The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
The Airway Epithelium is Central to the Pathogenesis of Asthma
Open accessAbstract
Asthma is an inflammatory disorder principally involving the conducting airways and characterised by infiltration of the airway wall with a range of inflammatory cells driven in large part by activation of Th2-type lymphocytes, mast cells and eosinophils. However a key component of asthma is the structural change that involves all of the elements of the airway wall. Here evidence is presented to suggest that the airway epithelium in asthma is fundamentally abnormal with increased susceptibility to environmental injury and impaired repair associated with activation of the epithelial-mesenchymal trophic unit (EMTU). In addition to adopting an activated phenotype, the barrier function of the epithelium is impaired through defective tight junction formation thereby facilitating penetration of potentially toxic or damaging environmental insults. Activated and repairing epithelial cells generate a range of growth factors that are involved in the early life origins of this disease as well as its progression in the form of mucous metaplasia and airway wall remodeling. By placing the epithelium at the forefront of asthma pathogenesis, different approaches to treatment can be devised focused more on protecting vulnerable airways against environmental injury rather than focusing on suppressing airway inflammation or manipulating the immune response.
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Cites
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Self-citationEder, W., Ege, M. J., & von Mutius, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054308 · Cited by 1,621
Long-Term Effects of Budesonide or Nedocromil in Children with Asthma
(2000) · New England Journal of Medicine · doi:10.1056/nejm200010123431501 · Cited by 1,365
Kim, K. K., Kugler, M. C., Wolters, P. J., Robillard, L., Galvez, M. G., Brumwell, A. N., Sheppard, D., & Chapman, H. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605669103 · Cited by 1,257
SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS
Roche, W., Williams, J., Beasley, R., & Holgate, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90067-6 · Cited by 1,120
Self-citationRespiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease
Rose, M. C., & Voynow, J. A. (2006) · Physiological Reviews · doi:10.1152/physrev.00010.2005 · Cited by 1,066
Long-Term Inhaled Corticosteroids in Preschool Children at High Risk for Asthma
Guilbert, T. W., Morgan, W. J., Zeiger, R. S., Mauger, D. T., Boehmer, S. J., Szefler, S. J., Bacharier, L. B., Lemanske, R. F., Strunk, R. C., Allen, D. B., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051378 · Cited by 1,054
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Allakhverdi, Z., Comeau, M. R., Jessup, H. K., Yoon, B.-R. P., Brewer, A., Chartier, S., Paquette, N., Ziegler, S. F., Sarfati, M., & Delespesse, G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062211 · Cited by 786
Cited by
Al-Muhsen, S., Johnson, J. R., & Hamid, Q. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.047 · Cited by 408
Untangling asthma phenotypes and endotypes
Agache, I., Akdis, C., Jutel, M., & Virchow, J. C. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02832.x · Cited by 345
Holt, P. G., & Sly, P. D. (2012) · Nature Medicine · doi:10.1038/nm.2768 · Cited by 296
Thevenot, P. T., Saravia, J., Jin, N., Giaimo, J. D., Chustz, R. E., Mahne, S., Kelley, M. A., Hebert, V. Y., Dellinger, B., Dugas, T. R., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0052oc · Cited by 110
RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking
Haley, K. J., Lasky-Su, J., Manoli, S. E., Smith, L. A., Shahsafaei, A., Weiss, S. T., & Tantisira, K. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00348.2010 · Cited by 58
Metadata
- Authors
- Holgate, S. T.
- Venue
- Allergology International
- Publisher
- Japanese Society of Allergology
- Published
- 2008
- Volume
- 57
- Issue
- 1
- Pages
- 1-10
- ISSN
- 1323-8930 (ISSN-L)
- OpenAlex
- W2092067512
- Cited by
- 332
- References
- 84
- FWCI
- 20.11
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
