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Cited by 75Cancer-related Molecular PathwaysCell death mechanisms and regulationMitochondrial Function and Pathology

Watching the watcher: Regulation of p53 by mitochondria

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Holley, Aaron K, St Clair, Daret K·2009·Future Oncology
DOI 10.2217/14796694.5.1.117PMC PMC2710969
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Abstract

p53 has been referred to as the 'guardian of the genome' because of its role in protecting the cell from DNA damage. p53 performs its duties by regulating cell-cycle progression and DNA repair and, in cases of irreparable DNA damage, by executing programmed cell death. Mitochondria are an important target of transcription-dependent and -independent actions of p53 to carry out the apoptotic function. However, increasing evidence suggests that p53 activity is regulated by mitochondria. Cellular insults that alter mitochondrial function can have important consequences on p53 activity. In light of these new findings, the following review focuses on p53/mitochondria connections, in particular how reactive oxygen species generated at mitochondria regulate p53 activity. A better understanding of the mechanisms by which mitochondria regulate p53 may have an impact on our understanding of the development and progression of many diseases, especially cancer.

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  1. [1]Vousden KH Lu X Live or let die: the cell’s response to p53 Nat. Rev. Cancer 2002 2 594 604 12154352
  2. [2]Vousden KH Outcomes of p53 activation - spoilt for choice J. Cell Sci 2006 119 5015 5020 17158908
  3. [3]Tokino T Nakamura Y The role of p53-target genes in human cancer Crit. Rev. Oncol. Hematol 2000 33 1 6 10714958
  4. [4]Ko LJ Prives C p53: puzzle and paradigm Genes Dev 1996 10 1054 1072 8654922
  5. [5]Oren M Decision making by p53: life, death and cancer Cell Death Differ 2003 10 431 442 12719720
  6. [6]Greenblatt MS Bennett WP Hollstein M Harris CC Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis Cancer Res 1994 54 4855 4878 8069852
  7. [7]Prives C Hall PA The p53 pathway J. Pathol 1999 187 112 126 10341712
  8. [8]Harris SL Levine AJ The p53 pathway: positive and negative feedback loops Oncogene 2005 24 2899 2908 15838523
  9. [10]Tang Y Luo J Zhang W Gu W Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis Mol. Cell 2006 24 827 839 17189186
  10. [11]Long X Goldenthal MJ Marin-Garcia J Oxidative stress enhances phosphorylation of p53 in neonatal rat cardiomyocytes Mol. Cell. Biochem 2007 303 167 174 17457521
  11. [12]Chuikov S Kurash JK Wilson JR Regulation of p53 activity through lysine methylation Nat. Rev. Cancer 2004 432 353 360 15525938
  12. [13]Ernster L Schatz G Mitochondria: a historical review J. Cell Biol 1981 91 3 227s 255s 7033239 PMC2112799
  13. [14]Frey TG Mannella CA The internal structure of mitochondria Trends Biochem. Sci 2000 25 319 324 10871882
  14. [15]Hatefi Y The mitochondrial electron transport chain and oxidative phosphorylation system Annu. Rev. Biochem 1985 54 1015 1069 2862839
  15. [17]Logan DC The mitochondrial compartment J. Exp. Bot 2006 57 1225 1243 16556626
  16. [18]Manoli I Alesci S Blackman MR Su YA Rennert OM Chrousos GP Mitochondria as key components of the stress response Trends Endocrinol. Metab 2007 18 5 190 198 17500006
  17. [19]Chen D Yu Z Zhu Z Lopez CD The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells Cancer Res 2006 66 7 3485 3494 16585172
  18. [20]Bowsher CG Tobin AK Compartmentation of metabolism within mitochondria and plastids J. Exp. Bot 2001 53 356 513 527 11373301
  19. [21]Newsholme P Bender K Kiely A Brennan L Amino acid metabolism, insulin secretion and diabetes Biochem. Soc. Trans 2007 35 5 1180 1186 17956307
  20. [22]Leverve XM Mitochondrial function and substrate availability Crit. Care Med 2007 35 S454 S460 17713393
  21. [23]Eaton S Bartlett K Pourfarzam M Mammalian mitochondrial β-oxidation Biochem. J 1996 320 345 357 8973539 PMC1217938
  22. [24]Spierings D McStay G Saleh M Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis Science 2005 310 66 67 16210526
  23. [25]Gulbins E Dreschers S Bock J Role of mitochondria in apoptosis Exp. Physiol 2003 88 85 90 12525857
  24. [26]Green DR Reed JC Mitochondria and apoptosis Science 1998 281 1309 1312 9721092
  25. [27]Scheffler IE Mitochondria 1999 NY, USA Wiley-Liss, Inc.
