The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Engineering Hydrogels as Extracellular Matrix Mimics
Open accessAbstract
Extracellular matrix (ECM) is a complex cellular environment consisting of proteins, proteoglycans, and other soluble molecules. ECM provides structural support to mammalian cells and a regulatory milieu with a variety of important cell functions, including assembling cells into various tissues and organs, regulating growth and cell-cell communication. Developing a tailored in vitro cell culture environment that mimics the intricate and organized nanoscale meshwork of native ECM is desirable. Recent studies have shown the potential of hydrogels to mimic native ECM. Such an engineered native-like ECM is more likely to provide cells with rational cues for diagnostic and therapeutic studies. The research for novel biomaterials has led to an extension of the scope and techniques used to fabricate biomimetic hydrogel scaffolds for tissue engineering and regenerative medicine applications. In this article, we detail the progress of the current state-of-the-art engineering methods to create cell-encapsulating hydrogel tissue constructs as well as their applications in in vitro models in biomedicine.
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Citations
Cites
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Cited by
A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds
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3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949
Self-healing gels based on constitutional dynamic chemistry and their potential applications
Wei, Z., Yang, J. H., Zhou, J., Xu, F., Zrínyi, M., Dussault, P. H., Osada, Y., & Chen, Y. M. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00219a · Cited by 896
Self-citationExtracellular matrix-based materials for regenerative medicine
Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
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Metadata
- Authors
- Geckil, H., Xu, F., Zhang, X., Moon, S., & Demirci, U.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2010-04
- Volume
- 5
- Issue
- 3
- Pages
- 469-484
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2039167655
- Cited by
- 944
- References
- 13
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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