Cited by 209Antioxidant Activity and Oxidative StressNutrition and Health StudiesVitamin C and Antioxidants Research

The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.

Vitamin E and All-Cause Mortality: A Meta-Analysis

Open access

L. Abner, Erin, A. Schmitt, Frederick, S. Mendiondo, Marta, L. Marcum, Jennifer, J. Kryscio, Richard·2011·Current Aging Sciencee

DOI 10.2174/1874609811104020158PMC PMC4030744

Open this paper in CoChat — free account

Abstract

The current analysis reexamines the relationship between supplemental vitamin E and all-cause mortality. All randomized, controlled trials testing the treatment effect of vitamin E supplementation in adults for at least one year were sought. MEDLINE, the Cochrane Library, and Biological Abstracts databases were searched using the terms "vitamin E," "alpha-tocopherol," "antioxidants," "clinical trial," and "controlled trial" for studies published through April 2010; results were limited to English, German, or Spanish language articles. Studies were also obtained through reference mining. All randomized controlled trials using vitamin E, with a supplementation period of at least one year, to prevent or treat disease in adults were identified and abstracted independently by two raters. Mortality data from trials with a supplementation period of at least one year were pooled. The selected trials (n = 57) were published between 1988 and 2009. Sample sizes range from 28 to 39,876 (median = 423), yielding 246,371 subjects and 29,295 all-cause deaths. Duration of supplementation for the 57 trials range from one to 10.1 years (median = 2.6 years). A random effects meta-analysis produce an overall risk ratio of 1.00 (95% confidence interval: 0.98, 1.02); additional analyses suggest no relationship between dose and risk of mortality. Based on the present meta-analysis, supplementation with vitamin E appears to have no effect on all-cause mortality at doses up to 5,500 IU/d.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2174/1874609811104020158