  26. [28]Adams JM Ways of dying: multiple pathways to apoptosis Genes Dev 2003 17 2481 2495 14561771
  27. [29]Goldenthal MJ Marin-Garcia J Mitochondrial signaling pathways: a receiver/integrator organelle Mol. Cell. Biochem 2004 262 1 16 15532704
  28. [30]Cannino G Di Liegro CM Rinaldi AM Nuclear-mitochondrial interaction Mitochondrion 2007 7 359 366 17822963
  29. [31]Owusu-Ansah E Yavari A Mandal S Banerjee U Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint Nat. Genet 2008 40 356 361 18246068
  30. [32]Travan A Wong JMS Xu D Sopta M Ingles CJ Altered nuclear gene expression profiles in a yeast mitochondiral DNA mutant J. Biol. Chem 2001 276 4020 4027 11054416
  31. [33]Ryan MT Hoogenraad NJ Mitochondrial-nuclear communications Annu. Rev. Biochem 2007 76 701 722 17227225
  32. [34]Nicholls DG Mitochondria and calcium signaling Cell Calcium 2005 38 311 317 16087232
  33. [35]Luo Y Bond JD Ingram VM Compromised mitochondrial function leads to increased cytosolic calcium annd to activation of MAP kinases Proc. Natl Acad. Sci. USA 1997 94 9705 9710 9275188 PMC23254
  34. [37]Arnould T Vankoningsloo S Renard P CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation EMBO J 2002 21 53 63 11782425 PMC125809
  35. [39]Psarra AM Sekeris CE Nuclear receptors and other nuclear transcription factors in mitochondria: regulatory molecules in a new environment Biochim. Biophys. Acta 2008 1783 1 11 18062929
  36. [40]Casas F Domenjoud L Rochard P A 45 kDa protein related to PPARγ2 induced by peroxisome proliferators, is located in the mitochondrial matrix FEBS Lett 2000 478 4 8 10922459
  37. [41]Cogswell PC Kashatus DF Keifer JA NF-κB and IκBα are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-κB J. Biol. Chem 2003 278 5 2963 2968 12433922
  38. [42]Casas F Daury L Grandemange S Endocrine regulation of mitochondrial activity: involvement of truncated RXRα and c-Erb Aα1 proteins FASEB J 2003 17 426 436 12631582
  39. [43]Berdanier CD Everts HB Hermoyian C Mathews CE Role of vitamin A in mitochondrial gene expression Diabetes. Res. Clin. Pract 2001 54 Suppl. 2 S11 S27 11733105
  40. [44]Katsumoto T Higaki K Ohno K Onodera K Cell-cycle dependent biosynthesis and localization of p53 protein in untransformed human cells Biol. Cell 1995 84 167 173 8720437
  41. [45]Marchenko ND Zaika A Moll UM Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling J. Biol. Chem 2000 275 21 16202 16212 10821866 ▪▪ This article is particularly interesting as it describes p53 translocation to mitochondria in response to stress, and its role in apoptosis.
