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Cited by 63Hormonal and reproductive studiesAdrenal Hormones and DisordersPancreatic function and diabetes

Two Years of Treatment With Dehydroepiandrosterone Does Not Improve Insulin Secretion, Insulin Action, or Postprandial Glucose Turnover in Elderly Men or Women

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Basu, Rita, Dalla Man, Chiara, Campioni, Marco, Basu, Ananda, Nair, K. Sree, Jensen, Michael D., Khosla, Sundeep, Klee, George +3 more·2007·Diabetes
DOI 10.2337/db06-1504
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Abstract

To determine if dehydroepiandrosterone (DHEA) replacement improves insulin secretion, insulin action, and/or postprandial glucose metabolism, 112 elderly subjects with relative DHEA deficiency ingested a labeled mixed meal and underwent a frequently sampled intravenous glucose tolerance test before and after 2 years of either DHEA or placebo. Despite restoring DHEA sulphate concentrations to values observed in young men and women, the changes over time in fasting and postprandial glucose concentrations, meal appearance, glucose disposal, and endogenous glucose production were identical to those observed after 2 years of placebo. The change over time in postmeal and intravenous glucose tolerance test insulin and C-peptide concentrations did not differ in men treated with DHEA or placebo. In contrast, postmeal and intravenous glucose tolerance test change over time in insulin and C-peptide concentrations were greater (P < 0.05) in women after DHEA than after placebo. However, since DHEA tended to decrease insulin action, the change over time in disposition indexes did not differ between DHEA- and placebo-treated women, indicating that the slight increase in insulin secretion was a compensatory response to a slight decrease in insulin action. We conclude that 2 years of replacement of DHEA in elderly men and women does not improve insulin secretion, insulin action, or the pattern of postprandial glucose metabolism.

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  • Use of the meal minimal model in conjunction with the triple tracer method permits robust model assessments of indices of insulin action on the periphery (SI) and on the liver (SIL), glucose effectiveness (SG), insulin secretion, and β-cell function (disposition index).

    “Furthermore, use of the meal minimal model in conjunction with the triple tracer method permits robust model assessments of indices of insulin action on the periphery (SI) and on the liver (SIL), glucose effectiveness (SG), insulin secretion, and β-cell function (disposition index).[49][50][51][52][53][54][55][56][57][58][59][60][61]”

    From Developing the UVA/Padova Type 1 Diabetes Simulator: Modeling, Validation, Refinements, and Utility (2023) · cites this paper as [51]

    The Research Design and Methods section describes meal minimal models estimating insulin sensitivity, glucose effectiveness, insulin secretion, and disposition indexes; it also describes tracer-based measurements of glucose turnover. It does not report a separate index of insulin action on the liver (SIL), and its statement that the tracer approach is virtually model independent concerns glucose-turnover measurements, not the robustness of all the listed model indices. Page numbers were not available in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • These sophisticated models became possible because of unique phenotypic data of carbohydrate metabolism obtained from studies in >200 adults and children applying the triple tracer technique.

    “These sophisticated models became possible because of unique phenotypic data of carbohydrate metabolism obtained from studies conducted in >200 adults and children applying the triple tracer technique to derive key metabolic indices and parameters.[48][49][50][51][52][53][54]”

    From Developing the UVA/Padova Type 1 Diabetes Simulator: Modeling, Validation, Refinements, and Utility (2023) · cites this paper as [51]

    The Research Design and Methods section says the study used a triple-tracer approach to calculate glucose turnover and glucose minimal models to derive metabolic parameters. Table 1 lists 113 elderly men and women, not children. This paper can serve as an example of a triple-tracer study, but it does not establish the citing sentence’s aggregate of more than 200 adults and children or say that its data made the models possible. (LLM, conf=0.85)

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Authors
Basu, R., Dalla Man, C., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C., & Rizza, R. A.
Affiliations
  • Mayo Clinic (US)
  • Department of Electronics and Informatics, University of Padova, Padova, Italy
  • University of Padua (IT)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2007-03-01
Volume
56
Issue
3
Pages
753-766
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db06-1504
OpenAlex
W2167285563
Semantic Scholar
cb7d03ba6fe1aecc8780192c7415f4d2d1a07450
Cited by
63
References
51
Citations by year
2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 4
FWCI
5.13
Type
journal article
Language
en
Open access
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
  • American Diabetes Association
  • Mayo Foundation for Medical Education and Research
  • Ministero dell’Istruzione, dell’Università e della Ricerca
  • Novo Nordisk
  • U.S. Public Health Service (DK29953, RR-00585)
  • National Institute on Aging (AG14383, P01AG014383)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, DK50456, DK 29953)
  • National Institute of Biomedical Imaging and Bioengineering (EB 01975, P41EB001975)
  • National Center for Research Resources (RR-00585, M01RR000585)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
dehydroepiandrosterone, DHEA replacement therapy, insulin secretion, insulin action, insulin resistance, postprandial glucose metabolism, glucose turnover, older adults, sex differences, C-peptide, disposition index, endogenous glucose production
MeSH terms
Insulin Secretion, Adjuvants, Immunologic, Aged, Body Composition, C-Peptide, Dehydroepiandrosterone, Double-Blind Method, Drug Administration Schedule, Estrogens, Female, Gastrointestinal Motility, Glucagon, Glucose, Humans, Hydrocortisone, Insulin, Liver, Male, Sex Characteristics, Growth Hormone, Testosterone, Time Factors, Dehydroepiandrosterone Sulfate, Postprandial Period

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