Cited by 341Statistical Methods in Clinical TrialsProbability and Statistical ResearchStatistical Methods and Bayesian Inference

Approximately Optimal One-Parameter Boundaries for Group Sequential Trials

Wang, Samuel K., Tsiatis, Anastasios A.·1987·Biometrics

Abstract

We present a class of group sequential tests, indexed by a single parameter, that yields approximately optimal results. We also provide tables of key values to help in the design of group sequential tests that meet selected specifications.

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Crossref · 10.2307/2531959

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4 of 4 references verified0 citation errors · 0 not checkable

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  • The interim analysis on patients who achieved stable remission did not show superiority of esketamine and antidepressant over antidepressant and placebo; the study continued, and the number of relapses was reestimated to 59 with an adjusted significance level of .046, ensuring conditional power of 90% or higher after the interim analysis.

    “The interim analysis on patients who achieved stable remission did not show superiority of esketamine and antidepressant over antidepressant and placebo (at a 2-sided significance level of .0097,log-rank test); therefore, the study continued, and the number of relapses in patients who achieved stable remission was reestimated to 59 relapses in total with an adjusted significance level of .046(2-s”

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Authors
Wang, S. K., & Tsiatis, A. A.
Venue
Biometrics
Publisher
JSTOR
Published
1987-03
Volume
43
Issue
1
Pages
193
ISSN
0006-341X (ISSN-L)
OpenAlex
W2090824711
Cited by
341
References
4
Citations by year
2026: 6 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 13 · 2017: 5 · 2016: 13 · 2015: 9 · 2014: 20 · 2013: 8 · 2012: 25
FWCI
4.23
Type
journal article
Language
en
Open access
closed
Locations
  • Biometrics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (CA23415, CA-35446)
Topics
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
  • Physical Sciences › Mathematics › Statistics and Probability › Probability and Statistical Research
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Bayesian Inference
Keywords
group sequential tests, approximate optimality, clinical trial design, stopping boundaries
MeSH terms
Clinical Trials as Topic, Humans, Statistics as Topic

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