The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters
Open accessAbstract
The proximal tubule of the kidney plays a crucial role in the renal handling of drugs (e.g., diuretics), uremic toxins (e.g., indoxyl sulfate), environmental toxins (e.g., mercury, aristolochic acid), metabolites (e.g., uric acid), dietary compounds, and signaling molecules. This process is dependent on many multispecific transporters of the solute carrier (SLC) superfamily, including organic anion transporter (OAT) and organic cation transporter (OCT) subfamilies, and the ATP-binding cassette (ABC) superfamily. We review the basic physiology of these SLC and ABC transporters, many of which are often called drug transporters. With an emphasis on OAT1 (SLC22A6), the closely related OAT3 (SLC22A8), and OCT2 (SLC22A2), we explore the implications of recent in vitro, in vivo, and clinical data pertinent to the kidney. The analysis of murine knockouts has revealed a key role for these transporters in the renal handling not only of drugs and toxins but also of gut microbiome products, as well as liver-derived phase 1 and phase 2 metabolites, including putative uremic toxins (among other molecules of metabolic and clinical importance). Functional activity of these transporters (and polymorphisms affecting it) plays a key role in drug handling and nephrotoxicity. These transporters may also play a role in remote sensing and signaling, as part of a versatile small molecule communication network operative throughout the body in normal and diseased states, such as AKI and CKD.
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Self-citationThe Organic Anion Transporter (OAT) Family: A Systems Biology Perspective
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Petrie, J. R., Chaturvedi, N., Ford, I., Brouwers, M. C. G. J., Greenlaw, N., Tillin, T., Hramiak, I., Hughes, A. D., Jenkins, A. J., Klein, B. E. K., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30194-8 · Cited by 357
Kidney-on-a-Chip technology for drug-induced nephrotoxicity screening
Wilmer, M. J., Ng, C. P., Lanz, H. L., Vulto, P., Suter-Dick, L., & Masereeuw, R. (2016) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.11.001 · Cited by 354
Metadata
- Authors
- Nigam, S. K., Wu, W., Bush, K. T., Hoenig, M. P., Blantz, R. C., & Bhatnagar, V.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2015-11
- Volume
- 10
- Issue
- 11
- Pages
- 2039-2049
- ISSN
- 1555-9041 (ISSN-L)
- OpenAlex
- W1801619426
- Cited by
- 269
- References
- 90
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Nigam, S. K., Wu, W., Bush, K. T., Hoenig, M. P., Blantz, R. C., & Bhatnagar, V. (2015). Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters. Clinical Journal of the American Society of Nephrology. https://doi.org/10.2215/cjn.02440314
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