  42. [46]Psarra AM Sekeris CE Steroid and thyroid hormone receptors in mitochondria IUBMB Life 2008 60 4 210 223 18344181
  43. [47]Morrish F Buroker NE Ge M Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for bindingto receptor elements on mtDNA Mitochondrion 2006 6 3 143 148 16730242
  44. [48]Solakidi S Psarra AMG Sekeris CE Differential distribution of glucocorticoid and estrogen receptor isoforms: localization of GRβ and ERα in nucleoli and GRα and ERβ in the mitochondria of human osteosarcoma SaOS-2 and hepatocarcinoma HepG2 cell lines J. Musculoskelet. Neuronal Interact 2007 7 240 245 17947807
  45. [49]Solakidi S Psarra AMG Nikolaropoulos S Sekeris CE Estrogen receptors α and β (ERα and ERβ) and androgen receptor (AR) in human sperm: localization of ERβ and AR in mitochondria of the midpiece Hum. Reprod 2005 20 3481 3487 16123086
  46. [50]Gavrilova-Jordan LP Price TM Actions of steroids in mitochondria Semin. Reprod. Med 2007 25 154 164 17447205
  47. [51]Gatenby RA Gillies RJ Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 2004 4 891 899 15516961
  48. [52]Bui T Thompson CB Cancer’s sweet tooth Cancer Cell 2006 9 419 420 16766260
  49. [53]Kim JW Dang CV Cancer’s molecular sweet tooth and the Warburg effect Cancer Res 2006 66 8927 8930 16982728
  50. [54]Assaily W Benchimol S Differential utilization fo two ATP-generating pathways is regulated by p53 Cancer Cell 2006 10 1 4 6 16843260
  51. [55]Ma W Sung HJ Park JY Matoba S Hwang PM A pivotal role for p53: balancing aerobic respiration and glycolysis J. Bioenerg. Biomembr 2007 39 243 246 17551815
  52. [56]Corcoran CA Huang Y Sheikh MS The regulation of energy generating metabolic pathways by p53 Cancer Biol. Ther 2006 5 1610 1613 17204863
  53. [57]Matoba S Kang JG Patino WD p53 regulates mitochondrial respiration Science 2006 312 1650 1653 16728594
  54. [58]Kondoh H Lleonart ME Gil J Glycolytic enzymes can modulate cellular life span Cancer Res 2005 65 177 185 15665293
  55. [59]Bensaad K Tsuruta A Selak MA TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 2006 126 107 120 16839880
  56. [60]de Souza-Pinto NC Harris CC Bohr VA p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria Oncogene 2004 23 6559 6568 15208669
  57. [61]Achanta G Sasaki R Feng L Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA pol-γ EMBO J 2005 24 3483 3492 PMC1276176 16163384
  58. [62]Nithipongvanitch R Ittarat W Velez JM Zhao R St Clair DK Oberley TD Evidence for p53 as guardian of the cardiomyocyte mitochondrial genome following acute adriamycin treatment J. Histochem. Cytochem 2007 55 6 629 639 17312011
  59. [63]Majno G Joris I Apoptosis, oncosis, and necrosis. An overview of cell death Am. J. Pathol 1995 146 3 15 7856735 PMC1870771
  60. [64]Afford S Randhawa S Demystified … apoptosis J. Clin. Pathol. Mol. Pathol 2000 53 55 63 PMC1186906 10889903
  61. [65]Schwartzman RA Cidlowski JA Apoptosis: the biochemistry and molecular biology of programmed cell death Endocr. Rev 1993 14 2 133 151 8325248
  62. [66]Reed JC Mechanisms of apoptosis Am. J. Pathol 2000 157 5 1415 1430 11073801 PMC1885741
  63. [67]Roy S Nicholson DW Cross-talk in cell death signaling J. Exp. Med 2000 192 8 F21 F25 11034612 PMC2195865
  64. [68]Basu A Castle VP Bouziane M Bhalla K Haldar S Crosstalk between extrinsic and intrainsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family Cancer Res 2006 66 8 4309 4318 16618756
  65. [69]Moll UM Zaika A Nuclear and mitochondrial apoptotic pathways of p53 FEBS Lett 2001 493 65 69 11286997 ▪ This review describes many of the transcriptional-dependent and -independent actions of p53 in apoptosis.
