The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Vitamin E and All-Cause Mortality: A Meta-Analysis
Open accessAbstract
The current analysis reexamines the relationship between supplemental vitamin E and all-cause mortality. All randomized, controlled trials testing the treatment effect of vitamin E supplementation in adults for at least one year were sought. MEDLINE, the Cochrane Library, and Biological Abstracts databases were searched using the terms "vitamin E," "alpha-tocopherol," "antioxidants," "clinical trial," and "controlled trial" for studies published through April 2010; results were limited to English, German, or Spanish language articles. Studies were also obtained through reference mining. All randomized controlled trials using vitamin E, with a supplementation period of at least one year, to prevent or treat disease in adults were identified and abstracted independently by two raters. Mortality data from trials with a supplementation period of at least one year were pooled. The selected trials (n = 57) were published between 1988 and 2009. Sample sizes range from 28 to 39,876 (median = 423), yielding 246,371 subjects and 29,295 all-cause deaths. Duration of supplementation for the 57 trials range from one to 10.1 years (median = 2.6 years). A random effects meta-analysis produce an overall risk ratio of 1.00 (95% confidence interval: 0.98, 1.02); additional analyses suggest no relationship between dose and risk of mortality. Based on the present meta-analysis, supplementation with vitamin E appears to have no effect on all-cause mortality at doses up to 5,500 IU/d.
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“However, as with all vitamins and nutrients, it is important to not surpass recommended doses, as high concentrations of vitamin E have been shown to be deleterious for health144.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [144]
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1 retracted
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Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
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Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
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Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers
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Vitamin E Consumption and the Risk of Coronary Disease in Women
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Metadata
- Authors
- L. Abner, E., A. Schmitt, F., S. Mendiondo, M., L. Marcum, J., & J. Kryscio, R.
- Venue
- Current Aging Sciencee
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-07-01
- Volume
- 4
- Issue
- 2
- Pages
- 158-170
- ISSN
- 1874-6098 (ISSN-L)
- PMC
- PMC4030744
- OpenAlex
- W2097034899
- Cited by
- 209
- References
- 98
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 12 · 2023: 17 · 2022: 17 · 2021: 25 · 2020: 18 · 2019: 16 · 2018: 17 · 2017: 14 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 11 · 2012: 9
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Aging Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG019241, P30AG028383)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Keywords
- vitamin E, alpha-tocopherol, vitamin E supplementation, all-cause mortality, antioxidants, dose-response relationship, randomized controlled trials, mortality risk
- MeSH terms
- Antioxidants, Cause of Death, Humans, Longevity, Risk Factors, Time Factors, Vitamin E, Treatment Outcome, Risk Assessment, Dietary Supplements
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