The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Scaffold Stiffness Influences Cell Behavior: Opportunities for Skeletal Tissue Engineering
Open accessAbstract
Skeletal defects resulting from trauma, tumors, or abnormal development frequently require surgical treatment to restore normal tissue function. To overcome the limitations associated with conventional surgical treatments, several tissue engineering approaches have been developed. In particular, the use of scaffolds enriched with stem cells appears to be a very promising strategy. A crucial issue in this approach is how to control stem cell behavior. In this respect, the effects of growth factors, scaffold surface characteristics, and external ‘active’ loading conditions on stem cell behavior have been investigated. Recently, it has become clear that the stiffness of a scaffold is a highly potent regulator of stem cell differentiation. In addition, the stiffness of a scaffold affects cell migration, which is important for the infiltration of host tissue cells. This review summarizes current knowledge on the role of the scaffold stiffness in the regulation of cell behavior. Furthermore, we discuss how this knowledge can be incorporated in scaffold design which may provide new opportunities in the context of orthopedic tissue engineering.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Cell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289
Designing materials for biology and medicine
Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198
Taking Cell-Matrix Adhesions to the Third Dimension
Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325
Myotubes differentiate optimally on substrates with tissue-like stiffness
Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405004 · Cited by 1,743
Repair of bone defects using synthetic mimetics of collagenous extracellular matrices
Lutolf, M. P., Weber, F. E., Schmoekel, H. G., Schense, J. C., Kohler, T., Müller, R., & Hubbell, J. A. (2003) · Nature Biotechnology · doi:10.1038/nbt818 · Cited by 850
Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties
Ghosh, K., Pan, Z., Guan, E., Ge, S., Liu, Y., Nakamura, T., Ren, X.-D., Rafailovich, M., & Clark, R. A. F. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.038 · Cited by 386
Cited by
Biomaterials & scaffolds for tissue engineering
O'Brien, F. J. (2011) · Materials Today · doi:10.1016/s1369-7021(11)70058-x · Cited by 3,437
Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering
Chen, C., Bai, X., Ding, Y., & Lee, I.-S. (2019) · Biomaterials Research · doi:10.1186/s40824-019-0176-8 · Cited by 444
Metwally, S., & Stachewicz, U. (2019) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.109883 · Cited by 382
Key players in the immune response to biomaterial scaffolds for regenerative medicine
Chung, L., Maestas, D. R., Housseau, F., & Elisseeff, J. H. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.006 · Cited by 328
Zhang, J.-S., Wang, Z.-B., Lai, Z.-Z., Yang, J.-W., Song, W.-J., Wei, Y.-B., Mei, J., & Wang, J.-G. (2023) · Hepatobiliary & Pancreatic Diseases International · doi:10.1016/j.hbpd.2022.10.007 · Cited by 11
Metadata
- Authors
- Breuls, R. G. M., Jiya, T. U., & Smit, T. H.
- Venue
- The Open Orthopaedics Journal
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2008-05-29
- Volume
- 2
- Issue
- 1
- Pages
- 103-109
- ISSN
- 1874-3250 (ISSN-L)
- OpenAlex
- W2111017388
- Cited by
- 224
- References
- 10
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Scaffold Stiffness Influences Cell Behavior: Opportunities for Skeletal Tissue Engineering. https://app.cochat.ai/papers/10.2174/1874325000802010103
- The paper
- Breuls, R. G. M., Jiya, T. U., & Smit, T. H. (2008). Scaffold Stiffness Influences Cell Behavior: Opportunities for Skeletal Tissue Engineering. The Open Orthopaedics Journal. https://doi.org/10.2174/1874325000802010103
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