Cites

98 of 98 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects
Chandra, R. K. (1992) · The Lancet · doi:10.1016/0140-6736(92)93151-c · Cited by 523
Retracted
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,345
Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers
Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,164
Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)
Stephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148
Vitamin E Consumption and the Risk of Coronary Disease in Women
Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282003 · Cited by 2,085
Untitled work
(1999) · PubMed · Cited by 2,062
Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
Brown, B. G., Zhao, X.-Q., Chait, A., Fisher, L. D., Cheung, M. C., Morse, J. S., Dowdy, A. A., Marino, E. K., Bolson, E. L., Alaupovic, P., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011090 · Cited by 1,979
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844
Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population
Blot, W. J., Li, J., Taylor, P. R., Guo, W., Dawsey, S. M., Wang, G.-Q., Yang, C. S., Zheng, S., Gail, M. H., Li, G.-Y., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.18.1483 · Cited by 1,758
What to add to nothing? Use and avoidance of continuity corrections in meta‐analysis of sparse data
J. Sweeting, M., J. Sutton, A., & C. Lambert, P. (2004) · Statistics in Medicine · doi:10.1002/sim.1761 · Cited by 1,734
MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial
(2002) · The Lancet · doi:10.1016/s0140-6736(02)09328-5 · Cited by 1,502
Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer: A Randomized Controlled Trial
(2005) · JAMA · doi:10.1001/jama.293.11.1338 · Cited by 1,209 · cited 5×
“In 2005, following a series of neutral effect vitamin E trials including HOPE [67], GISSI [58], ATBC [49], and MRC/BHF HPS [83], Brown and Crowley posed the question, “Is there any hope for vitamin E?””
BackgroundInfluential
Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women’s Health Study: A Randomized Controlled Trial
Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137
Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials
Vivekananthan, D. P., Penn, M. S., Sapp, S. K., Hsu, A., & Topol, E. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13637-9 · Cited by 1,083
Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial
Boaz, M., Smetana, S. S., Weinstein, T., Matas, Z., Gafter, U., Iaina, A., Knecht, A., Weissgarten, Y., Brunner, D., FAINARU, M., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02783-5 · Cited by 1,020
Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general Practice
Roncaglioni, M. C. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03539-x · Cited by 993
The SU.VI.MAX Study
Herçberg, S., Galan, P., Preziosi, P., Bertrais, S., Mennen, L. I., Malvy, D. J.-M., Roussel, A., Favier, A. E., & Briançon, S. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.21.2335 · Cited by 989
Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events
Bradburn, M. J., Deeks, J. J., Berlin, J. A., & Russell Localio, A. (2007) · Statistics in Medicine · doi:10.1002/sim.2528 · Cited by 938
Vitamins E and C in the Prevention of Cardiovascular Disease in Men: The Physicians' Health Study II Randomized Controlled Trial
Sesso, H. D. (2008) · JAMA · doi:10.1001/jama.2008.600 · Cited by 913
A Clinical Trial of Antioxidant Vitamins to Prevent Colorectal Adenoma
Greenberg, E. R., Baron, J. A., Tosteson, T. D., Freeman, D. H., Beck, G. J., Bond, J. H., Colacchio, T. A., Coller, J. A., Frankl, H. D., Haile, R. W., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199407213310301 · Cited by 757
A Randomized Controlled Trial of Metformin versus Vitamin E or Prescriptive Diet in Nonalcoholic Fatty Liver Disease
Bugianesi, E., Gentilcore, E., Manini, R., Natale, S., Vanni, E., Villanova, N., David, E., Rizzetto, M., & Marchesini, G. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41583.x · Cited by 690
Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis
Bjelaković, G., Nikolova, D., Simonetti, R. G., & Gluud, C. N. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17138-9 · Cited by 619
Effects of Hormone Replacement Therapy and Antioxidant Vitamin Supplements on Coronary Atherosclerosis in Postmenopausal Women
Waters, D. D., Alderman, E. L., Hsia, J. A., Howard, B. V., Cobb, F. R., Rogers, W. J., Ouyang, P., Thompson, P. D., Tardif, J., Higginson, L., et al. (2002) · JAMA · doi:10.1001/jama.288.19.2432 · Cited by 580
Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)
RICHER, S. P., Stiles, W. R., Statkute, L., Pulido, J. S., Frankowski, J., Rudy, D., Pei, K. Y., Tsipursky, M. S., & Nyland, J. (2004) · Optometry · doi:10.1016/s1529-1839(04)70049-4 · Cited by 563
A Randomized Factorial Trial of Vitamins C and E and Beta Carotene in the Secondary Prevention of Cardiovascular Events in Women
Cook, N. R. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.15.1610 · Cited by 485
Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data
Friedrich, J. O., Adhikari, N. K. J., & Beyene, J. (2007) · BMC Medical Research Methodology · doi:10.1186/1471-2288-7-5 · Cited by 460
A Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa
Marmor, M. F. (1993) · Archives of Ophthalmology · doi:10.1001/archopht.1993.01090110018004 · Cited by 459
Nutrition Intervention Trials in Linxian, China: Multiple Vitamin/Mineral Supplementation, Cancer Incidence, and Disease-Specific Mortality Among Adults With Esophageal Dysplasia
Li, J., Taylor, P. R., Li, B., Dawsey, S. M., Wang, G.-Q., Ershow, A. G., Guo, W., Liu, S.-F., Yang, C. S., Shen, Q., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.18.1492 · Cited by 422
Treatment of Asymptomatic Adults With Elevated Coronary Calcium Scores With Atorvastatin, Vitamin C, and Vitamin E
Arad, Y., Spadaro, L. A., Roth, M., Newstein, D., & Guerci, A. D. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.089 · Cited by 414
Randomized Placebo-Controlled Trial of Ursodeoxycholic Acid With Vitamin E in Nonalcoholic Steatohepatitis
Dufour, J., Oneta, C. M., Gonvers, J., Bihl, F. K., Cerny, A., Cereda, J., Zala, J., Helbling, B., Steuerwald, M., & Zimmermann, A. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.09.025 · Cited by 360
Effect of Wheat Fiber and Vitamins C and E on Rectal Polyps in Patients With Familial Adenomatous Polyposis
DeCosse, J. J., Miller, H. H., & LESSER, M. L. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.17.1290 · Cited by 350
Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis
Hodis, H. N., Mack, W. J., LABREE, L. D., Mahrer, P. R., Sevanian, A., Liu, C., Liu, C.-H., Hwang, J., Selzer, R. H., & Azen, S. P. (2002) · Circulation · doi:10.1161/01.cir.0000029092.99946.08 · Cited by 304
Impact of Trace Elements and Vitamin Supplementation on Immunity and Infections in Institutionalized Elderly Patients
Girodon, F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.7.748 · Cited by 292
Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial
Fang, J. C.-T., Kinlay, S., Beltrame, J. F., Hikiti, H., Wainstein, M. V., Behrendt, D., Suh, J. H., Frei, B. B., Mudge, G. H., Selwyn, A. P., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08154-0 · Cited by 291
Vitamin E and Respiratory Tract Infections in Elderly Nursing Home Residents: A Randomized Controlled Trial
Meydani, S. N., Leka, L. S., Fine, B. C., Dallal, G. E., Keusch, G. T., Singh, M. F., & Hamer, D. H. (2004) · JAMA · doi:10.1001/jama.292.7.828 · Cited by 290
Uncertain Effects of Rosiglitazone on the Risk for Myocardial Infarction and Cardiovascular Death
Diamond, G. A., Bax, L., & Kaul, S. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-8-200710160-00182 · Cited by 288
Vitamin E Supplementation Reduces Cardiovascular Events in a Subgroup of Middle-Aged Individuals With Both Type 2 Diabetes Mellitus and the Haptoglobin 2-2 Genotype
Milman, U., Blum, S., Shapira, C., Aronson, D., Miller‐Lotan, R., Anbinder, Y., Alshiek, J., Bennett, L. N., Kostenko, M., Landau, M., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.153965 · Cited by 283
A double-blind, placebo-controlled randomized clinical trial of α-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis
Desnuelle, C., Dib, M., Garrel, C., & Favier, A. E. (2001) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/146608201300079364 · Cited by 266
Lutein, but not α-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study
Olmedilla‐Alonso, B., Granado, F., Blanco, I., & Vaquero, M. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00861-4 · Cited by 237
Effect of Daily Vitamin E and Multivitamin-Mineral Supplementation on Acute Respiratory Tract Infections in Elderly Persons: A Randomized Controlled Trial
Graat, J. M., Schouten, E. G., & Kok, F. J. (2002) · JAMA · doi:10.1001/jama.288.6.715 · Cited by 230
Associations of Mortality With Ocular Disorders and an Interventionof High-Dose Antioxidants and Zinc in the Age-Related Eye Disease Study: AREDS Report No. 13
