Sensitive Periods in Epigenetics: Bringing us Closer to Complex Behavioral Phenotypes

Chromatin modifications and their function

Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,914

The language of covalent histone modifications

Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679

Epigenetic programming by maternal behavior

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492

Epigenetic differences arise during the lifetime of monozygotic twins

Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531

CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS

WADDINGTON, C. H. (1942) · Nature · doi:10.1038/150563a0 · Cited by 3,255

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170

Epigenetic Reprogramming in Mammalian Development

Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

He, Y.-F., Li, B.-Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, L., et al. (2011) · Science · doi:10.1126/science.1210944 · Cited by 2,770

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Ito, S., D’Alessio, A. C., Taranova, O. V., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,373

Hsp90 as a capacitor for morphological evolution

Rutherford, S. L., & Lindquist, S. (1998) · Nature · doi:10.1038/24550 · Cited by 2,270

Histone demethylation by a family of JmjC domain-containing proteins

Tsukada, Y.-I., Fang, J., Erdjument‐Bromage, H., Warren, M., Borchers, C. H., Tempst, P., & Zhang, Y. (2005) · Nature · doi:10.1038/nature04433 · Cited by 2,248

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020

Transposable elements: targets for early nutritional effects on epigenetic gene regulation

Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019

DNA Modification Mechanisms and Gene Activity During Development

Holliday, R., & Pugh, J. E. (1975) · Science · doi:10.1126/science.187.4173.226 · Cited by 1,973

Methylation-Induced Repression— Belts, Braces, and Chromatin

Bird, A. P., & Wolffe, A. P. (1999) · Cell · doi:10.1016/s0092-8674(00)81532-9 · Cited by 1,864

Sensitive periods in the development of the brain and behavior

Knudsen, E. I. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/0898929042304796 · Cited by 1,842

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

Metzger, E., Wissmann, M., Yin, N., Müller, J. M., Schneider, R., Peters, A. H. F. M., Günther, T., Buettner, R., & Schüle, R. (2005) · Nature · doi:10.1038/nature04020 · Cited by 1,733

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008) · Epigenetics · doi:10.4161/epi.3.2.6034 · Cited by 1,432

Hsp90 as a capacitor of phenotypic variation

Queitsch, C., Sangster, T. A., & Lindquist, S. (2002) · Nature · doi:10.1038/nature749 · Cited by 1,372

X inactivation, differentiation, and DNA methylation

Riggs, A. D. (1975) · Cytogenetic and Genome Research · doi:10.1159/000130315 · Cited by 1,342

Lasting epigenetic influence of early-life adversity on the BDNF gene

Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273

How Are Alkynes Scrambled?

Bunz, U. H. F. (2005) · Science · doi:10.1126/science.1111098 · Cited by 1,243

Recovery of learning and memory is associated with chromatin remodelling

Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227

Covalent Modification of DNA Regulates Memory Formation

Miller, C. A., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.022 · Cited by 1,182

Dynamic DNA methylation programs persistent adverse effects of early-life stress

Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162

Dnmt3a is essential for hematopoietic stem cell differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.1009 · Cited by 1,122

Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

Mueller, B. R., & Bale, T. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1424-08.2008 · Cited by 988

Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life

Weaver, I. C. G., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J., & Szyf, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3652-05.2005 · Cited by 905

Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

Alarcón, J. M., Malleret, G., Touzani, K., Vronskaya, S., Ishii, S., Kandel, E. R., & Barco, A. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.021 · Cited by 892

Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects

Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S. A., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0296-07.2007 · Cited by 831

CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation

Korzus, E., Rosenfeld, M. G., & Mayford, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.002 · Cited by 823

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

Lubin, F. D., Roth, T. L., & Sweatt, J. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1786-08.2008 · Cited by 793

Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis

Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773

Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood

Weaver, I. C. G., Meaney, M. J., & Szyf, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507526103 · Cited by 771

Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring

Champagne, F. A., Weaver, I. C. G., Diorio, J., Dymov, S., Szyf, M., & Meaney, M. J. (2006) · Endocrinology · doi:10.1210/en.2005-1119 · Cited by 675

