-Based Formulations in Controlled Drug Delivery
Desbrières, J., Peptu, C. A., Ochiuz, L., Savin, C. L., Popa, M., & Vasiliu, S. (2019) · Sustainable agriculture reviews · doi:10.1007/978-3-030-16581-9_7 · Cited by 10
MicroRNA-155 in neurodegeneration
Liu, Q., & Siadat, S. D. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120506 · Cited by 9
Nanomedicine: A New Frontier in Alzheimer’s Disease Drug Targeting
Pathak, K., Ahmad, M. Z., Saikia, R., Pathak, M. P., Sahariah, J. J., Kalita, P., Das, A., Islam, M. A., Pramanik, P., Tayeng, D., et al. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249281331240325042642 · Cited by 11
Activation of B Cells by a Dendritic Cell-Targeted Oral Vaccine
Sahay, B., Owen, J. L., Yang, T., Zadeh, M., Lightfoot, Y. L., Ge, J., & Mohamadzadeh, M. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201014666131226120512 · Cited by 9
Bio-Targets and Drug Delivery Approaches
Maiti, S., & Sen, K. K. (2016) · CRC Press eBooks · doi:10.1201/9781315370118 · Cited by 9
Functionalized Nanoparticles: A Promising Approach for Effective Management of Alzheimer’s Disease
Bogadi, S., Bhaskaran, M., Ravichandran, V., Nesamony, J., Selvam, C., Kuppusamy, G., Prakash, G., Karri, V. V. S. R., Mallick, S., Farahim, F., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04917-2 · Cited by 10
Granot, D., & Shapiro, E. M. (2013) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24788 · Cited by 8
A soft neural interface with a tapered peristaltic micropump for wireless drug delivery
Lee, H., Song, S., Ha, J., Lee, Y., & Jang, K. (2025) · npj Flexible Electronics · doi:10.1038/s41528-025-00463-y · Cited by 7
Mercer-Smith, A. R., Buckley, A. A., Valdivia, A., Jiang, W., Thang, M., Bell, N., Kumar, R. J., Bomba, H. N., Woodell, A. S., Luo, J., et al. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10375-3 · Cited by 7
Role of nanotechnology in neurosurgery: A review of recent advances and their applications
Iqbal, J., Courville, E., Kazim, S. F., Kogan, M., Schmidt, M. H., & Bowers, C. A. (2024) · World Neurosurgery X · doi:10.1016/j.wnsx.2024.100298 · Cited by 7
Nanotechnology-Mediated Nose-to-Brain Drug Delivery for Neurodegenerative Disorders
Pardeshi, C. V., Belgamwar, V. S., & Surana, S. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-30930-5_6 · Cited by 7
Bahuguna, R., Rehman, F., Awasthi, R., Babu, K. R., Akhter, M. H., Begum, M. Y., Kumar, D., Gupta, S. M., Singh, S., & Singh, P. A. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107759 · Cited by 6
Domínguez-Monedero, A., Díaz, A. D. L. Á. Á., Merino, B. S., & Goñi‐de‐Cerio, F. (2014) · Revista de Neurología · doi:10.33588/rn.5805.2013314 · Cited by 6
Advances in Neurotherapeutic Delivery Technologies
Mr Pradeep, K. (2015) · OMICS International eBooks · doi:10.4172/978-1-63278-036-2-037 · Cited by 6
Central Nervous System Drug Delivery After Ischemic or Hemorrhagic Stroke
Hoang, N., & Nimjee, S. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813997-4.00024-4 · Cited by 7
Yang, J.-U., Kim, S., Lee, K. C., Lee, Y. J., Kim, J. Y., & Park, J. A. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.2c00284 · Cited by 6
The involvement of perivascular spaces or tissues in the facial intradermal brain-targeted delivery
Yang, W. P., Jin, B., Chen, Y., Cao, C., Zhu, J., Zhao, Y., Yu, X., & Li, F. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1587044 · Cited by 6
Nanoparticle-mediated delivery of AChE inhibitors for the treatment of Alzheimer’s disease
Namdeo, P., Mathew, J., & Garg, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85544-0.00004-6 · Cited by 5
Koppal, A., R, V. H., Sivanesan, S., Ethirajan, S., & Vijayaraghavan, R. (2023) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2023.00346 · Cited by 5
Nanotechnology: Social Acceptance, Cultural Impact and Privacy
Singh, P., Gupta, P., Verma, V., Yadav, N., & Pandey, N. K. (2024) · Advanced technologies and societal change · doi:10.1007/978-981-97-6184-5_2 · Cited by 5
Solid Lipid Nanoparticles: A Modern Approach for the Treatment of Neurodegenerative Diseases
D’souza, A. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-99602-8_9 · Cited by 6
Convection-enhanced Diffusion: A Novel Tactics to Crack the BBB
Dhanawat, M., Garima, Wilson, K., Gupta, S., Chalotra, R., & Gupta, N. (2024) · Current Drug Delivery · doi:10.2174/0115672018266501231207095127 · Cited by 4
Wang, S., Song, Z., Yuan, Y., Guo, G., & Kang, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-02396-8 · Cited by 4
Artificial intelligence: Ways and means for central nervous system (CNS) delivery
Patel, S., Patel, K., & Patel, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23841-3.00015-7 · Cited by 4
Bioformulative Concepts on Intracellular Organ Specific Bioavailability
Shanmukhan, N. K., Radhakrishnan, A., Maniarasan, V., Kuppusamy, G., & Gideon, S. (2018) · Therapeutic Delivery · doi:10.4155/tde-2018-0032 · Cited by 4
Formulation and Evaluation of Mucoadhesive In-situ Nasal Gel of Tramadol Hydrochloride
Vishwakarma, S., Gupta, N., Sharma, N., Rajput, D. S., & Shukla, A. (2023) · Research Journal of Pharmaceutical Dosage Forms and Technology · doi:10.52711/0975-4377.2023.00022 · Cited by 4
Antioxidants and Stroke: Success and Pitfalls
Roleira, F. M. F., da Silva, E. J. T., Garrido, J. M. P. J., & Borges, F. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9530-8_6 · Cited by 4
CNS Delivery of Drugs: Challenges and Chances
Zaki, N. M. (2012) · Journal of Bioequivalence & Bioavailability · doi:10.4172/jbb.10000e20 · Cited by 4
Blood-brain barrier and central nervous system drug delivery: Challenges and opportunities
Bhavsar, N., Saxena, B., & Shah, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90773-6.00005-1 · Cited by 3
Nanotherapeutics a promising approach for treatment of Parkinson’s disease
Bhalothia, C., & Nagda, G. (2022) · Materials Today Proceedings · doi:10.1016/j.matpr.2022.10.311 · Cited by 4
Nanoengineering and nanotechnology for diagnosis and treatment of CNS and neurological diseases
Kumar, P., Dwivedi, A., Plaimas, K., Sagar, K., & Chauhan, L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91182-5.00006-1 · Cited by 3
Design, Development and Formulation of Mucoadhesive In-situ Nasal Gel of Meperidine Hydrochloride
Moazzam, N., Gupta, N., Sharma, N., Rajput, D. S., & Shukla, A. (2023) · Research Journal of Pharmaceutical Dosage Forms and Technology · doi:10.52711/0975-4377.2023.00018 · Cited by 3
Nanomedicine Based Drug Targeting in Alzheimer’s Disease: High Impact of Small Carter
Ahmad, M. Z., Akhter, S., Rahman, Z., Ahmad, J., Ahmad, I., & Ahmad, F. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-803959-5.50016-7 · Cited by 3
Self-citationCNS Drug Delivery for Diseases Eradication: An Overview
Kalvala, A. K., Giri, P., Kaligatla, J., Khan, W., & Kumar, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-63633-7_10 · Cited by 3
Disease Influence on BBB Transport in Neurodegenerative Disorders
de Lange, E. C. M. (2013) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-9105-7_22 · Cited by 3
Prodrug strategies for brain delivery
Alaofi, A. L., & Siahaan, T. J. (2015) · doi:10.4155/fseb2013.14.17 · Cited by 3
Nanophytomedicine in Disease and Therapy
Upadhyay, S., Bhushan, R., & Rudrapal, M. (2022) · Wiley eBooks · doi:10.1002/9781119811794.ch9 · Cited by 3
Drug Delivery to the Brain: Targeting Technologies to Deliver Therapeutics to Brain Lesions
Pathak, N., Vimal, S. K., Hongyi, C., & Bhattacharyya, S. (2022) · Methods and principles in medicinal chemistry · doi:10.1002/9783527827855.ch15 · Cited by 3
Liposome-based targeted delivery of anticancer drugs for effective therapy of brain tumors
Shah, M. R., Imran, M. A., & Ullah, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816773-1.00003-1 · Cited by 2
Carrier Mediated Target Drug Delivery Systems: A Novel Approach - (An Overview)
Pandey, S., & Jamini, M. (2013) · Cited by 2
Formulation and Evaluation of Mucoadhesive in-Situ Nasal Gel of Tapentadol Hydrochloride
Gotmare, R. B., Kushwaha, R., & Sharma, N. (2021) · Research Journal of Pharmaceutical Dosage Forms and Technology · doi:10.52711/0975-4377.2021.00047 · Cited by 2
Liposomes in drug targeting to brain tumors
Dahiya, S., & Dahiya, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90773-6.00006-3 · Cited by 2
An Investigation of CYP2B in Rat Brain: Regulation and Role in Drug and Toxin Response
Khokhar, J. Y. (2012) · TSpace (University of Toronto) · Cited by 2
CNS drugs: Classification, characterization and binding properties toward bio-macromolecules
Rupreo, V., & Bhattacharyya, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95735-9.00027-9 · Cited by 1
Lipid-based Nanomedicine for Alzheimer's Disease: A Comprehensive Review of Recent Advances
Dhankhar, S., Garg, N., Sharma, H., Chauhan, S., & Saini, M. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/0122117385300234240522100826 · Cited by 2
Garima, Imtiyaz, K., Pooja, P., Pannu, P., Sharma, A., Raina, S., Kumar, S., Anwer, S. T., Rizvi, M. M. A., Sinha, S. K., et al. (2024) · Springer eBooks · doi:10.1007/978-981-97-3115-2_9 · Cited by 1
Current Perspectives of Nanotherapeutics for the Treatment of Alzheimer’s Disease
Mishra, S., Senthilkumar, D., & Yadav, V. K. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815256505124010010 · Cited by 1
Introduction to Nanoparticles in Neurology
Sivamaruthi, B. S., Kesika, P., Varaprasad, K., Sisubalan, N., & Chaiyasut, C. (2025) · Nanotechnology in the life sciences · doi:10.1007/978-3-031-80185-3_1 · Cited by 1
Nanotechnology-based devices in the treatment for Alzheimer’s disease
Chokkareddy, R., Thondavada, N., Kabane, B., & Redhi, G. G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817923-9.00009-2 · Cited by 1
Nanoparticles – a novel theranostic approach to treat alzheimer’s disease
Bashir, W. Q., & Shahzadi, S. (2022) · Journal of Applied Biotechnology & Bioengineering · doi:10.15406/jabb.2022.09.00312 · Cited by 1
Toxicity and Safety Evaluation of Lipid‐Based Nanoparticles for Brain Delivery
Patel, M., & Patel, P. R. (2021) · Wiley eBooks · doi:10.1002/9781119769897.ch10 · Cited by 1
The application of hydrogels to spinal cord injury
Ma, W., Li, F., Tao, S., & Mansour, L. (2016) · European Journal of BioMedical Research · doi:10.18088/ejbmr.2.1.2016.pp57-62
Drug–Targeting Strategies to CNS Disorders
(2016) · CRC Press eBooks · doi:10.1201/9781315370118-6
Blood–brain barrier pathophysiology in brain tumors
Caruso, G., Merlo, L., & Caffo, M. (2014) · Elsevier eBooks · doi:10.1533/9781908818744.17
Obulesu, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819882-7.00002-7
Novel Treatment Strategies for Brain metastases of Breast Cancer
Mohammad, A. S. (2017) · doi:10.33915/etd.6242
Polymeric nanocarriers for delivery of combination drugs
Narang, J. K., Dogra, A., Ali, J., Baboota, S., & Narang, R. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820779-6.00007-4
Nanomedicines for CNS therapy: Fundamental aspects
Desai, D., Prabhakar, B. R., & Shende, P. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822522-6.00004-7
Kulkarni, A. D., Shinde, M. N., Sonawane, G. A., Raotole, H., Pande, R., & Pardeshi, C. V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822522-6.00016-3
(2016) · CRC Press eBooks · doi:10.1201/9781315370118-5
Novelistic Approaches for Parkinson's Disease Mitigation: Challenges and Opportunities
Katual, M. K., Singh, G., & Kumar, H. (2019) · Research Journal of Life Sciences Bioinformatics Pharmaceutical and Chemical Sciences · doi:10.26479/2019.0503.05
Bălașa, R. (2015) · Romanian Journal of Neurology · doi:10.37897/rjn.2015.4.3
Polymers in cancer research and clinical oncology
Jadoun, S., Chauhan, N. P. S., & Chinnam, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823797-7.00021-6
IGF-II conjugated nanocarrier for brain targeting
Akotkar, L., Aswar, U. M., Shruti, S. D., Tushar, S., & Dhanshree, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23841-3.00004-2
SR-B1 receptor targeting in CNS disorders
Soni, R., Modi, A., Khairnar, A., & Shah, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23841-3.00010-8
On-demand electrically controlled perampanel delivery from a PEDOT/SNP composite for seizure control
Zhu, Y., Li, S., Wang, Z., Zhou, J., Zhou, J., & Wang, C. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb02647k
Song, S., Lee, H., Lee, Y. K., & Jang, K.-I. (2026) · Soft Mechatronics and Wearable Systems · doi:10.1117/12.3086876
Multifunctional metal oxide nanoparticles for diverse therapeutic approaches in glioblastoma
Ortiz-Islas, E., Montes, P., Silva‐Adaya, D., Rodríguez-Pérez, C. E., Manríquez-Ramírez, M. E., Cerna-Cortés, J. F., & Campos‐Peña, V. (2026) · Nanotechnology Reviews · doi:10.1515/ntrev-2025-0289
Halabian, N., Park, C., Omoto, L., Bocca, L. F., Ramos-Palacios, G., Wu, K., Hamani, C., Rabin, J. S., Abrahão, A., Davidson, B., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.07.008
Emerging nano-drug delivery strategies for management of neuropsychiatric disorders
Jaiswal, A. K., Zai, I., Hasan, N., & Sultana, Y. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108806
Metadata
- Authors
- Pathan, S., Iqbal, Z., Zaidi, S., Talegaonkar, S., Vohra, D., Jain, G., Azeem, A., Jain, N., Lalani, J., Khar, R., & Ahmad, F.
- Affiliations
- Jamia Hamdard (IN)
- Corresponding author
- Ahmad, Farhan
- Venue
- Recent Patents on Drug Delivery & Formulation
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-01-01
- Volume
- 3
- Issue
- 1
- Pages
- 71-89
- ISSN
- 1872-2113 (ISSN-L)
- OpenAlex
- W2163840515
- Cited by
- 193
- References
- 76
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 14 · 2023: 12 · 2022: 17 · 2021: 12 · 2020: 9 · 2019: 14 · 2018: 12 · 2017: 10 · 2016: 16 · 2015: 16 · 2014: 11 · 2013: 16 · 2012: 9
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Recent Patents on Drug Delivery & Formulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- brain drug delivery, blood-brain barrier, blood-CSF barrier, brain tumors, neurodegenerative diseases, epilepsy, HIV encephalopathy, cerebrovascular disease, prodrugs, intranasal drug delivery, olfactory pathway, receptor-mediated drug delivery, blood-brain barrier disruption, intrathecal drug delivery, intracerebroventricular administration, patents
- MeSH terms
- Biological Transport, Blood-Brain Barrier, Brain, Central Nervous System Diseases, Pharmaceutical Preparations, Humans, Patents as Topic, Technology, Pharmaceutical, United States, Drug Design, Drug Delivery Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
