The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.
Methyl-CpG-Binding Domain Proteins: Readers of the Epigenome
Open accessAbstract
How DNA methylation is interpreted and influences genome regulation remains largely unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates for the readout of DNA methylation as they recruit chromatin remodelers, histone deacetylases and methylases to methylated DNA associated with gene repression. MBD protein binding requires both functional MBD domains and methyl-CpGs; however, some MBD proteins also bind unmethylated DNA and active regulatory regions via alternative regulatory domains or interaction with the nucleosome remodeling deacetylase (NuRD/Mi-2) complex members. Mutations within MBD domains occur in many diseases, including neurological disorders and cancers, leading to loss of MBD binding specificity to methylated sites and gene deregulation. Here, we summarize the current state of knowledge about MBD proteins and their role as readers of the epigenome.
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“5mC readers including proteins containing a methyl-CpG-binding domain such as MECP2 or MBD proteins can recognize 5mC and recruit co-regulators to methylated DNA (25).”
From Dynamic DNA methylation: In the right place at the right time (2018) · cites this paper as [25]
Citations
Cites
1 retracted
Sarraf, S. A., & Stancheva, I. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.043 · Cited by 501
RetractedCerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990
Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440
CpG Islands in vertebrate genomes
Gardiner‐Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,417
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,791
Linking DNA methylation and histone modification: patterns and paradigms
Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
Okano, M., Xie, S., & Li, E. (1998) · Nature Genetics · doi:10.1038/890 · Cited by 1,643
Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins
Hendrich, B., & Bird, A. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6538 · Cited by 1,386
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Items 501–553 of 553
Planques, A., Kerner, P., Ferry, L., Grunau, C., Gazave, E., & Vervoort, M. (2021) · Figshare · doi:10.6084/m9.figshare.15095530
Planques, A., Kerner, P., Ferry, L., Grunau, C., Gazave, E., & Vervoort, M. (2021) · Figshare · doi:10.6084/m9.figshare.15095515
Qu, M., Zhang, Z., Liang, T., Niu, P., Wu, M., Chi, W., Chen, Z., Chen, Z.-J., Zhang, S., & Chen, S. (2021) · Figshare · doi:10.6084/m9.figshare.14059522
Wang, D., Chen, J., Wu, G., Xiong, F., Liu, W., Wang, Q., Kuai, Y., Huang, W., Qi, Y., Wang, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27140835
Khan, M. A., Zheng, M., Fu, J., Tania, M., Li, J., & Fu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20164703
Wang, D., Chen, J., Wu, G., Xiong, F., Liu, W., Wang, Q., Kuai, Y., Huang, W., Qi, Y., Wang, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27140832
Wang, D., Chen, J., Wu, G., Xiong, F., Liu, W., Wang, Q., Kuai, Y., Huang, W., Qi, Y., Wang, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27140838
Zampieri, M., Bacalini, M. G., Barchetta, I., Scalea, S., Cimini, F. A., Bertoccini, L., Tagliatesta, S., MATTEIS, G. D., Zardo, G., Cavallo, M. G., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14608828
Khan, M. A., Zheng, M., Fu, J., Tania, M., Li, J., & Fu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20164706
Wang, D., Chen, J., Wu, G., Xiong, F., Liu, W., Wang, Q., Kuai, Y., Huang, W., Qi, Y., Wang, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27140823
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Wang, D., Chen, J., Wu, G., Xiong, F., Liu, W., Wang, Q., Kuai, Y., Huang, W., Qi, Y., Wang, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27140817
Khan, M. A., Zheng, M., Fu, J., Tania, M., Li, J., & Fu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20164712
Qu, M., Zhang, Z., Liang, T., Niu, P., Wu, M., Chi, W., Chen, Z., Chen, Z.-J., Zhang, S., & Chen, S. (2021) · Figshare · doi:10.6084/m9.figshare.14059507
Wang, D., Chen, J., Wu, G., Xiong, F., Liu, W., Wang, Q., Kuai, Y., Huang, W., Qi, Y., Wang, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27140820
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The function of DNA methylation in lung cancer: Diagnostic and clinical implications
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Kim, C.-H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27765-8.00020-5
Pathology of Methylation, Demethylation, and Methylated DNA Binding Machinery
Земляная, О. А., Strelnikov, V. V., & Zaletaev, D. V. (2026) · Molecular Biology · doi:10.1134/s0026893325700566
