Cited by 193Barrier Structure and Function StudiesAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 73 of the 76 references it cites were found in a registry or an index.

CNS Drug Delivery Systems: Novel Approaches

Pathan, Shadab, Iqbal, Zeenat, Zaidi, Syed, Talegaonkar, Sushma, Vohra, Divya, Jain, Gaurav, Azeem, Adnan, Jain, Nitin, Lalani, Jigar, Khar, Roop, Ahmad, Farhan·2009·Recent Patents on Drug Delivery & Formulation

DOI 10.2174/187221109787158355

Open this paper in CoChat — free account

Abstract

The brain is a delicate organ, and nature has very efficiently protected it. The brain is shielded against potentially toxic substances by the presence of two barrier systems: the blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB). Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. Despite aggressive research, patients suffering from fatal and/or debilitating central nervous system (CNS) diseases, such as brain tumours, HIV encephalopathy, epilepsy, cerebrovascular diseases and neurodegenerative disorders, far outnumber those dying of all types of systemic cancers or heart diseases. The abysmally low number of potential therapeutics reaching commercial success is primarily due to the complexity of the CNS drug development. The clinical failure of many probable candidates is often, ascribable to poor delivery methods which do not pervade the unyielding BBB. It restricts the passive diffusion of many drugs into the brain and constitutes a significant obstacle in the pharmacological treatment of central nervous system (CNS) disorders. General methods that can enhance drug delivery to the brain are, therefore, of great pharmaceutical interest. Various strategies like non-invasive methods, including drug manipulation encompassing transformation into lipophilic analogues, prodrugs, chemical drug delivery, carrier-mediated drug delivery, receptor/vector mediated drug delivery and intranasal drug delivery, which exploits the olfactory and trigeminal neuronal pathways to deliver drugs to the brain, are widely used. On the other hand the invasive methods which primarily rely on disruption of the BBB integrity by osmotic or biochemical means, or direct intracranial drug delivery by intracerebroventricular, intracerebral or intrathecal administration after creating reversible openings in the head, are recognised. Extensive review pertaining specifically, to the patents relating to drug delivery across the CNS is currently available. However, many patents e.g. US63722506, US2002183683 etc., have been mentioned in a few articles. It is the objective of this article to expansively review drug delivery systems for CNS by discussing the recent patents available.

Integrity signals

Registry

Crossref · 10.2174/187221109787158355

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art
MÃ¼ller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,836
Solid lipid nanoparticles Production, characterization and applications
Mehnert, W. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00105-3 · Cited by 3,158
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661
THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE
Endicott, J. A., & Ling, V. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.001033 · Cited by 2,071
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.
Cordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750
Nano-engineering block copolymer aggregates for drug delivery
Allen, C., Maysinger, D., & Eisenberg, A. (1999) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/s0927-7765(99)00058-2 · Cited by 1,358
Polymeric micelles—A new generation of colloidal drug carriers
Jones, M.-C., & Leroux, J.-C. (1999) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00039-9 · Cited by 1,256
Amphiphilic block copolymers for drug delivery
Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10397 · Cited by 1,078
Nanoparticulate systems for brain delivery of drugs
Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 965
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
Levin, V. A. (1980) · Journal of Medicinal Chemistry · doi:10.1021/jm00180a022 · Cited by 817