  66. [70]Robles AI Bemmels NA Foraker AB Harris CC APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis Cancer Res 2001 61 6660 6664 11559530
  67. [71]Mirza A McGuirk M Hockenberry TN Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway Oncogene 2002 21 2613 2622 11965534
  68. [72]Hoffman WH Biade S Zilfou JT Chen J Murphy M Transcriptional repression of the anti-apoptotic survivin gene by wild type p53 J. Biol. Chem 2002 277 5 3247 3257 11714700
  69. [73]Haldar S Negrini M Monne M Sabbioni S Croce CM Down-regulation of bcl-2 by p53 in breast cancer cells Cancer Res 1994 54 2095 2097 8174112
  70. [74]Miyashita T Harigai M Hanada M Reed JC Identification of a p53-dependent negative response element in the bcl-2 gene Cancer Res 1994 54 3131 3135 8205530
  71. [75]Nakano K Vousden KH PUMA, a novel proapoptotic gene, is induced by p53 Mol. Cell 2001 7 683 694 11463392
  72. [76]Thornborrow EC Manfredi JJ The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter J. Biol. Chem 2001 276 19 15598 15608 11278953
  73. [77]Thornborrow EC Patel S Mastropietro AE Schwartzfarb EM Manfredi JJ A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes Oncogene 2002 21 990 999 11850816
  74. [78]Murphy ME Leu JI George DL p53 moves to mitochondria. A turn on the path of apoptosis Cell Cycle 2004 3 7 836 839 15190209
  75. [79]Moll UM Wolff S Speidel D Deppert W Transcription-independent pro-apoptotic functions of p53 Curr. Opin. Cell Biol 2005 17 631 636 16226451
  76. [80]Mihara M Erster S Zaika A p53 has a direct apoptogenic role at the mitochondria Mol. Cell 2003 11 577 590 12667443
  77. [81]Deng X Gao F Flagg T Anderson J May WS Bcl2’s flexible loop domain regulates p53 binding and survival Mol. Cell. Biol 2006 26 12 4421 4434 16738310 PMC1489125
  78. [82]Leu JI Dumont P Hafey M Murphy ME George DL Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex Nat. Cell Biol 2004 6 5 443 450 15077116
  79. [83]Pietsch EC Perchiniak E Canutescu AA Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain J. Biol. Chem 2008 283 30 21294 21304 18524770 PMC2475706
  80. [85]Schuler M Bossy-Wetzel E Goldstein JC Fitzgerald P Green DR p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release J. Biol. Chem 2000 275 10 7337 7342 10702305
  81. [86]Chipuk JE Bouchier-Hayes L Kuwana T Newmeyer DD Green DR PUMA couples the nuclear and cytoplasmic proapoptotic function of p53 Science 2005 309 1732 1735 16151013
  82. [87]Pani G Bedogni B Anzevino R Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells Cancer Res 2000 60 4654 4660 10969820
  83. [88]Dhar SK Xu Y Chen Y St Clair DK Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression J. Biol. Chem 2006 281 21698 21709 16740634 PMC2640468
  84. [89]Fridovich I The biology of oxgen radicals Science 1978 201 875 880 210504
  85. [90]Forman HJ Torres M Fukuto J Redox signaling Mol. Cell. Biochem 2002 234–235 49 62 12162460
  86. [91]Forman HJ Fukuto JM Torres M Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers Am. J. Physiol. Cell Physiol 2004 287 C246 C256 15238356
  87. [92]Rhee SG Chang TS Bae YS Lee SR Kang SW Cellular regulation by hydrogen peroxide J. Am. Soc. Nephrol 2003 14 S211 S215 12874433
  88. [93]Droge W Free radicals in the physiological control of cell function Physiol. Rev 2002 82 47 95 11773609
  89. [94]Kabe Y Ando K Hirao S Yoshida M Handa H Redox regulation of NF-κB activation: Distinct redox regulation between the cytoplasm and the nucleus Antioxid. Redox Signal 2005 7 3–4 395 403 15706086
  90. [95]Sen CK Packer L Antioxidant and redox regulation of gene transcription FASEB J 1996 10 709 720 8635688
  91. [96]Poli G Leonarduzzi G Biasi F Chiarpotto E Oxidative stress and cell signaling Curr. Med. Chem 2004 11 1163 1182 15134513
  92. [97]Wang X Martindale JL Liu Y Holbrook NJ The cellular response to oxidative stress: influences of mitogen-activated protein kinase signaling pathways on cell survival Biochem. J 1998 333 291 300 9657968 PMC1219585
  93. [99]Boonstra J Post JA Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells Gene 2004 337 1 13 15276197
  94. [100]Waris G Ahsan H Reactive oxygen species: role in the development of cancer and various chronic conditions J. Carcinog 2006 5 14 21 16689993 PMC1479806
  95. [101]Storz P Reactive oxygen species in tumor progression Front. Biosci 2005 10 1881 1896 15769673
  96. [102]Behrend I Henderson G Zwacka RM Reactive oxygen species in oncogenic transformation Biochem. Soc. Trans 2003 31 6 1441 1444 14641084
  97. [103]Gius D Spitz DR Redox signaling in cancer biology Antioxid. Redox Signal 2006 8 7–8 1249 1252 16910772
  98. [104]Verkaart S Koopman WJH van Ernst-de Vries SE Superoxide production is inversely related to complex I activity in inherited complex I deficiency Biochim. Biophys. Acta 2007 1772 373 381 17289351
  99. [105]Genova ML Ventura B Giuliano G The site of production of superoxide radical in mitochondrial complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2 FEBS Lett 2001 505 364 368 11576529
  100. [106]Dlaskova A Hlavata L Jezek P Oxidative stress caused by blocking of mitochondrial complex I H+ pumping as a link in aging/disease vicious cycle Int. J. Biochem. Cell Biol 2008 40 1792 1805 18291703
  101. [107]Yen HC Oberley TD Gairola CG Szweda LI St Clair DK Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice Arch. Biochem. Biophys 1999 362 1 59 66 9917329
  102. [108]Kakkar P Singh BK Mitochondria: a hub of redox activities and cellular distress control Mol. Cell. Biochem 2007 305 235 253 17562131 ▪ Good review describing the generation of radical oxygen species (ROS) and radical nitrogen species in mitochondria and the role mitochondria play in various cellular processes.