(2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.5.716 · Cited by 215
Vitamin E in Human Health and Disease
Clarke, M. W., Burnett, J. R., & Croft, K. D. (2008) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360802118625 · Cited by 209
A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps.
McKeown‐Eyssen, G., Holloway, C. M. B., Jazmaji, V., Bright‐See, E., Dion, P. W., & Bruce, W. R. (1988) · PubMed · Cited by 205
Prevention of serious vascular events by aspirin amongst patients with peripheral arterial disease: randomized, double‐blind trial
Critical Leg Ischaemia Prevention Study (CLIPS) Group (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01763.x · Cited by 202
A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis
Stewart, S. F., Prince, M., Bassendine, M. F., Hudson, M., James, O., Jones, D. E., Record, C. O., & Day, C. P. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.03.027 · Cited by 195
The Roche European American Cataract Trial (REACT): A randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract
The REACT Group, Chylack, L. T., Brown, N. P., Bron, A. J., Hurst, M., Köpcke, W., Thien, U., & Schalch, W. (2002) · Ophthalmic Epidemiology · doi:10.1076/opep.9.1.49.1717 · Cited by 193
High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study
Graf, M., Ecker, D., Horowski, R., Krämer, B., Riederer, P. F., Gerlach, M., Hager, C., Ludolph, A. C., Krämer, B., Ecker, D., et al. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0220-1 · Cited by 192
Antioxidant vitamins supplementation and mortality: A randomized trial in head and neck cancer patients
Bairati, I., Meyer, F., Jobin, É., Gélinas, M., Fortin, A., Nabid, A., Brochet, F., & Têtu, B. (2006) · International Journal of Cancer · doi:10.1002/ijc.22042 · Cited by 177
Megadose Vitamins in Bladder Cancer: A Double-Blind Clinical Trial
Lamm, D. L., Riggs, D. R., Shriver, J. S., vanGilder, P. F., Rach, J. F., & DeHaven, J. I. (1994) · The Journal of Urology · doi:10.1016/s0022-5347(17)34863-2 · Cited by 173
Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis
Tomeo, A., Geller, M., Watkins, T. R., GAPOR, A., & Bierenbaum, M. L. (1995) · Lipids · doi:10.1007/bf02536621 · Cited by 159
Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas
Roncucci, L., Donato, P. D., Carati, L., Ferrari, A., Perini, M., Bertoni, G., Bedogni, G., Paris, B., Svanoni, F., Girola, M., et al. (1993) · Diseases of the Colon & Rectum · doi:10.1007/bf02053502 · Cited by 157
Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
Wright, M. E., Lawson, K. A., Weinstein, S. J., Pietinen, P., Taylor, P. R., Virtamo, J. R. K., & Albanes, D. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1200 · Cited by 150
Growth and Recurrence of Colorectal Polyps: A Double-Blind 3-Year Intervention with Calcium and Antioxidants
Hofstad, B., Almendingen, K., Vatn, M., Andersen, S. N., Owen, R. W., Larsen, S., & OSNES, M. (1998) · Digestion · doi:10.1159/000007480 · Cited by 147
Vitamin E supplementation and cataract
McNeil, J. J., Robman, L. D., Tikellis, G., Sinclair, M. I., McCarty, C. A., & Taylor, H. R. (2004) · Ophthalmology · doi:10.1016/j.ophtha.2003.04.009 · Cited by 143
Trial of d-alpha-tocopherol in Huntington's disease
Peyser, C. E., Folstein, M. F., Chase, G. A., STARKSTEIN, S. E., Brandt, J., Cockrell, J. R., Bylsma, F., Coyle, J. T., McHugh, P. R., & Folstein, S. E. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.12.1771 · Cited by 139
Effect of Micronutrient Supplementation on Infection in Institutionalized Elderly Subjects: A Controlled Trial
Girodon, F., Lombard, M., Galan, P., Brunet-Lecomte, P., Monget, A. L., Arnaud, J., Preziosi, P., & Herçberg, S. (1997) · Annals of Nutrition and Metabolism · doi:10.1159/000177984 · Cited by 134
Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study.
Wluka, A. E., STUCKEY, S. L., Brand, C. A., & Cicuttini, F. (2002) · PubMed · Cited by 125
Effect of vitamin and trace element supplementation on immune indices in healthy elderly.
Pike, J., & Chandra, R. K. (1995) · PubMed · Cited by 108
Effect of a Treatment Strategy Consisting of Pravastatin, Vitamin E, and Homocysteine Lowering on Carotid Intima-Media Thickness, Endothelial Function, and Renal Function in Patients With Mild to Moderate Chronic Kidney Disease
Nanayakkara, P. W. B. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.12.1262 · Cited by 107
Vitamin E can Reduce Blood Pressure in Mild Hypertensives
