Comparative efficacy of cemiplimab versus other systemic treatments for advanced cutaneous squamous cell carcinoma
Open accessAbstract
Aim: To estimate the comparative efficacy of cemiplimab, a programmed cell death protein 1 inhibitor, versus EGFR inhibitors, pembrolizumab and platinum-based chemotherapy in terms of overall survival (OS) and progression-free survival. Patients & methods: We performed an indirect treatment comparison of cemiplimab and other available systemic therapies for patients with advanced cutaneous squamous cell carcinoma. Results: Cemiplimab was associated with benefits in OS (hazard ratios range: 0.07–0.52) and progression-free survival (hazard ratios range: 0.30–0.67) versus EGFR inhibitors and pembrolizumab (data from KEYNOTE-629). Cemiplimab was more efficacious versus platinum-based chemotherapy in terms of OS. Conclusion: Cemiplimab may offer improvements in survival for advanced cutaneous squamous cell carcinoma patients compared with existing systemic therapies.
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Cemiplimab was linked to improved overall survival and progression-free survival in CSCC patients in comparison to EGFR inhibitors and chemotherapy.
“Cemiplimab was also linked to improved OS and PFS in CSCC patients in comparison to EGFR inhibitors and chemotherapy, showing that it has a lot of potential in treating CSCC patients [50].”
From Immune Checkpoint Inhibitors in Cancer Therapy (2022) · cites this paper as [50]
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Immune Checkpoint Inhibitors in Cancer Therapy
Shiravand, Y., Khodadadi, F., Kashani, S. M. A., Hosseini-Fard, S. R., Hosseini, S., Sadeghirad, H., Ladwa, R., O’Byrne, K., & Kulasinghe, A. (2022) · Current Oncology · doi:10.3390/curroncol29050247 · Cited by 1,353 · see citing works
- Authors
- Keeping, S., Xu, Y., Chen, C.-I., Cope, S., Mojebi, A., Kuznik, A., Konidaris, G., Ayers, D., Sasane, M., Allen, R., Huynh, T.-M.-T., Popoff, E., Freeman, M., Andria, M. L., Fury, M. G., Singh, K., Stockfleth, E., Challapalli, A., & Schmults, C. D.
- Affiliations
- Precision HEOR, Vancouver,BCV6H 3Y4,Canada
- Regeneron (United States) (US)
- Sanofi (United Kingdom) (GB)
- Sanofi, Bridgewater, NJ08807,USA
- Sanofi (France) (FR)
- City Of Hope National Medical Center (US)
- Sanofi (United States) (US)
- Ruhr University Bochum (DE)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Harvard University (US)
- ORCID
- Venue
- Future Oncology
- Publisher
- Informa UK Limited
- Published
- 2020-10-14
- Volume
- 17
- Issue
- 5
- Pages
- 611-627
- ISSN
- 1479-6694 (ISSN-L)
- 1744-8301
- OpenAlex
- W3091790864
- Cited by
- 51
- References
- 93
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 14 · 2022: 17 · 2021: 10 · 2013: 1
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Future Oncology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Regeneron Pharmaceuticals, Inc. and Sanofi Genzyme
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- cemiplimab, cutaneous squamous cell carcinoma, PD-1 inhibitors, EGFR inhibitors, pembrolizumab, platinum-based chemotherapy, overall survival, progression-free survival, indirect treatment comparison
- MeSH terms
- Cetuximab, Progression-Free Survival, Immune Checkpoint Inhibitors, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Cisplatin, Clinical Trials as Topic, Humans, Skin Neoplasms, Carboplatin, Programmed Cell Death 1 Receptor, Antibodies, Monoclonal, Humanized, Observational Studies as Topic, ErbB Receptors
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