The DOI matches its Crossref record; 160 of the 175 references it cites were found in a registry or an index.
Stepping Backward to Improve Assessment of PCB Congener Toxicities
Open accessAbstract
Polychlorinated biphenyls (PCBs) are ubiquitous global contaminants that have been intensively investigated for three decades.They are broad-acting toxicants occurring in complex mixtures and accurate risk assessment has proven to be elusive.Focusing on a limited set of end points and emphasizing a fixed set of congeners have led to more streamlined data sets that are meant to expedite hazard characterization and risk assessment for the most potent congeners-aryl hydrocarbon receptor (AhR) agonists.Unfortunately, this has made it impossible to confirm or deny significant contributions from the more prevalent components of the mixtures.PCBs may be only coincidentally present, rather than causal, in some diseases.Still, attempts to determine associations with incomplete residue data may lead to erroneous conclusions and make accurate risk assessment even more elusive.Responses not mediated through the AhR are presented and emphasize large data gaps.Dissimilar analytical reports emphasize that selection of analytes is not consistent.Collectively, these data confirm that AhR-focused objectives unintentionally created the impression that nonplanar PCBs have little if any potential for hazards to humans and wildlife.Near steady-state exposure of healthy adults are probably of minor consequence except for emerging correlations with non-Hodgkin's lymphoma; however, pulses of exposure to more labile mixtures may contribute to developmental effects without leaving a residue record.More broadly based criteria are suggested and harmonization of data collection and presentation are desirable.A more comprehensive list of PCB congeners is proposed that would provide more adequate data upon which to base associations with adverse outcomes.-
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“While there were significant differences in age, geographical location, and lifetime exposure levels to different PCBs between these study populations, these studies raise the possibility that the composition or congener profile of the PCB exposure is an important determinant of the outcome on the methylome [ 114 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [114]
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Illustrated handbook of physical-chemical properties and environmental fate for organic chemicals
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Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography
Ballschmiter, K., & Zell, M. (1980) · Fresenius Zeitschrift für Analytische Chemie · doi:10.1007/bf00469758 · Cited by 1,441
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Blood Levels of Organochlorine Residues and Risk of Breast Cancer
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Erickson, M. D. (1986) · Medical Entomology and Zoology · Cited by 810
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Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Van den Berg, M., Birnbaum, L. S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., et al. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl055 · Cited by 3,785
Zoeller, R. T., Brown, T. R., Doan, L. L., Gore, A. C., Skakkebæk, N. E., Soto, A. M., Woodruff, T. J., & Saal, F. S. V. (2012) · Endocrinology · doi:10.1210/en.2012-1422 · Cited by 1,185
Effects of PCB exposure on neuropsychological function in children.
Schantz, S. L., Widholm, J. J., & Rice, D. C. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5461 · Cited by 503
Metabolism and metabolites of polychlorinated biphenyls
Grimm, F. A., Hu, D., Kania‐Korwel, I., Lehmler, H., Ludewig, G., Hornbuckle, K. C., Duffel, M. W., Bergman, Å., & Robertson, L. W. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2014.999365 · Cited by 445
Metadata
- Authors
- Hansen, L. G.
- Venue
- Environmental Health Perspectives
- Publisher
- JSTOR
- Published
- 1998-02
- Volume
- 106
- Issue
- suppl 1
- Pages
- 171
- ISSN
- 0091-6765 (ISSN-L)
- OpenAlex
- W2073813648
- Cited by
- 336
- References
- 175
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 10 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 5 · 2015: 10 · 2014: 16 · 2013: 17 · 2012: 11
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- Environmental Health Perspectives (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- polychlorinated biphenyls, PCB congeners, risk assessment, aryl hydrocarbon receptor agonists, PCB mixtures, hazard characterization, non-Hodgkin lymphoma, early life exposure, data harmonization
- MeSH terms
- Animals, Body Burden, Cytochrome P-450 Enzyme System, Enzyme Induction, Humans, Polychlorinated Biphenyls, Thyroid Hormones, Receptors, Aryl Hydrocarbon, Risk Assessment
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