Neuronal activity modifies the DNA methylation landscape in the adult brain

Guo, J. U., Ma, D. K., Mo, H., Ball, M. P., Jang, M.-H., Bonaguidi, M. A., Balazer, J. A., Eaves, H. L., Xie, B., Ford, E., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2900 · Cited by 669

Decline in genomic DNA methylation through aging in a cohort of elderly subjects

Bollati, V., Schwartz, J. D., Wright, R. O., Litonjua, A. A., Tarantini, L., Suh, H. H., Sparrow, D., Vokonas, P., & Baccarelli, A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.003 · Cited by 619

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.Preprint

Watt, F., & Molloy, P. L. (1988) · Genes & Development · doi:10.1101/gad.2.9.1136 · Cited by 611

The genetics of schizophrenia and bipolar disorder: dissecting psychosis

Craddock, N., O’Donovan, M. C., & Owen, M. J. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.030718 · Cited by 574

Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications

Lillycrop, K. A., Slater-Jefferies, J. L., Hanson, M. A., Godfrey, K. M., Jackson, A. A., & Burdge, G. C. (2007) · British Journal of Nutrition · doi:10.1017/s000711450769196x · Cited by 564

Reelin promoter hypermethylation in schizophrenia

Grayson, D. R., Jia, X., Chen, Y., Sharma, R. P., Mitchell, C. P., Guidotti, A., & Costa, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503736102 · Cited by 553

Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear

Bredy, T. W., Wu, H., Crego, C., Zellhoefer, J., Sun, Y. E., & Barad, M. (2007) · Learning & Memory · doi:10.1101/lm.500907 · Cited by 548

Epigenetic and immune function profiles associated with posttraumatic stress disorder

Uddin, M., Aiello, A. E., Wildman, D. E., Koenen, K. C., Pawelec, G., de los Santos, R., Goldmann, E., & Galea, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910794107 · Cited by 518

Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor

Radtke, K. M., Ruf, M., Gunter, H. M., Dohrmann, K., Schauer, M., Meyer, A., & Elbert, T. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.21 · Cited by 511

The Transcription Factor Nerve Growth Factor-Inducible Protein A Mediates Epigenetic Programming: Altering Epigenetic Marks by Immediate-Early Genes

Weaver, I. C. G., D'Alessio, A. C., Brown, S. E., Hellstrom, I. C., Dymov, S., Sharma, S., Szyf, M., & Meaney, M. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4164-06.2007 · Cited by 508

Epigenetic mechanisms in mammals

Kim, J. K., Samaranayake, M., & Pradhan, S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8432-4 · Cited by 498

Genome-wide epigenetic regulation by early-life trauma

Labonté, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Mechawar, N., Szyf, M., Meaney, M. J., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2287 · Cited by 488

Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults

Tyrka, A. R., Price, L. H., Marsit, C., Walters, O. C., & Carpenter, L. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030148 · Cited by 486

The Epigenetics of Sex Differences in the Brain: Figure 1.

McCarthy, M. M., Auger, A. P., Bale, T. L., De Vries, G. J., Dunn, G. A., Forger, N. G., Murray, E. K., Nugent, B. M., Schwarz, J. M., & Wilson, M. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3331-09.2009 · Cited by 483

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr416 · Cited by 460

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice

Elliott, E., Ezra-Nevo, G., Regev, L., Neufeld-Cohen, A., & Chen, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2642 · Cited by 436

Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia

Ingrosso, D., Cimmino, A., Perna, A. F., Masella, L., De Santo, N. G., De Bonis, M. L., Vacca, M., D'Esposito, M., D'Urso, M., Galletti, P., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13372-7 · Cited by 427

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

Uchida, S., Hara, K., Kobayashi, A., Otsuki, K., Yamagata, H., Hobara, T., Suzuki, T., Miyata, N., & Watanabe, Y. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.023 · Cited by 398

Timing is everything: The when and how of environmentally induced changes in the epigenome of animals

Faulk, C., & Dolinoy, D. C. (2011) · Epigenetics · doi:10.4161/epi.6.7.16209 · Cited by 386

Identification of genetic elements that autonomously determine DNA methylation states

Lienert, F., Wirbelauer, C., Som, I., Dean, A., Mohn, F., & Schübeler, D. (2011) · Nature Genetics · doi:10.1038/ng.946 · Cited by 386