  103. [114]Hoye AT Davoren JE Wipf P Fink MP Kagan VE Targeting mitochondria Acc. Chem. Res 2008 41 1 87 97 18193822
  104. [115]Radi R Cassina A Hodara R Quijano C Castro L Peroxynitrite reactions and formation in mitochondria Free Radic. Biol. Med 2002 33 11 1451 1464 12446202
  105. [116]Fridovich I Oxygen toxicity: a radical explanation J. Exp. Biol 1998 201 1203 1209 9510531
  106. [117]Andreyev AY Kushnareva YE Starkov AA Mitochondrial metabolism of reactive oxygen species Biochemistry Mosc 2005 70 200 214 15807660
  107. [118]Koehler CM Beverley KN Leverich EP Redox pathways of the mitochondrion Antioxid. Redox Signal 2006 8 813 822 16771672
  108. [119]Fridovich I Superoxide dismutases. An adaptation to a paramagnetic gas J. Biol. Chem 1989 264 14 7761 7764 2542241
  109. [121]Okado-Matsumoto A Fridovich I Subcellular distribution of superoxide dismutases (SOD) in rat liver. Cu,Zn-SOD in mitochondria J. Biol. Chem 2001 276 42 38388 38393 11507097
  110. [122]Weisiger RA Fridovich I Mitochondrial superoxide dismutase. Site of synthesis and intramitochondrial localization J. Biol. Chem 1973 248 13 4793 4796 4578091
  111. [123]Hjalmarsson K Marklund SL Engstrom A Edlund T Isolation and sequence of complimentary DNA encoding human extracellular superoxide dismutase Proc. Natl Acad. Sci. USA 1987 84 6340 6344 3476950 PMC299071
  112. [124]Fridovich I Superoxide radical and superoxide dismutases Annu. Rev. Biochem 1995 64 97 112 7574505
  113. [125]Esworthy RS Ho YS Chu FF The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver Arch. Biochem. Biophys 1997 340 59 63 9126277
  114. [126]Maiorino M Scapin M Ursini F Biasolo M Bosello V Flohe L Distinct promoters determine alternative transcription of gpx-4 into phospholipid-hydroperoxide glutathione peroxidase variants J. Biol. Chem 2003 278 36 34286 34290 12819198
  115. [127]Kelner MJ Montoya MA Structural organization of the human glutathione reductase gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence Biochem. Biophys. Res. Commun 2000 269 366 368 10708558
  116. [128]Oberley TD Verwiebe E Zhong W Kang SW Rhee SG Localization of the thioredoxin system in normal rat kidney Free Radic. Biol. Med 2001 30 412 424 11182297
  117. [129]Chang TS Cho CS Park S Yu S Kang SW Rhee SG Peroxiredoxin III, a mitochondrion-specific peroxidase, regulate apoptotic signaling by mitochondria J. Biol. Chem 2004 279 40 41975 41984 15280382
  118. [130]Shibata E Nanri H Ejima K Enhancement of mitochondrial oxidative stress and up-regulation of antioxidant protein peroxiredosin III/SP-22 in the mitochondria of human pre-eclamptic placentae Placenta 2003 24 698 705 12828928
  119. [131]Seo MS Kang SW Kim K Baines IC Lee TH Rhee SG Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate J. Biol. Chem 2000 275 20346 20354 10751410
  120. [132]Lee SR Kim JR Kwon KS Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver J. Biol. Chem 1999 274 8 4722 4734 9988709
  121. [133]Choi JH Kim TN Kim S Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinoma Anticancer Res 2002 22 6A 3331 3335 12530083
  122. [134]Chelikani P Fita I Loewen PC Diversity of structures and properties among catalases Cell. Mol. Life Sci 2004 61 192 208 14745498 PMC11138816
  123. [135]Zamocky M Furtmuller PG Obinger C Evolution of catalases from bacteria to humans Antioxid. Redox Signal 2008 10 9 1527 1547 18498226 PMC2959186
  124. [136]Schrader M Fahimi HD Peroxisomes and oxidative stress Biochim. Biophys. Acta 2006 1763 1755 1766 17034877
  125. [137]Zhou Z Kang YJ Cellular and subcellular localization of catalase in the heart of transgenic mice J. Histochem. Cytochem 2000 48 5 585 594 10769042