Boshtam, M., Rafiei, M., Sadeghi, K. A., & Sarrafzadegan, N. (2002) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.72.5.309 · Cited by 100
Effects of long-term vitamin E supplementation in alcoholic cirrhotics.
de la Maza, M. P., Petermann, M., Bunout, D. C., & Hirsch, S. (1995) · Journal of the American College of Nutrition · doi:10.1080/07315724.1995.10718493 · Cited by 98
Chemoprevention of Precancerous Gastric Lesions With Antioxidant Vitamin Supplementation: A Randomized Trial in a High-Risk Population
Plummer, M., Vivas, J. H., Lopez, G., Bravo, J. C., Peraza, S., Carillo, E., Cano, E., Castro, D., Andrade, O., Sánchez, V., et al. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk017 · Cited by 95
Vitamin E plus aspirin compared with aspirin alone in patients with transient ischemic attacks
Steiner, M., Glantz, M., & Lekos, A. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1381s · Cited by 95
The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India
Gritz, D. C., Srinivasan, M., Smith, S. D. G., Kim, U. R., Lietman, T. M., Wilkins, J. H., Priyadharshini, B., John, R. K., Aravind, S., Prajna, N. V., et al. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.088104 · Cited by 91
Chemotherapy Alonevs.Chemotherapy Plus High Dose Multiple Antioxidants in Patients with Advanced Non Small Cell Lung Cancer
Pathak, A., Bhutani, M., Guleria, R., Bal, S., Mohan, A., Mohanti, B. K., Sharma, A., Pathak, R., Bhardwaj, N. K., Prasad, K. N., et al. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719438 · Cited by 90
Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial
Avenell, A., Campbell, M., Cook, J. A., Hannaford, P. C., Kilonzo, M. M., McNeill, G., Milne, A. C., Ramsay, C. R., Seymour, D. G., Stephen, A. I., et al. (2005) · BMJ · doi:10.1136/bmj.331.7512.324 · Cited by 84
Bayesian model averaging in meta-analysis: vitamin E supplementation and mortality
Berry, D. A., Wathen, J. K., & Newell, M. (2009) · Clinical Trials · doi:10.1177/1740774508101279 · Cited by 82
A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Multivitamin Supplementation for Age-Related Lens Opacities
⁎ (2008) · Ophthalmology · doi:10.1016/j.ophtha.2008.01.005 · Cited by 80
Antioxidant Vitamin Supplementation Reduces Benzo(a)pyrene-DNA Adducts and Potential Cancer Risk in Female Smokers
Mooney, L. A., Madsen, A. M., Tang, D. L., Orjuela, M. A., Tsai, W., Garduno, E. R., & Perera, F. P. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.237.14.1 · Cited by 80
Effect of glutathione S-transferase M1 genotype on progression of atherosclerosis in lifelong male smokers
Waart, F. G. D., Kok, F. J., Smilde, T. J., Hijmans, A., Wollersheim, H. C. H., & Stalenhoef, A. F. H. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00420-8 · Cited by 77
Is There Any Hope for Vitamin E?
Brown, B. (2005) · JAMA · doi:10.1001/jama.293.11.1387 · Cited by 73
Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer
Заридзе, Д. Г., Evstifeeva, T. V., & Boyle, P. (1993) · Annals of Epidemiology · doi:10.1016/1047-2797(93)90023-w · Cited by 72
Brief Communication: The Prevalence of High Intake of Vitamin E from the Use of Supplements among U.S. Adults
Ford, E. S., Ajani, U. A., & Mokdad, A. H. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-2-200507190-00010 · Cited by 72
Multicenter ophthalmic and nutritional age-related macular degeneration study--part 2: antioxidant intervention and conclusions.
Richer, S. (1996) · PubMed · Cited by 64
Meta‐analysis: antioxidant supplements for liver diseases – the Cochrane Hepato‐Biliary Group
Bjelaković, G., Gluud, L. L., Nikolova, D., Bjelaković, M., Nagorni, A. V., & Gluud, C. N. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04371.x · Cited by 63
An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity
You, W., CHANG, Y. S., Heinrich, J., Ma, J. L., Liu, W., Zhang, L., Brown, L. M., Yang, C. S., Gail, M. H., Fraumeni, J. F., et al. (2001) · European Journal of Cancer Prevention · doi:10.1097/00008469-200106000-00009 · Cited by 59
Risk of Mortality with Vitamin E Supplements: The Cache County Study
Hayden, K. M., Welsh-Bohmer, K. A., Wengreen, H. J., Zandi, P. P., Lyketsos, C. G., & Breitner, J. C. S. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.03.039 · Cited by 58
Effect of Intensive Lipid Lowering, With or Without Antioxidant Vitamins, Compared With Moderate Lipid Lowering on Myocardial Ischemia in Patients With Stable Coronary Artery Disease