Global profiling of DNA methylation erasure in mouse primordial germ cellsPreprint

Guibert, S., Forné, T., & Weber, M. (2012) · Genome Research · doi:10.1101/gr.130997.111 · Cited by 385

Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects

Keller, S., Sarchiapone, M., Zarrilli, F., Videtič, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.9 · Cited by 379

Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain

McGowan, P. O., Sasaki, A., Huang, T. C. T., Unterberger, A., Suderman, M., Ernst, C., Meaney, M. J., Turecki, G., & Szyf, M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002085 · Cited by 372

Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability

(2011) · Epigenetics · doi:10.4161/epi.6.7.16537 · Cited by 368

Epigenetic influences on brain development and plasticity

Fagiolini, M., Jensen, C. L., & Champagne, F. A. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.009 · Cited by 362

Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters

Huang, H.-S., Matevossian, A., Whittle, C., Kim, S. Y., Schumacher, A., Baker, S. P., & Akbarian, S. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3272-07.2007 · Cited by 352

Differential Glucocorticoid Receptor Exon 1B, 1C, and 1H Expression and Methylation in Suicide Completers with a History of Childhood Abuse

Labonte, B., Yerko, V., Gross, J., Mechawar, N., Meaney, M. J., Szyf, M., & Turecki, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.034 · Cited by 345

Epigenetic Reprogramming in Mammalian Development

Lepikhov, K., Arand, J., Wossidlo, M., & Walter, J. (2012) · Encyclopedia of Molecular Cell Biology and Molecular Medicine · doi:10.1002/3527600906.mcb.201100038 · Cited by 336

GABAA Receptor Promoter Hypermethylation in Suicide Brain: Implications for the Involvement of Epigenetic Processes

Poulter, M. O., Du, L., Weaver, I. C. G., Palkovits, M., Faludi, G., Merali, Z., Szyf, M., & Anisman, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.028 · Cited by 331

Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression: Characterization of Intracellular Mediators and Potential Genomic Target Sites

WEAVER, I. C. G., DIORIO, J., SECKL, J. R., SZYF, M., & MEANEY, M. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.099 · Cited by 327

MicroRNA Expression Is Down-Regulated and Reorganized in Prefrontal Cortex of Depressed Suicide Subjects

Smalheiser, N. R., Lugli, G., Rizavi, H. S., Torvik, V. I., Turecki, G., & Dwivedi, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033201 · Cited by 324

Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder

Roth, T. L., Zoladz, P. R., Sweatt, J. D., & Diamond, D. M. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.013 · Cited by 323

DNA Methylation and Silencing of Gene Expression

Newell-Price, J., Clark, A. J. L., & King, P. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00248-4 · Cited by 303

An evaluation of new criteria for CpG islands in the human genome as gene markers

Wang, Y., & Leung, F. C.-C. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth059 · Cited by 276

Maternal Care and DNA Methylation of a Glutamic Acid Decarboxylase 1 Promoter in Rat Hippocampus

Zhang, T.-Y., Hellstrom, I. C., Bagot, R. C., Wen, X., Diorio, J., & Meaney, M. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1039-10.2010 · Cited by 267

Long‐lasting depression‐like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury

Onishchenko, N., Karpova, N., Sabri, F., Castrén, E., & Ceccatelli, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05484.x · Cited by 263

A survey of genetic and epigenetic variation affecting human gene expression

Pastinen, T., Sladek, R., Gurd, S., Sammak, A., Ge, B., Lepage, P., Lavergne, K., Villeneuve, A., Gaudin, T., Brändström, H., et al. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00163.2003 · Cited by 260

Epigenetic lesions causing genetic lesions in human cancer

Esteller, M. (2000) · European Journal of Cancer · doi:10.1016/s0959-8049(00)00303-8 · Cited by 258

DNA Methylation Status ofSOX10Correlates with Its Downregulation and Oligodendrocyte Dysfunction in Schizophrenia

Iwamoto, K., Bundo, M., Yamada, K., Takao, H., Iwayama‐Shigeno, Y., Yoshikawa, T., & Kato, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0766-05.2005 · Cited by 243