  126. [138]Radi R Turrens JF Chang LY Bush KM Crapo JD Freeman BA Detection of catalase in rat heart mitochondria J. Biol. Chem 1991 266 32 22028 22034 1657986
  127. [139]Salvi M Battaglia V Brunati AM Catalase takes part in rat liver mitochondria oxidative stress defense J. Biol. Chem 2007 282 33 24407 24415 17576767
  128. [140]Oktyabrsky ON Smirnova GV Redox regulation of cellular functions Biochemistry Mosc 2007 72 132 145 17367290 ▪ This is a very good review concerning the production of ROS in the cell, cellular anti-oxidant defenses, and the role of ROS in myriad cellular functions.
  129. [141]Ghezzi P Oxidoreduction of protein thiols in redox regulation Biochem. Soc. Trans 2005 33 6 1378 1381 16246123
  130. [142]Yeo WS Lee SJ Lee JR Kim KP Nitrosative protein tyrosine modifications: biochemistry and functional significance BMB Rep 2008 41 194 203 18377722
  131. [143]Monteiro HP Arai RJ Travassos LR Protein tyrosine phosphorylation and protein tyrosine nitration in redox signaling Antioxid. Redox Signal 2008 10 843 889 18220476
  132. [144]Liu B Chen Y St Clair DK ROS and p53: a versatile partnership Free Radic. Biol. Med 2008 44 1529 1535 18275858 PMC2359898 ▪▪ This important review covers the redox regulation and modification of p53 by ROS and their effects on p53 activity.
  133. [145]Marshall HE Merchant K Stamler JS Nitrosation and oxidation in the regulation of gene expression FASEB J 2000 14 1889 1900 11023973
  134. [146]Sun Y Oberley LW Redox regulation of transcriptional activators Free Radic. Biol. Med 1996 21 3 335 348 8855444
  135. [147]Cobbs CS Samanta M Harkins LE Gillespie GY Merrick BA MacMillan-Crow LA Evidence for peroxynitrite-mediated modifications to p53 in human gliomas: possible functional consequences Arch. Biochem. Biophys 2001 394 2 167 172 11594730
  136. [148]Chazotte-Aubert L Hainaut P Ohshima H Nitrix oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells Biochem. Biophys. Res. Commun 2000 267 609 613 10631110
  137. [149]Cobbs CS Whisenhunt TR Wesemann DR Harkins LE Van Meir EG Samanta M Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells Cancer Res 2003 63 8670 8673 14695179
  138. [150]Furukawa A Tada-Oikawa S Kawanishi S Oikawa S H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion Cell. Physiol. Biochem 2007 20 45 54 17595514
  139. [151]Biswas S Chida AS Rahman I Redox modifications of protein-thiols: emerging roles in cell signaling Biochem. Pharmacol 2006 71 551 564 16337153
  140. [152]Klatt P Molina EP de Locaba MG Redox regulation of c-Jun DNA binding by reversible S-glutathionylation FASEB J 1999 13 1481 1490 10463938
  141. [153]Pineda-Molina E Klatt P Vazquez J Glutathionylation of the p50 subunit of NF-κB: a mechanism for redox-induced inhibition of DNA binding Biochemistry 2001 40 14134 14142 11714266
  142. [154]Rainwater R Parks D Anderson ME Tegtmeyer P Mann K Role of cysteine residues in regulation of p53 function Mol. Cell. Biol 1995 15 7 3892 3903 7791795 PMC230629
  143. [155]Wu HH Momand J Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation J. Biol. Chem 1998 273 30 18898 18905 9668066
  144. [156]Buzek J Latonen L Kurki S Peltonen K Laiho M Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine-277 Nucleic Acids Res 2002 30 11 2340 2348 12034820 PMC117181
  145. [157]Velu CS Niture SK Doneanu CE Pattabiraman N Srivenugopal KS Human p53 is inhibited by glutathionylationof cysteines present in the proximal DNA-binding domain during oxidative stress Biochemistry 2007 46 7765 7780 17555331 PMC2518322
  146. [158]Hainaut P Milner J Redox modulation of p53 conformation and sequence-specific DNA binding in vitro Cancer Res 1993 53 4469 4473 8402615 ▪▪ Demonstrates how redox modification of p53 affects its DNA binding activity.
