Cited by 553Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer-related gene regulation

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Methyl-CpG-Binding Domain Proteins: Readers of the Epigenome

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Du, Qian, Luu, Phuc-Loi, Stirzaker, Clare, Clark, Susan J·2015·Epigenomics

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Abstract

How DNA methylation is interpreted and influences genome regulation remains largely unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates for the readout of DNA methylation as they recruit chromatin remodelers, histone deacetylases and methylases to methylated DNA associated with gene repression. MBD protein binding requires both functional MBD domains and methyl-CpGs; however, some MBD proteins also bind unmethylated DNA and active regulatory regions via alternative regulatory domains or interaction with the nucleosome remodeling deacetylase (NuRD/Mi-2) complex members. Mutations within MBD domains occur in many diseases, including neurological disorders and cancers, leading to loss of MBD binding specificity to methylated sites and gene deregulation. Here, we summarize the current state of knowledge about MBD proteins and their role as readers of the epigenome.

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Authors: Du, Q., Luu, P.-L., Stirzaker, C., & Clark, S. J.
Affiliations: Garvan Institute of Medical Research (AU)
ORCID: Du, Qian
Luu, Phuc-Loi
Stirzaker, Clare
Clark, Susan J
Venue: Epigenomics
Publisher: Informa UK Limited
Published: 2015-04-30
Volume: 7
Issue: 6
Pages: 1051-1073
ISSN: 1750-1911 (ISSN-L)
1750-192X
DOI: 10.2217/epi.15.39
OpenAlex: W2040875973
Cited by: 544
References: 191
Citations by year: 2026: 34 · 2025: 61 · 2024: 55 · 2023: 53 · 2022: 74 · 2021: 72 · 2020: 43 · 2019: 47 · 2018: 34 · 2017: 35 · 2016: 23 · 2015: 5
FWCI: 3.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Epigenomics (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: NHMRC Fellowship and NHMRC (1088144)
Stirzaker and P-L Luu by NHMRC (1088144)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords: methyl-CpG binding domain proteins, DNA methylation, epigenetic reader protein, chromatin remodeling, histone deacetylase, gene repression, neurological disorders, cancer, gene expression regulation
MeSH terms: Animals, Binding Sites, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Multigene Family, Humans, Mutation, Neoplasms, Protein Binding, Down-Regulation, CpG Islands, DNA Methylation, Genetic Predisposition to Disease, Gene Silencing, Epigenesis, Genetic, Protein Interaction Domains and Motifs, Cellular Reprogramming

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Methyl-CpG-Binding Domain Proteins: Readers of the Epigenome

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