The role of MBD3 in cell biology and disease: Recent advances and future directions
Meng, J., Yang, X., Luo, H., Liao, Y., 魏平, Jian, H., 黄爱良, & Zhou, W. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.115002
Mouse embryonic stem cells exhibit cancer-like DNA methylation landscapes upon DNMT1 overexpressionPreprint
Elder, E., Lemieux, A., & McGraw, S. (2026) · Research Square · doi:10.21203/rs.3.rs-9052961/v1
Boiteux, E. L. (2019) · theses.fr (ABES) · doi:10.70675/fd2f33cazc6a6z47b4z8258zac9ac2e67e38
Dissection of coordinated interferon response by promoter elements with enhancer activity
Santiago‐Algarra, D. (2020) · theses.fr (ABES) · doi:10.70675/a064ee17zbea2z412azb9b6z12839deb2851
Functional genomics characterization of genetic predisposing factors in uveal melanoma
Derrien, A. (2021) · theses.fr (ABES) · doi:10.70675/a794a7dfz4352z46f0zb97az064f9ea78e46
Deregulation of alternative promoter usage in T-acute lymphoblastic leukemia
Flores, J. D. A. (2021) · theses.fr (ABES) · doi:10.70675/8a36b7f6z0e52z483cz961az87f8dae1b213
À la rencontre des "readers" de l'ADN méthylé
Erdmann, D. (2021) · theses.fr (ABES) · doi:10.70675/f2b76a23z3f81z46f4z85a7z4abc4c194eae
Identification and characterization of key epigenetic drivers of breast cancer
Araujo, M. G. D. S. (2024) · theses.fr (ABES) · doi:10.70675/de1e1ca7zb3fez4d95za929z354256240e6e
Huang, X., Luo, T., Ke, L., Guan, S., Wu, H., Li, B., Liu, Y., & Qi, J. (2026) · Cancer Biology & Therapy · doi:10.1080/15384047.2026.2667568
Turunen, T. A., Väänänen, M.-A., & Ylä-Herttuala, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-15734-9.00113-8
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Szyf, M. (2026) · Springer eBooks · doi:10.1007/978-3-032-24295-2_2
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Zheng, H., Feng, C., Tan, L., Zhuang, M., Yuan, D., Mei, J., Liu, Z.-Z., Han, H., Li, L., Chen, S., et al. (2026) · Journal of Integrative Plant Biology · doi:10.1111/jipb.70321
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Aphrham, S., Verheijden, M. L., & Huskens, J. (2026) · ACS Sensors · doi:10.1021/acssensors.6c01631
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Buckley, T. J., Burns, M. J., Jarry, L., Wang, S., Soe, S. M. L., & Jacobsen, S. E. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-026-01008-3
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Ramena, Y., Shelby, A., & Ramena, G. T. (2026) · Comparative Immunology Reports · doi:10.1016/j.cirep.2026.200320
Yaman, Ü., Gustavsson, E. K., Lee, J., Ugolini, H., Macpherson, H. L., Mumford, P., Wiseman, F. K., Hardy, J., & Salih, D. A. M. (2026) · STAR Protocols · doi:10.1016/j.xpro.2026.104827
Epigenetic regulation of humoral immunity: molecular mechanisms, diseases and therapeutic targets
Zhang, S., Yu, W. Z., Min, X., Wu, Y., & Liu, W. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02955-3
Mashayekhpour, M. A., Amani, H., Moghaddam, A. H., Moradi, A., Nohesara, S., & Abdolmaleky, H. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219502
DNA methylation in human disease: From biological mechanisms to clinical applications
Mallik, R., Gupta, P., Gupta, A. K., Chaturvedi, P., Pillai, V., & Muegge, K. (2026) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2026.102635
Beyond 5mC: 5hmC in the aging epigenome
Reale, A., Bari, D. D., Karpach, K., Zardo, G., Catizone, A., & Zampieri, M. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113374
Metadata
- Authors
- Du, Q., Luu, P.-L., Stirzaker, C., & Clark, S. J.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Venue
- Epigenomics
- Publisher
- Informa UK Limited
- Published
- 2015-04-30
- Volume
- 7
- Issue
- 6
- Pages
- 1051-1073
- ISSN
- 1750-1911 (ISSN-L)
- 1750-192X
- OpenAlex
- W2040875973
- Cited by
- 544
- References
- 191
- Citations by year
- 2026: 34 · 2025: 61 · 2024: 55 · 2023: 53 · 2022: 74 · 2021: 72 · 2020: 43 · 2019: 47 · 2018: 34 · 2017: 35 · 2016: 23 · 2015: 5
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Epigenomics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- NHMRC Fellowship and NHMRC (1088144)
- Stirzaker and P-L Luu by NHMRC (1088144)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- methyl-CpG binding domain proteins, DNA methylation, epigenetic reader protein, chromatin remodeling, histone deacetylase, gene repression, neurological disorders, cancer, gene expression regulation
- MeSH terms
- Animals, Binding Sites, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Multigene Family, Humans, Mutation, Neoplasms, Protein Binding, Down-Regulation, CpG Islands, DNA Methylation, Genetic Predisposition to Disease, Gene Silencing, Epigenesis, Genetic, Protein Interaction Domains and Motifs, Cellular Reprogramming
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