  147. [159]Fojta M Kubicarova T Vojtesek B Palecek E Effect of p53 protein redox states on binding to supercoiled and linear DNA J. Biol. Chem 1999 274 36 25749 25755 10464313
  148. [160]Fojta M Pivonkova H Brazdova M Nemcova K Palecek J Vojtesek B Investigations of the supercoil-selective DNA binding of wild type p53 suggest a novel mechanism for controlling p53 function Eur. J. Biochem 2004 271 3865 3876 15373832
  149. [161]Sun XZ Vinci C Makmura L Formation of disulfide bond in p53 correlates with inhibition of DNA binding and tetramerization Antioxid. Redox Signal 2003 5 5 655 665 14580323
  150. [162]Liu M Pelling JC Ju J Chu E Brash DE Antioxidant action via p53-mediated apoptosis Cancer Res 1998 58 1723 1729 9563490
  151. [163]Seo YR Kelley MR Smith ML Selenomethionine regulation of p53 by a ref1-dependent redox mechanism Proc. Natl Acad. Sci. USA 2002 22 14548 14553 12357032 PMC137920
  152. [164]Smith ML Lancia JK Mercer TI Ip C Selenium compounds regulate p53 by common and distinctive mechanisms Anticancer Res 2004 24 3a 1401 1408 15274301
  153. [166]Bolshakov S Walker CM Strom SS p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas Clin. Cancer Res 2003 9 228 234 12538474
  154. [167]Murphy ME Polymorphic variants in the p53 pathway Cell Death Differ 2006 13 916 920 16557270
  155. [168]Pietsch EC Humbey O Murphy ME Polymorphisms in the p53 pathway Oncogene 2006 25 1602 1611 16550160
  156. [169]Pezeshki A Sari-Aslani F Ghaderi A Doroudchi M p53 codon 72 polymorphism in basal cell carcinoma of the skin Pathol. Oncol. Res 2006 12 1 29 33 16554913
  157. [170]Bendesky A Rosales A Salazar AM Sordo M Peniche J Ostrosky-Wegman P p53 codon 72 polymorphism, DNA damage and repair, and risk of non-melanoma skin cancer Mutat. Res 2007 619 38 44 17403527
  158. [171]Dumont P Leu JI Pietra ACD 3rd George DL Murphy M The codon 72 polymorphic variants of p53 have markedly different apoptotic potential Nat. Genet 2003 33 357 365 12567188 ▪ The authors show the differences in apoptotic potential between a proline and arginine variants at codon 72 of p53. Part of the difference in apoptotic potential between the variants is the greater ability for the arginine variant to translocate to mitochondria.
  159. [172]Karawajew L Rhein P Czerwony G Ludwig WD Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species Blood 2005 105 4767 4775 15705792
  160. [173]Zhao Y Chaiswing L Velez JM p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase Cancer Res 2005 65 9 3745 3750 15867370 ▪▪ Shows that p53 transcriptional activity is affected by mitochondrial ROS. Treatment of cells with a MnSOD mimetic prevented TPA-induced transcription of p53 target gene bax.
  161. [174]Liu J St Clair DK Gu X Zhao Y Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion FEBS Lett 2008 582 1319 1324 18358838 PMC2367455
  162. [175]Chandel NS Schumacker PT Cellular oxygen sensing by mitochondria: old questions, new insight J. Appl. Physiol 2000 88 1880 1889 10797153 ▪▪ The authors demonstrate that mitochondrial ROS produced as a result of hypoxia leads to increased p53 stability.
