The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Sensitive Periods in Epigenetics: Bringing us Closer to Complex Behavioral Phenotypes
Abstract
Genetic studies have attempted to elucidate causal mechanisms for the development of complex disease, but genome-wide associations have been largely unsuccessful in establishing these links. As an alternative link between genes and disease, recent efforts have focused on mechanisms that alter the function of genes without altering the underlying DNA sequence. Known as epigenetic mechanisms, these include DNA methylation, chromatin conformational changes through histone modifications, ncRNAs and, most recently, 5-hydroxymethylcytosine. Although DNA methylation is involved in normal development, aging and gene regulation, altered methylation patterns have been associated with disease. It is generally believed that early life constitutes a period during which there is increased sensitivity to the regulatory effects of epigenetic mechanisms. The purpose of this review is to outline the contribution of epigenetic mechanisms to genomic function, particularly in the development of complex behavioral phenotypes, focusing on the sensitive periods.
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“Recent work has identified some of the GRN components activated in these periods (73, 74).”
From Behavior-related gene regulatory networks: A new level of organization in the brain (2020) · cites this paper as [73]
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Cites
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Epigenetic differences arise during the lifetime of monozygotic twins
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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
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Self-citationCANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS
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Research works printed but not linked: 1
- 10.1016/j.biopsych.2008.11.028 · DOI · Paper page
Cited by
Astrocytic abnormalities and global DNA methylation patterns in depression and suicide
Nagy, C., Suderman, M., Yang, J., Szyf, M., Mechawar, N., Ernst, C., & Turecki, G. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.21 · Cited by 301
Self-citationAt least eighty percent of brain grey matter is modifiable by physical activity: A review study
Batouli, S. A. H., & Saba, V. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.002 · Cited by 92
Behavior-related gene regulatory networks: A new level of organization in the brain
Sinha, S., Jones, B. M., Traniello, I. M., Bukhari, S. A., Halfon, M. S., Hofmann, H. A., Huang, S., Katz, P. S., Keagy, J., Lynch, V. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921625117 · Cited by 85
James, S. J., Shpyleva, S., Melnyk, S., Pavliv, O., & Pogribny, I. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.87 · Cited by 79
Maternal caregiving and DNA methylation in human infants and children: systematic review
Provenzi, L., Brambilla, M., Scotto di Minico, G., Montirosso, R., & Borgatti, R. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12616 · Cited by 60
Metadata
- Authors
- Nagy, C., & Turecki, G.
- Affiliations
- McGill Group for Suicide Studies, Douglas Hospital University Institute, 6875 Lasalle boul, Montreal, QC, Canada
- Venue
- Epigenomics
- Publisher
- Informa UK Limited
- Published
- 2012-08
- Volume
- 4
- Issue
- 4
- Pages
- 445-457
- ISSN
- 1750-1911
- 1750-192X
- Cited by
- 69
- References
- 135
- Language
- en
- Funders
- Canadian Institutes of Health Research (MOP 84291)
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