Radiation-induced endometriosis in Macaca mulatta
Abstract
Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy protons, 54%; mixed-energy protons, 73%; X rays, 71%; and electrons, 57%. The incidence of endometriosis in nonirradiated control monkeys was 26%. Monkeys exposed to single-energy protons, mixed-energy protons, and X rays developed endometriosis at a significantly higher rate than control monkeys (chi 2, P less than 0.05). Severity of endometriosis was staged as massive, moderate, and minimal. The incidence of these stages were 65, 16, and 19%, respectively. Observations of clinical disease included weight loss in 43% of the monkeys, anorexia in 35%, space-occupying masses detected by abdominal palpation in 55%, abnormal ovarian/uterine anatomy on rectal examination in 89%, and radiographic evidence of abdominal masses in 38%. Pathological lesions were endometrial cyst formation in 69% of the monkeys, adhesions of the colon in 66%, urinary bladder in 50%, ovaries in 86%, and ureters in 44%, focal nodules of endometrial tissue throughout the omentum in 59%, and metastasis in 9%. Clinical management of endometriosis consisted of debulking surgery and bilateral salpingo-oophorectomy combined in some cases with total abdominal hysterectomy. Postoperative survival rates at 1 and 5 years for monkeys recovering from surgery were 48 and 36%, respectively.
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Endometriosis developing after total body radiation in primates can have a delay of 5 years.
“In addition the endometriosis developing after total body radiation in primates can have a delay of 5 years, again suggesting a genomic effect.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [192]
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- Authors
- Fanton, J. W., & Golden, J. G.
- Affiliations
- United States Air Force (US)
- Venue
- Radiation Research
- Publisher
- JSTOR
- Published
- 1991-05
- Volume
- 126
- Issue
- 2
- Pages
- 141
- ISSN
- 0033-7587 (ISSN-L)
- OpenAlex
- W2034107951
- Cited by
- 84
- References
- 16
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2013: 4 · 2012: 4
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- ionizing radiation, rhesus monkeys, proton radiation, X-rays, electron radiation, endometrial cysts, adhesion, metastasis, cytoreductive surgery, salpingo-oophorectomy, hysterectomy, postoperative survival, radiation-induced cancer
- MeSH terms
- Animals, Endometriosis, Female, Macaca mulatta, Neoplasms, Radiation-Induced, Pelvic Neoplasms, Protons, Space Flight, Whole-Body Irradiation, Survival Rate
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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