  163. [176]Duranteau J Chandel NS Kulisz A Shao Z Schumacker PT Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes J. Biol. Chem 1998 273 19 11619 11624 9565580
  164. [177]Chandel NS Vander Heiden MG Thompson CB Schumacker PT Redox regulation of p53 during hypoxia Oncogene 2000 19 3840 3848 10951577
  165. [178]Sansome C zaika A Marchenko ND Moll UM Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells FEBS Lett 2001 488 110 115 11163756
  166. [179]Molho-Pessach V Lotem M Tur E Ultraviolet radiation and cutaneous carcinogenesis Current Problems in Dermatology 2007 Switzerland Karger, Basel 14 27 17641487
  167. [180]Agar NS Halliday GM Barnetson RS Ananthaswamy HN Wheeler M Jones AM The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: A role for UVA in human skin carcinogenesis Proc. Natl. Acad. Sci.USA 2004 101 4954 4959 15041750 PMC387355
  168. [182]He YY Council SE Feng L Chignell CF UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/cyclin D1 pathways in keratinocytes Cancer Res 2008 68 3752 3758 18483258 PMC2666770
  169. [183]Runger TM Kappes UP Mechanisms of mutation formation with long-wave ultraviolet light (UVA) Photodermatol. Photoimmunol. Photomed 2008 24 2 10 18201350
  170. [184]Pfeifer GP You YH Besaratinia A Mutations induced by ultraviolet light Mutat. Res 2005 571 19 31 15748635
  171. [186]Sander CS Chang H Hamm F Elsner P Thiele JJ Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis Int. J. Dermatol 2004 43 326 335 15117361
  172. [187]Phillipson RP Tobi SE Morris JA McMillan TJ UV-A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism Free Radic. Biol. Med 2002 32 5 474 480 11864787
  173. [188]Hazane F Sauvaigo S Douki T Favier A Beani JC Age-dependent DNA repair and cell cycle distribution of human skin fibroblasts in response to UVA irradiation J. Photochem. Photobiol. B, Biol 2006 82 214 223 16460955
  174. [189]Shorrocks J Paul ND McMillan TJ The dose rate of UVA treatment influences the cellular response of HaCaT keratinocytes J. Invest. Dermatol 2008 128 685 693 17762856
  175. [190]Latonen L Laiho M Cellular UV damage responses - Functions of tumor suppressor p53 Biochim. Biophys. Acta 2005 1755 71 89 15921859
  176. [192]Zhang H p53 plays a central role in UVA and UVB induced cell damage and apoptosis in melanoma cells Cancer Lett 2006 244 229 238 16504377
  177. [193]Tada-Oikawa S Oikawa S Kawanishi S Role of ultraviolet A-induced oxidative DNA damage in apoptosis via loss of mitochondrial membrane potential and caspase-3 activation Biomchem. Biophys. Res. Commun 1998 247 693 696 9647755
  178. [194]Gniadecki R Thorn T Vicanova J Petersen A Wulf HC Role of mitochondria in ultraviolet-induced oxidative stress J. Cell. Biochem 2000 80 216 222 11074592
  179. [195]Paz ML Maglio DHG Weill FS Bustamante J Leoni J Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes Photodermatol. Photoimmunol. Photomed 2008 24 115 122 18477129

Cited by

Sorted by citations

Authors
Holley, A. K., & St Clair, D. K.
Affiliations
  • University of Kentucky (US)
  • Graduate Center for Toxicology, 454 HSRB, University of Kentucky, Lexington, KY40536, USA.
Venue
Future Oncology
Publisher
Informa UK Limited
Published
2009-02-26
Volume
5
Issue
1
Pages
117-130
ISSN
  • 1479-6694 (ISSN-L)
  • 1744-8301
DOI
10.2217/14796694.5.1.117
PMC
PMC2710969
OpenAlex
W2013674982
Cited by
75
References
16
Citations by year
2025: 1 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 7 · 2012: 7
FWCI
0.85
Type
journal article
Language
en
Open access
Locations
  • Future Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA073599, R01CA139843, R01CA049797)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
p53, mitochondria, p53 regulation, reactive oxygen species, apoptosis, DNA damage response, cell cycle regulation, DNA repair, cancer
MeSH terms
Animals, Humans, Mitochondria, Neoplasms, Tumor Suppressor Protein p53, Apoptosis, Reactive Oxygen Species

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