Cited by 84Endometriosis Research and TreatmentEffects of Radiation ExposureEndometrial and Cervical Cancer Treatments

Radiation-induced endometriosis in Macaca mulatta

Fanton, John W., Golden, John G.·1991·Radiation Research

Abstract

Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy protons, 54%; mixed-energy protons, 73%; X rays, 71%; and electrons, 57%. The incidence of endometriosis in nonirradiated control monkeys was 26%. Monkeys exposed to single-energy protons, mixed-energy protons, and X rays developed endometriosis at a significantly higher rate than control monkeys (chi 2, P less than 0.05). Severity of endometriosis was staged as massive, moderate, and minimal. The incidence of these stages were 65, 16, and 19%, respectively. Observations of clinical disease included weight loss in 43% of the monkeys, anorexia in 35%, space-occupying masses detected by abdominal palpation in 55%, abnormal ovarian/uterine anatomy on rectal examination in 89%, and radiographic evidence of abdominal masses in 38%. Pathological lesions were endometrial cyst formation in 69% of the monkeys, adhesions of the colon in 66%, urinary bladder in 50%, ovaries in 86%, and ureters in 44%, focal nodules of endometrial tissue throughout the omentum in 59%, and metastasis in 9%. Clinical management of endometriosis consisted of debulking surgery and bilateral salpingo-oophorectomy combined in some cases with total abdominal hysterectomy. Postoperative survival rates at 1 and 5 years for monkeys recovering from surgery were 48 and 36%, respectively.

Integrity signals

Registry

Crossref · 10.2307/3577812

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16 of 16 references verified0 citation errors · 0 not checkable

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  • Endometriosis developing after total body radiation in primates can have a delay of 5 years.

    “In addition the endometriosis developing after total body radiation in primates can have a delay of 5 years, again suggesting a genomic effect.”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [192]

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Authors
Fanton, J. W., & Golden, J. G.
Affiliations
United States Air Force (US)
Venue
Radiation Research
Publisher
JSTOR
Published
1991-05
Volume
126
Issue
2
Pages
141
ISSN
0033-7587 (ISSN-L)
OpenAlex
W2034107951
Cited by
84
References
16
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2013: 4 · 2012: 4
FWCI
2.47
Type
journal article
Language
en
Open access
closed
Locations
  • Radiation Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords
ionizing radiation, rhesus monkeys, proton radiation, X-rays, electron radiation, endometrial cysts, adhesion, metastasis, cytoreductive surgery, salpingo-oophorectomy, hysterectomy, postoperative survival, radiation-induced cancer
MeSH terms
Animals, Endometriosis, Female, Macaca mulatta, Neoplasms, Radiation-Induced, Pelvic Neoplasms, Protons, Space Flight, Whole-Body Irradiation, Survival Rate

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