Stone, P. H., Lloyd‐Jones, D. M., Kinlay, S., Frei, B. B., Carlson, W., Rubenstein, J. J., Andrews, T. C., Johnstone, M. T., Sopko, G. S., Cole, H., et al. (2005) · Circulation · doi:10.1161/01.cir.0000160866.90148.76 · Cited by 53
Mortality in the CHAOS trial
Mitchinson, M. J., Stephens, N. G., Parsons, A., Bligh, E., Schofield, P. M., & Brown, M. J. (1999) · The Lancet · doi:10.1016/s0140-6736(05)74955-2 · Cited by 49
Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT)
Chesney, C. M., Elam, M. B., Herd, J. A., Davis, K. B., Garg, R., Hunninghake, D. B., Kennedy, J. W., & Applegate, W. B. (2000) · American Heart Journal · doi:10.1067/mhj.2000.109648 · Cited by 48
SIX-YEAR EFFECT OF COMBINED VITAMIN C AND E SUPPLEMENTATION ON ATHEROSCLEROTIC PROGRESSION
Salonen, R. M., Nyyssönen, K., & Kaikkonen, J. (2003) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200305000-00019 · Cited by 47
Beneficial effect of vitamin E supplementation on the biochemical and kinetic properties of Tamm–Horsfall glycoprotein in hypertensive and hyperoxaluric patients
Sumitra, K., Viswanathan, P., Sakthivel, R., Kalaiselvi, P., & Varalakshmi, P. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh794 · Cited by 46
The Melbourne Atherosclerosis Vitamin E Trial (MAVET): a study of high dose vitamin E in smokers
Magliano, D. J., McNeil, J. J., Branley, P., Shiel, L. M., Demos, L., Wolfe, R. S., Kotsopoulos, D., & McGrath, B. P. (2006) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000219108.10167.46 · Cited by 39
Serum Vitamin E and Oxidative Protein Modification in Hemodialysis: A Randomized Clinical Trial
Lu, L., Erhard, P., Salomon, R. G., & Weiss, M. F. (2007) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.05.001 · Cited by 34
Pilot Clinical Trial of the Use of Alpha-tocopherol for the Prevention of Hepatocellular Carcinoma in Patients with Liver Cirrhosis
Takagi, Kakizaki, Sohara, Sato, K., Tsukioka, Tago, Konaka, Kabeya, Kaneko, Takayama, et al. (2003) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.73.6.411 · Cited by 34
Effect of One‐year Oral α‐Tocopherol Administration on the Antioxidant Defense System in Hemodialysis Patients
Antoniadi, G., Eleftheriadis, T., Liakopoulos, V., Kakasi, E., Kartsios, C., Passadakis, P., & Vargemezis, V. A. (2008) · Therapeutic Apheresis and Dialysis · doi:10.1111/j.1744-9987.2008.00580.x · Cited by 33
Functional deterioration and selenium‐vitamin E treatment in myotonic dystrophy. A placebo‐controlled study
Örndahl, G., Grimby, G., Grimby, A., JOHANSSON, G., & Wilhelmsen, L. (1994) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1994.tb01061.x · Cited by 33
Effects on Health of Dietary Supplementation with 100 mg d -α-Tocopheryl Acetate, Daily for 6 Years
TAKAMATSU, S., TAKAMATSU, M., Satoh, K., Imaizumi, T., Yoshida, H., Hiramoto, M., Koyama, M., Ohgushi, Y., & Mizuno, S. (1995) · Journal of International Medical Research · doi:10.1177/030006059502300504 · Cited by 31
A Randomized Phase II Chemoprevention Trial of 13-CIS Retinoic Acid with Or without α Tocopherol or Observation in Subjects at High Risk for Lung Cancer
Kelly, K. L., Kittelson, J. K., Franklin, W. A., Kennedy, T. C., Klein, C. E., Keith, R. L., Dempsey, E. C., Lewis, M. T., Jackson, M. K., Hirsch, F. R., et al. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0136 · Cited by 31
Mortality According to a Prior Assessment of Biological Age
Bulpitt, C. J., Antikaínen, R., Markowe, H. L. J., & Shipley, M. J. (2009) · Current Aging Science · doi:10.2174/1874609810902030193 · Cited by 19
THE MODULATION OF PROSTATE CANCER RISK WITH α-TOCOPHEROL: A PILOT RANDOMIZED, CONTROLLED CLINICAL TRIAL
HERNÁANDEZ, J., Syed, S. K., Weiss, G. R., Fernandes, G., von Merveldt, D., Troyer, D. A., Basler, J. W., & Thompson, I. M. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000165151.08560.6a · Cited by 18
High-Dosage Vitamin E Supplementation and All-Cause Mortality
Lim, W. S., Liščić, R. M., Xiong, C., & Morris, J. C. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-2-200507190-00021 · Cited by 17
High-Dose α-Tocopherol Therapy Does Not Affect HDL Subfractions in Patients with Coronary Artery Disease on Statin Therapy
Singh, U. S., Otvos, J. D., Dasgupta, A., de Lemos, J. A., Devaraj, S., & Jialal, I. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.078865 · Cited by 16
Decrease of ornithine decarboxylase activity in premalignant gastric mucosa and regression of small intestinal metaplasia in patients supplemented with high doses of vitamin E.
Bukin, Y. V., Va, D.-K., Kuvshinov, Y. P., Poddubniy, B. K., & Ma, S. (1997) · PubMed · Cited by 16

