The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Tumor-Targeted Drug Delivery and MRI Contrast Enhancement by Chlorotoxin-Conjugated Iron Oxide Nanoparticles
Open accessAbstract
AIMS: This study examines the capabilities of an actively targeting superparamagnetic nanoparticle to specifically deliver therapeutic and MRI contrast agents to cancer cells. MATERIALS & METHODS: Iron oxide nanoparticles were synthesized and conjugated to both a chemotherapeutic agent, methotrexate, and a targeting ligand, chlorotoxin, through a poly(ethylene glycol) linker. Cytotoxicity of this nanoparticle conjugate was evaluated by Alamar Blue cell viability assays, while tumor-cell specificity was examined in vitro and in vivo by MRI. RESULTS & DISCUSSION: Characterization of these multifunctional nanoparticles confirms the successful attachment of both drug and targeting ligands. The targeting nanoparticle demonstrated preferential accumulation and increased cytotoxicity in tumor cells. Furthermore, prolonged retention of these nanoparticles was observed within tumors in vivo. CONCLUSION: The improved specificity, extended particle retention and increased cytotoxicity toward tumor cells demonstrated by this multifunctional nanoparticle system suggest that it possesses potential for applications in cancer diagnosis and treatment.
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Nanocarriers as an emerging platform for cancer therapy
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Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Maeda, H. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00013-3 · Cited by 2,495
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022749 · Cited by 1,971
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Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570
Magnetic Iron Oxide Nanoparticle (IONP) Synthesis to Applications: Present and Future
Ajinkya, N., Yu, X., Kaithal, P., Luo, H., Somani, P., & Ramakrishna, S. (2020) · Materials · doi:10.3390/ma13204644 · Cited by 362
Inorganic nanoparticles: A potential cancer therapy for human welfare
Pugazhendhi, A., Edison, T. N. J. I., Karuppusamy, I., & Kathirvel, B. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.01.034 · Cited by 325
Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications
Monteserín, M., Larumbe, S., Martínez, A. V., Burgui, S., & Francisco Martín, L. (2021) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2021.19062 · Cited by 27
Applications and Efficacy of Iron Oxide Nanoparticles in the Treatment of Brain Tumors
Varalli, L., Berlet, R., Abenojar, E., McDaid, J., Gascoigne, D. A., Bailes, J., & Aksenov, D. P. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17040499 · Cited by 23
Metadata
- Authors
- Sun, C., Fang, C., Stephen, Z., Veiseh, O., Hansen, S., Lee, D., Ellenbogen, R. G., Olson, J., & Zhang, M.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2008-08
- Volume
- 3
- Issue
- 4
- Pages
- 495-505
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2171827583
- Cited by
- 213
- References
- 4
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Sun, C., Fang, C., Stephen, Z., Veiseh, O., Hansen, S., Lee, D., Ellenbogen, R. G., Olson, J., & Zhang, M. (2008). Tumor-Targeted Drug Delivery and MRI Contrast Enhancement by Chlorotoxin-Conjugated Iron Oxide Nanoparticles. Nanomedicine. https://doi.org/10.2217/17435889.3.4.495
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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