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Cited by 22Mitochondrial Function and PathologyStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

The mitochondrion as a primary site of action of regulatory agents involved in neuroimmunomodulation

PSARRA, A.M.G., SOLAKIDI, S., SEKERIS, C.E.·2006·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1366.019
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Abstract

A major system of neuroimmunomodulation is the hypothalamic-pituitary-adrenocortical (HPA) axis, acting through glucocorticoids and their intracellular signaling components, exerting both stimulatory and inhibitory effects on the immune reaction. Glucocorticoids inhibit the production of proinflammatory cytokines by interacting with nuclear transcription factors (nuclear factor [NF]-kappaB, activated protein [AP]-1) and induce the production of several anti-inflammatory cytokines by gene activation. In some cells and/or in extreme stress conditions, apoptosis is evoked. In most processes related to neuroimmunomodulation a prominent role is emerging for mitochondria. These organelles generate more than 90% of the cell's energy requirements through oxidative phosphorylation (OXPHOS), which is regulated by several agents, including steroid and thyroid hormones. These hormones are inducers of nuclear and mitochondrial OXPHOS gene transcription and they exert a primary action not only on nuclear but also on mitochondrial genes by way of cognate receptors. Recently, additional nuclear transcription factors involved in neuroimmunomodulation have been detected in mitochondria (NF-kappaB, AP-1, p53, calcium/cAMP response element binding protein [CREB]), and binding sites of these and putative binding sites of other nuclear transcription factors have been identified in the mitochondrial genome. The interaction of these factors with mitochondrial regulatory proteins, with receptors and…

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  • Hormone-responsive elements are also found in nuclear genes encoding mitochondrial transcription factors that modulate OXPHOS gene expression.

    “tThese hormone-responsible elements are also found in nuclear gene encoding mitochondrial transcription factors that also modulate OXPHOS gene expression (Psarra et al., 2006).”

    From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Psarra et al., 2006

  • Appropriate receptors can interact with these sequences to induce hormone-dependent mitochondrial gene expression.

    “The appropriate receptors can interact with these sequences to induce hormone-dependent mitochondrial gene expression (Psarra et al., 2006).”

    From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Psarra et al., 2006

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Authors
PSARRA, A. M. G., SOLAKIDI, S., & SEKERIS, C. E.
Affiliations
  • Academy of Athens (GR)
  • National Hellenic Research Foundation (GR)
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2006-11
Volume
1088
Issue
1
Pages
12-22
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1366.019
OpenAlex
W2149072906
Cited by
22
References
48
Citations by year
2026: 1 · 2022: 3 · 2021: 1 · 2018: 1 · 2016: 2 · 2013: 1
FWCI
0.24
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 37 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation) (submittedVersion)
Funders
Bodossaki Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
mitochondria, neuroimmunomodulation, hypothalamic-pituitary-adrenal axis, glucocorticoids, oxidative phosphorylation, mitochondrial transcription, nuclear transcription factors, NF-κB, AP-1, p53, CREB, mitochondrial genome, apoptosis, steroid hormones, thyroid hormones, energy metabolism
MeSH terms
Animals, Humans, Mitochondria, Oxidative Phosphorylation, Receptors, Steroid, Transcription Factors, Neuroimmunomodulation, Apoptosis

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