Effects of PCB exposure on neuropsychological function in children.

Schantz, Susan L; Widholm, John J; Rice, Deborah C

doi:10.1289/ehp.5461

Cited by 503Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicalsPesticide Exposure and Toxicity

Effects of PCB exposure on neuropsychological function in children.

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Schantz, Susan L, Widholm, John J, Rice, Deborah C·2003·Environmental Health Perspectives

DOI 10.1289/ehp.5461PMC PMC1241394

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Abstract

In the last decade advances in the analytic methods for quantification of polychlorinated biphenyls (PCBs) have resulted in widespread availability of congener-specific analysis procedures, and large amounts of data on PCB congener profiles in soil, air, water, sediments, foodstuffs, and human tissues have become available. These data have revealed that the PCB residues in environmental media and human tissues may not closely resemble any of the commercial PCB mixtures, depending on source of exposure, bioaccumulation through the food chain, and weathering of PCBs in the environment. At the same time, toxicological research has led to a growing awareness that different classes of PCB congeners have different profiles of toxicity. These advances in analytic techniques and toxicological knowledge are beginning to influence the risk assessment process. As the data from ongoing PCB studies assessing the mediators of neurobehavioral outcomes in children are published, the weight of evidence for PCB effects on neurodevelopment is growing. Studies in Taiwan, Michigan (USA), New York (USA), Holland, Germany, and the Faroe Islands have all reported negative associations between prenatal PCB exposure and measures of cognitive functioning in infancy or childhood. The German study also reported a negative association between postnatal PCB exposure and cognitive function in early childhood--a result that had not been found in previous studies. Only one published study in North Carolina (USA) has failed to find an association between PCB exposure and cognitive outcomes. Despite the fact that several more recent studies have used congener-specific analytic techniques, there have been only limited attempts to assess the role of specific PCB congeners or classes of congeners in mediating neurodevelopmental outcomes. From a statistical standpoint, attempts to determine the role of individual congeners in mediating outcomes are hampered by the fact that concentrations of most individual congeners are highly correlated with each other and with total PCBs. From a toxicological standpoint, these efforts are hampered by the fact that many of the PCB congeners present in human tissues have never been studied in the laboratory, and their relative potency to produce nervous system effects is unknown. More complete information on the health effects of various congeners or congener classes would allow more informed scientific and risk assessment decisions.

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Studies on PCBs demonstrated negative effects on various intellectual, motor and verbal outcomes of relevance to autism.
“Studies on PCBs, previously used in coolant fluids in electrical apparatus, have focused on cognitive skills, demonstrating negative effects on various intellectual, motor and verbal outcomes of relevance to autism [212, 213].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [212]
The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood.
“The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood [ 56 , 95–99 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [96]

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“Epidemiological studies have demonstrated a negative association between developmental exposure to environmental PCBs and measures of neuropsychological function in infancy or childhood (Seegal, 1996; Schantz et al., 2003; Carpenter, 2006; Korrick and Sagiv, 2008; Winneke, 2011).”
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Authors: Schantz, S. L., Widholm, J. J., & Rice, D. C.
Affiliations: University of Illinois Urbana-Champaign (US)
ORCID: Rice, Deborah C
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 2003-03-01
Volume: 111
Issue: 3
Pages: 357-576
ISSN: 0091-6765 (ISSN-L)
1552-9924
DOI: 10.1289/ehp.5461
PMC: PMC1241394
OpenAlex: W2042268520
Cited by: 503
References: 86
Citations by year: 2026: 9 · 2025: 9 · 2024: 11 · 2023: 16 · 2022: 12 · 2021: 15 · 2020: 12 · 2019: 16 · 2018: 17 · 2017: 32 · 2016: 19 · 2015: 22 · 2014: 26 · 2013: 26 · 2012: 29
FWCI: 23.59
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/licenses/by/4.0/ (vor, 5417 d)
Locations: Environmental Health Perspectives (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
Keywords: polychlorinated biphenyls, PCB congeners, prenatal exposure, postnatal exposure, brain development, cognitive function, children, congener-specific analysis, environmental contamination, risk assessment, neurobehavioral outcomes
MeSH terms: Child, Child Development, Child Welfare, Child, Preschool, Cognition Disorders, Environmental Exposure, Environmental Pollutants, Humans, Intelligence, Nervous System, Neuropsychological Tests, Polychlorinated Biphenyls, Cohort Studies, Epidemiologic Studies

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Effects of PCB exposure on neuropsychological function in children.

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