Occurrence of 5-Methyl-Cytosine in Nucleic Acids

Wyatt, G. R. (1950) · Nature · doi:10.1038/166237b0 · Cited by 238

Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers

Ernst, C., Deleva, V., Deng, X., Sequeira, A., Pomarenski, A., Klempan, T., Ernst, N., Quirion, R., Gratton, A., Szyf, M., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archpsyc.66.1.22 · Cited by 235

GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia

Huang, H., & Akbarian, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000809 · Cited by 223

DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy

Sapienza, C., Lee, J. Y. H., Powell, J., Erinle, O., Yafai, F., Reichert, J., Siraj, E. S., & Madaio, M. P. (2011) · Epigenetics · doi:10.4161/epi.6.1.13362 · Cited by 208

A new theory of carcinogenesis

Holliday, R. (1979) · British Journal of Cancer · doi:10.1038/bjc.1979.216 · Cited by 206

The effect of early musical training on adult motor performance: evidence for a sensitive period in motor learning

Watanabe, D. H., Savion‐Lemieux, T., & Penhune, V. B. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0619-z · Cited by 206

RESEARCHES ON PYRIMIDINES. C111. THE DISCOVERY OF 5-METHYL-CYTOSINE IN TUBERCULINIC ACID, THE NUCLEIC ACID OF THE TUBERCLE BACILLUS1

Johnson, T. B., & Coghill, R. D. (1925) · Journal of the American Chemical Society · doi:10.1021/ja01688a030 · Cited by 201

Peripubertal environmental enrichment reverses the effects of maternal care on hippocampal development and glutamate receptor subunit expression

Bredy, T. W., Zhang, T. Y., Grant, R. J., Diorio, J., & Meaney, M. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03599.x · Cited by 196

Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons

Iwamoto, K., Bundo, M., Ueda, J., Oldham, M. C., Ukai, W., Hashimoto, E., Saito, T., Geschwind, D. H., & Kato, T. (2011) · Genome Research · doi:10.1101/gr.112755.110 · Cited by 189

Stress-Related Methylation of the Catechol- O -Methyltransferase Val 158 Allele Predicts Human Prefrontal Cognition and Activity

Ursini, G., Bollati, V., Fazio, L., Porcelli, A., Iacovelli, L., Catalani, A., Sinibaldi, L., Gelao, B., Romano, R., Rampino, A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6631-10.2011 · Cited by 188

Sequential DNA Methylation of the Nanog and Oct-4 Upstream Regions in Human NT2 Cells during Neuronal Differentiation

Deb‐Rinker, P., Ly, D., Jezierski, A., Sikorska, M., & Walker, P. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400479200 · Cited by 185

The impact of early identification of permanent childhood hearing impairment on speech and language outcomes

Pimperton, H., & Kennedy, C. (2012) · Archives of Disease in Childhood · doi:10.1136/archdischild-2011-301501 · Cited by 185

Rhythm synchronization performance and auditory working memory in early- and late-trained musicians

Bailey, J. A., & Penhune, V. B. (2010) · Experimental Brain Research · doi:10.1007/s00221-010-2299-y · Cited by 176

Early Stress and Adult Emotional Reactivity in Rhesus Monkeys

Suomi, S. J. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514047.ch11 · Cited by 167

Epigenetics in atherosclerosis and inflammation

Wierda, R. J., Geutskens, S. B., Jukema, J. W., Quax, P. H. A., & van den Elsen, P. J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01022.x · Cited by 165

Impulsivity, aggression and suicidal behavior in unipolar and bipolar disorders

Perroud, N. A., Baud, P., Mouthon, D., Courtet, P., & Malafosse, A. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.05.048 · Cited by 157

Epigenetic regulation of BDNF expression according to antidepressant response

Lopez, J. P., Mamdani, F., Labonte, B., Beaulieu, M.-M., Yang, J. P., Berlim, M. T., Ernst, C., & Turecki, G. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.38 · Cited by 146

Genomic imprinting.Preprint

Monk, M. (1988) · Genes & Development · doi:10.1101/gad.2.8.921 · Cited by 142

KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress

Jakobsson, J., Cordero, M. I., Bisaz, R., Groner, A. C., Busskamp, V., Bensadoun, J., Cammas, F. M., Losson, R., Mansuy, I. M., Sandi, C., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.036 · Cited by 137