Research works printed but not linked: 3

[30]Bonelli L Camoriano A Ravelli P Missale G Bruzzi P Aste H Reduction of the incidence of metachronous adenomas of the large bowel by means of antioxidants 1998 Brussels, Belgium Se-Te Press 1998 91 4
[71]Antoniadi G Eleftheriadis T Liakopoulos V Kakasi E Kartsios C Passadakis P Vargemezis V Effect of one-year oral α-tocopherol administration on hemodialysis patients Therapeutic Apherisis and Dialysis 2008 12 237 42 18503702
[91]Marras C Oakes D Tanner CM Fahn S Vitamin E supplementation was not associated with mortality in the DATATOP cohort Ann Intern Med 2005 143 152 3 16027463

Sorted by citations

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239
Nonalcoholic Steatohepatitis
Sheka, A. C., Adeyi, O. A., Thompson, J., Hameed, B., Crawford, P. A., & Ikramuddin, S. (2020) · JAMA · doi:10.1001/jama.2020.2298 · Cited by 1,432
NAFLD as a Continuum: From Obesity to Metabolic Syndrome and Diabetes
Godoy-Matos, A. F., Silva Júnior, W. S., & Valerio, C. M. (2020) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-00570-y · Cited by 643
Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis
Leoni, S., Tovoli, F., Napoli, L., Serio, I., Ferri, S., & Bolondi, L. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i30.3361 · Cited by 560
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534

See all 209

Authors: L. Abner, E., A. Schmitt, F., S. Mendiondo, M., L. Marcum, J., & J. Kryscio, R.
Venue: Current Aging Sciencee
Publisher: Bentham Science Publishers Ltd.
Published: 2011-07-01
Volume: 4
Issue: 2
Pages: 158-170
ISSN: 1874-6098 (ISSN-L)
DOI: 10.2174/1874609811104020158
PMC: PMC4030744
OpenAlex: W2097034899
Cited by: 209
References: 98
Citations by year: 2026: 2 · 2025: 8 · 2024: 12 · 2023: 17 · 2022: 17 · 2021: 25 · 2020: 18 · 2019: 16 · 2018: 17 · 2017: 14 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 11 · 2012: 9
FWCI: 8.35
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Current Aging Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG019241, P30AG028383)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Keywords: vitamin E, alpha-tocopherol, vitamin E supplementation, all-cause mortality, antioxidants, dose-response relationship, randomized controlled trials, mortality risk
MeSH terms: Antioxidants, Cause of Death, Humans, Longevity, Risk Factors, Time Factors, Vitamin E, Treatment Outcome, Risk Assessment, Dietary Supplements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vitamin E and All-Cause Mortality: A Meta-Analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks