Cited by 209Antioxidant Activity and Oxidative StressNutrition and Health StudiesVitamin C and Antioxidants Research

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Vitamin E and All-Cause Mortality: A Meta-Analysis

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L. Abner, Erin, A. Schmitt, Frederick, S. Mendiondo, Marta, L. Marcum, Jennifer, J. Kryscio, Richard·2011·Current Aging Sciencee

DOI 10.2174/1874609811104020158PMC PMC4030744

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Abstract

The current analysis reexamines the relationship between supplemental vitamin E and all-cause mortality. All randomized, controlled trials testing the treatment effect of vitamin E supplementation in adults for at least one year were sought. MEDLINE, the Cochrane Library, and Biological Abstracts databases were searched using the terms "vitamin E," "alpha-tocopherol," "antioxidants," "clinical trial," and "controlled trial" for studies published through April 2010; results were limited to English, German, or Spanish language articles. Studies were also obtained through reference mining. All randomized controlled trials using vitamin E, with a supplementation period of at least one year, to prevent or treat disease in adults were identified and abstracted independently by two raters. Mortality data from trials with a supplementation period of at least one year were pooled. The selected trials (n = 57) were published between 1988 and 2009. Sample sizes range from 28 to 39,876 (median = 423), yielding 246,371 subjects and 29,295 all-cause deaths. Duration of supplementation for the 57 trials range from one to 10.1 years (median = 2.6 years). A random effects meta-analysis produce an overall risk ratio of 1.00 (95% confidence interval: 0.98, 1.02); additional analyses suggest no relationship between dose and risk of mortality. Based on the present meta-analysis, supplementation with vitamin E appears to have no effect on all-cause mortality at doses up to 5,500 IU/d.

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Authors: L. Abner, E., A. Schmitt, F., S. Mendiondo, M., L. Marcum, J., & J. Kryscio, R.
Venue: Current Aging Sciencee
Publisher: Bentham Science Publishers Ltd.
Published: 2011-07-01
Volume: 4
Issue: 2
Pages: 158-170
ISSN: 1874-6098 (ISSN-L)
DOI: 10.2174/1874609811104020158
PMC: PMC4030744
OpenAlex: W2097034899
Cited by: 209
References: 98
Citations by year: 2026: 2 · 2025: 8 · 2024: 12 · 2023: 17 · 2022: 17 · 2021: 25 · 2020: 18 · 2019: 16 · 2018: 17 · 2017: 14 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 11 · 2012: 9
FWCI: 8.35
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Current Aging Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG019241, P30AG028383)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Keywords: vitamin E, alpha-tocopherol, vitamin E supplementation, all-cause mortality, antioxidants, dose-response relationship, randomized controlled trials, mortality risk
MeSH terms: Antioxidants, Cause of Death, Humans, Longevity, Risk Factors, Time Factors, Vitamin E, Treatment Outcome, Risk Assessment, Dietary Supplements

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Vitamin E and All-Cause Mortality: A Meta-Analysis

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