Methylation Status of the Reelin Promoter Region in the Brain of Schizophrenic Patients

Tochigi, M., Iwamoto, K., Bundo, M., Komori, A., Sasaki, T., Kato, N., & Kato, T. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.003 · Cited by 136

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Kaminsky, Z. A., Tochigi, M., Jia, P., Pal, M., Mill, J. S., Kwan, A., Ioshikhes, I. P., Vincent, J. B., Kennedy, J. L., Strauss, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.64 · Cited by 136

Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans

Martino, D., Tulić, M. K., Gordon, L., Hodder, M. L., Richman, T. R., Metcalfe, J. R., Prescott, S. L., & Saffery, R. (2011) · Epigenetics · doi:10.4161/epi.6.9.16401 · Cited by 135

Histone Deacetylases and Mood Disorders: Epigenetic Programming in Gene‐Environment Interactions

Machado‐Vieira, R., Ibrahim, L. A., & Zarate, C. A. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00203.x · Cited by 121

Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 17 glucocorticoid receptor promoter region

Daniels, W. M. U., Fairbairn, L., van Tilburg, G., McEvoy, C. R. E., Zigmond, M. J., Russell, V. A., & Stein, D. J. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-009-9163-4 · Cited by 118

Aging and epigenetics: Longitudinal changes in gene-specific DNA methylation

Madrigano, J., Baccarelli, A., Mittleman, M. A., Sparrow, D., Vokonas, P., Tarantini, L., & Schwartz, J. D. (2012) · Epigenetics · doi:10.4161/epi.7.1.18749 · Cited by 114

MECP2 promoter methylation and X chromosome inactivation in autism

Nagarajan, R. P., Patzel, K. A., Martin, M. R., Yasui, D. H., Swanberg, S. E., Hertz‐Picciotto, I., Hansen, R. L., de Water, J. V., Pessah, I. N., Jiang, R., et al. (2008) · Autism Research · doi:10.1002/aur.24 · Cited by 109

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Bailey, J. A., & Penhune, V. B. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06434.x · Cited by 109

MicroRNA in schizophrenia: Genetic and expression analysis of miR-130b (22q11)

Burmistrova, O., Goltsov, A. Y., Abramova, L. I., Каледа, В. Г., Александровна, О. В., & Rogaev, E. I. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907050161 · Cited by 102

Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers

Ernst, C., Chen, E. S., & Turecki, G. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.35 · Cited by 98

DiseaseMeth: a human disease methylation database

Lv, J., Liu, H., Su, J., Wu, X., Liu, H., Li, B., Xiao, X., Wang, F., Wu, Q., & Zhang, Y. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1169 · Cited by 98

From Waddington’s epigenetic landscape to small noncoding RNA: some important milestones in the history of epigenetics research

Choudhuri, S. (2011) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2011.559695 · Cited by 91

Regulation of Expression and Activity of DNA (Cytosine-5) Methyltransferases in Mammalian Cells

Kinney, S. R. M., & Pradhan, S. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-387685-0.00009-3 · Cited by 88

Age-associated epigenetic modifications in human DNA increase its immunogenicity

Agrawal, A., Tay, J., Yang, G., Agrawal, S., & Gupta, S. (2010) · Aging · doi:10.18632/aging.100121 · Cited by 84

The role of microRNAs in synaptic plasticity, major affective disorders and suicidal behavior

Serafini, G., Pompili, M., Innamorati, M., Giordano, G., Montebovi, F., Sher, L., Dwivedi, Y., & Girardi, P. (2012) · Neuroscience Research · doi:10.1016/j.neures.2012.04.001 · Cited by 82

Leukocyte DNA Methylation Signature Differentiates Pancreatic Cancer Patients from Healthy Controls

Pedersen, K. S., Bamlet, W. R., Oberg, A. L., de Andrade, M., Matsumoto, M., Tang, H. D., Thibodeau, S. N., Petersen, G. M., & Wang, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018223 · Cited by 80

Characterization of QKI Gene Expression, Genetics, and Epigenetics in Suicide Victims with Major Depressive Disorder

Klempan, T. A., Ernst, C., Deleva, V., Labonté, B., & Turecki, G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.010 · Cited by 78

DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2

Chertkow-Deutsher, Y., Cohen, H., Klein, E., & Ben‐Shachar, D. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570999071x · Cited by 74

Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior

Guipponi, M., Deutsch, S., Kohler, K., Perroud, N. A., Gal, F. L., Vessaz, M., Laforge, T., Petit, B., Jollant, F., Guillaume, S., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30901 · Cited by 71

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Fiori, L. M., & Turecki, G. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.015 · Cited by 69

Sensitive period for white‐matter connectivity of superior temporal cortex in deaf people

Li, Y., Ding, G., Booth, J. R., Huang, R., Lv, Y., Zang, Y., Yong He, A., & Peng, D. (2011) · Human Brain Mapping · doi:10.1002/hbm.21215 · Cited by 68

MethylomeDB: a database of DNA methylation profiles of the brain

Xin, Y., Chanrion, B., O’Donnell‐Luria, A., Milekic, M. H., Costa, R., Ge, Y., & Haghighi, F. G. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1193 · Cited by 67

Epigenetic regulation of aging.

Rodríguez‐Rodero, S., Fernández-Morera, J. L., Fernández, A. F., Torre, E. L. M., & Fraga, M. F. (2010) · PubMed · Cited by 66

Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse

Busuttil, R. A., García, A. M., Reddick, R. L., Dollé, M. E. T., Calder, R. B., Nelson, J. F., & Vijg, J. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000876 · Cited by 61

Evidence of Altered Polyamine Concentrations in Cerebral Cortex of Suicide Completers

Chen, G. G., Fiori, L. M., Moquin, L., Gratton, A. P., Mamer, O., Mechawar, N., & Turecki, G. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.17 · Cited by 61

Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide

Fiori, L. M., Gross, J. A., & Turecki, G. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001520 · Cited by 58

Epigenetic regulation of self‐renewal and fate determination in neural stem cells

Ariff, I. M., Mitra, A., & Basu, A. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22804 · Cited by 49

Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice

Hager, R., Cheverud, J. M., & Wolf, J. B. (2009) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2009.0515 · Cited by 48

Stage‐ and site‐specific DNA demethylation during neural cell development from embryonic stem cells

Shimozaki, K., Namihira, M., Nakashima, K., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03031.x · Cited by 47

Global leukocyte DNA methylation is not altered in euthymic bipolar patients

Bromberg, A., Bersudsky, Y., Levine, J., & Agam, G. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.01.031 · Cited by 44

CpG Methylation in Neurons: Message, Memory, or Mask?

Sharma, R. P., Gavin, D. P., & Grayson, D. R. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.85 · Cited by 43

RESEARCHES ON PYRIMIDINES

Johnson, T. B., & Cretcher, L. H. (1916) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)87445-2 · Cited by 33

Serum- and glucocorticoid-inducible kinase1 enhances contextual fear memory formation through down-regulation of the expression of Hes5

Lee, C. T., Ma, Y. L., & Lee, E. H. Y. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04284.x · Cited by 32

Variation in the Large-Scale Organization of Gene Expression Levels in the Hippocampus Relates to Stable Epigenetic Variability in Behavior

Alter, M. D., Rubin, D. B., Ramsey, K. M., Halpern, R., Stephan, D. A., Abbott, L. F., & Hen, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003344 · Cited by 30

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Garcia, S. N., & Pereira‐Smith, O. M. (2008) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-008-9006-7 · Cited by 20

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Gotlib, I. H., & Hamilton, J. P. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.033 · Cited by 7

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Nagy, C., Suderman, M., Yang, J., Szyf, M., Mechawar, N., Ernst, C., & Turecki, G. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.21 · Cited by 301

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Batouli, S. A. H., & Saba, V. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.002 · Cited by 92

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Sinha, S., Jones, B. M., Traniello, I. M., Bukhari, S. A., Halfon, M. S., Hofmann, H. A., Huang, S., Katz, P. S., Keagy, J., Lynch, V. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921625117 · Cited by 85

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James, S. J., Shpyleva, S., Melnyk, S., Pavliv, O., & Pogribny, I. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.87 · Cited by 79

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Provenzi, L., Brambilla, M., Scotto di Minico, G., Montirosso, R., & Borgatti, R. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12616 · Cited by 60