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Cited by 619Chronic Kidney Disease and DiabetesDialysis and Renal Disease ManagementBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.

Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations with Kidney Function

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Lash, James P., Go, Alan S., Appel, Lawrence J., He, Jiang, Ojo, Akinlolu, Rahman, Mahboob, Townsend, Raymond R., Xie, Dawei, Cifelli, Denise, Cohan, Janet, Fink, Jeffrey C., Fischer, Michael J., Gadegbeku, Crystal, Hamm, L. Lee, Kusek, John W., Landis, J. Richard, Narva, Andrew, Robinson, Nancy, Teal, Valerie, Feldman, Harold I.·2009·Clinical Journal of the American Society of Nephrology
DOI 10.2215/cjn.00070109PMC PMC2723966
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Abstract

BACKGROUND AND OBJECTIVES: The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for the progression of chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with CKD. We examined baseline demographic and clinical characteristics. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Seven clinical centers recruited adults who were aged 21 to 74 yr and had CKD using age-based estimated GFR (eGFR) inclusion criteria. At baseline, blood and urine specimens were collected and information regarding health behaviors, diet, quality of life, and functional status was obtained. GFR was measured using radiolabeled iothalamate in one third of participants. RESULTS: A total of 3612 participants were enrolled with mean age +/- SD of 58.2 +/- 11.0 yr; 46% were women, and 47% had diabetes. Overall, 45% were non-Hispanic white, 46% were non-Hispanic black, and 5% were Hispanic. Eighty-six percent reported hypertension, 22% coronary disease, and 10% heart failure. Mean body mass index was 32.1 +/- 7.9 kg/m(2), and 47% had a BP >130/80 mmHg. Mean eGFR was 43.4 +/- 13.5 ml/min per 1.73 m(2), and median (interquartile range) protein excretion was 0.17 g/24 h (0.07 to 0.81 g/24 h). Lower eGFR was associated with older age, lower socioeconomic and educational level, cigarette smoking, self-reported CVD, peripheral arterial disease, and elevated BP. CONCLUSIONS: Lower level of eGFR was associated with a greater burden of CVD as well as lower socioeconomic and educational status. Long-term follow-up of participants will provide critical insights into the epidemiology of CKD and its relationship to adverse outcomes.

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Metadata

Authors
Lash, J. P., Go, A. S., Appel, L. J., He, J., Ojo, A., Rahman, M., Townsend, R. R., Xie, D., Cifelli, D., Cohan, J., Fink, J. C., Fischer, M. J., Gadegbeku, C., Hamm, L. L., Kusek, J. W., Landis, J. R., Narva, A., Robinson, N., Teal, V., & Feldman, H. I.
Affiliations
  • University of Illinois Chicago (US)
  • Kaiser Permanente (US)
  • Johns Hopkins University (US)
  • Tulane University (US)
  • University of Michigan (US)
  • University of Maryland, Baltimore (US)
  • Edward Hines, Jr. VA Hospital (US)
  • National Institutes of Health (US)
Corresponding author
  • Lash, James P.
  • Rahman, Mahboob
  • Cohan, Janet
  • Fischer, Michael J.
  • Kusek, John W.
  • Narva, Andrew
ORCID
Venue
Clinical Journal of the American Society of Nephrology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-08
Volume
4
Issue
8
Pages
1302-1311
ISSN
1555-9041 (ISSN-L)
DOI
10.2215/cjn.00070109
PMC
PMC2723966
OpenAlex
W2160134719
Cited by
619
References
52
Citations by year
2026: 37 · 2025: 36 · 2024: 42 · 2023: 40 · 2022: 58 · 2021: 52 · 2020: 51 · 2019: 39 · 2018: 34 · 2017: 32 · 2016: 48 · 2015: 34 · 2014: 27 · 2013: 37 · 2012: 23
FWCI
11.94
Type
journal article
Language
en
Open access
Locations
  • Clinical Journal of the American Society of Nephrology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k24dk002651-10)
  • University of Illinois at Urbana-Champaign
  • National Institute of Diabetes and Digestive and Kidney Diseases (5U01DK06102, 5K24DK002651, R01DK072231, K24-DK002651, U01DK060990, 5U01 DK60980, T32DK060455, U01DK060984, U01DK060902, U01DK060980, U01DK060963, U01DK061021, U01DK061028)
  • National Center for Research Resources (UL1RR024131, RR-05096, UL1RR024989, UL1RR025005, M01RR013987, M01RR016500, M01RR-013987-06, UL1RR024986, M01RR005096, M01 RR-024986, M01RR 16500, M01RR000042)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
chronic kidney disease, estimated glomerular filtration rate, cardiovascular disease, chronic kidney disease progression, risk factors, socioeconomic status, educational attainment, hypertension, diabetes mellitus, proteinuria, peripheral arterial disease, smoking, quality of life, functional status, CRIC study
MeSH terms
Adult, Age Factors, Aged, Blood Pressure, Cardiovascular Diseases, Educational Status, Female, Glomerular Filtration Rate, Humans, Kidney, Kidney Failure, Chronic, Male, Middle Aged, Prospective Studies, Proteinuria, Risk Factors, Smoking, Social Class, United States, Disease Progression, Risk Assessment, Patient Selection, Renal Insufficiency, Chronic, Young Adult

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