Show all 76 references

Sorted by citations

Modern methods for delivery of drugs across the blood–brain barrier
Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,038
Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
Booth, R., & Kim, H. (2012) · Lab on a Chip · doi:10.1039/c2lc40094d · Cited by 746
Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting
Pardeshi, C. V., & Belgamwar, V. S. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.790887 · Cited by 482
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease
Fonseca‐Santos, B., Chorilli, M., & Gremião, M. P. D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s87148 · Cited by 320
Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs
Naqvi, S., Panghal, A., & Flora, S. J. S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00494 · Cited by 305
“…difficulty in delivering agents such as drugs, nucleic acids, proteins, imaging agents and other macromolecules to the CNS across the peripheral barriers, namely blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), particularly the BBB (Pathan et al., 2009; Wong et al., 2012).”
Background
Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles
Kanazawa, T., Akiyama, F., Kakizaki, S., Takashima, Y., & Seta, Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.036 · Cited by 242
Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics
Akhtar, A., Andleeb, A., Waris, T. S., Bazzar, M., Moradi, A., Awan, N. R., & Yar, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.021 · Cited by 245
Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?
Sanchez‐Covarrubias, L., Slosky, L. M., Thompson, B. J., Davis, T. P., & Ronaldson, P. T. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990463 · Cited by 244
Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease
Karthivashan, G., Ganesan, P., Park, S., Kim, J.-S., & Choi, D. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1428243 · Cited by 229
In Vitro Models of the Blood–Brain Barrier for the Study of Drug Delivery to the Brain
Wilhelm, I., & Krizbai, I. A. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500046f · Cited by 221
Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise
Meeran, M. F. N., Goyal, S. N., Suchal, K., Sharma, C., Patil, C. R., & Ojha, S. K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00892 · Cited by 201
Intranasal administration of oxytocin: behavioral and clinical effects, a review
Veening, J. G., & Olivier, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.012 · Cited by 169
Cell-Penetrating Peptide-Mediated Therapeutic Molecule Delivery into the Central Nervous System
Zou, L., Ma, J.-L., Wang, T., Yang, T., & Liu, C.-B. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311020006 · Cited by 165
Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration
Cohen-Pfeffer, J. L., Gururangan, S., Lester, T. L., Lim, D. A., Shaywitz, A. J., Westphal, M., & Slavc, I. (2016) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2016.10.022 · Cited by 165
Polymer scaffolds facilitate spinal cord injury repair
Zhang, Q., Shi, B., Ding, J., Yan, L., Thawani, J. P., Fu, C., & Chen, X. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.01.056 · Cited by 160
Low molecular weight protamine-functionalized nanoparticles for drug delivery to the brain after intranasal administration
Xia, H., Gao, X., Gu, G., Liu, Z., Zeng, N., Hu, Q., Song, Q., Yao, L., Pang, Z., Jiang, X., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.004 · Cited by 152
Blood-CNS Barrier Impairment in ALS patients versus an animal model
Garbuzova-Davis, S. N., & Sanberg, P. R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00021 · Cited by 152
Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke
Wang, Y., Cooke, M. J., Sachewsky, N., Morshead, C. M., & Shoichet, M. S. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.07.032 · Cited by 145
Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics
Shakeri, S., Ashrafizadeh, M., Zarrabi, A., Roghanian, R., Afshar, E. G., Pardakhty, A., Mohammadinejad, R., Kumar, A., & Thakur, V. K. (2020) · Biomedicines · doi:10.3390/biomedicines8010013 · Cited by 136
NanoART, NeuroAIDS and CNS Drug Delivery
Nowacek, A. S., & Gendelman, H. E. (2009) · Nanomedicine · doi:10.2217/nnm.09.38 · Cited by 131
Nanomaterials for the treatment and diagnosis of Alzheimer's disease: An overview
Bilal, M., Barani, M., Sabir, F., Rahdar, A., & Kyzas, G. Z. (2020) · NanoImpact · doi:10.1016/j.impact.2020.100251 · Cited by 131
Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders
Alajangi, H. K., Kaur, M., Sharma, A., Rana, S., Thakur, S., Chatterjee, M., Singla, N., Jaiswal, P. K., Singh, G., & Barnwal, R. P. (2022) · Molecular Brain · doi:10.1186/s13041-022-00937-4 · Cited by 137
Neurotheranostics as Personalized Medicines
Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J., Gorantla, S., Bronich, T. K., Edagwa, B., & Gendelman, H. E. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.011 · Cited by 124
NanoART Synthesis, Characterization, Uptake, Release and Toxicology for Human Monocyte–Macrophage Drug Delivery
Nowacek, A. S., Miller, R. L., McMillan, J., Kanmogne, G. D., Kanmogne, M., Mosley, R. L., Ma, Z., Graham, S., Chaubal, M. V., Werling, J. O., et al. (2009) · Nanomedicine · doi:10.2217/nnm.09.71 · Cited by 124
Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans
Ruigrok, M. J. R., & de Lange, E. C. M. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9724-x · Cited by 126
Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer’s Disease-Like Condition in a Rat Model
Bhuvanendran, S., Kumari, Y., Othman, I., & Shaikh, M. F. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00665 · Cited by 120
Liposomes for brain delivery
Lai, F., Fadda, A. M., & Sinico, C. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.766714 · Cited by 119
Biocompatibility of poly(ethylene glycol)‐based hydrogels in the brain: An analysis of the glial response across space and time
Bjugstad, K. B., Lampe, K. J., Kern, D. S., & Mahoney, M. J. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32809 · Cited by 122
Novel Central Nervous System Drug Delivery Systems
Stockwell, J., Abdi, N., Lu, X., Maheshwari, O., & Taghibiglou, C. (2013) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12268 · Cited by 114
Nanotechnology-mediated nose to brain drug delivery for Parkinson's disease: a mini review
Kulkarni, A. D., Vanjari, Y. H., Sancheti, K. H., Belgamwar, V. S., Surana, S. J., & Pardeshi, C. V. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1020809 · Cited by 117
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections
Schiffer, J. T., Aubert, M., Weber, N. D., Mintzer, E., Stone, D., & Jerome, K. R. (2012) · Journal of Virology · doi:10.1128/jvi.00052-12 · Cited by 111
Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications and enhanced translational potential
Agrahari, V., Burnouf, P., Burnouf, T., & Agrahari, V. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.02.008 · Cited by 115
The blood-brain barrier and nasal drug delivery to the central nervous system
Miyake, M. M., & Bleier, B. S. (2015) · American Journal of Rhinology & Allergy · doi:10.2500/ajra.2015.29.4149 · Cited by 106
Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective
Soni, S., Ruhela, R. K., & Medhi, B. (2016) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2016.044 · Cited by 103
PEGylated poly(2-(dimethylamino) ethyl methacrylate)/DNA polyplex micelles decorated with phage-displayed TGN peptide for brain-targeted gene delivery
Qian, Y. J., Zha, Y., Feng, B. C., Pang, Z., Zhang, B., Sun, X., Ren, J., Zhang, C., Shao, X., Zhang, Q., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.11.050 · Cited by 98
The Role of Cell-Penetrating Peptide and Transferrin on Enhanced Delivery of Drug to Brain
Sharma, G., Lakkadwala, S., Modgil, A., & Singh, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060806 · Cited by 95
Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies
Edagwa, B., Zhou, T., McMillan, J., Liu, X. M., & Gendelman, H. E. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140826114135 · Cited by 87
Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy
Martins, C., Araújo, F., Gomes, M. J., Fernandes, C., Nunes, R., Li, W., Santos, H. A., Borges, F., & Sarmento, B. F. C. C. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.01.014 · Cited by 85
Nanomedicine: A Promising Way to Manage Alzheimer’s Disease
Khan, N. H., Mir, M., Ngowi, E. E., Zafar, U., Khakwani, M. M. A. K., Khattak, S., Zhai, Y., Jiang, E., Zheng, M., Duan, S., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.630055 · Cited by 84
Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data
Gaohua, L., Neuhoff, S., Johnson, T. N., Rostami‐Hodjegan, A., & Jamei, M. (2016) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2016.03.005 · Cited by 82
Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination
Silvestroff, L., Bartucci, S. L., Pasquini, J. M., & Franco, P. G. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.02.018 · Cited by 77
Nano-enabled delivery systems across the blood–brain barrier
Hwang, S. R., & Kim, K. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0272-6 · Cited by 74
The Nasal Route as a Potential Pathway for Delivery of Erythropoietin in the Treatment of Acute Ischemic Stroke in Humans
García-Rodríguez, J. C., & Testé, I. S. (2009) · The Scientific World JOURNAL · doi:10.1100/tsw.2009.103 · Cited by 65
Advancements in drug delivery methods for the treatment of brain disease
