A Multiple Testing Procedure for Clinical Trials

O'Brien, Peter C., Fleming, Thomas R.·1979·Biometrics
DOI 10.2307/2530245

Cited by (124)

Items 101–124 of 124

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  2. Subcutaneous infusion of exenatide and cardiovascular outcomes in type 2 diabetes: a non-inferiority randomized controlled trial
    Ruff, Christian T., Baron, Michelle, Im, KyungAh, O’Donoghue, Michelle L., Fiedorek, Fred T., Sabatine, Marc S. · 2022 · Nature Medicine
  3. Hierarchical testing of multiple endpoints in group‐sequential trials
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  4. Challenges and recommendations for blinding in behavioral interventions illustrated using a case study of a behavioral intervention to lower blood pressure
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  5. Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial
    Schneider, Lon S., Geffen, Yona, Rabinowitz, Jonathan, Thomas, Ronald G., Schmidt, Reinhold, Ropele, Stefan, Weinstock, Marta, on behalf of the Ladostigil Study Group · 2019 · Neurology
  6. Evidence Why Paroxetine Dose Escalation is Not Effective in Major Depressive Disorder: A Randomized Controlled Trial With Assessment of Serotonin Transporter Occupancy
    Ruhé, Henricus G, Booij, Jan, Weert, Henk C v, Reitsma, Johannes B, Fransen, Eric J F, Michel, Martin C, Schene, Aart H · 2009 · Neuropsychopharmacology
  7. Laser Treatment in Patients with Bilateral Large Drusen
    2006 · Ophthalmology
  8. A randomized, phase III multicenter trial of gemcitabine in combination with carboplatin or paclitaxel versus paclitaxel plus carboplatin in patients with advanced or metastatic non-small-cell lung cancer
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  9. Guidance on interim analysis methods in clinical trials
    Ciolino, Jody D., Kaizer, Alexander M., Bonner, Lauren Balmert · 2023 · Journal of Clinical and Translational Science
  10. Safety of sertindole versus risperidone in schizophrenia: principal results of the sertindole cohort prospective study (SCoP)
    Thomas, S. H. L., Drici, M. D., Hall, G. C., Crocq, M. A., Everitt, B., Lader, M. H., Jeunne, C. Le., Naber, D., Priori, S., Sturkenboom, M. et al. · 2010 · Acta Psychiatrica Scandinavica
  11. A general inefficacy interim monitoring rule for randomized clinical trials
    Freidlin, Boris, Korn, Edward L, Gray, Robert · 2010 · Clinical Trials
  12. Efficacy and safety of the dual GIP and GLP-1 receptor agonist tirzepatide for weight loss: a meta-analysis of randomized controlled trials
    de Mesquita, Yasmin Luz Lima, Pera Calvi, Izabela, Reis Marques, Isabela, Almeida Cruz, Sara, Padrao, Eduardo Messias Hirano, Carvalho, Pedro Emanuel de Paula, da Silva, Caroliny Hellen Azevedo, Cardoso, Rhanderson, Moura, Filipe Azevedo, Rafalskiy, Vladimir Vitalievich · 2023 · International Journal of Obesity
  13. The alpha spending function approach to interim data analyses
    DeMets, David L., Lan, Gordon · 1995 · Cancer Treatment and Research
  14. The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design
    Dimairo, Munyaradzi, Pallmann, Philip, Wason, James, Todd, Susan, Jaki, Thomas, Julious, Steven A., Mander, Adrian P., Weir, Christopher J., Koenig, Franz, Walton, Marc K. et al. · 2020 · Trials
  15. Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance Intervention after Stroke Trial
    Viscoli, Catherine M., Brass, Lawrence M., Carolei, Antonio, Conwit, Robin, Ford, Gary A., Furie, Karen L., Gorman, Mark, Guarino, Peter D., Inzucchi, Silvio E., Lovejoy, Anne M. et al. · 2014 · American Heart Journal
  16. Reported use of data monitoring committees in the main published reports of randomized controlled trials: a cross-sectional study
    Sydes, Matthew R, Altman, Douglas G, Babikera, Abdel B, Parmar, Mahesh KB, Spiegelhalter, David J, DAMOCLES group · 2004 · Clinical Trials
  17. Sequential meta-analysis to determine the sufficiency of cumulative knowledge: the case of early intensive behavioral intervention for children with autism spectrum disorders
    Kuppens, S., Onghena, P. · 2012 · Research in Autism Spectrum Disorders
  18. Pragmatic Randomized Study of Afatinib Versus Chemotherapy for Patients With Non-Small Cell Lung Cancer With Uncommon Epidermal Growth Factor Receptor Mutations: ACHILLES/TORG1834
    Miura, Satoru, Tanaka, Hiroshi, Misumi, Toshihiro, Yoshioka, Hiroshige, Tokito, Takaaki, Fukuhara, Tatsuro, Sato, Yuki, Shiraishi, Yoshimasa, Naoki, Katsuhiko, Akamatsu, Hiroaki et al. · 2025 · Journal of Clinical Oncology
  19. Independent data monitoring committees: rationale, operations and controversies
    Ellenberg, Susan S. · 2001 · Statistics in Medicine
  20. Trends in study design and the statistical methods employed in a leading general medicine journal
    Gosho, M., Sato, Y., Nagashima, K., Takahashi, S. · 2018 · Journal of Clinical Pharmacy and Therapeutics
  21. Tafasitamab, lenalidomide, and rituximab in relapsed or refractory follicular lymphoma (inMIND): a global, phase 3, randomised controlled trial
    Sehn, Laurie H, Hübel, Kai, Luminari, Stefano, Scholz, Christian W, Salar, Antonio, Paneesha, Shankara, Wahlin, Björn Engelbrekt, Panayiotidis, Panayiotis, Lee, Hui-Peng, Jiménez-Ubieto, Ana et al. · 2026 · The Lancet
  22. Prospective approaches to accumulating evidence
    Thomas, James, Askie, Lisa M, Berlin, Jesse A, Elliott, Julian H, Ghersi, Davina, Simmonds, Mark, Takwoingi, Yemisi, Tierney, Jayne F, Higgins, Julian PT · 2019 · Cochrane Handbook for Systematic Reviews of Interventions
  23. Statistical rules for safety monitoring in clinical trials
    Martens, Michael J, Logan, Brent R · 2024 · Clinical Trials
  24. Stop Guessing When to Stop Testing: Efficient Model Evaluation with Just Enough Data
    Arviv, Ofir, Greenewald, Kristjan, Perlitz, Yotam, Mulian, Hadar, Shmueli-Scheuer, Michal, Choshen, Leshem · 2026 · Findings of the Association for Computational Linguistics: ACL 2026