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Cited by 86Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

Risk factors for endometriosis in the rhesus monkey (Macaca mulatta): a case-control study

Hadfield, R.·1997·Human Reproduction Update
DOI 10.1093/humupd/3.2.109
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Abstract

The autopsy records between 1980 and 1995 of 399 female rhesus monkeys (Macaca mulatta) at the Wisconsin Regional Primate Research Center were examined. Spontaneous endometriosis was found in 81 (20%) of the animals. The mean (+/- SD) ages at death for animals with and without endometriosis were 20.7 +/- 5.5 (range 10-35) and 13.4 +/- 7.7 (range 4-37) years respectively. Many of the animals had been exposed to experimental procedures, including laparoscopies, hysterotomies and oestradiol implants, and these were examined as possible risk factors for endometriosis. Of the 81 affected animals, 62 were matched to unaffected controls for age at death (to within 1 year) and year of death (to within 2 years) and the effect of various factors on the development of endometriosis was determined using conditional logistic regression. Exposure to three or more oestradiol implants or one or more hysterotomies were both significant risk factors, with estimated relative risks of 9.7 (95% confidence interval 2.5-37.2) and 5.8 (95% confidence interval 1.6-20.2) respectively. Animals that had been exposed to one or more laparoscopies showed no increased risk for developing endometriosis. These findings provide insight into the aetiology of the disease in women. ?2P51 4RR00167

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Crossref · 10.1093/humupd/3.2.109

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Only a history of application of estrogen patches (in addition to a history of trauma by hysterotomy) showed a significant association with endometriosis.

    “Only a history of application of estrogen patches (in addition to a history of trauma by hysterotomy) showed a significant association with endometriosis [67].”

    From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [67]

  • A history of hysterotomy in colonized rhesus monkeys showed a significant association with the later development of endometriosis in these animals.

    “A history of hysterotomy in colonized rhesus monkeys showed a significant association with the later development of endometriosis in these animals [67].”

    From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [67]

  • Familial clustering of endometriosis is well established in humans and primates.

    “Well established are familial clustering in humans (156) and primates (157).”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [157]

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Authors
Hadfield, R.
Affiliations
John Radcliffe Hospital (GB)
Corresponding author
Hadfield, R.
ORCID
Hadfield, R.
Venue
Human Reproduction Update
Publisher
Oxford University Press (OUP)
Published
1997-03-01
Volume
3
Issue
2
Pages
109-115
ISSN
  • 1355-4786 (ISSN-L)
  • 1460-2369
DOI
10.1093/humupd/3.2.109
OpenAlex
W2125954943
Cited by
86
References
38
Citations by year
2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 5 · 2014: 1 · 2013: 1 · 2012: 6
FWCI
3.03
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction Update (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
endometriosis, rhesus monkeys, risk factors, estradiol implants, hysterotomy, laparoscopy, spontaneous endometriosis, etiology, female primates, age at death
MeSH terms
Aging, Animals, Drug Implants, Endometriosis, Estradiol, Female, Macaca mulatta, Postoperative Complications, Risk Factors, Uterus, Logistic Models, Case-Control Studies

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