Partridge, B. R., Eardley, A., Morales, B. E., Campelo, S. N., Lorenzo, M. F., Mehta, J. N., Kani, Y., Mora, J. K. G., Campbell, E.-O. Y., Arena, C. B., et al. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.1039745 · Cited by 67
Plant Derived Phytocompound, Embelin in CNS Disorders: A Systematic Review
Kundap, U. P., Bhuvanendran, S., Kumari, Y., Othman, I., & Shaikh, M. F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00076 · Cited by 62
Self-assembled amphiphilic core-shell nanocarriers in line with the modern strategies for brain delivery
Elezaby, R. S., Gad, H. A., Metwally, A. A., Geneidi, A. S., & Awad, G. A. S. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.06.019 · Cited by 56
Advances in designing of polymeric micelles for biomedical application in brain related diseases
Kaur, J., Gulati, M., Kapoor, B., Jha, N. K., Gupta, P. K., Gupta, G., Chellappan, D. K., Devkota, H. P., Prasher, P., Ansari, M. S., et al. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109960 · Cited by 55
Brain Uptake of Neurotherapeutics after Intranasal versus Intraperitoneal Delivery in Mice.
Chauhan, M., & Chauhan, N. B. (2015) · PubMed · Cited by 55
Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles
Kanazawa, T. (2015) · Medical Devices Evidence and Research · doi:10.2147/mder.s70856 · Cited by 54
Supramolecular devices to improve the treatment of brain diseases
Paolino, D., Cosco, D., Molinaro, R., Celia, C., & Fresta, M. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.02.006 · Cited by 53
Strategies to optimize the brain availability of central nervous system drug candidates
Wager, T. T., Villalobos, A., Verhoest, P. R., Hou, X., & Shaffer, C. L. (2011) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.564158 · Cited by 53
Lipid-Based Nanocarriers via Nose-to-Brain Pathway for Central Nervous System Disorders
Nguyen, T. T., Nguyen, T. T. D., An, T. N. M., & Giau, V. V. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03488-7 · Cited by 53
Comparative manufacture and cell-based delivery of antiretroviral nanoformulations
Gendelman, H. E., Balkundi, Nowacek, Veerhubhotla, Chen, Martinez-Skinner, Roy, U. B., Mosley, Kanmogne, Kabanov, A. V., et al. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s27830 · Cited by 51
The application of nanotechnology in treatment of Alzheimer’s disease
Cao, Y., & Zhang, R. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1042986 · Cited by 54
Nose-to-brain drug delivery: Challenges and progress towards brain targeting in the treatment of neurological disorders
Raghav, M., Gupta, V., Awasthi, R., Singh, A. K., & Kulkarni, G. T. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104756 · Cited by 53
Preparation, Optimization, and Evaluation of Methoxy Poly(ethylene glycol)-co-Poly(ε-caprolactone) Nanoparticles Loaded by Rivastigmine for Brain Delivery
Mohamadpour, H., Azadi, A., Rostamizadeh, K., Andalib, S., Zanjani, M. R. S., & Hamidi, M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00691 · Cited by 48
Development of poly(butylene succinate) microspheres for delivery of levodopa in the treatment of Parkinson's disease
Mohanraj, K., Sethuraman, S., & Krishnan, U. M. (2013) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.32888 · Cited by 47
Development of Engineered Nanoparticles Expediting Diagnostic and Therapeutic Applications Across Blood–Brain Barrier
Sardoiwala, M. N., Kaundal, B., & Choudhury, S. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813351-4.00038-9 · Cited by 49
Direct and enhanced delivery of nanoliposomes of anti schizophrenic agent to the brain through nasal route
Upadhyay, P., Trivedi, J., Pundarikakshudu, K., & Sheth, N. R. (2016) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2016.07.003 · Cited by 45
Central nervous system diseases and the role of the blood-brain barrier in their treatment
Domínguez, A., Alvarez, A. A., Hilario, E., Suárez-Merino, B., & Goñi‐de‐Cerio, F. (2013) · Neuroscience Discovery · doi:10.7243/2052-6946-1-3 · Cited by 45
Molecular Insights into Therapeutic Potentials of Hybrid Compounds Targeting Alzheimer’s Disease
Jana, A., Bhattacharjee, A., Das, S. S., Srivastava, A., Choudhury, A., Bhattacharjee, R., De, S., Perveen, A., Iqbal, D., Gupta, P. K., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02779-6 · Cited by 46
Design, synthesis, structural characterization and in vitro evaluation of new 1,4-disubstituted-1,2,3-triazole derivatives against glioblastoma cells
da Silva, V. D., de Faria, B. M., COLOMBO, E. H. F., Ascari, L. M., de Freitas, G. P. A., Flôres, L. S., Cordeiro, Y., Romão, L. F., & Buarque, C. D. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.10.003 · Cited by 46
Treatment with Nasal Neuro-EPO Improves the Neurological, Cognitive, and Histological State in a Gerbil Model of Focal Ischemia
Cruz, Y. R., Mengana, T. Y., Cernada, A. M., Martinez, N. S., González‐Quevedo, A., Testé, I. S., & Rodríguez, J. C. G. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.215 · Cited by 42
Delayed adverse effects of neonatal exposure to polymeric nanoparticle poly(ethylene glycol)-block-polylactide methyl ether on hypothalamic–pituitary–ovarian axis development and function in Wistar rats
Rollerová, E., Jur̀čovičová, J., Mlynarčíková, A. B., Sadlonová, I., Bilaničová, D., Wsólová, L., Kiss, A., Kovrižnych, J. A., Kronek, J., ČIAMPOR, F. J., et al. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.07.072 · Cited by 41
A strategy for bypassing the blood-brain barrier: Facial intradermal brain-targeted delivery via the trigeminal nerve
Yu, X., Yang, J., Jin, B., Xu, H., Zhang, H., Xiao, J., Lu, C., Zhao, Y., & Yang, W. P. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.05.001 · Cited by 39
Transependymal Cerebrospinal Fluid Flow: Opportunity for Drug Delivery?
Casaca-Carreira, J., Temel, Y., Hescham, S., & Jahanshahi, A. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0501-y · Cited by 39
Nose to brain delivery of antiretroviral drugs in the treatment of neuroAIDS
Sarma, A., & Das, M. K. (2020) · Molecular Biomedicine · doi:10.1186/s43556-020-00019-8 · Cited by 39
A Synopsis of Nano-Technological Approaches Toward Anti-Epilepsy Therapy: Present and Future Research Implications
Jabir, N. R., Tabrez, S. S. M., Firoz, C. K., Zaidi, S. K., Baeesa, S. S., Gan, S. H., Shakil, S., & Kamal, M. A. (2015) · Current Drug Metabolism · doi:10.2174/1389200215666141125142605 · Cited by 38
Self-citation
Formulation strategies for nose-to-brain delivery of therapeutic molecules
Pandey, V., Gadeval, A., Asati, S., Jain, P., Jain, N., Roy, R. K., Tekade, M., Soni, V., & Tekade, R. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814487-9.00007-7 · Cited by 36
Self-citation
Insights into the novel three ‘D's of epilepsy treatment: drugs, delivery systems and devices
Pathan, S. A., Jain, G. K., Akhter, S., Vohora, D., Ahmad, F. J., & Khar, R. K. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.06.014 · Cited by 34
Self-citation
Blood-brain barrier and neuro-AIDS.
Yl, Z., Yb, O., Lg, L., & Dx, C. (2015) · PubMed · Cited by 34
Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology
Komane, P. P., Choonara, Y. E., du Toit, L. C., Kumar, P., Kondiah, P. P. D., Modi, G., & Pillay, V. (2016) · Journal of Nanomaterials · doi:10.1155/2016/9417874 · Cited by 33
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library
Larbanoix, L., Burtéa, C., Ansciaux, E., Laurent, S., Mahieu, I., Elst, L. V., & Müller, R. N. (2011) · Peptides · doi:10.1016/j.peptides.2011.04.026 · Cited by 34
Peptidyl α-Ketoamides with Nucleobases, Methylpiperazine, and Dimethylaminoalkyl Substituents as Calpain Inhibitors
Ovat, A., Li, Z. Z., Hampton, C. Y., Asress, S. A., Fernández, F. M., Glass, J. D., & Powers, J. C. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm901221v · Cited by 32
Shear Containment of BDNF within Molecular Hydrogels Promotes Human Stem Cell Engraftment and Postinfarction Remodeling in Stroke
Nisbet, D. R., Wang, T., Bruggeman, K. F., Niclis, J. C., Somaa, F. A., Penna, V., Hunt, C. J., Wang, Y., Kauhausen, J. A., Williams, R. J., et al. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800113 · Cited by 32
Intermedin in Paraventricular Nucleus Attenuates Sympathetic Activity and Blood Pressure via Nitric Oxide in Hypertensive Rats
Zhou, Y., Sun, H., Chen, D., Liu, T., Han, Y., Wang, J., Tang, C., Kang, Y., & Zhu, G. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01681 · Cited by 32
Targeted delivery of large fusion protein into hippocampal neurons by systemic administration
Xiang, L., Zhou, R., Fu, A., Xu, X., Huang, Y., & Hu, C. (2010) · Journal of drug targeting · doi:10.3109/1061186x.2010.523788 · Cited by 32
Inhibitory effects and actions of pentacyclic triterpenes upon glycation
Yin, M. (2015) · Biomedicine · doi:10.7603/s40681-015-0013-x · Cited by 30
Anti-glycative potential of triterpenes: A mini-review
Yin, M. (2012) · Biomedicine · doi:10.1016/j.biomed.2011.12.001 · Cited by 29
Embelin, a Potent Molecule for Alzheimer's Disease: A Proof of Concept From Blood-Brain Barrier Permeability, Acetylcholinesterase Inhibition and Molecular Docking Studies
Bhuvanendran, S., Hanapi, N. A., Ahemad, N., Othman, I., Yusof, S. R., & Shaikh, M. F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00495 · Cited by 29
Potential applications of nanomedicine for treating Parkinson's disease
Shankar, J., Geetha, K. M., & Wilson, B. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102793 · Cited by 29
Direct hippocampal injection of pseudo lentivirus-delivered nerve growth factor gene rescues the damaged cognitive function after traumatic brain injury in the rat
Lin, Y., Wan, J., Gao, G., Pan, Y., Ding, S., Fan, Y.-L., Wang, Y., & Jiang, J. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.010 · Cited by 28
Nano-ART and NeuroAIDS
Das, M. K., Sarma, A., & Chakraborty, T. (2016) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0293-z · Cited by 28
Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: screening based on pharmacological and physiological properties
Pandya, J. D., Musyaju, S., Modi, H. R., Okada-Rising, S. L., Bailey, Z. S., Scultetus, A. H., & Shear, D. A. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04908-2 · Cited by 33
Novel Treatment Strategies for Brain Tumors and Metastases
El-Habashy, S. E., Nazief, A. M., Adkins, C. E., Wen, M. M., El-Kamel, A. H., Hamdan, A. M., Hanafy, A. S., Terrell-Hall, T. B., Mohammad, A. S., Lockman, P. R., et al. (2014) · Pharmaceutical Patent Analyst · doi:10.4155/ppa.14.19 · Cited by 27
Embelin Protects Against Acute Pentylenetetrazole-Induced Seizures and Positively Modulates Cognitive Function in Adult Zebrafish
Kundap, U. P., Choo, B. K. M., Kumari, Y., Ahemad, N., Othman, I., & Shaikh, M. F. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01249 · Cited by 25
L- MYC Expression Maintains Self-Renewal and Prolongs Multipotency of Primary Human Neural Stem Cells
Li, Z., Oganesyan, D., Mooney, R., Rong, X., Christensen, M. J., Shahmanyan, D., Perrigue, P. M., Benetatos, J., Tsaturyan, L., Aramburo, S., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.07.013 · Cited by 25
Direct CNS delivery of proteins using thermosensitive liposome-in-gel carrier by heterotopic mucosal engrafting
Pawar, G. N., Parayath, N. N., Nocera, A. L., Bleier, B. S., & Amiji, M. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208122 · Cited by 25
Fabrication and statistical optimization of surface engineered PLGA nanoparticles for naso-brain delivery of ropinirole hydrochloride:in-vitro–ex-vivostudies
Patil, G. B., & Surana, S. J. (2013) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2013.798880 · Cited by 25
Nanoparticles combined with growth factors: recent progress and applications
Chu, C., Deng, J., Liu, L., Cao, Y., Wei, X., Li, J., & Man, Y. (2016) · RSC Advances · doi:10.1039/c6ra13636b · Cited by 24
Formulation of Intranasal Mucoadhesive Thermotriggered In Situ Gel Containing Mirtazapine as an Antidepressant Drug
Ghazwani, M., Vasudevan, R., Kandasamy, G., Naredla, M., Devanandan, P., Puvvada, R. C., Veeramani, V. P., Paulsamy, P., Venkatesan, K., Chidmabaram, K., et al. (2023) · Gels · doi:10.3390/gels9060457 · Cited by 23
NIOSOMES AS AN EMERGING FORMULATION TOOL FOR DRUG DELIVERY-A REVIEW
S., S. T., Mothilal, M., & Jaganathan, M. K. (2019) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2019v11i2.30534 · Cited by 21
Nanotheragnostic Applications for Ischemic and Hemorrhagic Strokes: Improved Delivery for a Better Prognosis
Mouhieddine, T. H., Itani, M. M., Nokkari, A., Ren, C., Daoud, G., Zeidan, A., Mondello, S., & Kobeissy, F. H. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0505-1 · Cited by 21
Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer’s Disease
Vishwas, S., Bashir, B., Birla, D., Khandale, N. B., Chaitanya, M., Chellappan, D. K., Gupta, G., Negi, P., Dua, K., & Singh, S. K. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266296001240327090111 · Cited by 22
Development of Lipid Based Nanoparticulate Drug Delivery Systems and Drug Carrier Complexes for Delivery to Brain
Salunkhe, S. S., Bhatia, N. M., Kawade, V., & Bhatia, M. S. (2015) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2015.50521 · Cited by 24
Central nervous system circuits modified in heart failure: pathophysiology and therapeutic implications
Sousa‐Pinto, B., Ferreira‐Pinto, M. J., Santos, M., & Leite-Moreira, A. F. (2014) · Heart Failure Reviews · doi:10.1007/s10741-014-9427-x · Cited by 19
Local strategies and delivery systems for the treatment of malignant gliomas
Yu, F. G., Asghar, S., Zhang, M., Zhang, J., Ping, Q., & Xiao, Y. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1509982 · Cited by 20
Therapeutic and Diagnostic Applications of Nanocomposites in the Treatment Alzheimer’s Disease Studies
(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac121.940960 · Cited by 21
Advancements in Hydrogel Application for Ischemic Stroke Therapy
Bai, Y., Han, B., Zhang, Y., Zhang, Y., Cai, Y., Shen, L., & Jia, Y. (2022) · Gels · doi:10.3390/gels8120777 · Cited by 19
Brain Tumors: Development, Drug Resistance, and Sensitization – An Epigenetic Approach
Sarkar, S., Deyoung, T., Ressler, H., & Chandler, W. (2023) · Epigenetics · doi:10.1080/15592294.2023.2237761 · Cited by 18

Authors: Pathan, S., Iqbal, Z., Zaidi, S., Talegaonkar, S., Vohra, D., Jain, G., Azeem, A., Jain, N., Lalani, J., Khar, R., & Ahmad, F.
Affiliations: Jamia Hamdard (IN)
Corresponding author: Ahmad, Farhan
ORCID: Iqbal, Zeenat
Zaidi, Syed
Jain, Gaurav
Jain, Nitin
Ahmad, Farhan
Venue: Recent Patents on Drug Delivery & Formulation
Publisher: Bentham Science Publishers Ltd.
Published: 2009-01-01
Volume: 3
Issue: 1
Pages: 71-89
ISSN: 1872-2113 (ISSN-L)
DOI: 10.2174/187221109787158355
OpenAlex: W2163840515
Cited by: 193
References: 76
Citations by year: 2026: 4 · 2025: 6 · 2024: 14 · 2023: 12 · 2022: 17 · 2021: 12 · 2020: 9 · 2019: 14 · 2018: 12 · 2017: 10 · 2016: 16 · 2015: 16 · 2014: 11 · 2013: 16 · 2012: 9
FWCI: 5.31
Type: journal article
Language: en
Open access: closed
Locations: Recent Patents on Drug Delivery & Formulation (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: brain drug delivery, blood-brain barrier, blood-CSF barrier, brain tumors, neurodegenerative diseases, epilepsy, HIV encephalopathy, cerebrovascular disease, prodrugs, intranasal drug delivery, olfactory pathway, receptor-mediated drug delivery, blood-brain barrier disruption, intrathecal drug delivery, intracerebroventricular administration, patents
MeSH terms: Biological Transport, Blood-Brain Barrier, Brain, Central Nervous System Diseases, Pharmaceutical Preparations, Humans, Patents as Topic, Technology, Pharmaceutical, United States, Drug Design, Drug Delivery Systems

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

CNS Drug Delivery Systems: Novel Approaches

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks